$129 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$720
Bogotá
Bogotá1 stop$414
Santiago
Santiago2 stops$714
Quito
Quito2 stops$664
Guayaquil
Guayaquil1 stop$401
Lima
Lima2 stops$720
Bogotá
Bogotá1 stop$414
Santiago
Santiago2 stops$714
Quito
Quito2 stops$664
Guayaquil
Guayaquil1 stop$401

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Sat, Mar 14 - Fri, Mar 20
Spirit Airlines Logo
6:37 pm - 11:18 pm
MYR
-
GYE
29h 41m1 stop
Spirit Airlines Logo
12:13 am - 5:39 pm
GYE
-
MYR
16h 26m1 stop
$401Spirit Airlines
Fri, Feb 13 - Thu, Feb 19
Spirit Airlines Logo
9:09 am - 12:04 am
MYR
-
GYE
14h 55m1 stop
Spirit Airlines Logo
12:59 am - 8:13 am
GYE
-
MYR
31h 14m1 stop
$403Spirit Airlines
Sat, Feb 14 - Fri, Feb 20
Multiple Airlines Logo
9:09 am - 8:05 am
MYR
-
BOG
46h 56m2 stops
Multiple Airlines Logo
3:06 pm - 8:13 am
BOG
-
MYR
17h 07m1 stop
$430Multiple Airlines
Fri, Feb 13 - Thu, Feb 19
Multiple Airlines Logo
6:18 pm - 12:04 am
MYR
-
GYE
29h 46m2 stops
Multiple Airlines Logo
12:59 am - 8:13 am
GYE
-
MYR
31h 14m1 stop
$432Multiple Airlines
Sun, Mar 1 - Sat, Mar 21
American Airlines Logo
9:30 am - 9:10 pm
MYR
-
MDE
11h 40m2 stops
American Airlines Logo
7:00 am - 11:55 pm
MDE
-
MYR
15h 55m2 stops
$532American Airlines
Mon, Feb 2 - Thu, Feb 5
LATAM Airlines Logo
6:00 am - 7:30 pm
MYR
-
BOG
13h 30m1 stop
LATAM Airlines Logo
9:00 am - 11:41 pm
BOG
-
MYR
14h 41m1 stop
$543LATAM Airlines
Mon, Feb 2 - Thu, Feb 5
LATAM Airlines Logo
6:00 am - 7:30 pm
MYR
-
BOG
13h 30m1 stop
LATAM Airlines Logo
10:55 am - 11:41 pm
BOG
-
MYR
12h 46m2 stops
$548LATAM Airlines
Sun, Mar 1 - Sat, Mar 21
American Airlines Logo
5:10 am - 9:10 pm
MYR
-
MDE
16h 00m2 stops
American Airlines Logo
2:10 pm - 9:57 am
MDE
-
MYR
18h 47m2 stops
$554American Airlines
Tue, Feb 10 - Tue, Feb 17
Delta Logo
10:33 am - 3:30 pm
MYR
-
SCL
26h 57m2 stops
Delta Logo
6:30 pm - 3:02 pm
SCL
-
MYR
22h 32m2 stops
$714Delta
Wed, Mar 18 - Wed, Mar 25
Delta Logo
6:00 am - 5:35 am
MYR
-
SCL
22h 35m2 stops
Delta Logo
10:30 pm - 12:06 am
SCL
-
MYR
26h 36m2 stops
$3,359Delta
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Myrtle Beach and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Myrtle Beach to South America.

There are 3 airlines that fly nonstop from Myrtle Beach to South America. They are: LATAM Airlines, Delta and Spirit Airlines. The cheapest price of all airlines flying this route was found with Spirit Airlines at $327 for a round-trip flight to Medellín Jose Maria Cordova Intl Airport (MDE). On average, Spirit Airlines offers the best prices for nonstop flights between Myrtle Beach and South America.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($401) and LATAM Airlines ($543).

Good to know

Low seasonAugust
Cheapest flight$129
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 53% increase in price.
Flight from Myrtle Beach to Guayaquil

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8011 reviews
7.9Comfort
8.5Crew
7.8Entertainment
7.2Food
8.1Boarding
Airline reviews

A 12 hour flight during the day with one real meal service - are you kidding? Also the breakfast was one of the worst and not what was listed

4.0 OkayAvik, Dec 2025
SEA - ICN
Read more Delta reviews

A 12 hour flight during the day with one real meal service - are you kidding? Also the breakfast was one of the worst and not what was listed

Flight was delayed several times. At one point, they "pulled back" 15 minutes from the delayed boarding and sent a text saying we would board sooner than previously advised. The flight then was delayed again. And when we boarded, there was an unspecified technical issue which had us waiting in the plane for about an hour.

Delta is a good airline. I've never had an issue with Delta. I'll continue to fly with them until they show me that I shouldn't.

The only thing nice I can say is the flight crew was really nice and apologetic about the situation. They shared as much information as they had and advised us on what we could do about missing connecting flights. The boarding process was so slow. The gate agent was working by herself and should have had someone working with her. It took almost an hour to board because she was trying to board a full flight of people and provide customer service to everyone who was flying standby and/or had questions. It was really chaotic. This didn't help the fact that we were delayed and folks were missing connections the longer it took.

The gate attendants and the crew were terrible. Because of high winds, they needed to carry more fuel, so they had to get volunteers to take the next flight at 6 am the next day. They did a terrible job of it - our flight ended up taking off just under 3 hours of the scheduled time. I hope to never fly Delta again.

Did not realize internet screen was hidden between seats and no info printed!!!!

2 of the seats in row 31 the entertainment system was not working, and one seat the tray table did not go all the way down. Flight arrived early and departed on time which was great.

Very good flight crew and very nice people staff were incredible especially the gate agent

Waited at the usual crowded gate at DCA where one ends up standing up because there aren't enough seats.

The flight was delayed for about 2 hrs. Other than it, it was good.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

I arrived two hours early, and at 9:20 I was still queuing for security.

We had too many delays for the crew not the plane

I liked that the crew looked well put together. I also liked that there were little turbulences.

The front desk personnel at ORF ticketing were the only good experience I had during my round trip. I encourage spirit to re-assess all aspects of their internal operations. This includes their website with constant issues connecting to their data base and questionable system practices. The employees of spirit airlines I will not comment on, as I believe primary issues had been a direct result of poor work conditions and expectations placed upon them. The holidays cause high emotions for everyone, this is an excellent time to take the opportunity to provide solutions for them, not take monetary advantage.

I knew what I was getting into, but never again. Hour long bag drop. 1.5 hour delay. 1 hr 45 mins sitting on the tarmac after landing. They lost a bunch of bags but luckily not mine. Awful experience.

The counter people was very disrespectful screaming and not helpful to find another flight soon. Having to cancel the flight

Canceled flight without any explanation at last moment. No replacement options. Not a weather related event. Completely messed up our holiday plans.

There wan no flight and they didn’t tell the reason for cancellation.

Delays due to a "power bank removal", no wifi, pilot said wrong arrival city, stewardess mumbled the word drinks as she rushed past, loud passengers with no enforcement of rules (blasting music out loud on their phones), screaming children

They cancelled my flight same day with no explanation why. They offered to rebook me but it would not be until 2 days later. I will never use them again.

Everything you need to know for your flight to South America

Information on your arrival and departure airports