ECP - SFO

$140 Find Cheap Flights from Panama City to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to San Francisco departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to San Francisco

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to San Francisco, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to San Francisco, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to San Francisco (ECP-SFO)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to San Francisco

Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
12:40 pm - 6:37 pmECP-SFO
7h 57m1 stop
American Airlines Logo
6:12 am - 2:02 pmSFO-ECP
5h 50m1 stop
$279American Airlines
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Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
2:57 pm - 10:40 pmECP-SFO
9h 43m2 stops
American Airlines Logo
6:12 am - 2:02 pmSFO-ECP
5h 50m1 stop
$284American Airlines
Find Deal
Tue, Oct 28 - Wed, Oct 29
United Airlines Logo
3:00 pm - 10:59 pmECP-SFO
9h 59m1 stop
United Airlines Logo
12:43 am - 9:19 amSFO-ECP
6h 36m1 stop
$299United Airlines
Find Deal
Tue, Oct 28 - Thu, Oct 30
Southwest Logo
4:05 pm - 9:10 pmECP-SFO
7h 05m1 stop
Southwest Logo
10:25 am - 10:35 pmSFO-ECP
10h 10m1 stop
$304Southwest
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Sun, Feb 15 - Wed, Feb 18
Delta Logo
6:00 am - 1:57 pmECP-SFO
9h 57m1 stop
Delta Logo
6:00 am - 3:17 pmSFO-ECP
7h 17m1 stop
$309Delta
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Tue, Oct 28 - Thu, Oct 30
Southwest Logo
4:05 pm - 11:05 pmECP-SFO
9h 00m2 stops
Southwest Logo
10:25 am - 10:35 pmSFO-ECP
10h 10m1 stop
$310Southwest
Find Deal
Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
2:57 pm - 10:40 pmECP-SFO
9h 43m2 stops
American Airlines Logo
6:45 am - 8:17 pmSFO-ECP
11h 32m2 stops
$328American Airlines
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Sat, Dec 6 - Tue, Jan 6
United Airlines Logo
6:30 am - 12:09 pmECP-SFO
7h 39m1 stop
United Airlines Logo
5:00 am - 4:12 pmSFO-ECP
9h 12m1 stop
$338United Airlines
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Sat, Feb 14 - Tue, Feb 17
United Airlines Logo
4:55 pm - 11:59 pmECP-SFO
9h 04m1 stop
United Airlines Logo
12:43 am - 11:53 amSFO-ECP
9h 10m1 stop
$340United Airlines
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Sun, Feb 15 - Wed, Feb 18
Delta Logo
7:45 am - 10:30 pmECP-SFO
16h 45m2 stops
Delta Logo
6:00 am - 3:17 pmSFO-ECP
7h 17m1 stop
$357Delta
Find Deal

Everything you should know

Top airlines
American Airlines
Cheapest • from $279 (round-trip)
Southwest
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
April
Cheapest • 26% price drop
June
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$279
Overall average: $379
American Airlines
Sat 2/14Wed 2/18
ECP - SFO • 1 stop
Cheapest one-way
$140
Typical prices: $198-483
Delta
Wed 10/22
ECP - SFO • 1 stop
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to San Francisco!
Booking Insights

KAYAK's insights & trends for Panama City to San Francisco flights

Get data-powered insights and trends into flights from Panama City to San Francisco to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to San Francisco?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to San Francisco, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to San Francisco is April, where tickets cost $342 (return) on average. On the other hand, the most expensive months are May and December, where the average cost of round-trip tickets is $596 and $536 respectively.

Good to know

Low seasonApril
Cheapest flight$140
Best time to beat the crowds with an average 26% drop in price.
Most popular time to fly and prices are also 16% lower on average.
Flight from Panama City to San Francisco

When to book flights from Panama City to San Francisco

Are your dates flexible? Find out the best times to travel from Panama City to San Francisco based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to San Francisco

  • What is the cheapest flight from Panama City to San Francisco?

    In the last 3 days, the lowest price for a flight from Panama City to San Francisco was $140 for a one-way ticket and $279 for a round-trip.

  • Do I need a passport to fly between Panama City and San Francisco?

    No

  • Which airports will I be using when flying from Panama City to San Francisco?

    When flying out of Panama City you will be using Panama City NW Florida Beaches. You will be landing at San Francisco, also known as San Francisco.

  • Which aircraft models fly most regularly from Panama City to San Francisco?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to San Francisco?

    oneworld, and SkyTeam are the airline alliances operating flights between Panama City and San Francisco, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Panama City to San Francisco, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Panama City to San Francisco are Southwest and Delta. With an average price for the route of $498 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $429 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from Panama City to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to Panama City with another airline. Booking your flights between Panama City and SFO can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Panama City to San Francisco

 
See real verified KAYAK customer reviews for airlines flying from Panama City to San Francisco. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4248 reviews
7.0Food
8.6Crew
8.0Comfort
8.1Boarding
7.5Entertainment
Airline reviews

Connecting flight is on time and boarding was a breeze!

10.0 ExcellentGabriel, Sep 2025DEN - SMF
Read more Southwest reviews

Connecting flight is on time and boarding was a breeze!

Very smooth checking in our luggage with a super pleasant SW agent. I enjoyed a fun entertaining movie.

