MYR - DSM

$325 Find Cheap Flights from Myrtle Beach to Des Moines - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$353
Typical prices: $366-$536
American Airlines
Mon 10/1Fri 10/5
MYR - DSM • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Myrtle Beach and Des Moines. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
February
Cheapest • 25% price drop
May
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Chicago O'Hare Intl (ORD)
Cheapest • Avg $366 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 59m (one-way)
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Insights
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Flight Deals

Cheap Flights from Myrtle Beach to Des Moines (MYR-DSM)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Des Moines

Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
8:08 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 56m1 stop Charlotte Douglas
American Airlines Logo
4:12 pm - 10:52 pmDSM  Des Moines-MYR Myrtle Beach Intl
5h 40m1 stop Dallas/Fort Worth
$353American Airlines
Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
8:08 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 56m1 stop Charlotte Douglas
American Airlines Logo
2:01 pm - 10:02 pmDSM  Des Moines-MYR Myrtle Beach Intl
7h 01m2 stops Chicago O'Hare Intl Charlotte Douglas
$368American Airlines
Thu, Oct 29 - Tue, Nov 3
American Airlines Logo
5:00 am - 10:42 amMYR  Myrtle Beach Intl-DSM Des Moines
6h 42m1 stop Charlotte Douglas
American Airlines Logo
3:31 pm - 10:34 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 03m1 stop Dallas/Fort Worth
$381American Airlines
Thu, Oct 29 - Tue, Nov 3
American Airlines Logo
5:00 am - 10:42 amMYR  Myrtle Beach Intl-DSM Des Moines
6h 42m1 stop Charlotte Douglas
American Airlines Logo
3:31 pm - 10:34 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 03m1 stop Dallas/Fort Worth
$381American Airlines
Thu, Oct 29 - Tue, Nov 3
Southwest Logo
6:40 am - 11:10 amMYR  Myrtle Beach Intl-DSM Des Moines
5h 30m1 stop Chicago Midway
Southwest Logo
7:00 am - 7:20 pmDSM  Des Moines-MYR Myrtle Beach Intl
11h 20m2 stops Denver Intl Nashville Intl
$386Southwest
Thu, Oct 29 - Tue, Nov 3
Southwest Logo
6:40 am - 11:10 amMYR  Myrtle Beach Intl-DSM Des Moines
5h 30m1 stop Chicago Midway
Southwest Logo
7:00 am - 7:20 pmDSM  Des Moines-MYR Myrtle Beach Intl
11h 20m2 stops Denver Intl Nashville Intl
$386Southwest
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
8:08 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 56m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 3:32 pmDSM  Des Moines-MYR Myrtle Beach Intl
8h 32m2 stops Philadelphia Charlotte Douglas
$386American Airlines
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
8:08 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 56m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 3:32 pmDSM  Des Moines-MYR Myrtle Beach Intl
8h 32m2 stops Philadelphia Charlotte Douglas
$386American Airlines
Thu, Oct 29 - Tue, Nov 3
Southwest Logo
1:25 pm - 10:20 pmMYR  Myrtle Beach Intl-DSM Des Moines
9h 55m2 stops Baltimore/Washington Denver Intl
Southwest Logo
7:00 am - 7:20 pmDSM  Des Moines-MYR Myrtle Beach Intl
11h 20m2 stops Denver Intl Nashville Intl
$391Southwest
Thu, Oct 29 - Tue, Nov 3
Southwest Logo
1:25 pm - 10:20 pmMYR  Myrtle Beach Intl-DSM Des Moines
9h 55m2 stops Baltimore/Washington Denver Intl
Southwest Logo
7:00 am - 7:20 pmDSM  Des Moines-MYR Myrtle Beach Intl
11h 20m2 stops Denver Intl Nashville Intl
$391Southwest
Booking Insights

Price, demand and travel trends for Myrtle Beach to Des Moines flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Myrtle Beach to Des Moines with more confidence.

How much is a round-trip flight from Myrtle Beach to Des Moines?

Round-trip flights from Myrtle Beach to Des Moines start at $353. Prices are below average for this route right now, with typical round-trip fares ranging from $366 to $536. The lowest price found in the past 5 days was $353 on American Airlines.

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Key details for Myrtle Beach to Des Moines flights

Low season

February
Best time to beat the crowds with an average 25% drop in price.
Most popular time to fly with an average 8% increase in price.

When to book flights from Myrtle Beach to Des Moines

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Myrtle Beach to Des Moines flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Myrtle Beach to Des Moines?

    Flights from Myrtle Beach to Des Moines usually depart from Myrtle Beach Intl (MYR) and arrive at Des Moines (DSM).

  • What cabin classes can I book on flights from Myrtle Beach to Des Moines?

    Only Economy Class is available on flights from Myrtle Beach to Des Moines.

  • Which airports do connecting flights from Myrtle Beach to Des Moines pass through?

    One-stop flights from Myrtle Beach to Des Moines most commonly connect through:

    • Charlotte Douglas (CLT) - 78% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 17% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 6% of one-stop connections

    Charlotte Douglas (CLT) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Myrtle Beach to Des Moines?

    Yes. Being flexible with your travel dates can save you up to 42% on the Myrtle Beach to Des Moines route. Friday is the cheapest departure day at $312 round-trip on average, while Wednesday is the most expensive at $536, a difference of $224. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What popular places can I visit in Des Moines?

    Some of the most popular sights in Des Moines are Iowa Events Center, UnityPoint Health - Des Moines and Des Moines Civic Center. These are among the most viewed places in Des Moines on KAYAK.

  • How long is a flight from Myrtle Beach to Des Moines?

    A nonstop flight from Myrtle Beach to Des Moines takes 0h 00m, covering 969 miles.

  • Do I need a passport to fly from Myrtle Beach to Des Moines?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Myrtle Beach to Des Moines changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $353 to $1,141. That means the highest observed fare was about 3x higher than the lowest one.

  • How much time can I save by choosing a different layover airport from Myrtle Beach to Des Moines?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 59m, compared with 5h 09m via Charlotte Douglas (CLT) and 7h 24m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Myrtle Beach and Des Moines?

    Des Moines is 1 hour behind Myrtle Beach (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Des Moines Airport (DSM)?

    Des Moines Airport (DSM) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    • Hertz
    • Payless
    • Budget
    • Alamo
    • Avis

  • How much should I expect to pay for a Myrtle Beach to Des Moines flight?

    Round-trip flights from Myrtle Beach to Des Moines range from $366 to $536, with an average of $416 over the past 12 months. Anything below $366 counts as a good deal.

Your guide to booking Myrtle Beach to Des Moines flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Friday departure instead of Wednesday. On this route, Friday flights average $312 - about $224 less than Wednesday (42% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Myrtle Beach to Des Moines trip for February. Fares historically average $312 round-trip in that month - typically $474 less than the most expensive month, which is July (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Des Moines Airport.
    - Days Inn & Suites by Wyndham Des Moines Airport
    - Quality Inn & Suites Des Moines Airport
    - Holiday Inn Des Moines-Airport/Conf Center By IHG

More options for your flight from Myrtle Beach to Des Moines

Complete your trip to Des Moines with a hotel stay or car rental

Car rentals in Des Moines
Hotels in Des Moines
Vacations in Des Moines