MYR - DSM

$201 Find Cheap Flights from Myrtle Beach to Des Moines - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$488
Typical prices: $345-$530
Delta
Mon 11/19Fri 11/23
MYR - DSM • 1 stop
Cheapest one-way
$201
Typical prices: $203-$373
American Airlines
Mon 1/1
MYR - DSM • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Myrtle Beach and Des Moines. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
February
Cheapest • 21% price drop
May
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Chicago O'Hare Intl (ORD)
Cheapest • Avg $366 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 59m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Myrtle Beach to Des Moines (MYR-DSM)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Des Moines

Thu, Nov 19 - Mon, Nov 23
Delta Logo
10:52 am - 2:13 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 21m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:59 pm - 10:54 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 55m1 stop Atlanta Hartsfield-Jackson
$488Delta
Thu, Nov 12 - Mon, Nov 16
American Airlines Logo
8:35 pm - 11:57 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 22m1 stop Charlotte Douglas
American Airlines Logo
3:31 pm - 10:34 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 03m1 stop Dallas/Fort Worth
$537American Airlines
Thu, Nov 12 - Mon, Nov 16
American Airlines Logo
11:03 am - 6:56 pmMYR  Myrtle Beach Intl-DSM Des Moines
8h 53m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
3:31 pm - 10:34 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 03m1 stop Dallas/Fort Worth
$542American Airlines
Thu, Nov 12 - Mon, Nov 16
American Airlines Logo
11:03 am - 6:56 pmMYR  Myrtle Beach Intl-DSM Des Moines
8h 53m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
1:58 pm - 10:29 pmDSM  Des Moines-MYR Myrtle Beach Intl
7h 31m2 stops Chicago O'Hare Intl Charlotte Douglas
$548American Airlines
Thu, Nov 19 - Mon, Nov 23
American Airlines Logo
7:00 am - 10:48 amMYR  Myrtle Beach Intl-DSM Des Moines
4h 48m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 3:41 pmDSM  Des Moines-MYR Myrtle Beach Intl
8h 41m2 stops Washington, D.C. Reagan-National Charlotte Douglas
$594American Airlines
Thu, Nov 19 - Mon, Nov 23
American Airlines Logo
5:10 am - 1:28 pmMYR  Myrtle Beach Intl-DSM Des Moines
9h 18m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
1:58 pm - 11:54 pmDSM  Des Moines-MYR Myrtle Beach Intl
8h 56m2 stops Chicago O'Hare Intl Charlotte Douglas
$600American Airlines
Thu, Dec 17 - Mon, Dec 28
Southwest Logo
10:45 am - 10:05 pmMYR  Myrtle Beach Intl-DSM Des Moines
12h 20m2 stops Nashville Intl Denver Intl
Southwest Logo
5:10 am - 6:40 pmDSM  Des Moines-MYR Myrtle Beach Intl
12h 30m2 stops Chicago Midway Baltimore/Washington
$611Southwest
Thu, Dec 17 - Mon, Dec 28
Delta Logo
6:59 pm - 10:38 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 39m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:45 pm - 11:02 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 17m1 stop Atlanta Hartsfield-Jackson
$638Delta
Thu, Dec 17 - Mon, Dec 28
American Airlines Logo
5:30 am - 2:56 pmMYR  Myrtle Beach Intl-DSM Des Moines
10h 26m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
6:16 pm - 8:35 amDSM  Des Moines-MYR Myrtle Beach Intl
13h 19m1 stop Charlotte Douglas
$711American Airlines
Thu, Nov 19 - Mon, Nov 23
United Airlines Logo
11:27 am - 10:59 pmMYR  Myrtle Beach Intl-DSM Des Moines
12h 32m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
3:24 pm - 10:21 amDSM  Des Moines-MYR Myrtle Beach Intl
17h 57m3 stops Chicago O'Hare Intl Portland Newark
$812United Airlines
Booking Insights

Price, demand and travel trends for Myrtle Beach to Des Moines flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Myrtle Beach to Des Moines?

Round-trip flights from Myrtle Beach to Des Moines typically range from $345 to $530. The lowest price found in the past 5 days was $488, on Delta.

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Key details for Myrtle Beach to Des Moines flights

Low season

February

Cheapest flight

$201
Beat the crowds with an average 63% drop in travelers.
The most popular month to fly with an average 48% increase in travelers.
One-way flight from Myrtle Beach to Des Moines

When to book flights from Myrtle Beach to Des Moines

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Myrtle Beach to Des Moines flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Myrtle Beach to Des Moines?

    Only Economy Class is available on flights from Myrtle Beach to Des Moines.

  • How long is a flight from Myrtle Beach to Des Moines?

    A nonstop flight from Myrtle Beach to Des Moines takes 00m, covering 969 miles.

  • Do I need a passport to fly from Myrtle Beach to Des Moines?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Myrtle Beach to Des Moines flight?

    Round-trip flights from Myrtle Beach to Des Moines range from $345 to $530, with an average of $396 over the past 12 months. Anything below $345 counts as a good deal.

  • Have flight prices from Myrtle Beach to Des Moines changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $488 to $1,107. That means the highest observed fare was about 2x higher than the lowest one.

  • How are flight prices from Myrtle Beach to Des Moines looking right now?

    One-way fares from Myrtle Beach to Des Moines are currently higher than usual. Average one-way flight prices are about $317, which is 42% above the typical average for this route.

  • What car rental options are available at Des Moines Airport (DSM)?

    Des Moines Airport (DSM) hosts 5 major car rental companies, with daily rates averaging $81 for economy cars. Top options include:

    • Hertz
    • Payless
    • Budget
    • Alamo
    • Avis

  • Which airports can I use when flying from Myrtle Beach to Des Moines?

    Flights from Myrtle Beach to Des Moines usually depart from Myrtle Beach Intl (MYR) and arrive at Des Moines (DSM).

  • Which airports do connecting flights from Myrtle Beach to Des Moines pass through?

    One-stop flights from Myrtle Beach to Des Moines most commonly connect through:

    • Charlotte Douglas (CLT) - 82% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 14% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 5% of one-stop connections

  • Can I save money by using flexible dates for flights from Myrtle Beach to Des Moines?

    Yes. Flexible dates can save you up to 37% on flights from Myrtle Beach to Des Moines. Monday is the cheapest departure day at $324 round-trip on average, while Tuesday is the most expensive at $513, a difference of $189.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Myrtle Beach to Des Moines?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 59m, compared with 5h 11m via Charlotte Douglas (CLT) and 7h 24m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Myrtle Beach and Des Moines?

    Des Moines is 1 hour behind Myrtle Beach (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Des Moines?

    Some of the most popular sights in Des Moines are UnityPoint Health - Des Moines, Science Center of Iowa and Hy Vee Hall. These are among the most viewed places in Des Moines on KAYAK.

Your guide to booking Myrtle Beach to Des Moines flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Monday departure and avoid flying on Tuesday. On this route, Monday flights average $324, about $189 less than Tuesday fares (37% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Myrtle Beach to Des Moines trip for February. Fares historically average $312 round-trip in that month - typically $474 less than the most expensive month, which is July (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Des Moines Airport.

    • Days Inn & Suites by Wyndham Des Moines Airport
    • Quality Inn & Suites Des Moines Airport
    • Homewood Suites by Hilton - Des Moines Airport

More options for your flight from Myrtle Beach to Des Moines

Complete your trip to Des Moines with a hotel stay or car rental

Car rentals in Des Moines
Hotels in Des Moines
Vacations in Des Moines