$216 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$427
Bogotá
Bogotá1 stop$381
Santiago
Santiago2 stops$820
Cartagena
Cartagena1 stop$436
Quito
Quito3 stops$507
Guayaquil
Guayaquil1 stop$336
Lima
Lima1 stop$427
Bogotá
Bogotá1 stop$381
Santiago
Santiago2 stops$820
Cartagena
Cartagena1 stop$436
Quito
Quito3 stops$507
Guayaquil
Guayaquil1 stop$336

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Thu, Feb 5 - Mon, Feb 9
Multiple Airlines Logo
8:15 pm - 12:21 am
MYR
-
GYE
28h 06m1 stop
Multiple Airlines Logo
4:40 am - 7:10 pm
GYE
-
MYR
14h 30m2 stops
$336Multiple Airlines
Sat, Jan 31 - Sun, Feb 8
Spirit Airlines Logo
10:00 am - 12:21 am
MYR
-
GYE
14h 21m2 stops
Spirit Airlines Logo
1:26 am - 7:20 pm
GYE
-
MYR
17h 54m1 stop
$340Spirit Airlines
Sat, Jan 31 - Sun, Feb 8
Spirit Airlines Logo
8:15 pm - 12:21 am
MYR
-
GYE
28h 06m1 stop
Spirit Airlines Logo
1:26 am - 7:20 pm
GYE
-
MYR
17h 54m1 stop
$345Spirit Airlines
Thu, Feb 5 - Mon, Feb 9
Spirit Airlines Logo
8:15 pm - 12:21 am
MYR
-
GYE
28h 06m1 stop
Spirit Airlines Logo
1:26 am - 7:10 pm
GYE
-
MYR
17h 44m1 stop
$346Spirit Airlines
Sun, Mar 1 - Fri, Mar 20
American Airlines Logo
5:10 am - 9:10 pm
MYR
-
MDE
16h 00m2 stops
American Airlines Logo
12:20 am - 6:44 pm
MDE
-
MYR
17h 24m2 stops
$533American Airlines
Tue, Feb 24 - Tue, Mar 3
American Airlines Logo
6:54 am - 10:10 pm
MYR
-
BOG
15h 16m2 stops
American Airlines Logo
3:15 pm - 9:36 am
BOG
-
MYR
18h 21m2 stops
$550American Airlines
Wed, Feb 25 - Wed, Mar 4
LATAM Airlines Logo
4:00 pm - 5:00 am
MYR
-
LIM
13h 00m1 stop
LATAM Airlines Logo
11:40 pm - 9:45 am
LIM
-
MYR
10h 05m1 stop
$595LATAM Airlines
Mon, Feb 2 - Thu, Feb 5
LATAM Airlines Logo
10:33 am - 7:30 pm
MYR
-
BOG
8h 57m1 stop
LATAM Airlines Logo
9:00 am - 5:59 pm
BOG
-
MYR
8h 59m1 stop
$604LATAM Airlines
Thu, Apr 2 - Tue, Apr 7
GOL Logo
5:10 am - 8:15 pm
MYR
-
MDE
16h 05m2 stops
GOL Logo
1:53 pm - 12:17 pm
MDE
-
MYR
21h 24m2 stops
$830GOL
Thu, Apr 9 - Sun, Apr 12
United Airlines Logo
5:55 pm - 2:30 am
MYR
-
MAO
32h 35m2 stops
United Airlines Logo
3:35 am - 2:17 pm
MAO
-
MYR
34h 42m2 stops
$1,331United Airlines
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Myrtle Beach and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Myrtle Beach to South America.

There are 3 airlines that fly nonstop from Myrtle Beach to South America. They are: LATAM Airlines, Delta and Spirit Airlines. The cheapest price of all airlines flying this route was found with Spirit Airlines at $327 for a round-trip flight to Medellín Jose Maria Cordova Intl Airport (MDE). On average, Spirit Airlines offers the best prices for nonstop flights between Myrtle Beach and South America.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($340) and American Airlines ($533).

Good to know

Low seasonAugust
Cheapest flight$138
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 53% increase in price.
Flight from Myrtle Beach to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8034 reviews
7.8Entertainment
8.5Crew
7.2Food
8.1Boarding
7.9Comfort
Airline reviews

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

8.0 ExcellentG, Jan 2026
FLL - ATL
Read more Delta reviews

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

Air travel sucks. It continues to be awful for all airlines. No shame on delta alone.

It was Delta, but the flight attendants were stressful and disrespectful. I am a diamond member a travel weekly. I have not had a negative thing to share in quite some time. But this was noticeable.

Comfort Plus seat 11E seemed smaller than prior flights. The movie selection is good. Watched most of the most recent Tron movie. I'll watch the remaining part later as my movie is saved in the Delta Seatback Experience.

Flight was late from Newark to Atlanta, I asked flight attendant to please let my family of 3 out first when we landed to Atlanta because we were late for our connecting flight to Quito. She didn't and we were late for 5 minutes we couldn't board the plane and spend hours trying to get another flight with customer service for the next day.

I really liked the legroom. I am 6’4”.a at For some reason our seats were not together and using the app to fix it didn’t work. Passengers were nice enough to move for us but you should absolutely ensure a parent sits with their child.

Late delayed flight delays boarding and delays leaving and delays on arrival too. Cramped plane no room no food.

DTW line is too long. The flights from DTW to BWI are always delayed for unknown reasons.

Delta canceled our flight and we had to scramble to find another airline to get home. Phoenix is not a delta hub so they didn’t have another plane. It would have been a red eye though Salt Lake City. Getting in at 5am. No bueno.

This flight was no comparison to our prior flight. I'm thinking it all has to do with the age of the aircraft.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Everything went well. The flight was slightly delayed however we landed on time.

I've flown two Spirit flights recently - boarding for one was somewhat chaotic, with the board listing the wrong flight and causing much confusion; boarding for the other was very smooth and easy. My seat (for which I did not pay extra) was a bit narrow and without great legroom, but it was fine for a NY-Florida trip and was more than worth the low price I paid. The crew was friendly and one flight landed early and the other was only very slightly delayed. All in all a very good experience.

Had to pay for water if wanted it. Seats are close unless you get upgraded. Flight was fine. Will travel again with spirit.

Good! But your flight crews don’t need to ‘eat the mics’ when making announcements. If they held the mics 3 to 4 inches away from their mouths, we could understand them so much better. Otherwise, all is well.

Your flight crew and boarding area crew need to have microphone use training. They all hold the microphone right up to their mouths, way to close making understanding them almost impossible. The microphone should be held about 3 to 4 inches away from their mouths. This would provide for much better clarity through the PA system. ‘Eating the mic’ DOES NOT work.

It was the first time I flew on that airline and had a very positive experience. Nearly identical to Jetblue which consider the standard of airlines excellence.

A bottled or canned drink, whether water or soda would have been appreciated upon settling in and flying, without being charged for it.

Horrible experience. First and last time using this airline. Made an announcement that boarding will start in 15 minutes, canceled the flight 5 minutes later due to no airline staff. Had to book another flight on Delta since Spirit had no other flights arriving to my original destination the same day. I wouldn't recommend anyone to fly with Spirit. No wonder why it consistently ranks high among worst airlines.

Once again, the staff seem to think they are above the customers and treat everyone with disdain, belittling people.

Sadly there was a crew member very rude with my kid and with me.

Everything you need to know for your flight to South America

Information on your arrival and departure airports