$225 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$436
Bogotá
Bogotá2 stops$543
Santiago
Santiago1 stop$1,074
Cartagena
Cartagena1 stop$379
Quito
Quito2 stops$543
Guayaquil
Guayaquil1 stop$443
Lima
Lima1 stop$436
Bogotá
Bogotá2 stops$543
Santiago
Santiago1 stop$1,074
Cartagena
Cartagena1 stop$379
Quito
Quito2 stops$543
Guayaquil
Guayaquil1 stop$443

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Fri, Dec 5 - Fri, Dec 12
Spirit Airlines Logo
9:54 am - 1:12 amMYR-BOG
15h 18m1 stop
Spirit Airlines Logo
2:17 am - 5:48 pmBOG-MYR
15h 31m1 stop
$322Spirit Airlines
Find Deal
Fri, Dec 5 - Fri, Dec 12
Spirit Airlines Logo
2:15 pm - 1:12 amMYR-BOG
10h 57m2 stops
Spirit Airlines Logo
2:17 am - 5:48 pmBOG-MYR
15h 31m1 stop
$366Spirit Airlines
Find Deal
Fri, Dec 5 - Sat, Dec 13
Multiple Airlines Logo
9:54 am - 1:12 amMYR-BOG
15h 18m1 stop
Multiple Airlines Logo
10:00 pm - 5:48 pmBOG-MYR
19h 48m2 stops
$404Multiple Airlines
Find Deal
Fri, Dec 5 - Sat, Dec 13
Multiple Airlines Logo
9:54 am - 10:25 amMYR-BOG
24h 31m2 stops
Multiple Airlines Logo
10:00 pm - 5:48 pmBOG-MYR
19h 48m2 stops
$406Multiple Airlines
Find Deal
Tue, Mar 10 - Fri, Mar 13
Delta Logo
10:55 am - 7:30 pmMYR-BOG
9h 35m1 stop
Delta Logo
3:55 pm - 10:08 amBOG-MYR
17h 13m1 stop
$543Delta
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Tue, Mar 10 - Fri, Mar 13
Delta Logo
6:00 am - 8:20 pmMYR-BOG
15h 20m2 stops
Delta Logo
3:55 pm - 10:08 amBOG-MYR
17h 13m1 stop
$548Delta
Find Deal
Tue, Mar 10 - Thu, Mar 12
LATAM Airlines Logo
6:00 am - 10:10 pmMYR-CLO
17h 10m2 stops
LATAM Airlines Logo
6:22 am - 10:08 amCLO-MYR
26h 46m2 stops
$647LATAM Airlines
Find Deal
Tue, Mar 3 - Fri, Mar 6
American Airlines Logo
6:52 am - 9:10 pmMYR-MDE
14h 18m2 stops
American Airlines Logo
3:10 pm - 10:10 amMDE-MYR
19h 00m2 stops
$726American Airlines
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Wed, Dec 24 - Wed, Dec 31
LATAM Airlines Logo
7:00 am - 8:55 pmMYR-LIM
13h 55m2 stops
LATAM Airlines Logo
8:50 am - 10:24 amLIM-MYR
25h 34m2 stops
$728LATAM Airlines
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Tue, Mar 10 - Thu, Mar 12
American Airlines Logo
2:33 pm - 12:55 pmMYR-CLO
23h 22m2 stops
American Airlines Logo
3:00 pm - 5:10 pmCLO-MYR
25h 10m2 stops
$743American Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Myrtle Beach and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Myrtle Beach to South America.

There are 2 airlines that fly nonstop from Myrtle Beach to South America. They are LATAM Airlines and Spirit Airlines. The cheapest airline for this route is Spirit Airlines, with the best round-trip deal found costing $327 and arriving in Medellín Jose Maria Cordova Intl Airport (MDE). On average, Spirit Airlines offers the best prices for nonstop flights between Myrtle Beach and South America.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($322) and Delta ($543).

Good to know

Low seasonAugust
Cheapest flight$225
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 60% increase in price.
Flight from Myrtle Beach to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the evening, when round-trip flights cost $844 on average. Morning departures are around 1% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally in the morning, which is peak travel time and where the average cost of a ticket is $853.

Reviews of the top airlines flying from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1874 reviews
7.0Entertainment
7.3Comfort
7.6Boarding
6.7Food
8.0Crew
Airline reviews

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

10.0 ExcellentRon, Oct 2025MVD - SCL
Read more LATAM Airlines reviews

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Check in -- in business took over 30 mins as there was only one attendant. Boarding was also a mess. The seat was too narrow and was not working properly. Food was very bad and the entertainment very poor. Crew was very polite and helpful, in fairness.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

The Hawaiian lady that boarded me was rude and the one help me a the ticket counter was rude

My experience was terrible. They cancelled my flight twice. They kept delaying it and leading me on, acting like the flight was going to go when it never had a chance. I missed out on valuable family time because of spirit and I won’t be flying with them again.

Prices for bags are extremely expensive and if you go higher on weight, the charge is ridiculous.

The flight was cancelled at the last minute. Will never fly Spirit again. Without a doubt the worst airline around.

My flight was delayed several times and eventually cancelled. Then the re-booked flight for 8pm was delayed multiple times over, and eventually it would have forced me to be at the airport for 9 hours. I accepted a rebook for the following day, fortunately I was able to stay with my friend again in New York, but if I didn’t have him as a resource it would have been much more upsetting.

Horrible, delay after delay due to our plane needing fuel.

Rough landings but comfortable and affordable if you can pack light

the plane was not full so the flight attendant had me move to an empty row which made for a good flight. The software for logging on and booking and confirming the flight is much too cumbersome.

Always comes in handy when I want a quick weekend getaway.

For the price I could have taken a “name brand” airline. No drink no snack and constant emails trying to get addition money for EVERYTHING other airlines include in the price. It looks cheaper but it’s Judy bait and switch and emails non stop!

Everything you need to know for your flight to South America

Information on your arrival and departure airports

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