$159 Find Cheap Flights from Panama City to Florida Keys

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Florida Keys departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Florida Keys

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Florida Keys, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Florida Keys, as well as popular online travel agencies
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Cheap Flights from Panama City to Florida Keys

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Miami
Miami1 stop$317
Key West
Key West1 stop$307
Miami
Miami1 stop$317
Key West
Key West1 stop$307

Book Cheap Panama City to Florida Keys Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Florida Keys that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Florida Keys

Wed, Mar 4 - Tue, Mar 10
Delta Logo
12:10 pm - 7:42 pm
ECP
-
EYW
6h 32m1 stop
Delta Logo
2:40 pm - 7:47 pm
EYW
-
ECP
6h 07m1 stop
$307Delta
Wed, Mar 4 - Tue, Mar 10
American Airlines Logo
1:50 pm - 10:23 pm
ECP
-
EYW
7h 33m1 stop
American Airlines Logo
3:56 pm - 10:17 pm
EYW
-
ECP
7h 21m2 stops
$312American Airlines
Tue, Mar 10 - Wed, Mar 11
Delta Logo
7:05 am - 2:10 pm
ECP
-
MIA
6h 05m1 stop
Delta Logo
7:02 am - 10:20 am
MIA
-
ECP
4h 18m1 stop
$317Delta
Wed, Mar 4 - Tue, Mar 10
American Airlines Logo
8:20 am - 7:20 pm
ECP
-
EYW
10h 00m2 stops
American Airlines Logo
3:56 pm - 10:17 pm
EYW
-
ECP
7h 21m2 stops
$317American Airlines
Fri, Jan 23 - Wed, Jan 28
American Airlines Logo
12:03 pm - 6:01 pm
ECP
-
EYW
4h 58m1 stop
American Airlines Logo
7:08 am - 11:33 am
EYW
-
ECP
5h 25m1 stop
$327American Airlines
Sat, Feb 14 - Thu, Feb 19
Delta Logo
5:00 pm - 10:47 pm
ECP
-
MIA
4h 47m1 stop
Delta Logo
1:28 pm - 7:30 pm
MIA
-
ECP
7h 02m1 stop
$327Delta
Fri, Jan 23 - Wed, Jan 28
American Airlines Logo
12:03 pm - 6:01 pm
ECP
-
EYW
4h 58m1 stop
American Airlines Logo
12:00 pm - 5:33 pm
EYW
-
ECP
6h 33m2 stops
$332American Airlines
Thu, Apr 2 - Tue, Apr 7
American Airlines Logo
4:34 pm - 11:43 pm
ECP
-
MIA
6h 09m1 stop
American Airlines Logo
6:00 am - 9:24 am
MIA
-
ECP
4h 24m1 stop
$337American Airlines
Sun, Jan 18 - Tue, Jan 27
Delta Logo
1:32 pm - 10:26 am
ECP
-
MIA
19h 54m2 stops
Delta Logo
10:29 am - 2:56 pm
MIA
-
ECP
5h 27m1 stop
$344Delta
Sun, Feb 15 - Thu, Feb 26
American Airlines Logo
4:30 pm - 11:11 pm
ECP
-
MIA
5h 41m1 stop
American Airlines Logo
5:30 pm - 11:52 pm
MIA
-
ECP
7h 22m1 stop
$357American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to Florida Keys flights

Get data-powered insights and trends into flights from Panama City to Florida Keys to help you find the cheapest flights, the best time to fly and much more.

Can I save money by flying with a layover from Panama City to Florida Keys?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $398, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Panama City to Florida Keys?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Florida Keys, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Florida Keys is August, when tickets cost $298 (return) on average. On the other hand, the most expensive months are January and December, when the average cost of round-trip tickets is $536 and $496 respectively.

How far in advance should I book a flight from Panama City to Florida Keys?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Panama City to Florida Keys, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Panama City to Florida Keys, you should book around 5 weeks before departure, which saves you about 42% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 15 weeks before departure.

Good to know

Low seasonApril
Cheapest flight$159
Best time to beat the crowds but there is an average 19% increase in price.
Most popular time to fly and prices are also 19% lower on average.
Flight from Panama City to Miami

FAQs - booking Florida Keys flights

  • How does KAYAK find such low prices on flights from Panama City to Florida Keys?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Florida Keys.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Florida Keys?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Florida Keys?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to Florida Keys with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Florida Keys?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Panama City to Florida Keys

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Florida Keys. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Florida Keys? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4258 reviews
8.1Boarding
8.0Comfort
7.5Entertainment
8.6Crew
7.0Food
Airline reviews

Flight was on time. Wi-fi was a little spotty/slow. Boarding and exit were efficient.

8.0 ExcellentChad, Dec 2025
PNS - BNA
Read more Southwest reviews

Flight was on time. Wi-fi was a little spotty/slow. Boarding and exit were efficient.

Okay, not wonderful. Short flight. Wi-fi didn't work properly. Stuck waiting for a gate to open upon arrival for 20 or so minutes.

They sent a notice that they were boarding an hour early. We had to leave the club and run to the gate. They said sorry, that came from corporate and was a mistake. They did not have enough seating because the flight before it had not taken off on time. They moved our gate and delayed it for an hour.

Near 4 hour flight with only 1 service. Had to use call button to request water. Internet and power not working until into flight. Internet would stop working during flight.

My flight was delayed 50 minutes and we were rushed to board to then sit for 15 minutes until the pilot arrived. Unacceptable since we could have waited to board. Also the delayed flight was updated AFTER we boarded to more than the 10 minutes as originally stated.

If we are going to have to pay for luggage, make it easier to do. Put something on the app during check-in so I don't need to do it at the kiosk. I've done it twice recently and I ended up having to pay at the desk because something went wrong at the kiosk in Tampa.

The quality of Southwest Airlines continues to degrade each time I fly with them. If it were not for the free luggage, I would probably choose another airline. Their prices are a little bit competitive, but way too high for the quality of the service. Southwest is not unique in this way. Domestic flight in the United States of America has continued to be a lower and lower quality product. Very sad when you compare the quality of domestic airlines to that of many international airlines around the world.

Everything was on time. I was disappointed by the front section female, African American flight attendant. I did not see her name tag or would have identified by name not race. As passengers moved to the bathroom early in flight, she would say with a disdainful tone “I have to say the seat belt light is on” then go back to her book. Better trained flight attendants say something like be careful the seat belt light is on.

I'm not a fan of Southwest's model. I don't like the herding style of boarding.

It is southwest seat was ok. Not the most comfortable seat

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

The food is terrible. The staff is wonderful. Comfort is good.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

Delays to take off and to leave the plane after landing added a lot of time to this flight.

It was a red eye flight, so no meals were provided, but it was fine with snacks. The seats felt cramped and almost too narrow.

We didn't take off until an hour after we boarded.

Wish they had the seat-back video screens for watching movies or playing games.

Very good but wish they had the seat-back video screens for movies & games

Everything you need to know for your flight to Florida Keys

Information on your arrival and departure airports