$350 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$633
Bogotá
Bogotá1 stop$463
Santiago
Santiago1 stop$1,074
Cartagena
Cartagena1 stop$604
Guayaquil
Guayaquil2 stops$568
Lima
Lima2 stops$633
Bogotá
Bogotá1 stop$463
Santiago
Santiago1 stop$1,074
Cartagena
Cartagena1 stop$604
Guayaquil
Guayaquil2 stops$568

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Sun, Dec 7 - Mon, Dec 15
Spirit Airlines Logo
9:54 am - 12:55 amMYR-BOG
15h 01m1 stop
Spirit Airlines Logo
3:05 pm - 5:48 pmBOG-MYR
26h 43m1 stop
$463Spirit Airlines
Find Deal
Sun, Dec 7 - Mon, Dec 15
Multiple Airlines Logo
9:54 am - 12:55 amMYR-BOG
15h 01m1 stop
Multiple Airlines Logo
5:10 pm - 5:48 pmBOG-MYR
24h 38m2 stops
$473Multiple Airlines
Find Deal
Tue, Nov 11 - Tue, Nov 18
Spirit Airlines Logo
11:13 am - 12:57 amMYR-MDE
13h 44m2 stops
Spirit Airlines Logo
2:57 pm - 10:08 amMDE-MYR
19h 11m2 stops
$481Spirit Airlines
Find Deal
Tue, Mar 10 - Fri, Mar 13
Delta Logo
6:45 pm - 12:05 pmMYR-BOG
18h 20m2 stops
Delta Logo
2:55 pm - 11:35 pmBOG-MYR
7h 40m1 stop
$543Delta
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Sat, Feb 7 - Sun, Feb 22
LATAM Airlines Logo
4:00 pm - 7:30 pmMYR-BOG
27h 30m1 stop
LATAM Airlines Logo
3:55 pm - 11:35 pmBOG-MYR
7h 40m1 stop
$550LATAM Airlines
Find Deal
Tue, Mar 10 - Fri, Mar 13
LATAM Airlines Logo
6:00 am - 6:40 pmMYR-BOG
13h 40m2 stops
LATAM Airlines Logo
7:00 am - 11:35 pmBOG-MYR
15h 35m2 stops
$564LATAM Airlines
Find Deal
Sun, Jan 11 - Mon, Jan 26
American Airlines Logo
7:19 pm - 2:15 pmMYR-BOG
18h 56m2 stops
American Airlines Logo
3:15 pm - 9:43 amBOG-MYR
18h 28m2 stops
$565American Airlines
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Tue, Mar 10 - Fri, Mar 13
Delta Logo
6:00 am - 1:15 pmMYR-CTG
8h 15m1 stop
Delta Logo
8:05 am - 11:35 pmCTG-MYR
14h 30m2 stops
$604Delta
Find Deal
Tue, Mar 3 - Fri, Mar 6
American Airlines Logo
11:14 am - 11:24 pmMYR-MDE
12h 10m2 stops
American Airlines Logo
4:10 pm - 8:24 amMDE-MYR
16h 14m2 stops
$726American Airlines
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Mon, Mar 16 - Wed, Mar 18
Air Canada Logo
1:00 pm - 11:15 amMYR-SCL
21h 15m2 stops
Air Canada Logo
7:55 pm - 5:04 pmSCL-MYR
22h 09m2 stops
$3,282Air Canada
Find Deal
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Myrtle Beach and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Myrtle Beach to South America.

There are 2 airlines that fly nonstop from Myrtle Beach to South America. They are LATAM Airlines and Spirit Airlines. The cheapest airline for this route is Spirit Airlines, with the best round-trip deal found costing $327 and arriving in Medellín Jose Maria Cordova Intl Airport (MDE). On average, Spirit Airlines offers the best prices for nonstop flights between Myrtle Beach and South America.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($463) and Delta ($543).

Good to know

Low seasonAugust
Cheapest flight$343
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 60% increase in price.
Flight from Myrtle Beach to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the evening, when round-trip flights cost $844 on average. Morning departures are around 1% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally in the morning, which is peak travel time and where the average cost of a ticket is $853.

Reviews of the top airlines flying from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1866 reviews
7.3Comfort
7.0Entertainment
8.0Crew
7.6Boarding
6.7Food
Airline reviews

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

2.0 MediocreMarcos, Oct 2025SCL - LAX
Read more LATAM Airlines reviews

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

My entertainment did not work. I was very tired from the botched connection, and the poor sleep

Lost ,y connection due to a mechanical delay, huge line to get new connection and vouchers

Vegas is such a quick flight that amenities aren’t the important part, in my opinion. Just get me there efficiently and safely, and that’s exactly what they did!

The flight was severely delayed due to the missing flight attendants.

Absolutely horrible. Usually pay $40-$50 to check luggage in. I tried to check my suitcase in and the price is raised to $70. That's ridiculously greedy c'mon. I had to leave my suitcase with all my clothes and hygiene products and repurchase once i landed in Atlanta. You guys make it really stressful to travel. Don't even want to travel anymore.

They cancelled the flight 3 hours prior departure. Had to spend $400 for a ne way flight with Delta Airlines! Spirit Airlines are not serios!

My luggage didn’t arrive at LAX, so that wasn’t a good experience.

Terrible seat, no in flight entertainment. No complimentary food or drinks. Seats really hurt my back after flying spirit for the day.

Plastic seat really hurt my back. Cannot even recline on the flight. Very hard to sleep on the plane due to terrible seats . Food and drinks were expensive and not very good. There were like 2 open exit rows behind me. My isle was full so I asked flight attendants if I could sit there. They told me it was a safety issue??? I think it more unsafe to have no one sitting there. In case of emergency, you’d want someone there to help.

The delays and the lack of communication and organization within the airport itself for Staffing this flight and coordinating the paper log necessary to depart was ridiculous and deplorable

It was a no show, so we got put in hotels for a nite. The A320 plane was very modern and flite and crew (if a pilot shows up were fine). Price was very good.

The entire staff from check in agents to flight attendants were pleasant and professional. Would suggest a complimentary water.

Everything you need to know for your flight to South America

Information on your arrival and departure airports

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