$295 Find Cheap Flights from Panama to Missouri - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama to Missouri departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama to Missouri

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama to Missouri

Thu, Oct 29 - Thu, Nov 12
United Airlines Logo
7:55 am - 9:51 pm
PTY
-
MCI
13h 56m
2 stops
United Airlines Logo
6:10 am - 8:02 pm
MCI
-
PTY
12h 52m
1 stop
$583United Airlines
Wed, Oct 7 - Mon, Oct 12
United Airlines Logo
10:00 am - 9:07 am
PTY
-
MCI
23h 07m
2 stops
United Airlines Logo
6:19 am - 6:37 pm
MCI
-
PTY
12h 18m
1 stop
$583United Airlines
Wed, Oct 7 - Mon, Oct 12
Delta Logo
2:24 pm - 11:56 pm
PTY
-
MCI
9h 32m
1 stop
Delta Logo
6:00 am - 12:59 pm
MCI
-
PTY
6h 59m
1 stop
$583Delta
Thu, Oct 29 - Thu, Nov 12
United Airlines Logo
7:55 am - 4:52 pm
PTY
-
MCI
8h 57m
1 stop
United Airlines Logo
6:10 am - 8:02 pm
MCI
-
PTY
12h 52m
1 stop
$583United Airlines
Wed, Jan 20 - Mon, Jan 25
United Airlines Logo
8:55 am - 9:49 pm
PTY
-
MCI
13h 54m
2 stops
United Airlines Logo
5:00 pm - 2:45 pm
MCI
-
PTY
20h 45m
2 stops
$583United Airlines
Wed, Oct 7 - Mon, Oct 12
Delta Logo
2:24 pm - 11:56 pm
PTY
-
MCI
9h 32m
1 stop
Delta Logo
6:00 am - 12:59 pm
MCI
-
PTY
6h 59m
1 stop
$604Delta
Wed, Oct 7 - Mon, Oct 12
American Airlines Logo
1:52 pm - 3:15 pm
PTY
-
MCI
25h 23m
2 stops
American Airlines Logo
6:32 pm - 12:52 pm
MCI
-
PTY
18h 20m
2 stops
$607American Airlines
Wed, Oct 7 - Mon, Oct 12
American Airlines Logo
1:52 pm - 3:15 pm
PTY
-
MCI
25h 23m
2 stops
American Airlines Logo
6:32 pm - 12:52 pm
MCI
-
PTY
18h 20m
2 stops
$608American Airlines
Wed, Oct 7 - Mon, Oct 12
American Airlines Logo
1:52 pm - 11:49 am
PTY
-
MCI
21h 57m
2 stops
American Airlines Logo
4:46 pm - 12:52 pm
MCI
-
PTY
20h 06m
1 stop
$608American Airlines
Wed, Oct 14 - Wed, Oct 21
Copa Airlines Logo
10:00 am - 10:35 pm
PTY
-
MCI
12h 35m
1 stop
Copa Airlines Logo
6:19 am - 6:37 pm
MCI
-
PTY
12h 18m
1 stop
$642Copa Airlines
Booking Insights

KAYAK's insights & trends for flights to Missouri

Get data-powered insights and trends for flights to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama to Missouri?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights from Panama to Missouri, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama to Missouri is September, when tickets cost $349 (return) on average. On the other hand, the most expensive months are November and April, when the average cost of round-trip tickets is $1,069 and $609 respectively.

Good to know

Low season

March

Cheapest flight

$295
Best time to beat the crowds with an average 45% drop in price.
Most popular time to fly and prices are also 23% lower on average.
Flight from Panama City to St. Louis

FAQs for booking flights from Panama to Missouri

  • How does KAYAK find such low prices on flights from Panama to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama to Missouri

 
See real verified KAYAK customer reviews for airlines flying to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline from Panama to Missouri. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 10052 reviews
7.7Boarding
7.1Entertainment
7.3Comfort
6.6Food
8.1Crew
Airline reviews

Flight was delayed “due to earlier delays of that plane”, so we were nearly three hours late.

8.0 ExcellentTodd, Jul 2026
DEN - STL
Read more United Airlines reviews

Flight was delayed “due to earlier delays of that plane”, so we were nearly three hours late.

Crew was amazing, takeoff wonderful. The bathroom was disgusting from before takeoff the odor made the flight uncomfortable as you could smell the bathroom from the center of the plane where we were sitting. Smelled like raw sewage. My daughter was throwing up as we landed due to the smell and horrible turbulence as we approached Newark.

It was terrible. sat on airplane 2 hours then flight was canceled. made to pick up bags and go through Panama immagration to rebook another flight. worst experice ever at a airport.

Airport terminal was outdated, flight was on a small jet with no wifi

Essy to get on. The hostess gave very little pop, the plane was late getting in, and we are still waiting for our bags. This sucks. :/

Lately I like the planes have been exceptionally filthy. There’s lines of dust and dirt all across the ceiling in the vents, and the cracks in between the seats are literally full of food. It’s definitely not the quality of service that I was used to with United. I’m also very disappointed with the Wi-Fi! All I wanna do is knock out a few work jobs while I’m trapped in my seat And it spools so bad. They did provide me with a refund, but the process of getting that refund is so complicated. It’s unfortunate.

Excellent flight. Smooth, efficient boarding. Quick flight. Arrived early at STL.

Short flight - no food understandable. Flight was delayed for over an hour. Overall, it was good.

We boarded and buckled and then deplaned due to no pilot. Had to wait over 3 hours for a new pilot. Not weather related, just poor management.

Last minute gate change nearly caused us to miss our flight. Change was not announced or displayed in the main board at the old gate. Terrible communication. When we landed we had to wait 20 minutes because there was another plane at the assigned gate. Not the crew’s fault, but adding 20 minutes to a 45 minute flight sucked.

Flight was 3 hours delayed. They gave our plan to two other routes. Need to knock that off.

We called Kayak for a change due to the TSA situation in Atlanta. What we got was a canceled return flight (in error) and we had to find the mistake. Not happy with Kayak who blamed it on AA.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Boarding delayed 20 minutes for no reason, no wifi, in flight entertainment, or snacks / waters?

This flight captain and crew were amazing, started ahead of time of departure and reached 30 mins before arrival time. Amazing!

Improvements in communication and empathy are absolutely necessary for American Airlines staff (top down). It’s like they are numb to the needs of their customers.

I had a TERRIBLE experience with the AA crew. I believe it was disability-related. It’s unlikely I will fly AA again.

I like the speed of boarding and deplaning and the fact that everything was on time. The crew (attendants) were probably quite new and did not begin the in cabin service until 30 min before landing even though there was little to no air turbulence for the last 1.5 hours of the flight. It made for a mad scramble at the end to get trash collected and carts stowed before touch down.

The flights was delayed by hours and it was the firmest landing I have experienced in my life. My back is still sore.

Flight delayed, boarding time kept changing, not good. Nee firm information given each time.

Everything you need to know for your flight to Missouri

Cabin class types available on flights to Missouri

Cabin classes available on flights to Missouri. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.