ECP - SFO

$159 Find Cheap Flights from Panama City to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to San Francisco departing on 9/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to San Francisco

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to San Francisco, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to San Francisco, as well as popular online travel agencies
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Flights Deals

Cheap Flights from Panama City to San Francisco (ECP-SFO)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to San Francisco

Tue, Sep 23 - Wed, Sep 24
American Airlines Logo
12:01 pm - 7:58 pmECP-SFO
9h 57m1 stop
American Airlines Logo
8:00 am - 5:36 pmSFO-ECP
7h 36m1 stop
$317American Airlines
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Tue, Sep 23 - Wed, Sep 24
American Airlines Logo
6:32 am - 4:03 pmECP-SFO
11h 31m2 stops
American Airlines Logo
8:00 am - 5:36 pmSFO-ECP
7h 36m1 stop
$322American Airlines
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Fri, Oct 24 - Tue, Oct 28
Delta Logo
9:23 am - 5:01 pmECP-SFO
9h 38m1 stop
Delta Logo
11:30 am - 10:43 pmSFO-ECP
9h 13m1 stop
$347Delta
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Tue, Sep 23 - Wed, Sep 24
American Airlines Logo
6:32 am - 4:03 pmECP-SFO
11h 31m2 stops
American Airlines Logo
8:00 am - 9:12 pmSFO-ECP
11h 12m2 stops
$357American Airlines
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Wed, Jul 30 - Mon, Aug 4
Delta Logo
11:36 am - 6:46 pmECP-SFO
9h 10m1 stop
Delta Logo
9:35 pm - 8:33 amSFO-ECP
8h 58m1 stop
$367Delta
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Fri, Oct 24 - Tue, Oct 28
Delta Logo
4:10 pm - 10:52 pmECP-SFO
8h 42m1 stop
Delta Logo
4:15 pm - 8:18 amSFO-ECP
14h 03m2 stops
$390Delta
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Fri, Aug 1 - Mon, Aug 4
Southwest Logo
10:00 am - 7:00 pmECP-SFO
11h 00m2 stops
Southwest Logo
10:45 pm - 9:05 amSFO-ECP
8h 20m1 stop
$413Southwest
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Tue, Sep 23 - Tue, Sep 23
United Airlines Logo
3:03 pm - 8:15 pmECP-SFO
7h 12m1 stop
United Airlines Logo
12:43 am - 9:53 amSFO-ECP
7h 10m1 stop
$417United Airlines
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Wed, Jul 30 - Sun, Aug 3
United Airlines Logo
5:02 pm - 11:59 pmECP-SFO
8h 57m1 stop
United Airlines Logo
12:30 am - 9:56 amSFO-ECP
7h 26m1 stop
$467United Airlines
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Wed, Dec 24 - Sat, Jan 3
Southwest Logo
3:15 pm - 10:30 pmECP-SFO
9h 15m2 stops
Southwest Logo
8:10 am - 5:25 pmSFO-ECP
7h 15m1 stop
$472Southwest
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KAYAK's insights & trends for Panama City to San Francisco flights

Get data-powered insights and trends into flights from Panama City to San Francisco to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to San Francisco?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to San Francisco, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to San Francisco is April, where tickets cost $342 (return) on average. On the other hand, the most expensive months are May and December, where the average cost of round-trip tickets is $596 and $536 respectively.

Good to know

Low seasonApril
High seasonOctober
Cheapest flight$159
Best time to beat the crowds with an average 21% drop in price.
Most popular time to fly and prices are also 1% lower on average.
Flight from Panama City to San Francisco

When to book flights from Panama City to San Francisco

Are your dates flexible? Find out the best times to travel from Panama City to San Francisco based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to San Francisco

  • What is the cheapest flight from Panama City to San Francisco?

    In the last 3 days, the lowest price for a flight from Panama City to San Francisco was $159 for a one-way ticket and $317 for a round-trip.

  • Do I need a passport to fly between Panama City and San Francisco?

    No

  • Which airports will I be using when flying from Panama City to San Francisco?

    When flying out of Panama City you will be using Panama City NW Florida Beaches. You will be landing at San Francisco, also known as San Francisco.

  • Which aircraft models fly most regularly from Panama City to San Francisco?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to San Francisco?

    SkyTeam, oneworld, and Star Alliance are the airline alliances operating flights between Panama City and San Francisco, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Panama City to San Francisco, Delta or Southwest?

    The two airlines most popular with KAYAK users for flights from Panama City to San Francisco are Delta and Southwest. With an average price for the route of $427 and an overall rating of 8.0, Delta is the most popular choice. Southwest is also a great choice for the route, with an average price of $471 and an overall rating of 8.0.

  • How does KAYAK find such low prices on flights from Panama City to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to Panama City with another airline. Booking your flights between Panama City and SFO can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Panama City to San Francisco

 
See real verified KAYAK customer reviews for airlines flying from Panama City to San Francisco. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4278 reviews
7.6Entertainment
8.0Comfort
7.0Food
8.6Crew
8.2Boarding
Airline reviews

First time traveling on Southwest since bag fees were implemented. Usual good service. Just more expensive now.

8.0 ExcellentMichael, Jun 2025PHX - SAN
Read more Southwest reviews

First time traveling on Southwest since bag fees were implemented. Usual good service. Just more expensive now.

