MYR - DSM

$149 Find Cheap Flights from Myrtle Beach to Des Moines

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Des Moines

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Des Moines, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Des Moines, as well as popular online travel agencies
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Flights Deals

Cheap Flights from Myrtle Beach to Des Moines (MYR-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Des Moines

Thu, Jul 24 - Sun, Jul 27
Logo
7:34 pm - 12:46 pmMYR-DSM
18h 12m1 stop
Logo
6:32 pm - 10:17 pmDSM-MYR
26h 45m2 stops
$264
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Thu, Jul 24 - Sun, Jul 27
Logo
6:10 am - 10:38 pmMYR-DSM
17h 28m2 stops
Logo
6:32 pm - 10:17 pmDSM-MYR
26h 45m2 stops
$267
Find Deal
Thu, Jul 24 - Sun, Jul 27
Logo
6:10 am - 10:38 pmMYR-DSM
17h 28m2 stops
Logo
6:32 pm - 10:17 pmDSM-MYR
26h 45m3 stops
$308
Find Deal
Fri, Aug 1 - Mon, Aug 11
American Airlines Logo
5:50 pm - 11:49 pmMYR-DSM
6h 59m1 stop
American Airlines Logo
5:29 pm - 11:11 pmDSM-MYR
4h 42m1 stop
$319American Airlines
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Fri, Aug 1 - Mon, Aug 11
American Airlines Logo
5:50 pm - 11:49 pmMYR-DSM
6h 59m1 stop
American Airlines Logo
3:20 pm - 11:11 pmDSM-MYR
6h 51m2 stops
$324American Airlines
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Thu, Jul 24 - Sun, Jul 27
American Airlines Logo
5:16 pm - 11:44 pmMYR-DSM
7h 28m1 stop
American Airlines Logo
5:17 pm - 12:02 amDSM-MYR
5h 45m1 stop
$367American Airlines
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Fri, Aug 1 - Mon, Aug 11
American Airlines Logo
6:16 pm - 11:44 pmMYR-DSM
6h 28m2 stops
American Airlines Logo
5:00 am - 3:23 pmDSM-MYR
9h 23m2 stops
$369American Airlines
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KAYAK's insights & trends for Myrtle Beach to Des Moines flights

Get data-powered insights and trends into flights from Myrtle Beach to Des Moines to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Des Moines?

The average price of all round-trip flights from Myrtle Beach to Des Moines clicked on KAYAK for each day over the last 12 months.

When flying from Myrtle Beach to Des Moines, you should consider leaving on a Tuesday and avoid Thursdays if you are looking for the best rates. For your return to Myrtle Beach, you’ll find the best rates on Tuesdays and the most expensive ones on Thursdays.

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Good to know

Cheapest flight$149
Flight from Myrtle Beach to Des Moines

When to book flights from Myrtle Beach to Des Moines

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to Des Moines

  • What is the cheapest flight from Myrtle Beach to Des Moines?

    In the last 3 days, the lowest price for a flight from Myrtle Beach to Des Moines was $149 for a one-way ticket and $264 for a round-trip.

  • Do I need a passport to fly between Myrtle Beach and Des Moines?

    A passport is not required to fly from Myrtle Beach to Des Moines.

  • Which airports will I be using when flying from Myrtle Beach to Des Moines?

    When flying out of Myrtle Beach you will be using Myrtle Beach Intl. You will be landing at Des Moines, also known as Des Moines.

  • Which aircraft models fly most regularly from Myrtle Beach to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Myrtle Beach to Des Moines?

    SkyTeam, and oneworld are the airline alliances operating flights between Myrtle Beach and Des Moines, with SkyTeam being the most commonly used for this route.

  • How does KAYAK find such low prices on flights from Myrtle Beach to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top airline flying from Myrtle Beach to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 10000 reviews
6.5Food
7.5Boarding
6.9Entertainment
7.2Comfort
8.0Crew
Airline reviews

It was one of my worst flight ever. First they were changing the gate for at least 4 times, changing from gate D7 to D12 to D44. Considering the size of the Miami Airport, we are talking about long distance and the train at the airport was not working. Then the flight was delayed around one hour. Then finally we boarded into the plane and when everybody was seated, there was an announcement that there is an issue with one of the tire of the plane, so we all had to get out of the plane with our belongings, to replace the tire. So we had around 2.5-hour delay

2.0 MediocreJose David, Jun 2025MIA - DTW
Read more American Airlines reviews

It was one of my worst flight ever. First they were changing the gate for at least 4 times, changing from gate D7 to D12 to D44. Considering the size of the Miami Airport, we are talking about long distance and the train at the airport was not working. Then the flight was delayed around one hour. Then finally we boarded into the plane and when everybody was seated, there was an announcement that there is an issue with one of the tire of the plane, so we all had to get out of the plane with our belongings, to replace the tire. So we had around 2.5-hour delay

Most miserable flight ever. We waited almost 2 hours on the runway because the flight was oversold. American offered $1200 credit. Then there was some nonsense about weight distribution. Ridiculous. No food for 8 plus hours on the flight. I will be writing a letter.

Honestly, I haven’t flown American in years, probably due to the pandemic and my being unable to travel for certain periods in the last two years, but it was a good experience to dig out or obtain a new American Airlines account after many years of traveling for business with American in the past.

The plane was probably full boarding was easy. We were able to check our carry-on luggage for free. It was a return flight through Philly to LA. Never saw a stewardess do a demonstration of emergency Procedures. I think my flight was pretty full

Plane, flight, crew, captain were all great. The first flight had a Chipotle box lunch...delicious.

Plane, flight, crew, captain were all great. The first flight had a Chipotle box lunch...delicious. this return flight not as tasty, but filling.

The flight was 2 hour delayed, otherwise everything was excellent. The delay was due to the hourly limit requirement so given that as a reason, I'm happy with the flight!

Weather delay for 2.5 hours followed by half hour crew delay, did not have ginger ale, uncomfortable seats

So awful Unreliable Unfriendly Bad Mad Mean Smelly Hot Late Overbooked Understaffed Expensive Cramped Narcs If they were a fruit they’d be rotten durian

It’s a great flight. Service is good. Staff is awesome.

Everything you need to know for your flight from Myrtle Beach to Des Moines

Information on your arrival and departure airports

Myrtle Beach (MYR)
Des Moines (DSM)

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