MYR - DSM

$163 Find Cheap Flights from Myrtle Beach to Des Moines - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$315
Multiple Airlines
Thu 10/1Mon 10/5
MYR - DSM • 1 stop
Cheapest one-way
$163
Southwest
Tue 8/25
MYR - DSM • 1 stop
Top airlines
American Airlines
Cheapest • from $317 (round-trip)
American Airlines
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Myrtle Beach and Des Moines. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Chicago (ORD)
Cheapest • Avg $366 (round-trip)
Charlotte (CLT)
Shortest trip • 4h 42m (one-way)
Insights
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Insights
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We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Myrtle Beach to Des Moines (MYR-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Des Moines

Thu, Oct 1 - Mon, Oct 5
Multiple Airlines Logo
6:25 pm - 7:54 am
MYR
-
DSM
14h 29m
1 stop
Multiple Airlines Logo
11:00 am - 10:05 am
DSM
-
MYR
22h 05m
1 stop
$315Multiple Airlines
Thu, Oct 1 - Tue, Oct 6
American Airlines Logo
8:08 am - 12:04 pm
MYR
-
DSM
4h 56m
1 stop
American Airlines Logo
1:14 pm - 6:44 pm
DSM
-
MYR
4h 30m
1 stop
$317American Airlines
Thu, Oct 1 - Tue, Oct 6
Southwest Logo
6:40 am - 11:10 am
MYR
-
DSM
5h 30m
1 stop
Southwest Logo
5:35 am - 1:30 pm
DSM
-
MYR
6h 55m
2 stops
$322Southwest
Wed, Sep 30 - Mon, Oct 5
American Airlines Logo
6:30 am - 12:04 pm
MYR
-
DSM
6h 34m
1 stop
American Airlines Logo
11:22 am - 7:27 pm
DSM
-
MYR
7h 05m
1 stop
$325American Airlines
Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
5:01 pm - 11:12 pm
MYR
-
DSM
7h 11m
1 stop
American Airlines Logo
6:00 am - 11:40 am
DSM
-
MYR
4h 40m
1 stop
$325American Airlines
Wed, Sep 30 - Mon, Oct 5
American Airlines Logo
8:08 am - 12:04 pm
MYR
-
DSM
4h 56m
1 stop
American Airlines Logo
6:00 am - 11:40 am
DSM
-
MYR
4h 40m
1 stop
$325American Airlines
Thu, Oct 1 - Tue, Oct 6
Southwest Logo
10:25 am - 9:55 pm
MYR
-
DSM
12h 30m
2 stops
Southwest Logo
5:35 am - 1:30 pm
DSM
-
MYR
6h 55m
2 stops
$327Southwest
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
6:40 am - 11:10 am
MYR
-
DSM
5h 30m
1 stop
Southwest Logo
7:10 pm - 9:45 am
DSM
-
MYR
13h 35m
2 stops
$336Southwest
Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
8:08 am - 12:04 pm
MYR
-
DSM
4h 56m
1 stop
American Airlines Logo
11:22 am - 7:27 pm
DSM
-
MYR
7h 05m
1 stop
$337American Airlines
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
10:25 am - 9:55 pm
MYR
-
DSM
12h 30m
2 stops
Southwest Logo
7:10 pm - 9:45 am
DSM
-
MYR
13h 35m
2 stops
$341Southwest
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Des Moines flights

Get data-powered insights and trends into flights from Myrtle Beach to Des Moines to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Myrtle Beach to Des Moines?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 5 days, the cheapest round-trip tickets from Myrtle Beach to Des Moines were found on American Airlines ($317) and Southwest ($322).

Find deals

Good to know

Cheapest flight

$163
Flight from Myrtle Beach to Des Moines

When to book flights from Myrtle Beach to Des Moines

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to Des Moines

  • What is the cheapest flight from Myrtle Beach to Des Moines?

    In the last 5 days, the lowest price for a flight from Myrtle Beach to Des Moines was $163 for a one-way ticket and $315 for a round-trip.

  • Do I need a passport to fly between Myrtle Beach and Des Moines?

    A passport is not required to fly from Myrtle Beach to Des Moines.

  • Which airports will I be using when flying from Myrtle Beach to Des Moines?

    When flying out of Myrtle Beach you will be using Myrtle Beach Intl. You will be landing at Des Moines, also known as Des Moines.

  • Which aircraft models fly most regularly from Myrtle Beach to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Myrtle Beach to Des Moines?

    oneworld is the only airline alliance operating flights between Myrtle Beach and Des Moines.

  • How does KAYAK find such low prices on flights from Myrtle Beach to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Myrtle Beach to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11839 reviews
6.8Entertainment
7.5Boarding
7.9Crew
6.4Food
7.2Comfort
Airline reviews

Very good I can’t complain one bit. Thank you American Airlines for making my flight enjoyable and safe!

10.0 ExcellentAnonymous, Apr 2026
GSP - ORD
Read more American Airlines reviews

Very good I can’t complain one bit. Thank you American Airlines for making my flight enjoyable and safe!

Flight was fine, but not having WiFi was a major negative

Everything was excellent and I enjoyed myself. Thank for everything

One of our group members was struggling to walk. In Charlotte we asked for a wheelchair and she was accompanied by Desmond. I was impressed by his patience and attention. In Boston she received the same service. I didn’t get the name of the helper but she went above and beyond in assisting us. A great AA service

The boarding by groups is pointless. The first two groups worked fine, but almost Noone boarded in goups three thru five leaving the vast majority boarding when group six was called. It defeated the purpose of spreading out the crowd.

I blame kayak for my last trip to dca. Kayak cancelled my direct flight and put on a one stop flight and made lost whole day from my vacation and had not even refunded my ticket.

delayed multiple times. no resolution on anything from AA customer service. was put on hold in chat to talk to manager. was 6th in line to talk to manager for more than TWELVE HOURS - from sometime around 9AM until well after I had gone to bed that evening. no explanation, no attempt to make it right. just a five hour delay because of repeated maintenance claims

Flight was delayed 5 hours causing me to miss my connecting flights

Was the most uncomfortable I ever had in the air. Felt like I was trapped in the seat legs cramped and was just horrible. The flight to DSM was a lot better. Even being on a smaller plane was better. Staff are outstanding. No complaints about the people.

It was exactly as I expected, on time, smooth flight, courteous staff.

Everything you need to know for your flight from Myrtle Beach to Des Moines

Information on your arrival and departure airports

Myrtle Beach (MYR)
Des Moines (DSM)