$145 Find Cheap Flights from Myrtle Beach to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to South America departing on 5/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Myrtle Beach to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$663
Bogotá
Bogotá1 stop$372
Cartagena
Cartagena2 stops$485
Quito
Quito2 stops$610
Guayaquil
Guayaquil2 stops$1,040
Lima
Lima1 stop$663
Bogotá
Bogotá1 stop$372
Cartagena
Cartagena2 stops$485
Quito
Quito2 stops$610
Guayaquil
Guayaquil2 stops$1,040

Book Cheap Myrtle Beach to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to South America

Sat, Mar 28 - Sat, Apr 4
Multiple Airlines Logo
6:28 pm - 1:19 pm
MYR
-
CLO
19h 51m
1 stop
Multiple Airlines Logo
2:24 pm - 10:05 am
CLO
-
MYR
18h 41m
2 stops
$339Multiple Airlines
Sat, Mar 28 - Sat, Apr 4
Multiple Airlines Logo
6:28 pm - 1:11 pm
MYR
-
BOG
19h 43m
1 stop
Multiple Airlines Logo
2:10 pm - 10:05 am
BOG
-
MYR
18h 55m
2 stops
$372Multiple Airlines
Sat, Mar 28 - Sat, Apr 4
Spirit Airlines Logo
6:28 pm - 1:11 pm
MYR
-
BOG
19h 43m
1 stop
Spirit Airlines Logo
12:50 pm - 11:05 am
BOG
-
MYR
21h 15m
1 stop
$391Spirit Airlines
Sat, Mar 28 - Sat, Apr 4
Spirit Airlines Logo
6:28 pm - 11:55 am
MYR
-
BOG
18h 27m
2 stops
Spirit Airlines Logo
2:10 pm - 11:05 am
BOG
-
MYR
19h 55m
2 stops
$392Spirit Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
8:41 pm - 12:53 pm
MYR
-
MDE
17h 12m
2 stops
American Airlines Logo
12:30 am - 12:28 pm
MDE
-
MYR
10h 58m
2 stops
$566American Airlines
Sat, Mar 28 - Sat, Apr 4
American Airlines Logo
5:10 am - 10:04 pm
MYR
-
UIO
17h 54m
2 stops
American Airlines Logo
11:44 pm - 10:28 pm
UIO
-
MYR
21h 44m
2 stops
$610American Airlines
Sat, Mar 14 - Sat, Mar 21
LATAM Airlines Logo
4:00 pm - 9:20 pm
MYR
-
LIM
30h 20m
1 stop
LATAM Airlines Logo
10:45 am - 9:33 am
LIM
-
MYR
21h 48m
2 stops
$663LATAM Airlines
Sat, Mar 28 - Fri, Apr 3
LATAM Airlines Logo
4:00 pm - 6:59 pm
MYR
-
UIO
27h 59m
1 stop
LATAM Airlines Logo
12:59 am - 12:04 am
UIO
-
MYR
22h 05m
1 stop
$671LATAM Airlines
Sat, Mar 14 - Sat, Mar 21
Delta Logo
10:23 am - 9:20 am
MYR
-
LIM
23h 57m
2 stops
Delta Logo
10:45 am - 9:33 am
LIM
-
MYR
21h 48m
2 stops
$812Delta
Sat, Mar 14 - Fri, Mar 20
Delta Logo
10:23 am - 9:20 am
MYR
-
LIM
23h 57m
2 stops
Delta Logo
10:40 am - 9:33 am
LIM
-
MYR
21h 53m
2 stops
$875Delta
Booking Insights

KAYAK's insights & trends for Myrtle Beach to South America flights

Get data-powered insights and trends into flights from Myrtle Beach to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Myrtle Beach to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Myrtle Beach to South America were found on Spirit Airlines ($391) and American Airlines ($566).

