MYR - DSM

$342 Find Cheap Flights from Myrtle Beach to Des Moines

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Des Moines

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Des Moines, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Des Moines, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$342
Multiple Airlines
Thu 5/28Sun 5/31
MYR - DSM • 1 stop
Cheapest one-way
Multiple Airlines
Mon 1/26
MYR - DSM • multi-stop
Top airlines
Delta
Cheapest • from $387 (round-trip)
American Airlines
Best reviews • 7.2 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
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We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Myrtle Beach to Des Moines (MYR-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Des Moines

Thu, May 28 - Sun, May 31
Multiple Airlines Logo
7:31 pm - 2:00 pm
MYR
-
DSM
19h 29m
1 stop
Multiple Airlines Logo
7:30 am - 6:56 pm
DSM
-
MYR
10h 26m
1 stop
$342Multiple Airlines
Wed, May 27 - Sun, May 31
Multiple Airlines Logo
3:29 pm - 2:16 pm
MYR
-
DSM
23h 47m
1 stop
Multiple Airlines Logo
7:30 am - 6:56 pm
DSM
-
MYR
10h 26m
1 stop
$350Multiple Airlines
Wed, May 27 - Sun, May 31
Multiple Airlines Logo
3:29 pm - 2:16 pm
MYR
-
DSM
23h 47m
1 stop
Multiple Airlines Logo
2:10 pm - 9:42 am
DSM
-
MYR
18h 32m
2 stops
$365Multiple Airlines
Wed, Jun 17 - Tue, Jun 23
Delta Logo
1:05 pm - 5:42 pm
MYR
-
DSM
5h 37m
1 stop
Delta Logo
5:45 am - 12:19 pm
DSM
-
MYR
5h 34m
1 stop
$387Delta
Wed, Jun 17 - Tue, Jun 23
American Airlines Logo
8:34 pm - 11:51 pm
MYR
-
DSM
4h 17m
1 stop
American Airlines Logo
1:45 pm - 9:43 pm
DSM
-
MYR
6h 58m
2 stops
$392American Airlines
Wed, May 27 - Sat, May 30
American Airlines Logo
6:50 am - 1:15 pm
MYR
-
DSM
7h 25m
2 stops
American Airlines Logo
1:45 pm - 9:43 pm
DSM
-
MYR
6h 58m
2 stops
$398American Airlines
Wed, Jun 17 - Tue, Jun 23
American Airlines Logo
6:50 am - 12:56 pm
MYR
-
DSM
7h 06m
1 stop
American Airlines Logo
8:53 am - 5:17 pm
DSM
-
MYR
7h 24m
2 stops
$402American Airlines
Thu, May 28 - Sun, May 31
Multiple Airlines Logo
7:51 pm - 2:00 pm
MYR
-
DSM
19h 09m
2 stops
Multiple Airlines Logo
7:30 am - 6:56 pm
DSM
-
MYR
10h 26m
1 stop
$431Multiple Airlines
Thu, May 28 - Sat, May 30
American Airlines Logo
4:35 pm - 11:12 pm
MYR
-
DSM
7h 37m
1 stop
American Airlines Logo
1:45 pm - 9:43 pm
DSM
-
MYR
6h 58m
2 stops
$462American Airlines
Tue, Feb 10 - Thu, Feb 12
Delta Logo
4:00 pm - 10:29 pm
MYR
-
DSM
7h 29m
1 stop
Delta Logo
5:27 am - 1:33 pm
DSM
-
MYR
7h 06m
1 stop
$467Delta
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Des Moines flights

Get data-powered insights and trends into flights from Myrtle Beach to Des Moines to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Myrtle Beach to Des Moines?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to Des Moines were found on Delta ($387) and American Airlines ($392).

Find deals

Good to know

Cheapest flight$342
Flight from Myrtle Beach to Des Moines

When to book flights from Myrtle Beach to Des Moines

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to Des Moines

  • What is the cheapest flight from Myrtle Beach to Des Moines?

    In the last 3 days, the lowest price for a flight from Myrtle Beach to Des Moines was $342 for a round-trip ticket.

  • Do I need a passport to fly between Myrtle Beach and Des Moines?

    A passport is not required to fly from Myrtle Beach to Des Moines.

  • Which airports will I be using when flying from Myrtle Beach to Des Moines?

    When flying out of Myrtle Beach you will be using Myrtle Beach Intl. You will be landing at Des Moines, also known as Des Moines.

  • Which aircraft models fly most regularly from Myrtle Beach to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Myrtle Beach to Des Moines?

    oneworld is the only airline alliance operating flights between Myrtle Beach and Des Moines.

  • How does KAYAK find such low prices on flights from Myrtle Beach to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Myrtle Beach to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11189 reviews
7.5Boarding
7.2Comfort
6.9Entertainment
6.4Food
8.0Crew
Airline reviews

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

10.0 ExcellentRicciyah, Jan 2026
PBI - PHL
Read more American Airlines reviews

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

Pilot navigated severe weather/snow storm with skill. Described his intentions clearly

one crew said "he" didn't serve double alcohol drinks for travelers in exit rows. crew on prior flight did. Is this a AA rule, and the prior crew was being nice? Also, I think we deserve more than a 25% refund for losing first class seats when rescheduling a flight due to weather

It was a little concerning to hear the ground crew arguing with the flight crew over baggage space. Instead of taking them and checking them, they started checking for space in the first class cabin moving items around like the flight crew didn't know what they were doing. I was embarrassed for them.

2 hour delay due to equipment failure. No updates via the app and airport screens (which continued to show a departure time in the past). AA eventually switched planes and the new plane was not catered or cleaned correctly.

I booked an aisle seat and was given a middle. At 6'4" 230lbs, it is not ideal to fly in the middle row for myself and passengers.

Trip delayed for 2 hours because of rain. We boarded and have to get down the flight and reboard again.

The aircraft had several problems - from excess fuel to non operational ac. Two hours of delay in Chicago could have been avoided with proper planning and aircraft maintenance.

This flight captain and crew were amazing, started ahead of time of departure and reached 30 mins before arrival time. Amazing!

Long delays, lack of information about the status of the flight. The flight was delayed 4 times.

Everything you need to know for your flight from Myrtle Beach to Des Moines

Information on your arrival and departure airports

Myrtle Beach (MYR)
Des Moines (DSM)