$365 Find Cheap Flights from Panama City to Chicago - Compare and Save

Your flight ticket price will generally be cheaper if you fly to Chicago on a Saturday and more expensive on a Sunday. On your return trip to Panama City, you should consider flying back on a Tuesday, and avoid Saturdays for better deals.

The cheapest month for flights from Panama City to Chicago O'Hare Intl Airport is October, where tickets cost $465 (return) on average. On the other hand, the most expensive months are August and June, where the average cost of round-trip tickets is $883 and $801 respectively.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $354 on average.

To get a below average price on the flight from Panama City to Chicago O'Hare Intl Airport, you should book around 3 weeks before departure, which saves you about 23% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 14 weeks before departure.

In the past 5 days, the cheapest round-trip tickets from Panama City to Chicago were found on Avianca ($419) and JetBlue ($657).

There is just one airline that flies from Panama City to Chicago O'Hare Intl Airport direct and that is Copa Airlines. The best round-trip deal found from Copa Airlines for the route is $417.

Houston (IAH) is the top choice – 91% of KAYAK users who clicked on 1-stop flights from Panama City to Chicago picked an itinerary connecting there.

Flights via Bogotá (BOG) offer the most affordable fares, with an average round-trip price of $354.

Consider flying via Houston (IAH) for the shortest journey. The average one-way travel time for flights connecting there is 9h 22m.

If you prefer a quick connection, Houston (IAH) often has the shortest layovers from Panama City to Chicago, with an average of 2h 13m.

There are 3 cabin class options for the route. These are Business, Economy and Prem Economy. Perform a search on KAYAK to find the latest prices and availability for all cabin fares, which differ across airlines.

Each day, there are between 1 and 2 nonstop flights that take off from Panama City and land in Chicago O'Hare Intl Airport, with an average flight time of 5h 43m. The most common departure time is 7:00 pm and most flights take off in the evening. Each week, there are 13 flights. The most frequent day of departure is Monday, when 15% of all weekly flights depart. The fewest flights depart on a Thursday.