It was a perfect flight in all aspects! Both legs!

Boarding process, crew were good. But the seats were so uncomfortable that was all I could focus on. I literally had to sit forward so that all 3 of us could fit in row. I will try to avoid Southwest in the future for any flights over 60 minutes.

Great flight, 47 passengers on a 180 seat plane. Stewardess was pleasant and cheerful.

Great experience flying Southwest. The crew was really kind and helpful, and very friendly with our toddler.

Plane late from DC to Austin 30 minutes. Crew made up much of the time enroute to San Diego.

Fine, but how to board on SW versus othrr airlines, is just lame. Goood staff though and all was solid otherwise.

Was as expected. Crowed planes. Too many carryons delaying takeoff. But the ride only took an hour and saved me a lot of time SFO is a not a great airport.

Was as expected. Crowed planes. Too many carryons delaying takeoff. But the ride only took an hour and saved me a lot of time SFO is a hell hole of an airport. It is the new LaGuardia. Everything Cobbled together. Security gates closed. Terri directional signage

I will be flying again Southwest Airlines. Friendly crew, comfortable and affordable.

Not a "Delta" issue, but a JFK issue: We booked a connecting flight with 3 1/2 hours between to clearn immigration and customs. Our inbound flight (BCN to JFK) was on the taxiway 45 minutes which ate into our layover time. Immigtration was insanely quick with the CBP MPC app; however, clearing TSA (again, after we were ALREADY cleared in Spain on the inbound international flight) took over 95 minutes. This left us with 10 minutes before boarding the connecting flight (JFK to SAN) to walk to the far end of Terminal 4 and try to find food. We didn't find any food that could promise to serve us in under 10 minutes so we boarded the Delta flight after coming off a plance and an 8-hour flight knowing that we wouldn't be served any food on the next 5 1/2 hour flight. I feel like Delta needs to put pressure on the JFK TSA to open more screening stations (by our count, we saw only 5 scanners open and a line of - as we said - over 90 minutes. The insult is that we WERE ALREADY SCREENED through TSA, but as you come off one flight into the USA, you have to go through the whole process again. It seems like if you have a connecting flight, there should be a way to pass through immigration and customs without needing to return through TSA.

There are 4 flights in consecutive gates with about the same departure time. Two flights were boarding at the same time. One was delayed or boarding would be happening at the same time. I am not sure what Delta and LAX need to do to have a better layout at the end of Terminal 2

5 hours of delay that could've been much shorter if Delta had taken the 1 hour delay they imposed on the flight before boarding to run any of the plane checks required for flight to find the hydraulic issue that required nearly 3 hours to fix. $24 of meal credit buys a sandwich and a soft drink. Poor communication within the terminal about what gate we'd be re-boarding from and when we'd be re-boarding.

The entertainment and wifi mostly didn't work on this flight.

Terrible entertainment system - kept freezing and audio kept cutting out. Snacks were mediocre at best for a 5 hour flight.

I am still upset that my bag was lost on a recent trip to Rome ; we were inconvenienced and out €150 Euros ; delta has refused to reimburse us

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

Seats are much much more comfortable than United, which is what I usually fly

If I pay extra for "comfort+" I expect leg room where I can stretch my legs. I was seated with an attendant's seat blocking my feet. Knee space was fine but my feet had less room than the non-"comfort+" seats. Also, don't go cheap on food when you have flights of 3+ hours. It's insulting.

Only one side of the heafphone jack work. Crew was friendly and helpful.

This was a horrible experience. For a first class experience, my chair was held together by 3M tape - and I have a photo. The crew weren’t very attentive, somewhat dismissive and forgot my drink and snack, the chair reclined about 3 inches on a 6-hour cross country flight. I was also not informed that there was no lounge available in Newark airport because of renovations, so all around this was one of the worst experiences and I would actively avoid both American and Alaska Air going forward.

Boarding was very efficient. Everyone got on board and we got on our way very quickly. It was frustrating that the entertainment app was not functioning properly. I was not able to activate some of the movies offered. The crew on this flight appears to be pretty grumpy. They had no smile on their faces. I felt like they were doing us a favor for being there.

Loved the staff, boarding and drink options! Wish the comfort of the seat could have been better nevertheless

Honestly, I haven’t flown American in years, probably due to the pandemic and my being unable to travel for certain periods in the last two years, but it was a good experience to dig out or obtain a new American Airlines account after many years of traveling for business with American in the past.

Long 5 hour and 45 min flight and only one drink service and cookie snack

One bottle of water and a package of cookies for comfort plus. We had to literally beg a flight attendant for an extra bottle of water later in the flight due to feeling dehydrated.

Flight boarded from Gate 39 at OGG, the farthest gate in the terminal. There were no Hawaiian themed amenities for the flight. The first class service was mediocre at best; I received not special welcome or recognition as an executive platinum member of American Advantage program. The flight attendants were more concerned with their cell phones than saying "thank you" to the passengers as we disembarked. Fortunately, the flight arrived at LAX a few minutes early.

Bigger seats. Board back to front! Disembark front to back!

Extraordinary service in business class, and very good breakfast and snacks. A really lovely flight.

This flight didn’t happen because AA agents didn’t let us board the flight

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