$202 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$472
Bogotá
Bogotá1 stop$330
Santiago
Santiago2 stops$870
Cartagena
Cartagena1 stop$341
Quito
Quito2 stops$813
Guayaquil
Guayaquil1 stop$287
Lima
Lima1 stop$472
Bogotá
Bogotá1 stop$330
Santiago
Santiago2 stops$870
Cartagena
Cartagena1 stop$341
Quito
Quito2 stops$813
Guayaquil
Guayaquil1 stop$287

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Fri, Mar 6 - Fri, Mar 13
Spirit Airlines Logo
9:09 am - 12:04 am
MYR
-
GYE
14h 55m
1 stop
Spirit Airlines Logo
11:59 pm - 5:39 pm
GYE
-
MYR
16h 40m
1 stop
$287Spirit Airlines
Mon, Feb 23 - Mon, Mar 23
Spirit Airlines Logo
9:09 am - 2:13 pm
MYR
-
MDE
29h 04m
1 stop
Spirit Airlines Logo
2:17 pm - 5:39 pm
MDE
-
MYR
26h 22m
1 stop
$297Spirit Airlines
Mon, Feb 23 - Mon, Mar 23
Spirit Airlines Logo
9:09 am - 2:13 pm
MYR
-
MDE
29h 04m
1 stop
Spirit Airlines Logo
2:17 pm - 2:32 pm
MDE
-
MYR
23h 15m
2 stops
$326Spirit Airlines
Fri, Feb 20 - Sun, Feb 22
Spirit Airlines Logo
9:09 am - 2:10 pm
MYR
-
BOG
29h 01m
1 stop
Spirit Airlines Logo
3:06 pm - 8:13 am
BOG
-
MYR
17h 07m
1 stop
$330Spirit Airlines
Sun, Feb 15 - Sat, Feb 21
Multiple Airlines Logo
12:39 pm - 12:47 pm
MYR
-
BOG
24h 08m
1 stop
Multiple Airlines Logo
1:45 pm - 9:50 am
BOG
-
MYR
20h 05m
1 stop
$371Multiple Airlines
Thu, Feb 5 - Mon, Feb 9
Multiple Airlines Logo
8:15 pm - 12:21 am
MYR
-
GYE
28h 06m
1 stop
Multiple Airlines Logo
4:40 am - 7:10 pm
GYE
-
MYR
14h 30m
2 stops
$388Multiple Airlines
Sun, Mar 1 - Fri, Mar 20
American Airlines Logo
6:23 pm - 2:06 pm
MYR
-
MDE
19h 43m
2 stops
American Airlines Logo
12:20 am - 6:44 pm
MDE
-
MYR
17h 24m
2 stops
$589American Airlines
Thu, Apr 16 - Mon, May 4
LATAM Airlines Logo
6:00 am - 8:20 pm
MYR
-
LIM
15h 20m
2 stops
LATAM Airlines Logo
8:55 am - 11:58 pm
LIM
-
MYR
14h 03m
2 stops
$615LATAM Airlines
Sat, Mar 7 - Fri, Mar 13
Delta Logo
10:35 am - 7:40 am
MYR
-
SCL
19h 05m
1 stop
Delta Logo
12:20 am - 12:04 am
SCL
-
MYR
24h 44m
2 stops
$900Delta
Sat, Mar 7 - Sat, Mar 14
LATAM Airlines Logo
6:00 am - 7:40 am
MYR
-
SCL
23h 40m
1 stop
LATAM Airlines Logo
10:10 pm - 9:33 am
SCL
-
MYR
12h 23m
1 stop
$927LATAM Airlines
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($287) and Delta ($900).

Good to know

Low seasonAugust
Cheapest flight$202
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 53% increase in price.
Flight from Myrtle Beach to Medellín

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8086 reviews
7.9Comfort
8.5Crew
8.1Boarding
7.8Entertainment
7.2Food
Airline reviews

There was no wifi available on this flight. And there were no screens, no onboard entertainment, no entertainment options at all. It was like travelling in the 1990s again, except without even a main screen for options. Seats, as usual, were tight and uncomfortable.

4.0 OkayJohn, Jan 2026
DAL - ATL
Read more Delta reviews

There was no wifi available on this flight. And there were no screens, no onboard entertainment, no entertainment options at all. It was like travelling in the 1990s again, except without even a main screen for options. Seats, as usual, were tight and uncomfortable.

Good seat comfort ORF to ATL. Bad seat ATL to SEA (terrible lumbar support, hard, ouch)..

Because I was moved to an exit row, the snacks in economy comfort, the selection of snacks was better.

I upgraded to first. Quick and easy boarding. Comfortable seat with power and a nice IPA.

Probably not the fault of Delta but there was delay after delay after delay and I ended up getting home 4 hours later then I should have at 1:30 in the morning

Easiest airport experience ever in my life at MSP with Delta check-in and flight attendant gave us a bottle of champagne in celebration of our 10-year wedding anniversary, so overall amazing!

No in flight service, no explanation - FC got service, C+ did not, unsure about Economy. No turbulence to speak of, so I guess another way to cut cost, or promote health and well being of Delta employees? Also, boarding in MEM combined zones, and with overhead space already full on both flights after Zone 2/ Diamond, presents a huge challenge to find a space for a bag. Delta, other than point A to B, is no longer reasonable to fly - very poor experiences, not even taking into account the chastising at the gate and rude crews, across the board.

It would have been better if the flight wasn't delayed by 2.5 hours

Delta’s staff is unmatched. From the gate agents, to the pilots, to the flight attendants… all top of the industry.

Delta flight Delay for ,more that two hours i.e original flight was 6.30 PM and it starts at 8.45 PM, When we connect Delta team for meal vouchers as it is late arrival in designation,But we did not get it as per delta policy , which is not good for mid night arrival,

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Extra legroom with my upgrade bundle. Clean aircraft, on-time departure, early arrival. Good value for the price.

I didn't have a flight because of a ticking problem that was discovered at the airport at checkin for the initial flight of the round trip.

Even though the plane was delayed from the previous airport, the staff recognized this and kept us informed. The flight crew was absolutely awesome from on my flight from Ft. Meyers to AC. Great experience all around!

Flight was delayed would have liked it to have been on time. I didn't experience the food or entertainment but the boarding process was smooth and the flight crew worked well together and did a great job!

Not seat assigned because overbooking. We could go because some people decided to give their seats.

Spirit loves to pick and choose when to harass you about your personal item. I’ve flown numerous times with the same bag with no problem yet flying out of Orlando they forced me to pay $99 for a carry on and then ran out of overhead space. Do better!

For the price of the fare, there really isn’t much to complain about.

didn't order food on board. there's no way to hold a water botton on the way. otherwise it was a pleasant flight, thanks to the crew.

Even though there was a delay the crew was exceptional.

Cheap, only one short delay. No issues despite bad weather. Able to take a big backpack for free.

Everything you need to know for your flight to South America

Information on your arrival and departure airports