- Argentina (Español)
- Australia (English)
- Österreich (Deutsch)
- Belgique (Français)
- België (Nederlands)
- Bolivia (Español)
- Brasil (Português)
- Canada (English)
- Canada (Français)
- Chile (Español)
- Colombia (Español)
- Costa Rica (Español)
- Česká republika (Čeština)
- Danmark (Dansk)
- Deutschland (Deutsch)
- Germany (English)
- Ecuador (Español)
- El Salvador (Español)
- España (Español)
- Espanya (Català)
- France (Français)
- Ελλάδα (Ελληνική)
- Guatemala (Español)
- Honduras (Español)
- Hong Kong (English)
- 香港 (中文)
- India (English)
- Indonesia (Bahasa Indonesia)
- Indonesia (English)
- Ireland (English)
- Israel (English)
- ישראל (עִבְרִית)
- Italia (Italiano)
- 日本 (日本語)
- Malaysia (English)
- Malaysia (Melayu)
- México (Español)
- Nederland (Nederlands)
- New Zealand (English)
- Nicaragua (Español)
- Norge (Norsk)
- Panamá (Español)
- Paraguay (Español)
- Perú (Español)
- Philippines (English)
- Polska (Polski)
- Portugal (Português)
- Puerto Rico (Español)
- República Dominicana (Español)
- România (Română)
- المملكة العربية السعودية (العَرَبِيَّة)
- Saudi Arabia (English)
- Suisse (Français)
- Schweiz (Deutsch)
- Singapore (English)
- South Africa (English)
- 대한민국 (한국어)
- Suomi (Suomi)
- Sverige (Svenska)
- 台灣 (中文)
- ประเทศไทย (ภาษาไทย)
- Thailand (English)
- Türkiye (Türkçe)
- Україна (Українська)
- United Arab Emirates (English)
- United Kingdom (English)
- United States (English)
- Estados Unidos (Español)
- Uruguay (Español)
- Venezuela (Español)
- Vietnam (English)
- Việt Nam (Việt)

Flight Deals
Cheap Flights from Louisville to South America
Cheapest round-trip prices found by our users on KAYAK in the last 5 daysBook Cheap Louisville to South America Plane Tickets
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Louisville to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.
Recent round-trip flight deals from Louisville to South America
Fri, Jan 8 - Sat, Jan 16
11:39 am - 11:30 amSDF Louisville Intl-CTG Cartagena Rafael Nunez
23h 51m2 stops New Orleans Louis Armstrong Orlando
12:45 pm - 3:14 pmCTG Cartagena Rafael Nunez-SDF Louisville Intl
26h 29m1 stop Orlando
$545Multiple Airlines
Sat, Jan 2 - Sat, Jan 16
7:36 pm - 12:00 pmSDF Louisville Intl-MDE Medellín Jose Maria Cordova Intl
16h 24m2 stops Raleigh-Durham Orlando
1:10 pm - 3:14 pmMDE Medellín Jose Maria Cordova Intl-SDF Louisville Intl
26h 04m1 stop Orlando
$550Multiple Airlines
Wed, Mar 3 - Mon, Mar 8
5:49 am - 2:10 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
8h 21m1 stop Atlanta Hartsfield-Jackson
3:30 pm - 10:35 pmCTG Cartagena Rafael Nunez-SDF Louisville Intl
7h 05m1 stop Atlanta Hartsfield-Jackson
$605Delta
Thu, Jan 7 - Thu, Jan 14
7:00 am - 2:50 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
7h 50m1 stop Houston George Bush Intcntl
4:00 pm - 1:26 pmCTG Cartagena Rafael Nunez-SDF Louisville Intl
21h 26m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
$609United Airlines
Tue, Jan 5 - Thu, Jan 14
7:00 am - 2:50 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
7h 50m1 stop Houston George Bush Intcntl
4:00 pm - 1:26 pmCTG Cartagena Rafael Nunez-SDF Louisville Intl
21h 26m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
$609United Airlines
Tue, Jan 5 - Wed, Jan 13
5:00 am - 1:36 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
8h 36m1 stop Miami
2:35 pm - 11:59 pmCTG Cartagena Rafael Nunez-SDF Louisville Intl
9h 24m1 stop Miami
$647American Airlines
Wed, Mar 3 - Mon, Mar 8
6:00 am - 1:30 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
7h 30m1 stop Miami
4:27 pm - 10:55 amCTG Cartagena Rafael Nunez-SDF Louisville Intl
18h 28m2 stops Miami Washington, D.C. Reagan-National
