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MFR - TYS

$389 Find Cheap Flights from Medford to Knoxville - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$522
Typical prices: $444-$721
United Airlines
Tue 1/30Sat 2/3
MFR - TYS • 1 stop
Cheapest one-way
$389
Typical prices: $274-$427
United Airlines
Sun 11/11
MFR - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Medford and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
April
Cheapest • 32% price drop
April
Most popular
Good to know
+1
Good to know
+1
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Flight Deals

Cheap Flights from Medford to Knoxville (MFR-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medford to Knoxville

Sat, Jan 30 - Wed, Feb 3
United Airlines Logo
5:10 am - 2:36 pmMFR  Medford-TYS Knoxville McGhee Tyson
6h 26m1 stop Denver Intl
United Airlines Logo
10:45 am - 7:55 pmTYS  Knoxville McGhee Tyson-MFR Medford
12h 10m2 stops Chicago O'Hare Intl San Francisco
$522United Airlines
Sat, Jan 30 - Wed, Feb 3
United Airlines Logo
6:00 am - 12:05 amMFR  Medford-TYS Knoxville McGhee Tyson
15h 05m2 stops San Francisco Washington, D.C. Dulles Intl
United Airlines Logo
10:45 am - 7:55 pmTYS  Knoxville McGhee Tyson-MFR Medford
12h 10m2 stops Chicago O'Hare Intl San Francisco
$527United Airlines
Sat, Jan 30 - Wed, Feb 3
United Airlines Logo
5:10 am - 2:36 pmMFR  Medford-TYS Knoxville McGhee Tyson
6h 26m1 stop Denver Intl
United Airlines Logo
4:25 pm - 9:10 pmTYS  Knoxville McGhee Tyson-MFR Medford
7h 45m1 stop Denver Intl
$563United Airlines
Mon, Feb 8 - Thu, Feb 11
Delta Logo
6:05 am - 11:46 pmMFR  Medford-TYS Knoxville McGhee Tyson
14h 41m2 stops Seattle/Tacoma Intl Atlanta Hartsfield-Jackson
Delta Logo
12:00 pm - 11:12 pmTYS  Knoxville McGhee Tyson-MFR Medford
14h 12m2 stops Atlanta Hartsfield-Jackson Seattle/Tacoma Intl
$758Delta
Mon, Feb 8 - Thu, Feb 11
Delta Logo
6:05 am - 11:46 pmMFR  Medford-TYS Knoxville McGhee Tyson
14h 41m2 stops Seattle/Tacoma Intl Atlanta Hartsfield-Jackson
Delta Logo
12:00 pm - 11:12 pmTYS  Knoxville McGhee Tyson-MFR Medford
14h 12m2 stops Atlanta Hartsfield-Jackson Seattle/Tacoma Intl
$758Delta
Mon, Nov 23 - Fri, Nov 27
American Airlines Logo
5:04 am - 9:41 pmMFR  Medford-TYS Knoxville McGhee Tyson
13h 37m2 stops Phoenix Sky Harbor Intl Charlotte Douglas
American Airlines Logo
7:50 am - 4:47 pmTYS  Knoxville McGhee Tyson-MFR Medford
11h 57m2 stops Philadelphia Phoenix Sky Harbor Intl
$967American Airlines
Wed, Nov 25 - Sun, Nov 29
American Airlines Logo
5:04 am - 8:50 pmMFR  Medford-TYS Knoxville McGhee Tyson
12h 46m2 stops Phoenix Sky Harbor Intl Philadelphia
American Airlines Logo
5:30 am - 12:58 pmTYS  Knoxville McGhee Tyson-MFR Medford
10h 28m2 stops Dallas/Fort Worth Phoenix Sky Harbor Intl
$1,346American Airlines
Wed, Nov 25 - Sun, Nov 29
American Airlines Logo
5:04 am - 8:50 pmMFR  Medford-TYS Knoxville McGhee Tyson
12h 46m2 stops Phoenix Sky Harbor Intl Philadelphia
American Airlines Logo
5:30 am - 12:58 pmTYS  Knoxville McGhee Tyson-MFR Medford
10h 28m2 stops Dallas/Fort Worth Phoenix Sky Harbor Intl
$1,346American Airlines
Booking Insights

Price, demand and travel trends for Medford to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Medford to Knoxville?

Round-trip flights from Medford to Knoxville typically range from $444 to $721. The lowest price found in the past 5 days was $522, on United Airlines.

Find deals

Key details for Medford to Knoxville flights

Low season

July

Cheapest flight

$389
Beat the crowds with an average 44% drop in travelers.
The most popular month to fly with an average 122% increase in travelers.
One-way flight from Medford to Knoxville

When to book flights from Medford to Knoxville

Are your dates flexible? Find out the best times to travel from Medford to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Medford to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Medford to Knoxville?

    Two cabin classes are available on flights from Medford to Knoxville:

    • Economy Class
    • First Class

  • How long is a flight from Medford to Knoxville?

    A nonstop flight from Medford to Knoxville takes 00m, covering 2,113 miles.

  • Do I need a passport to fly from Medford to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Medford to Knoxville flight?

    Round-trip flights from Medford to Knoxville range from $444 to $721, with an average of $615 over the past 12 months. Anything below $444 counts as a good deal.

  • Have flight prices from Medford to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $522 to $1,564. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Medford to Knoxville looking right now?

    One-way fares from Medford to Knoxville are currently higher than usual. Average one-way flight prices are about $439, which is 17% above the typical average for this route.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:

    • Budget
    • Alamo
    • Thrifty
    • Enterprise Rent-A-Car
    • Payless

  • Which airports can I use when flying from Medford to Knoxville?

    Flights from Medford to Knoxville usually depart from Medford (MFR) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Medford to Knoxville pass through?

    Most connecting flights from Medford to Knoxville pass through Denver Intl (DEN), which handles 100% of one-stop traffic on this route.

  • Can I save money by using flexible dates for flights from Medford to Knoxville?

    Yes. Flexible dates can save you up to 47% on flights from Medford to Knoxville. Tuesday is the cheapest departure day at $444 round-trip on average, while Thursday is the most expensive at $828, a difference of $384.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What is the time difference between Medford and Knoxville?

    Knoxville is 3 hours ahead of Medford (Eastern Time vs Pacific Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Medford to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Tuesday departure and avoid flying on Thursday. On this route, Tuesday flights average $444, about $384 less than Thursday fares (46% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Medford to Knoxville trip for April. Fares historically average $417 round-trip in that month - typically $495 less than the most expensive month, which is October (based on the last 12 months).

More options for your flight from Medford to Knoxville

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