MFR - TYS

$449 Find Cheap Flights from Medford to Knoxville

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Medford to Knoxville departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medford to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medford to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$449
Typical prices: $544-$421
United Airlines
Tue 4/14Sat 4/18
MFR - TYS • 1 stop
Cheapest one-way
$453
United Airlines
Tue 4/7
MFR - TYS • 1 stop
Top airlines
United Airlines
Cheapest • from $449 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Medford and Knoxville. You'll need at least 1 connection.
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We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Medford to Knoxville (MFR-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Medford to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medford to Knoxville

Tue, Apr 14 - Sat, Apr 18
United Airlines Logo
5:00 am - 3:06 pm
MFR
-
TYS
7h 06m
1 stop
United Airlines Logo
4:30 pm - 9:38 pm
TYS
-
MFR
8h 08m
1 stop
$449United Airlines
Tue, Apr 14 - Sat, Apr 18
United Airlines Logo
5:00 am - 3:06 pm
MFR
-
TYS
7h 06m
1 stop
United Airlines Logo
7:00 am - 5:53 pm
TYS
-
MFR
13h 53m
2 stops
$454United Airlines
Tue, Apr 14 - Sat, Apr 18
Delta Logo
5:28 pm - 9:22 am
MFR
-
TYS
12h 54m
2 stops
Delta Logo
6:15 am - 11:47 am
TYS
-
MFR
8h 32m
2 stops
$459Delta
Thu, Apr 16 - Mon, Apr 20
United Airlines Logo
5:00 am - 3:06 pm
MFR
-
TYS
7h 06m
1 stop
United Airlines Logo
4:30 pm - 9:37 pm
TYS
-
MFR
8h 07m
1 stop
$476United Airlines
Thu, Apr 16 - Mon, Apr 20
United Airlines Logo
12:50 pm - 10:29 pm
MFR
-
TYS
6h 39m
1 stop
United Airlines Logo
4:30 pm - 9:37 pm
TYS
-
MFR
8h 07m
1 stop
$650United Airlines
Thu, Apr 16 - Mon, Apr 20
United Airlines Logo
12:50 pm - 10:29 pm
MFR
-
TYS
6h 39m
1 stop
United Airlines Logo
4:30 pm - 9:37 pm
TYS
-
MFR
8h 07m
1 stop
$693United Airlines
Thu, Apr 16 - Mon, Apr 20
United Airlines Logo
12:50 pm - 10:29 pm
MFR
-
TYS
6h 39m
1 stop
United Airlines Logo
5:15 pm - 11:48 am
TYS
-
MFR
21h 33m
2 stops
$698United Airlines
Mon, May 4 - Sun, May 10
United Airlines Logo
6:36 pm - 10:49 am
MFR
-
TYS
13h 13m
2 stops
United Airlines Logo
4:20 pm - 9:31 pm
TYS
-
MFR
8h 11m
1 stop
$710United Airlines
Thu, Apr 16 - Mon, Apr 20
United Airlines Logo
12:50 pm - 10:29 pm
MFR
-
TYS
6h 39m
1 stop
United Airlines Logo
7:00 am - 9:37 pm
TYS
-
MFR
17h 37m
2 stops
$719United Airlines
Thu, Apr 16 - Mon, Apr 20
United Airlines Logo
12:50 pm - 10:29 pm
MFR
-
TYS
6h 39m
1 stop
United Airlines Logo
5:53 pm - 11:48 am
TYS
-
MFR
20h 55m
2 stops
$724United Airlines
Booking Insights

KAYAK's insights & trends for Medford to Knoxville flights

Get data-powered insights and trends into flights from Medford to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Medford to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Medford to Knoxville departing in April.
Find deals

Good to know

Low seasonNovember
Cheapest flight$449
Best time to beat the crowds with an average 31% drop in price.
Most popular time to fly and prices are also 8% lower on average.
Flight from Medford to Knoxville

When to book flights from Medford to Knoxville

Are your dates flexible? Find out the best times to travel from Medford to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Medford to Knoxville

  • What is the cheapest flight from Medford to Knoxville?

