$173 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$735
Bogotá
Bogotá1 stop$341
Santiago
Santiago3 stops$824
Cartagena
Cartagena1 stop$361
Quito
Quito2 stops$652
Guayaquil
Guayaquil2 stops$859
Lima
Lima2 stops$735
Bogotá
Bogotá1 stop$341
Santiago
Santiago3 stops$824
Cartagena
Cartagena1 stop$361
Quito
Quito2 stops$652
Guayaquil
Guayaquil2 stops$859

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Sat, Apr 18 - Sun, Apr 26
Spirit Airlines Logo
11:52 am - 1:12 pm
MYR
-
BOG
26h 20m
1 stop
Spirit Airlines Logo
2:07 pm - 11:29 pm
BOG
-
MYR
8h 22m
1 stop
$341Spirit Airlines
Fri, Apr 10 - Fri, Apr 17
Spirit Airlines Logo
6:28 pm - 12:06 pm
MYR
-
CTG
18h 38m
1 stop
Spirit Airlines Logo
1:11 pm - 11:29 pm
CTG
-
MYR
9h 18m
1 stop
$361Spirit Airlines
Sat, Apr 18 - Sun, Apr 26
Spirit Airlines Logo
11:52 am - 12:06 pm
MYR
-
CTG
25h 14m
1 stop
Spirit Airlines Logo
1:11 pm - 11:29 pm
CTG
-
MYR
9h 18m
1 stop
$386Spirit Airlines
Thu, Apr 30 - Thu, May 7
Multiple Airlines Logo
11:52 am - 1:12 pm
MYR
-
BOG
26h 20m
1 stop
Multiple Airlines Logo
2:07 pm - 2:20 pm
BOG
-
MYR
23h 13m
1 stop
$412Multiple Airlines
Thu, Apr 30 - Thu, May 7
Multiple Airlines Logo
11:52 am - 8:00 am
MYR
-
BOG
21h 08m
2 stops
Multiple Airlines Logo
9:05 am - 8:58 pm
BOG
-
MYR
10h 53m
1 stop
$416Multiple Airlines
Wed, May 13 - Sat, May 23
American Airlines Logo
6:04 am - 8:15 pm
MYR
-
MDE
15h 11m
2 stops
American Airlines Logo
1:53 pm - 12:28 pm
MDE
-
MYR
21h 35m
2 stops
$575American Airlines
Tue, Apr 28 - Tue, May 5
American Airlines Logo
6:30 pm - 12:09 pm
MYR
-
CTG
18h 39m
2 stops
American Airlines Logo
1:25 pm - 12:17 pm
CTG
-
MYR
21h 52m
2 stops
$586American Airlines
Tue, May 5 - Tue, Jul 21
Delta Logo
6:00 am - 9:35 pm
MYR
-
LIM
16h 35m
2 stops
Delta Logo
8:55 am - 10:09 am
LIM
-
MYR
24h 14m
2 stops
$735Delta
Tue, Apr 21 - Thu, Apr 23
LATAM Airlines Logo
1:43 pm - 4:43 am
MYR
-
UIO
16h 00m
2 stops
LATAM Airlines Logo
6:50 pm - 12:57 pm
UIO
-
MYR
17h 07m
2 stops
$738LATAM Airlines
Tue, May 5 - Mon, Jul 20
LATAM Airlines Logo
7:02 pm - 9:55 pm
MYR
-
LIM
27h 53m
1 stop
LATAM Airlines Logo
12:05 am - 12:19 pm
LIM
-
MYR
11h 14m
1 stop
$773LATAM Airlines
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($361) and LATAM Airlines ($642).

Good to know

Low seasonAugust
Cheapest flight$173
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 51% increase in price.
Flight from Myrtle Beach to Medellín

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8292 reviews
7.8Entertainment
8.5Crew
8.1Boarding
7.9Comfort
7.2Food
Airline reviews

8 hours late and the plane smelled like urine, that smell in the morning when your child wet the bed in the night.

2.0 MediocreDouglas, Mar 2026
MSP - SEA
Read more Delta reviews

8 hours late and the plane smelled like urine, that smell in the morning when your child wet the bed in the night.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

Miserable. This entire round trip was miserable. I booked evening flights to and from Detroit on consecutive days that should have had me at my destination by 10:30. Instead I arrived after 3am on my flight to Detroit and after midnight on my return. Multiple unforced errors like awaiting bags to get put on the plane for almost an hour in Detroit and a 20 minute delay to pull up to the gate in Atlanta has me rethinking my assumption that delta is the best and most reliable airline

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

First class is comfortable. Enjoyed a movie and was able to relax compared to coach.

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

The WiFi was not working. That made for a long flight.

With Aeromexico it ended up good but with Delta it was bad because we did everything through Delta... Showed up at the Delta terminal... It was the wrong place! Nothing ever told us to go to the Aeromexico terminal. It said "in partnership with Aeromexico" but I was never instructed to check in with them or go to their terminal. We had to haul @$$ running through the airport and almost didn't make it thanks to this poor communication. 👎🏽

Absolutely no communication on why there's a delay and multiple flight time reschedules. I would have canceled the flight and drove back home if I known it was going to be rescheduled 3 or 4 times.

It was delayed for 2 hours. Then when we arrived they took us on a very uncomfortable bus and left us there. The bus driver wouldn't let us out because no one from Latam was there. Everything was disaster.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

Delayed 11 hours with two being on our destinations tarmac, no compensation or refund and was told I would actually get charged a $200 cancellation fee if I decided to switch airlines for my return flight. For their inconvenience they gave a $10 meal voucher to split between two people in a airport.

Absolutely terrible, flight was cancelled and we missed our cruise. Will never fly Spirit again.

Horrendous and unprofessional staff and will never fly spirit again

Like Spirit but bad that you have to pay for water 🙃

My flight was ultimately cancelled but the lack of updates and professionalism from the crew leading up to the cancellation announcement was frustrating for all passengers.

Delay due to personnel issues on Spirit’s end. Original departure time 9:30pm. Took off at 2:15am. Lost an entire night’s sleep bc Spirit couldn’t get a crew together. Very poor.

Sadly the flight was delayed by 4 hours due to the weather snd sir traffic control staffing. Otherwise the crew was amazing and the flight was perfect.

If there are delays, it takes less than a minute for a Spirit employee to make an announcement. It’s very simple.

I’m still waiting to get on the flight. No one knows what’s happening. The passengers have gotten no updates. We have been up all night and waiting at the airport. This is no way to operate and we should be refunded for this lack of respect for their passengers.

Not enough crew members so we had to wait for more to arrive and they could never give us updates timing. Not even water for free on board. Bare bones airplane- there wasn’t even a seat back pocket to put things into. Spirit is cheap for a reason but this was dismal

Everything you need to know for your flight to South America

Information on your arrival and departure airports