MFR - TYS

$230 Find Cheap Flights from Medford to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Medford to Knoxville departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medford to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medford to Knoxville, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 22% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flights Deals
Booking Insights
Flights Deals

Cheap Flights from Medford to Knoxville (MFR-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Medford to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medford to Knoxville

Sat, Aug 30 - Sat, Sep 6
United Airlines Logo
6:35 pm - 10:28 amMFR-TYS
12h 53m2 stops
United Airlines Logo
4:40 pm - 9:04 pmTYS-MFR
7h 24m1 stop
$314United Airlines
Find Deal
Sat, Aug 30 - Sat, Sep 6
United Airlines Logo
6:35 pm - 10:13 amMFR-TYS
12h 38m2 stops
United Airlines Logo
10:54 am - 5:51 pmTYS-MFR
9h 57m2 stops
$319United Airlines
Find Deal
Tue, Aug 19 - Tue, Aug 26
American Airlines Logo
5:33 am - 9:45 pmMFR-TYS
13h 12m2 stops
American Airlines Logo
12:03 pm - 7:29 pmTYS-MFR
10h 26m2 stops
$349American Airlines
Find Deal
Tue, Aug 19 - Tue, Aug 26
United Airlines Logo
5:00 am - 3:15 pmMFR-TYS
7h 15m1 stop
United Airlines Logo
4:40 pm - 9:04 pmTYS-MFR
7h 24m1 stop
$409United Airlines
Find Deal
Tue, Aug 19 - Tue, Aug 26
United Airlines Logo
5:00 am - 3:15 pmMFR-TYS
7h 15m1 stop
United Airlines Logo
10:54 am - 9:04 pmTYS-MFR
13h 10m2 stops
$414United Airlines
Find Deal
Sat, Aug 30 - Sat, Sep 6
United Airlines Logo
6:35 pm - 10:28 amMFR-TYS
12h 53m2 stops
United Airlines Logo
7:00 am - 9:04 pmTYS-MFR
17h 04m3 stops
$424United Airlines
Find Deal
Fri, Aug 15 - Tue, Aug 19
Alaska Airlines Logo
8:45 am - 12:19 amMFR-TYS
12h 34m2 stops
Alaska Airlines Logo
2:23 pm - 10:55 pmTYS-MFR
11h 32m2 stops
$479Alaska Airlines
Find Deal
Mon, Nov 10 - Mon, Nov 17
Alaska Airlines Logo
8:45 pm - 11:23 amMFR-TYS
11h 38m2 stops
Alaska Airlines Logo
12:08 pm - 8:07 pmTYS-MFR
10h 59m2 stops
$490Alaska Airlines
Find Deal
Wed, Aug 13 - Sun, Aug 17
American Airlines Logo
5:33 am - 9:13 pmMFR-TYS
12h 40m2 stops
American Airlines Logo
12:56 pm - 11:17 pmTYS-MFR
13h 21m2 stops
$782American Airlines
Find Deal
Tue, Nov 25 - Sun, Nov 30
Alaska Airlines Logo
5:42 am - 9:31 pmMFR-TYS
12h 49m2 stops
Alaska Airlines Logo
12:08 pm - 10:45 pmTYS-MFR
13h 37m2 stops
$1,096Alaska Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Medford to Knoxville flights

Get data-powered insights and trends into flights from Medford to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Medford to Knoxville?

The average price of all round-trip flights from Medford to Knoxville clicked on KAYAK for each day over the last 12 months.

When flying from Medford to Knoxville, you should consider leaving on a Tuesday and avoid Sundays if you are looking for the best rates. For your return to Medford, you’ll find the best rates on Tuesdays and the most expensive ones on Saturdays.

What is the cheapest month to fly from Medford to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Medford to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Medford to Knoxville is December, where tickets cost $454 (return) on average. On the other hand, the most expensive months are March and June, where the average cost of round-trip tickets is $1,068 and $964 respectively.

Good to know

Low seasonFebruary
Cheapest flight$230
Best time to beat the crowds with an average 2% drop in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from Medford to Knoxville

When to book flights from Medford to Knoxville

Are your dates flexible? Find out the best times to travel from Medford to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Medford to Knoxville

  • What is the cheapest flight from Medford to Knoxville?

    In the last 3 days, the lowest price for a flight from Medford to Knoxville was $230 for a one-way ticket and $314 for a round-trip.

  • Do I need a passport to fly between Medford and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which aircraft models fly most regularly from Medford to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Medford to Knoxville?

    oneworld, and Star Alliance are the airline alliances operating flights between Medford and Knoxville, with oneworld being the most commonly used for this route.

  • How does KAYAK find such low prices on flights from Medford to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Medford to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Medford to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Medford is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Medford to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Medford with another airline. Booking your flights between Medford and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Medford to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Medford up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Medford to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Medford to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Medford to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 8896 reviews
7.3Comfort
7.7Boarding
6.6Food
8.1Crew
7.1Entertainment
Airline reviews

Was on time until within 1 hour of flight-how does that happen? Staff very friendly.

8.0 ExcellentHal, Jul 2025IAD - MSY
Read more United Airlines reviews

Was on time until within 1 hour of flight-how does that happen? Staff very friendly.

Weather delay in Chicago?. No sense of urgency to make connection in Chicago for our connecting flight that wasn't delayed. Connection was missed.

Our flight was understandably diverted to a small regional airport in Laramie, Wyoming due to weather conditions, which I fully recognize and appreciate. However, the low rating stems from the experience that followed: passengers remained on board for over an hour without the option to deplane and stretch, despite the aircraft being stationary. Although the pilot opened the cabin door, only he was permitted to exit. Meanwhile, passengers grew increasingly uncomfortable as warm summer air entered the cabin through the open door, and being in the second row meant we were impacted immediately. While the flight attendants made efforts to keep everyone at ease, I believe allowing passengers to deplane briefly, given the extended delay, would have significantly improved the overall experience.

I never flew. Flight was canceled. DIA worst airport in the country. Avoid at all costs.

I learned that seating towards the end of plane that a line forms for the restroom and people use your chair as a hand railing, bumping your seat consistently. I was seated in the aisle. I think that next time if I am towards the back row I would want to sit in the middle or window seat.

United sent me a mileage plus number last year but that number is invalid so I can’t use it to check into flights or collect mileage. There is human to speak about the problem, only computers who keep asking me if I am using the correct email. It’s so frustrating and I cannot resolve it.

It was delayed instead of departing at 9:20pm, we departed at 11pm… putting us in Columbus after 2am! It was awful. Had I known about the delay, I could have spent some time in the United Lounge… I was starving because I started my journey in Budapest… so I was exhausted and hungry. Plus I had to make new arrangements to be picked up at the airport in Columbus, instead of midnight it was 2:30 am after getting luggage and out of airport. Not feasible. I would have just stayed in Chicago for the night and gotten a morning flight.

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

I liked the choice of lemon ginger tea. I think stewardesses can be more considerate of older people needs.

It was great, I’m very grateful for the pilots and crew flight attendants for everything.

Everything you need to know for your flight from Medford to Knoxville

Information on your arrival and departure airports

Not what you’re looking for? Find thousands of other hotels, flights, car rentals and package deals with KAYAK.