First time traveling on Southwest since bag fees were implemented. Usual good service. Just more expensive now.

It was a perfect flight in all aspects! Both legs!

Boarding process, crew were good. But the seats were so uncomfortable that was all I could focus on. I literally had to sit forward so that all 3 of us could fit in row. I will try to avoid Southwest in the future for any flights over 60 minutes.

Great flight, 47 passengers on a 180 seat plane. Stewardess was pleasant and cheerful.

Great experience flying Southwest. The crew was really kind and helpful, and very friendly with our toddler.

Plane late from DC to Austin 30 minutes. Crew made up much of the time enroute to San Diego.

Fine, but how to board on SW versus othrr airlines, is just lame. Goood staff though and all was solid otherwise.

Was as expected. Crowed planes. Too many carryons delaying takeoff. But the ride only took an hour and saved me a lot of time SFO is a not a great airport.

Gate agent rushed to fill hot jetway with crowd so it took over 12 minutes to go from gate to plane. Just like a discount airline Pooly prepared cabin and third time that claim of rough air prevented any cabin service. Friends on a Southwest flight at similar time had service.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

I was uncomfortably cold on the plane. Other than that it was uneventful and therefore as enjoyable as a plane ride can be.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Food was surprisingly good but the WiFi was not great

My flight was extremely cold. I had a jacket and a cover was left in each seat. The cover was extremely thin and I have a disability, fibromyalgia and arthrithis and AC air is the worst. I closed my vent and my husbands vent and it still was frigid. I asked the attendant if I could get another cover and she quickly almost dismissively and totally unconcerned stating, (I quote) (one per chair) and walked off so quickly that I didn't get a chance to explain to her that I literally have adisability. I didnt want to make a seen so I set on that flight for over 5 hours in pain, joints locking up and extremely uncomfortable. When my fibromyalgia flares up my joints not only ache but they will lock up also and it takes me days to get back to my regular self even though I take medication for it. I felt like it would not have hurt anyone at all for her to just give me an extra cover because I'm sure they have all types of medical issues in people that fly every day.

Not a "Delta" issue, but a JFK issue: We booked a connecting flight with 3 1/2 hours between to clearn immigration and customs. Our inbound flight (BCN to JFK) was on the taxiway 45 minutes which ate into our layover time. Immigtration was insanely quick with the CBP MPC app; however, clearing TSA (again, after we were ALREADY cleared in Spain on the inbound international flight) took over 95 minutes. This left us with 10 minutes before boarding the connecting flight (JFK to SAN) to walk to the far end of Terminal 4 and try to find food. We didn't find any food that could promise to serve us in under 10 minutes so we boarded the Delta flight after coming off a plance and an 8-hour flight knowing that we wouldn't be served any food on the next 5 1/2 hour flight. I feel like Delta needs to put pressure on the JFK TSA to open more screening stations (by our count, we saw only 5 scanners open and a line of - as we said - over 90 minutes. The insult is that we WERE ALREADY SCREENED through TSA, but as you come off one flight into the USA, you have to go through the whole process again. It seems like if you have a connecting flight, there should be a way to pass through immigration and customs without needing to return through TSA.

There are 4 flights in consecutive gates with about the same departure time. Two flights were boarding at the same time. One was delayed or boarding would be happening at the same time. I am not sure what Delta and LAX need to do to have a better layout at the end of Terminal 2

5 hours of delay that could've been much shorter if Delta had taken the 1 hour delay they imposed on the flight before boarding to run any of the plane checks required for flight to find the hydraulic issue that required nearly 3 hours to fix. $24 of meal credit buys a sandwich and a soft drink. Poor communication within the terminal about what gate we'd be re-boarding from and when we'd be re-boarding.

The entertainment and wifi mostly didn't work on this flight.

The flight crew was rude. We were in first class and no one even offered water until an hour after we were in the air. Horrible experience

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

The stewardess hit me with the food kart twice on the head and didn't say I'm sorry once. The same stewardess gave me a warm Apple Juice with No ice. The Flight was delayed for Departure 6 times, starting from 2:36pm, finally taking off 7:50pm. I was late picking up my child from the sitter by 3 hours.

Did not get the seat I selected and paid for.

My flight was delayed for several hours. Sitting at gate 16 for several hours, I got a text from Kayak the gate changed to 9 before it was announced. Very bad communication at each gate from American Airlines employees. I received 10 notifications of delay from Kayak. My vacation started off horrible! I will write to American Airlines corporate office also.

Delayed flight that lead to a missed connection and a 5-hour trip became a 12-hour flight 🙄

There is no room, no gluten free options, or any free internet/entertainment. You have to bring your own tablet or smartphone because there are no screens.

Amazing food, great staff, with one noticable detail missing ...but no seat entertainment in any of aircraft ...I am not a fan

Boarding gate in Honolulu was staffed with a great clerk with a soothing voice despite the flight delay of over an hour. Flight attendants in the plane were all grumpy, not pleasant looking bunch. Their sour attitude showed throughout the flight. Inly able to get a select few movies started. Most of the movie links in the “free entertainment” did not work.

I flew Business Class. Rory, one of the Cabin stewards, was attentive, explained the menu, provided appropriate drinks. was

Everything you need to know for your flight from Panama City to San Francisco

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