MFR - TYS

$138 Find Cheap Flights from Medford to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Medford to Knoxville departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medford to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medford to Knoxville, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Medford to Knoxville (MFR-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Medford to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medford to Knoxville

Thu, Jan 8 - Sat, Jan 17
American Airlines Logo
5:32 am - 10:54 pmMFR-TYS
14h 22m2 stops
American Airlines Logo
10:11 am - 7:38 pmTYS-MFR
12h 27m2 stops
$319American Airlines
Find Deal
Tue, Feb 24 - Sat, Feb 28
Delta Logo
6:05 am - 9:32 pmMFR-TYS
12h 27m2 stops
Delta Logo
6:45 am - 1:03 pmTYS-MFR
9h 18m2 stops
$323Delta
Find Deal
Tue, Feb 24 - Sat, Feb 28
Delta Logo
6:05 am - 8:47 pmMFR-TYS
11h 42m2 stops
Delta Logo
1:30 pm - 11:16 pmTYS-MFR
12h 46m2 stops
$359Delta
Find Deal
Thu, Jan 8 - Sat, Jan 17
United Airlines Logo
5:00 am - 3:14 pmMFR-TYS
7h 14m1 stop
United Airlines Logo
9:30 am - 5:52 pmTYS-MFR
11h 22m2 stops
$485United Airlines
Find Deal
Mon, Jan 5 - Fri, Jan 9
United Airlines Logo
6:34 pm - 10:57 amMFR-TYS
13h 23m2 stops
United Airlines Logo
7:20 pm - 9:02 pmTYS-MFR
28h 42m2 stops
$513United Airlines
Find Deal
Tue, Feb 24 - Sat, Feb 28
United Airlines Logo
5:02 am - 7:29 pmMFR-TYS
11h 27m2 stops
United Airlines Logo
4:15 pm - 9:18 pmTYS-MFR
8h 03m1 stop
$533United Airlines
Find Deal
Tue, Feb 24 - Sat, Feb 28
United Airlines Logo
5:02 am - 3:05 pmMFR-TYS
7h 03m1 stop
United Airlines Logo
4:15 pm - 9:18 pmTYS-MFR
8h 03m1 stop
$599United Airlines
Find Deal
Mon, Jan 5 - Fri, Jan 9
United Airlines Logo
6:34 pm - 10:57 amMFR-TYS
13h 23m2 stops
United Airlines Logo
4:25 pm - 9:02 pmTYS-MFR
7h 37m1 stop
$690United Airlines
Find Deal
Mon, Jan 5 - Fri, Jan 9
United Airlines Logo
5:00 am - 3:00 pmMFR-TYS
7h 00m1 stop
United Airlines Logo
4:25 pm - 9:02 pmTYS-MFR
7h 37m1 stop
$722United Airlines
Find Deal
Tue, Nov 25 - Sun, Nov 30
American Airlines Logo
8:00 am - 10:54 pmMFR-TYS
11h 54m2 stops
American Airlines Logo
1:25 pm - 11:09 pmTYS-MFR
12h 44m2 stops
$1,575American Airlines
Find Deal

Everything you should know

Top airlines
American Airlines
Cheapest • from $319 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
December
Cheapest • 28% price drop
April
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$319
Overall average: $551
American Airlines
Thu 1/8Sat 1/17
MFR - TYS • 2 stops
Cheapest one-way
$138
Allegiant Air
Thu 1/29
MFR - TYS • 1 stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Booking Insights

KAYAK's insights & trends for Medford to Knoxville flights

Get data-powered insights and trends into flights from Medford to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Medford to Knoxville?

The average price of all round-trip flights from Medford to Knoxville clicked on KAYAK for each day over the last 12 months.

When flying from Medford to Knoxville, you should consider leaving on a Tuesday and avoid Sundays if you are looking for the best rates. For your return to Medford, you’ll find the best rates on Tuesdays and the most expensive ones on Saturdays.

What is the cheapest month to fly from Medford to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Medford to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Medford to Knoxville is December, where tickets cost $454 (return) on average. On the other hand, the most expensive months are March and June, where the average cost of round-trip tickets is $1,068 and $964 respectively.