    In the last 3 days, the lowest price for a flight from Medford to Knoxville was $453 for a one-way ticket and $449 for a round-trip.

  • Do I need a passport to fly between Medford and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which aircraft models fly most regularly from Medford to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Medford to Knoxville?

    Star Alliance is the only airline alliance operating flights between Medford and Knoxville.

  • How does KAYAK find such low prices on flights from Medford to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Medford to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Medford to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Medford is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Medford to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Medford with another airline. Booking your flights between Medford and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Medford to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Medford up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Medford to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Medford to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Medford to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9529 reviews
7.7Boarding
7.3Comfort
7.1Entertainment
6.6Food
8.1Crew
Airline reviews

Just a bad day to fly. Flight was delayed from scheduled 6:50 pm departure to 8:50 pm. Combination of factors mostly related to weather at the destination airport (which is where the incoming flight originated) which delayed the inbound flight over an hour. Once on board, we taxied but had to hold again on the taxiway for 10 minutes or so. We did not get wheels up until after 9 pm. The flight was smooth but about 18 minutes from our destination, we had to hold for several minutes more due to weather at ORD. We finally landed at ORD about 11:08 pm (accounting for the time difference, that was about a 3 hour delay from our scheduled departure time). It felt like we were never going to get to our destination. But the flight crew and attendants were very good. The movie selection onboard was also very nice. Got to watch half of a movie just during our taxi from the gate at ATL due to the delay!

2.0 MediocreDr. Joseph, Apr 2026
ATL - ORD
Read more United Airlines reviews

Just a bad day to fly. Flight was delayed from scheduled 6:50 pm departure to 8:50 pm. Combination of factors mostly related to weather at the destination airport (which is where the incoming flight originated) which delayed the inbound flight over an hour. Once on board, we taxied but had to hold again on the taxiway for 10 minutes or so. We did not get wheels up until after 9 pm. The flight was smooth but about 18 minutes from our destination, we had to hold for several minutes more due to weather at ORD. We finally landed at ORD about 11:08 pm (accounting for the time difference, that was about a 3 hour delay from our scheduled departure time). It felt like we were never going to get to our destination. But the flight crew and attendants were very good. The movie selection onboard was also very nice. Got to watch half of a movie just during our taxi from the gate at ATL due to the delay!

Fine. The issues I had were associated with luggage being delayed from Turkey to Tanzania

No meal service to the back of the plane as it started late or was too slow to get it out before it was time to land.

Terrible, if possible won't be flying again anytime soon!

Efficient boarding and early departure. Very smooth flight. Early arrival in ATL. Great flight.

We purchase first class seats for the first time for multiples of standard economy ticket. There was no access to the club lounge and no priority boarding. The meal and the service once on the plane were superior and the seat was nicer, but not worth the price difference. I will be happy to seat in economy and spend the difference on more travel.

Wonderful in-seat entertainment with seatback screens and huge selection of quality movies. The ability to bluetooth connect headphones was amazing.

Smooth and easy boarding, comfortable for the entire 5 hour flight, and the seat back entertainment was great! I appreciated all the features, from location info and maps, movies, the ability to connect with Bluetooth headphones, and good selection of movies. Food was good, normal airline snacks (I didn’t purchase anything)

They promise free wi-fi prior to boarding and then once on board you are informed you have to purchase wifi even after being a mileagePlus member.

I've been flying American mostly, and it's been very frustrating. This united flight makes me realize maybe the issue isn't flying, but the airline. United was a significantly better experience. The plane was more comfortable, with a normal amount of leg room (vs the ridiculous reductions AA has made), more comfortable seats, screens to watch movies. It was a much better experience!

Everything you need to know for your flight from Medford to Knoxville

Information on your arrival and departure airports

Medford (MFR)
Knoxville (TYS)