Good to know

Low seasonAugust
Cheapest flight$145
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 51% increase in price.
Flight from Myrtle Beach to Guayaquil

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Myrtle Beach to South America

 
Need help choosing which airline to fly with from Myrtle Beach to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8181 reviews
8.5Crew
7.2Food
7.8Entertainment
8.1Boarding
7.9Comfort
Airline reviews

Was forced to check in my small carry on, even though I informed the crew it has very fragile items inside

2.0 MediocreJaspreet, Feb 2026
SEA - SMF
Read more Delta reviews

Was forced to check in my small carry on, even though I informed the crew it has very fragile items inside

This was one of the worst flights I’ve been on in years. I upgraded to comfort and had such an uncomfortable experience. The person next to me was oversized - which I understand - however, they took up their space and mine. I could only use about 50% of my seat space to not be physically touching this person the entire flight and there was no spatial awareness. I also could not use the seat outlet because their body was obstructing it. It was very inconvenient. Their body kept touching me repeatedly during the flight and I felt very uncomfortable. To pay more for an upgraded space and then not even being able to use it was highly disappointing.

No wheel chair as requested at Atlanta arrival on first flight.

Only freetext wifi was available in flight; browsing WiFi required payment. Since the seats had no in flight entertainment, Delta should revisit this policy on this longer flight.

Only water, tea or coffee served midflight, even to comfort seating. Man next to me needed two seats and took up a portion of my seat and Delta did nothing.

The flight was great as well as the airline staff

First class and monitors weren’t working for mine & my husbands. Eventually fixed, but quite annoyed as we bought first class. Also, No foot rests.

Prior to takeoff, the pilot told us there was a possibility of not being able to land and going to Portland. Well that happened, we took off and then did 8 loops around Spokane before the pilot told us we ran out of fuel and had to go to Portland. So for a 35 minute flight we have now been on the plane for 3 hours (boarded at 6:50 am and landed in Portland at 10:30). Then, we just sat in Portland's airport with no updates of when we can start heading back. All of a sudden, our pilots and crew just left, leaving us stranded in a different city and state. We continued to sit in Portland until we finally got a new crew assigned and boarded the plane (This was from 10:30-2). We then sat on the plane for an additional hour before take off because they had to count us multiple times. We finally landed in Spokane at 3:55 PM. So a flight that should have taken at max an hour took us 10 hours and we missed the majority of the recruiting event we went for.

It was delayed but other than that it was great.

Got on the plane and sat there for an hour before departure.

There absolutely needs to be WiFi on flights. Not sure why this new aircraft did not have the capability, but it made for a very frustrating flight. I honestly would have paid twice as much for another airline to have WiFi as an option, especially as a mom with kids who have disabilities.

More comfortable seats, free snacks and soft drinks, some sort of entertainment or WiFi.

Delay at the gate without any communication such as announcement, sign, monitor, email or text. Found out later we were boarded with the knowledge of a significant delay, awaiting communication from Europe. Pilot was the only source of information regarding the delay after a long gate delay and sitting for more than 30 minutes after boarding. More than 2 hour delay, landing at 2 AM. Offered to deplane and reboard, but probably should have just waited rather than repeat the process. Not the first time experiencing the lack of communication with Spirit airlines. This morning was not as bad as showing up to a terminal without an agent (or aircraft) without any sort of communication. Much later an email was sent that stated our flight was rescheduled for a week later. Situations do arise, but simple communication can alleviate a lot of the frustration. Hard to believe a corporation doesn't understand that. But, you get what you pay for...

This was a horrible experience for both KAYAK and Spirit. My flight was canceled with no alternative flight option. I paid $600 for a last minute flight and didn't receive an email from KAYAK regarding the cancelled flight until hours after it was canceled. Never again for either.

No complaints with pricing so don’t expect a lot of extras.

Flight out was great but this flight was canceled and nothing was available for 2 days after this so I had to purchase an expensive ticket from another airline so I could go home. The flight cancellation was said to be a crew issue, it wasn’t weather or maintenance.

Flight got cancelled 1.5 hours prior to gate open and logistics of travel got delayed.

They cancelled the flight due to crew unavailability. The next day they cancelled the flight again.

They cancelled my flight last minute, forcing me to rebook with another airline.

the fligh was delay form 9am to 10, delayed again from 10 to 11, than delay and gate change to 12 and delay another gate change to 3;25 pm

Everything you need to know for your flight to South America

Information on your arrival and departure airports