$649American Airlines
Sun, Jan 24 - Wed, Feb 17
7:59 pm - 8:10 pmSDF Louisville Intl-BOG Bogotá El Dorado
24h 11m2 stops Atlanta Hartsfield-Jackson Miami
9:00 am - 12:16 amBOG Bogotá El Dorado-SDF Louisville Intl
15h 16m1 stop Atlanta Hartsfield-Jackson
$754LATAM Airlines
Sun, Jan 24 - Wed, Feb 17
7:59 pm - 8:10 pmSDF Louisville Intl-BOG Bogotá El Dorado
24h 11m2 stops Atlanta Hartsfield-Jackson Miami
9:00 am - 12:16 amBOG Bogotá El Dorado-SDF Louisville Intl
15h 16m2 stops Orlando Atlanta Hartsfield-Jackson
$759LATAM Airlines
Thu, Dec 10 - Tue, Dec 22
8:05 am - 8:05 amSDF Louisville Intl-LIM Lima J Chavez Intl
24h 00m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado
12:10 pm - 12:23 amLIM Lima J Chavez Intl-SDF Louisville Intl
12h 13m1 stop Atlanta Hartsfield-Jackson
$966Delta
Recent one-way flight deals from Louisville to South America
Tue, Dec 29
6:22 pm - 12:00 pmSDF Louisville Intl-MDE Medellín Jose Maria Cordova Intl
17h 38m1 stop Orlando Sanford Intl
$267Multiple Airlines
Sat, Dec 5
5:12 pm - 8:35 amSDF Louisville Intl-CTG Cartagena Rafael Nunez
39h 23m3 stops Raleigh-Durham Orlando Panama City Tocumen Intl
$295Multiple Airlines
Sat, Dec 5
7:00 pm - 1:36 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
18h 36m2 stops Charlotte Douglas Miami
$400American Airlines
Tue, Dec 15
5:31 pm - 1:36 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
20h 05m2 stops Dallas/Fort Worth Miami
$413American Airlines
Mon, Dec 28
2:00 pm - 1:10 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
23h 10m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$424United Airlines
Mon, Dec 28
6:00 pm - 10:35 pmSDF Louisville Intl-BOG Bogotá El Dorado
28h 35m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
$434United Airlines
Sat, Nov 28
8:05 am - 7:30 pmSDF Louisville Intl-BOG Bogotá El Dorado
11h 25m1 stop Atlanta Hartsfield-Jackson
$474Delta
Mon, Dec 28
6:03 am - 2:01 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
7h 58m1 stop Atlanta Hartsfield-Jackson
$528Delta
Wed, Dec 16
7:05 am - 2:05 pmSDF Louisville Intl-BOG Bogotá El Dorado
31h 00m2 stops Atlanta Hartsfield-Jackson Cartagena Rafael Nunez
$641LATAM Airlines
Tue, Dec 22
6:56 pm - 8:55 pmSDF Louisville Intl-UIO Quito Mariscal Sucr
25h 59m1 stop Atlanta Hartsfield-Jackson
$666LATAM Airlines
Recent last minute flight deals from Louisville to South America
Wed, Nov 18 - Mon, Nov 23
8:05 am - 7:30 pmSDF Louisville Intl-BOG Bogotá El Dorado
11h 25m1 stop Atlanta Hartsfield-Jackson
9:00 am - 12:10 amBOG Bogotá El Dorado-SDF Louisville Intl
15h 10m1 stop Atlanta Hartsfield-Jackson
$787LATAM Airlines
Wed, Nov 18 - Mon, Nov 23
8:05 am - 7:30 pmSDF Louisville Intl-BOG Bogotá El Dorado
11h 25m1 stop Atlanta Hartsfield-Jackson
12:15 pm - 12:10 amBOG Bogotá El Dorado-SDF Louisville Intl
11h 55m2 stops Cartagena Rafael Nunez Atlanta Hartsfield-Jackson
$798LATAM Airlines
Wed, Nov 18 - Mon, Nov 23
7:30 am - 10:20 pmSDF Louisville Intl-BOG Bogotá El Dorado
14h 50m2 stops Philadelphia Miami
8:00 am - 10:30 pmBOG Bogotá El Dorado-SDF Louisville Intl
14h 30m2 stops Miami Philadelphia
$806American Airlines
Thu, Nov 12 - Tue, Nov 17
6:54 pm - 3:36 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez
20h 42m2 stops Dallas/Fort Worth Miami
4:37 pm - 10:47 amCTG Cartagena Rafael Nunez-SDF Louisville Intl
18h 10m2 stops Miami Washington, D.C. Reagan-National
$827American Airlines
Thu, Nov 12 - Sun, Nov 15
9:55 am - 12:55 amSDF Louisville Intl-LIM Lima J Chavez Intl
15h 00m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl
4:40 pm - 6:32 pmLIM Lima J Chavez Intl-SDF Louisville Intl
25h 52m2 stops Panama City Tocumen Intl Chicago O'Hare Intl
$1,014Copa Airlines