Good to know

Low seasonFebruary
Cheapest flight$138
Best time to beat the crowds with an average 0% drop in price.
Most popular time to fly and prices are also 15% lower on average.
Flight from Medford to Knoxville

When to book flights from Medford to Knoxville

Are your dates flexible? Find out the best times to travel from Medford to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Medford to Knoxville

  • What is the cheapest flight from Medford to Knoxville?

    In the last 3 days, the lowest price for a flight from Medford to Knoxville was $138 for a one-way ticket and $319 for a round-trip.

  • Do I need a passport to fly between Medford and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which aircraft models fly most regularly from Medford to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Medford to Knoxville?

    Star Alliance is the only airline alliance operating flights between Medford and Knoxville.

  • How does KAYAK find such low prices on flights from Medford to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Medford to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Medford to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Medford is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Medford to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Medford with another airline. Booking your flights between Medford and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Medford to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Medford up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Medford to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Medford to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Medford to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 8994 reviews
7.7Boarding
8.1Crew
7.3Comfort
7.1Entertainment
6.6Food
Airline reviews

Short flight but an "eager to help" crew made the journey more enjoyable!

10.0 ExcellentAlan, Oct 2025IAD - PVD
Read more United Airlines reviews

Short flight but an "eager to help" crew made the journey more enjoyable!

Flight was delayed only slightly before takeoff due to traffic control. However, the flight arrived early to ORD. Good flight. United has been very reliable for me.

The person I bought the ticket for didn’t make the flight.

Lately I like the planes have been exceptionally filthy. There’s lines of dust and dirt all across the ceiling in the vents, and the cracks in between the seats are literally full of food. It’s definitely not the quality of service that I was used to with United. I’m also very disappointed with the Wi-Fi! All I wanna do is knock out a few work jobs while I’m trapped in my seat And it spools so bad. They did provide me with a refund, but the process of getting that refund is so complicated. It’s unfortunate.

Another delayed flight. When the delays exceed the duration of the flight, it’s a problem.

Excellent flight. Smooth, efficient boarding. Quick flight. Arrived early at STL.

After boarding the plane in Chicago, the passengers were told that there was a technical problem with the plane. Passengers remained on the plane as they tried to fix the problem. After what was probably an hour passengers were told that there was a need to change planes as the problem was not solved. Passengers disembarked and boarded another plane. After taxing to the runway and waiting for takeoff, passengers were told that owing to the thunderstorm the flight was unable to take off but would try and reroute. After some time passengers were told there wasn't enough fuel for the new route and the plane had to return to the gate for additional fuel. after another log delay the flight got underway. On the plane there was food, drinks, ice or entertainment. We were a glass of water, which appeared rationed. Flight arrived about 5 hours late. The pilot was fantastic and communicated with the passengers throughout the ordeal.

The flight attendants were great, I joked with one I can’t remember her name, a blond, really sweet. I thought it was run well very professional. This was great i survived Spirit, I know for which I speak.

During booking, I kept trying submitting my payment from the Mexican website and it didn't work. After I had the idea to change it to the Canadian website, it worked but I had to be charged the equivalent of 50 CAD more. I received the clear instruction that I would only be able to check-in at the airport and that it was impossible to select a seat 24 hours before departure, that I had to pay 144 CAD to do so, although not only was I able to check-in 24 hours before departure, but I could have selected my seats for free then. All in all, I almost threw $200 out the window due to misleading information. Besides, the app kept crashing, the information to get to the gate on the app was inaccurate, my gate was switched and I was only informed once in the air (luckily I had noticed the departure pannel), I was not addressed in my language beforehand and even if I tried I was immediately answered in English (which meant the crew understood but didn't want to answer accordingly), there was only one snack & beverage service on my medium haul flight and no beverage service on my short haul flight. To be fair, the planes were comfortable, the crew apart from the language issue was helpful, dynamic and engaging, the plane was clean and the directions were clear and direct. United has a lot of potential to be one of my favourite airlines, but the devil is in the details and a lot of them missed the target.

Flight was timely, relatively comfortable, with decent entertainment and food served. Only problem encountered was with the free messaging which I highly appreciate, but it did not work from iphone to non-iphones.

Everything you need to know for your flight from Medford to Knoxville

Information on your arrival and departure airports

Not what you’re looking for? Find thousands of other hotels, flights, car rentals and package deals with KAYAK.