$216 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$614
Bogotá
Bogotá1 stop$543
Santiago
Santiago1 stop$1,074
Cartagena
Cartagena1 stop$604
Quito
Quito2 stops$700
Guayaquil
Guayaquil2 stops$520
Lima
Lima2 stops$614
Bogotá
Bogotá1 stop$543
Santiago
Santiago1 stop$1,074
Cartagena
Cartagena1 stop$604
Quito
Quito2 stops$700
Guayaquil
Guayaquil2 stops$520

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Tue, Mar 31 - Mon, Apr 13
Multiple Airlines Logo
6:37 pm - 6:50 pmMYR-MDE
25h 13m1 stop
Multiple Airlines Logo
10:20 am - 11:09 amMDE-MYR
23h 49m2 stops
$498Multiple Airlines
Find Deal
Sat, Mar 14 - Sat, Mar 21
Multiple Airlines Logo
6:37 pm - 9:40 pmMYR-MDE
28h 03m1 stop
Multiple Airlines Logo
6:25 am - 5:42 pmMDE-MYR
10h 17m2 stops
$507Multiple Airlines
Find Deal
Wed, Jan 28 - Tue, Feb 10
Spirit Airlines Logo
9:55 pm - 12:21 amMYR-GYE
26h 26m2 stops
Spirit Airlines Logo
1:26 am - 2:34 pmGYE-MYR
13h 08m2 stops
$520Spirit Airlines
Find Deal
Wed, Jan 28 - Wed, Feb 11
American Airlines Logo
12:18 pm - 11:22 pmMYR-GYE
11h 04m2 stops
American Airlines Logo
7:15 am - 8:54 pmGYE-MYR
13h 39m2 stops
$539American Airlines
Find Deal
Tue, Mar 10 - Fri, Mar 13
Delta Logo
10:55 am - 7:30 pmMYR-BOG
9h 35m1 stop
Delta Logo
3:55 pm - 10:08 amBOG-MYR
17h 13m1 stop
$543Delta
Find Deal
Tue, Mar 10 - Fri, Mar 13
Delta Logo
6:00 am - 4:45 pmMYR-BOG
11h 45m2 stops
Delta Logo
3:55 pm - 10:08 amBOG-MYR
17h 13m1 stop
$548Delta
Find Deal
Sat, Mar 14 - Fri, Mar 20
American Airlines Logo
10:22 am - 10:15 pmMYR-MDE
12h 53m2 stops
American Airlines Logo
12:20 am - 2:28 pmMDE-MYR
13h 08m2 stops
$574American Airlines
Find Deal
Sun, Apr 19 - Sun, Apr 26
LATAM Airlines Logo
2:15 pm - 6:25 amMYR-LIM
17h 10m2 stops
LATAM Airlines Logo
8:25 am - 11:38 pmLIM-MYR
14h 13m2 stops
$619LATAM Airlines
Find Deal
Tue, Mar 10 - Wed, Mar 11
Spirit Airlines Logo
9:10 am - 9:35 pmMYR-LIM
13h 25m1 stop
Spirit Airlines Logo
10:30 pm - 5:42 pmLIM-MYR
18h 12m1 stop
$621Spirit Airlines
Find Deal
Sun, Apr 19 - Sun, Apr 26
LATAM Airlines Logo
6:45 pm - 9:10 pmMYR-LIM
27h 25m1 stop
LATAM Airlines Logo
4:00 pm - 10:09 amLIM-MYR
41h 09m2 stops
$626LATAM Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Myrtle Beach and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Myrtle Beach to South America.

There are 2 airlines that fly nonstop from Myrtle Beach to South America. They are LATAM Airlines and Spirit Airlines. The cheapest airline for this route is Spirit Airlines, with the best round-trip deal found costing $327 and arriving in Medellín Jose Maria Cordova Intl Airport (MDE). On average, Spirit Airlines offers the best prices for nonstop flights between Myrtle Beach and South America.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($520) and American Airlines ($539).

Good to know

Low seasonAugust
Cheapest flight$216
Best time to beat the crowds with an average 7% drop in price.
Most popular time to fly with an average 59% increase in price.
Flight from Myrtle Beach to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the evening, when round-trip flights cost $844 on average. Morning departures are around 1% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally in the morning, which is peak travel time and where the average cost of a ticket is $853.

Reviews of the top airlines flying from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1874 reviews
6.7Food
7.3Comfort
7.6Boarding
8.0Crew
7.0Entertainment
Airline reviews

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

8.0 ExcellentAnonymous, Nov 2025LIM - JFK
Read more LATAM Airlines reviews

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Check in -- in business took over 30 mins as there was only one attendant. Boarding was also a mess. The seat was too narrow and was not working properly. Food was very bad and the entertainment very poor. Crew was very polite and helpful, in fairness.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

It was better than expected. But there were two delays in taking off.

To be Honest they canceled my flight and didn't have other options. Until 4 says later and I have a 2yr old very disappointed.

The whole thing everything was poorly managed poorly handled spirit doent deserve to be in business period.

Nothing. It was delayed three times and then canceled and we had to drive 15 hours to get home and rent a car.

Flight was delayed. (To be excepted because of TSA shortage) I’m super short and still struggled with leg room, there was no screen, and the seat didn’t recline at all.

The pilot would speak it was painfully load a d the crew had to know this! Maybe the were hesitant to tell him. It was just a mediocre experience and I was in Spirit first class!

My flight was cancelled last minute and I had to pay $1600 for flights, when my original flights were $300. It was a terrible experience.

Boarding was easy. I loved that they sat our family together even though we didn't pay for specific seats. I thought $5+ was a lot for pretzels and wish they had a small free snack.

The Hawaiian lady that boarded me was rude and the one help me a the ticket counter was rude

My experience was terrible. They cancelled my flight twice. They kept delaying it and leading me on, acting like the flight was going to go when it never had a chance. I missed out on valuable family time because of spirit and I won’t be flying with them again.

Everything you need to know for your flight to South America

Information on your arrival and departure airports