Sat, Nov 14 - Mon, Nov 16
9:10 am - 11:55 pmSDF Louisville Intl-LIM Lima J Chavez Intl
14h 45m1 stop Houston George Bush Intcntl
1:50 am - 1:23 pmLIM Lima J Chavez Intl-SDF Louisville Intl
11h 33m1 stop Houston George Bush Intcntl
$1,033United Airlines
Thu, Nov 12 - Sat, Nov 14
5:10 am - 11:55 pmSDF Louisville Intl-LIM Lima J Chavez Intl
18h 45m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
1:50 am - 8:52 pmLIM Lima J Chavez Intl-SDF Louisville Intl
19h 02m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$1,037United Airlines
Thu, Nov 12 - Sun, Nov 15
10:00 am - 9:20 pmSDF Louisville Intl-LIM Lima J Chavez Intl
11h 20m1 stop Atlanta Hartsfield-Jackson
11:40 pm - 11:56 amLIM Lima J Chavez Intl-SDF Louisville Intl
12h 16m1 stop Atlanta Hartsfield-Jackson
$1,039LATAM Airlines
Tue, Nov 17 - Sat, Nov 28
1:01 pm - 9:40 amSDF Louisville Intl-EZE Buenos Aires Ministro Pistarini
18h 39m1 stop Atlanta Hartsfield-Jackson
11:35 pm - 11:56 amEZE Buenos Aires Ministro Pistarini-SDF Louisville Intl
14h 21m1 stop Atlanta Hartsfield-Jackson
$1,220Multiple Airlines
Sat, Nov 14 - Mon, Nov 23
7:05 am - 6:25 amSDF Louisville Intl-GIG Rio de Janeiro–Galeão Intl
21h 20m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl
5:30 pm - 2:15 pmGIG Rio de Janeiro–Galeão Intl-SDF Louisville Intl
22h 45m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson
$1,251Delta
Booking Insights
KAYAK's insights & trends for Louisville to South America flights
Get data-powered insights and trends into flights from Louisville to South America to help you find the cheapest flights, the best time to fly and much more.
Prices
Airlines
More
Good to know
Low season | February |
|---|---|
High season | June |
FAQs - booking South America flights
Reviews of the top 4 airlines serving from Louisville to South America
7.8
DeltaOverall score based on 8707 reviews
8.5Crew
8.1Boarding
7.8Entertainment
7.8Comfort
7.2Food
Airline reviews
The bathroom is disgustingly dirty. It looks like the crew members didn’t clean it on a regular basis. Also, who made the bathroom so small?. I am not a big girl but I still feel very cramped inside. Def unpleasant experience to use the bathroom.
4.0 OkaySue, Nov 2026
The bathroom is disgustingly dirty. It looks like the crew members didn’t clean it on a regular basis. Also, who made the bathroom so small?. I am not a big girl but I still feel very cramped inside. Def unpleasant experience to use the bathroom.
My experience with Delta is always pleasant. My return flight #1426 from ATL to RIC was very delayed with departure and landing. It also took a substantial amount of time for baggage claim. It was already late at night, so the delays made for a very long day. I did not get home until after 12 midnight.
I had a great flight with delta. Plane was clean and the staff was nice, I would fly again with delta.
After flying with Qatar Airways and Kenya Airlines. Delta leaves a lot to be desired
Bad. Flight was delayed due to maintenance issue with Delta. Seats were small, no service, bag got broken on initial flight. Cramped and hot. Sitting inside with no ac.
No snacks not been water was offered I fly weekly and have to select Economy or extra comfort per business rules but will choose American at least they offer mid seat class passengers water. on short flights. The WIFI was awful on the plane as well. The thing I can not figure out is why you treat business class people this way we spend more money that your one trip first class passengers cumulative than others maybe look at the company name of the people flying and treat us better as there are thousands of us flying weekly and choose what airline we want to select.
