$203 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$502
Bogotá
Bogotá2 stops$499
Santiago
Santiago1 stop$754
Cartagena
Cartagena2 stops$520
Quito
Quito2 stops$649
Guayaquil
Guayaquil1 stop$459
Lima
Lima1 stop$502
Bogotá
Bogotá2 stops$499
Santiago
Santiago1 stop$754
Cartagena
Cartagena2 stops$520
Quito
Quito2 stops$649
Guayaquil
Guayaquil1 stop$459

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Thu, Dec 11 - Fri, Dec 12
Spirit Airlines Logo
9:54 am - 1:09 amMYR-MDE
15h 15m1 stop
Spirit Airlines Logo
3:10 pm - 8:49 amMDE-MYR
17h 39m2 stops
$313Spirit Airlines
Find Deal
Thu, Dec 11 - Fri, Dec 12
Spirit Airlines Logo
9:54 am - 1:09 amMYR-MDE
15h 15m1 stop
Spirit Airlines Logo
3:10 pm - 8:49 amMDE-MYR
17h 39m2 stops
$331Spirit Airlines
Find Deal
Mon, Jan 5 - Mon, Jan 12
Multiple Airlines Logo
9:54 am - 5:25 amMYR-BOG
19h 31m2 stops
Multiple Airlines Logo
9:15 am - 7:20 pmBOG-MYR
10h 05m1 stop
$499Multiple Airlines
Find Deal
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
8:15 pm - 10:35 pmMYR-LIM
26h 20m1 stop
Multiple Airlines Logo
11:33 pm - 2:13 pmLIM-MYR
14h 40m1 stop
$502Multiple Airlines
Find Deal
Tue, Jan 6 - Tue, Jan 13
American Airlines Logo
5:29 pm - 3:30 pmMYR-CTG
22h 01m2 stops
American Airlines Logo
2:30 pm - 9:48 amCTG-MYR
19h 18m2 stops
$553American Airlines
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Sat, Apr 18 - Sat, Apr 25
Delta Logo
6:00 am - 8:20 pmMYR-LIM
15h 20m2 stops
Delta Logo
8:55 am - 10:09 amLIM-MYR
24h 14m2 stops
$634Delta
Find Deal
Sat, Apr 18 - Fri, Apr 24
Delta Logo
6:45 pm - 5:00 amMYR-LIM
11h 15m1 stop
Delta Logo
12:15 am - 11:38 pmLIM-MYR
22h 23m2 stops
$639Delta
Find Deal
Tue, Jan 6 - Tue, Jan 13
LATAM Airlines Logo
10:33 am - 2:17 pmMYR-CTG
27h 44m1 stop
LATAM Airlines Logo
3:32 pm - 11:41 pmCTG-MYR
8h 09m1 stop
$653LATAM Airlines
Find Deal
Sat, Apr 18 - Sat, Apr 25
LATAM Airlines Logo
6:45 pm - 9:10 pmMYR-LIM
27h 25m1 stop
LATAM Airlines Logo
11:20 pm - 5:58 pmLIM-MYR
17h 38m1 stop
$661LATAM Airlines
Find Deal
Wed, Jan 7 - Fri, Jan 9
American Airlines Logo
10:48 am - 9:10 pmMYR-MDE
10h 22m2 stops
American Airlines Logo
1:00 am - 5:04 pmMDE-MYR
16h 04m2 stops
$758American Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Myrtle Beach and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Myrtle Beach to South America.

There are 2 airlines that fly nonstop from Myrtle Beach to South America. They are LATAM Airlines and Spirit Airlines. The cheapest airline for this route is Spirit Airlines, with the best round-trip deal found costing $327 and arriving in Medellín Jose Maria Cordova Intl Airport (MDE). On average, Spirit Airlines offers the best prices for nonstop flights between Myrtle Beach and South America.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($313) and American Airlines ($553).

Good to know

Low seasonAugust
Cheapest flight$203
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 48% increase in price.
Flight from Myrtle Beach to Cartagena

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the evening, when round-trip flights cost $844 on average. Morning departures are around 1% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally in the morning, which is peak travel time and where the average cost of a ticket is $853.

Reviews of the top airlines flying from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1887 reviews
7.0Entertainment
6.7Food
7.3Comfort
7.6Boarding
8.0Crew
Airline reviews

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

10.0 ExcellentRon, Oct 2025MVD - SCL
Read more LATAM Airlines reviews

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Check in -- in business took over 30 mins as there was only one attendant. Boarding was also a mess. The seat was too narrow and was not working properly. Food was very bad and the entertainment very poor. Crew was very polite and helpful, in fairness.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

The plane was freezing and everyone had on their winter coats. I pulled out my sweaters out of my carryon to cover myself and put on an extra pair of socks. They offered NO FREE drinks or snacks on a 6 hour flight. The seats don’t have plugs or charges or any form of entertainment- so I just played my one downloaded game on my phone because I couldn’t sleep because I was too cold. Miserable flight though we landed safely.

Bought round trip tickets. Ended up upgrading to first class. Both flights were new planes but hadn’t been equipped with WiFi and there were no charging ports at my seat despite it being new and first class accommodations.

The flight was on time and the crew was very professional and accommodating. When other airlines are canceling flights Spirit is still flying with on time flights. I have no complaints and will continue to choose Spirit when it is the best option for me.

Very uncomfortable seat. Hard bar under cushion. Flight had no solution except to walk a around at times

Endless, trip oof my life, we still are in in plane waiting for getting off.after 3 hours delay. Not even a glass of water.

It was cheap. Spirit is what it is. I got to my destination and home safely. There was no food or entertainment without paying extra, which is fine. That’s why the flight was inexpensive.

Like: seats that don't move; fast boarding; engaging crew; low-prices; individual gate at LGA; access to restrooms at the gate Dislike: no water on the flight

No leg room. My knee was sore for a day.

It was better than expected. But there were two delays in taking off.

To be Honest they canceled my flight and didn't have other options. Until 4 says later and I have a 2yr old very disappointed.

Everything you need to know for your flight to South America

Information on your arrival and departure airports