$194 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$591
Bogotá
Bogotá1 stop$442
Santiago
Santiago2 stops$1,100
Quito
Quito2 stops$590
Guayaquil
Guayaquil2 stops$376
Lima
Lima1 stop$591
Bogotá
Bogotá1 stop$442
Santiago
Santiago2 stops$1,100
Quito
Quito2 stops$590
Guayaquil
Guayaquil2 stops$376

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Wed, May 13 - Tue, May 19
Multiple Airlines Logo
7:51 pm - 9:25 pm
MYR
-
MDE
26h 34m
1 stop
Multiple Airlines Logo
1:00 pm - 9:41 am
MDE
-
MYR
19h 41m
1 stop
$362Multiple Airlines
Wed, May 13 - Wed, May 20
Multiple Airlines Logo
7:51 pm - 9:25 pm
MYR
-
MDE
26h 34m
1 stop
Multiple Airlines Logo
1:00 pm - 9:41 am
MDE
-
MYR
19h 41m
1 stop
$364Multiple Airlines
Mon, Mar 16 - Mon, Mar 23
Spirit Airlines Logo
6:28 pm - 11:04 pm
MYR
-
GYE
29h 36m
1 stop
Spirit Airlines Logo
11:59 pm - 5:33 pm
GYE
-
MYR
16h 34m
1 stop
$380Spirit Airlines
Tue, Mar 3 - Thu, Mar 5
Spirit Airlines Logo
9:09 am - 12:04 am
MYR
-
GYE
14h 55m
1 stop
Spirit Airlines Logo
12:59 am - 8:13 am
GYE
-
MYR
31h 14m
1 stop
$520Spirit Airlines
Wed, May 13 - Wed, May 20
American Airlines Logo
9:14 am - 8:15 pm
MYR
-
MDE
12h 01m
2 stops
American Airlines Logo
6:00 am - 11:57 pm
MDE
-
MYR
16h 57m
2 stops
$553American Airlines
Mon, Mar 30 - Mon, Apr 6
American Airlines Logo
6:00 am - 10:10 pm
MYR
-
BOG
17h 10m
2 stops
American Airlines Logo
1:40 pm - 9:45 am
BOG
-
MYR
19h 05m
2 stops
$565American Airlines
Sat, May 16 - Sun, May 24
United Airlines Logo
3:14 pm - 5:00 am
MYR
-
UIO
14h 46m
2 stops
United Airlines Logo
7:25 am - 9:59 am
UIO
-
MYR
25h 34m
2 stops
$610United Airlines
Mon, May 11 - Tue, May 19
Delta Logo
6:00 am - 8:20 pm
MYR
-
LIM
15h 20m
2 stops
Delta Logo
12:10 am - 11:57 pm
LIM
-
MYR
22h 47m
2 stops
$615Delta
Tue, Mar 31 - Mon, Apr 6
United Airlines Logo
3:15 pm - 11:25 pm
MYR
-
UIO
33h 10m
2 stops
United Airlines Logo
12:35 am - 2:17 pm
UIO
-
MYR
36h 42m
2 stops
$624United Airlines
Mon, Apr 6 - Thu, Apr 16
Delta Logo
6:00 am - 6:59 pm
MYR
-
UIO
13h 59m
1 stop
Delta Logo
6:50 pm - 3:03 pm
UIO
-
MYR
19h 13m
2 stops
$650Delta
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($380) and Delta ($546).

Good to know

Low seasonAugust
Cheapest flight$194
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 51% increase in price.
Flight from Myrtle Beach to Guayaquil

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8207 reviews
7.2Food
7.9Comfort
8.1Boarding
8.5Crew
7.8Entertainment
Airline reviews

First flight out and was 85 minutes delayed. Notification came out way too late

4.0 OkayJason, Feb 2026
SEA - SLC
Read more Delta reviews

First flight out and was 85 minutes delayed. Notification came out way too late

Delta flights recently are always delayed AND at jfk tney get the gates further away (need To walk 20’ to get to them/all the way at the end of the terminal). Not sure whats happening but price doesnt match experience!

Everything I mentioned earlier - the airbus was more comfortable indeed and the experience was further enhanced.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Good experience and the flight landed early. There was no food I had or entertainment.

Flight was delayed and no reasons provided. After the passengers were boarded, the crew made announcement that the captain has jot arrived and he would take another 15 mins. All passengers patiently sat until the captain came and started. Terrible experience!

Flight was delayed. No information on why it was delayed. After we boarded the flight, , the crew made announcement that the captain hs not arrived and he will take 15 mins more to arrive. Passengers were just sitting patiently for the captain to arrive and start, Terrible experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

Smallest leg room I've ever had on a plane.

I paid for the seats in row 3 to embark and disembark quicker but the passengers in the 2 rows in front of me take all the overhead bin space so I am forced to put my luggage 5 rows back. I even opened one up right above my seat which had room but as I was going to fit my carry on a flight atendant said it "was reserved", Just giving my money to a regular airline next time.

Terrible Flight was cancelled last minute with no other flights available

I was not informed via text about flight delay and gate change. There should have been a notice by the original gate letting us know that there was a change. A half hour before original flight time we realized there was no one there and were told that the gate was changed so we ran across the airport (I was traveling with my aunt who is in her upper 60s) to try to make the flight and then saw that the flight was actually delayed an hour . If you can do something for us to makeup for this we would appreciate it. Thank you

Terrible. Spirit cancelled the flight with 3 hours notice and were absolutely no help getting another flight. Had to make my own reservation on another airline and arrived in Dallas 12 hours later.

The flight itself was great except for an air traffic controller delay. We left 30 min late but they made up most of the time in flight. The booking was frustrating, as we chose a certain flight and it was changed four times. We got to Orlando several hours later than the original flight we chose.

Crew was very nice. Take off and landing were great. Economy seats are not comfortable. Extra cost for snacks.

Less than acceptable. Family members had flights cancelled with no reason. Multiple hour delay, gate changes, poor communication, less than satisfactory. I will never fly with spirit again, which is a shame because it’s a budget friendly option but quite frankly with all of the hassle and hoops that come with flying spirit. Completely unacceptable.

Everything was terrible. Flight was delayed several hours, crew was abrasive. Stuck on runway for over a hour. There was an argument between passengers that nearly turned into a fight while waiting to exit plane, crew did nothing. Took nearly 3 hours to retrieve luggage at baggage claim. Lost an entire day of vacation. Will never fly spirit again under any circumstance

There absolutely needs to be WiFi on flights. Not sure why this new aircraft did not have the capability, but it made for a very frustrating flight. I honestly would have paid twice as much for another airline to have WiFi as an option, especially as a mom with kids who have disabilities.

More comfortable seats, free snacks and soft drinks, some sort of entertainment or WiFi.

Everything you need to know for your flight to South America

Information on your arrival and departure airports