The boarding agent guy in Lexington on 7/23 that boarded the flights to Atlanta is very rude for working in customer service. I know there were delays but he was dismissive rude and arrogant. Most native Kentucky residents are nice and very cordial he needs to eat a big ole piece of humble pie. I watched him be rude to several people and as much as he could of filled up a delayed flight to save you money and he was so rude to people it was ridiculous. Next no water or snacks on short flights is awful 1st you delay a flight then do not even offer water on the flight.. No thanks I like delta better but I travel ever week and to be treated like this might as well fly American at least they offer water and have better rewards.
The staff was fine. The plane was extremely tight, and I paid for the wifi and it did not work at all. I was actually going to ask for a refund.
Left on time and arrived early this extending our 31 minute transfer. Bags made it also!
The crew was very polite as I have a few handicaps and everything was made pleasant. Check-in was easy as I was brought on board by the wheelchair assistant. One flight attendant did make sure my personal item was carefully stored under the seat in front of me. I was made to feel welcome as a customer as I made my first trip with a few disabilities. Entertainment and wifi worked quite well. The only food service were snacks and drinks. Those were okay. Overall it was a very smooth flight and encouraged me to use Delta again.
Abysmal overall. Delayed flight caused me to get in with an only 9 minute connection. No help from flight attendants or gate agents to try to make the connection. Second flight left 5 minutes early despite not having at least 10 people on it, including me. Rebooked 24 hours later. I asked four separate delta agents how to ensure my bag would get on the rebooked flight and all assured me it would be there. Landing in Rio right now, 24 hours late, and just got an alert that my bag didn’t make it. Horrible overall experience.
4 hour delay. So our flight schedule mass up. Your worker told me you should rebooking myself. I was very angry. Latam Airline always get the money more through any way. But They have no concern passenger.
Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.
Deleted flight made me loose my connection flight now stuck in Atlanta for a day
Apart of Sky miles delta. And they go everywhere in Brazil
We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing
I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money
Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.
The flight was late. Please do not delay next time.
I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.
Very uncomfortable and cramped seats. Everything else was okay, the crew members were nice but nothing was exceptional.
Check in went smoothly. Flight attendant who was assigned my area barely paid any attention to me! She acted as though she was extremely busy and flustered. Maybe she was new?! I told her to change the language on my screen, she said she’d come back to help me but never did so I was able to solve the problem on my own. She came back and said she’d made adjustments on her end. Highly doubt it because I found the setting to change the language! Also, I noticed everyone was eating before we landed so I pushed my help button and she never came so I got up to find her to ask her if I can have breakfast. She said they are not serving breakfast but I can have a sandwich. Yes, that was her response as I saw everyone eating breakfast!!!
United staff were very communicative, the new starlink Wifi is amazing as I was able to work easily.
Starlink internet made the flight time shrink and I was able to work.
Tiny seat made for midgets. You can’t put a normal size human in such a tiny seat for 8 god damn hours! Hot plane, no air. Lost bags at Rome airport for 8 hours, lucky to have found them. Horrible flying experience, United Airlines should be embarrassed!
The issue is the flight is delayed, which causes me Missing the connecting flight by 3 mins. Remember the connecting flight is a US codeshare flight so UA should be able to inform the operating airline about the delay.
Seats are made for children. An 8 hour flight with tiny seats is more like a cattle car. Lost bags at Rome airport caused a 7 hour delay.
The first leg of my trip the Republic Airlines aircraft was late due to a maintenance problem. Then I called United to reroute. Their reroute airline lost my bag but found it and returned it two days later. Hopefully my return trip home is better.
The male air hostess was rude and didn’t provide good customer service. Didn’t even offer me a drink
This trip was a Christmas gift to our family. We were flying from Lexington to Palm Springs. When we were checking in the ticket agent said one bags was over weight by 4 LBS. We were flying first class which has baggage weight of 70 LBS per bag, one bag was 54LBS. We then had to take items from one bag to another. The agent also saw we had a dog with us. Once on the plane we were seated with the dog in the carrier. The United ticket agent came in the plane with two other people, I believe one was TSA and the other some security officer. The United agent said we had not paid for the dog ticket. We had paid for the ticket when we purchased our tickets. She did not give me time to find the email receipt. She then threatened all three of us with either I come with her or she would have all three of physically removed from the plane. I left the plane to pay for another ticket. She had to take my credit back to where we checked in. She acted as if it needed to be done immediately. She said we had 3 minutes. We then sat at the gate for approximately another 45 minutes. This was so embarrassing…to be threatened to be removed from a plane that we paid for all tickets including the dog. The flight attendance on the next leg of our trip were not very attentive to the passengers. On the plus side all the flights were on time. All in all, this was a miserable way to start a holiday vacation. United Airlines showed no compassion towards the whole incident. I feel we were purposely neglected.
All good. Flight crew was super friendly at the end of a long day
Ultimately fine but plane seemed dated and creaky and landing was hard…. At no time did I feel unsafe so thank you.
Better perks for corporate employees whom travel often and spend a lot of money with the airlines. Snacks were terrible chips crackers are ideas. Flight and crew were great comfort was fine entertainment not so great so so called status members means nothing
Flight had mechanical issues and it was delayed 30 mins - some of us boarded and then had to deplane.
Delayed flight. Missed connection, AA put us on a later connecting flight. The connection flight was delayed 4 times and we had to deplane. Didnt get home until 3am, when I was supposed to be home at 8:30p. Zero compensation offered from American. I would not fly them again.
Better snacks but flight and crew were amazing on this flight
The AA app really sucks ... Every flight & connecting flights were delayed over 30 mins. One connecting flight on American Eagle said it was delayed in its arrival ... when it was actually parked across from the gate for over 1 hr before they pulled it to the gate. Seats in the economy/ main cabin are packed together like sardines ... no leg room.
To start, I’d like to say that every American Airline personnel I interacted with on the ground, especially flight crew, was very friendly and did their best to help me out. Despite this, however, my experience with the airline was an entire mess. The 7:19 PM flight was heavily delayed due to weather, and pushed to 10:30 AM the next morning. Because of this, I had to spend the night inside of the airport. At some point later in the night, I got an email saying that the flight had been canceled. I called the support number, and the representative on the other line told me that the flight was still on and that I didn’t need to rebook. The next morning, no one came to the gate to open the door for the crew until almost 11 AM. By this time the flight crew had been waiting for over an hour, and they had called management to get someone to open the door for them multiple times. Around 11:30, the gate screen had changed to a different flight. I ended up buying a last minute ticket with Southwest airline just to get to Chicago, because the next flight with American wasn’t until 7:19 pm that day. Now, earlier that morning my suitcase had been sent ahead of me to ORD. I went to baggage claim to ask them if I could have my suitcase forwarded to where I was staying. The representative at SDF baggage claim said they could and put the claim in for me. As I was going back through TSA, I got an email that the airline had found my suitcase, but the next step was to send it BACK to SDF. I called the airline support number again, and I made it clear that my suitcase needed to stay in Chicago and to not come back to SDF. The representative told me that they would hold my suitcase at ORD and that it wasn’t going to be forwarded anywhere. Once I got there, I found that they had loaded my suitcase onto a plane to send it back to SDF. Thankfully, I had gotten to the baggage claim counter in time for them to put in a request to bring my suitcase back up. My refund with the airline is processing already, but because of this entire experience and miscommunication at every turn of the way, I will not book with American Airlines in the future.
Cabin was roomy enough to easily slide my carry on under the seat in front of me!
They needed to de-ice the plane. Apparently airlines have a problem keeping their de-icing vehicles in good repair. After we backed away from the gate we sat and didn't move for nearly an hour. Nearly an HOUR with minimal communication from the flight crew. Eventually the sun took care of what American Airlines could not and melted the minimal ice. We finally took of a hour late which, in turn, jacked up our connection in Chicago.
More options for your flight to South America
Complete your trip to South America with a hotel stay or car rental
Information on your arrival and departure airports
Cabin class types available on flights to Louisville
Cabin classes available on flights to South America. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights from domestic origins to Louisville
Flights from all regions of Louisville to South America. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights to other popular destinations
The most popular flights on KAYAK according to clicks in the last 2 weeks. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights to popular destinations in South America
Flights to Argentinafrom $1,076
Flights to Boliviafrom $942
Flights to Brazilfrom $1,142
Flights to Chilefrom $1,171
Flights to Colombiafrom $764
Flights to Ecuadorfrom $991
Flights to Perufrom $856
Flights to Uruguayfrom $1,225