$99 Find Cheap Flights from Pittsburgh to St. Louis - Compare and Save

If your flying dates are flexible, you should consider flying to St. Louis on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Saturday is the most expensive day to fly from Pittsburgh to St. Louis. For your return ticket, we recommend flying on a Wednesday and avoiding Sundays for the best deals.

The cheapest month for flights from Pittsburgh to St. Louis is November, where tickets cost $286 (return) on average. On the other hand, the most expensive months are June and April, where the average cost of round-trip tickets is $471 and $440 respectively.

No, with an average price for the route of $303, prices are generally cheapest when you fly direct.

To get a below average price on the flight from Pittsburgh to St. Louis, you should book around 4 weeks before departure, which saves you about 36% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 13 weeks before departure.

In the past 5 days, the cheapest round-trip tickets from Pittsburgh to St. Louis were found on American Airlines ($217) and Southwest ($227).

There is just one airline that flies from Pittsburgh to St. Louis direct and that is Southwest. The best round-trip deal found from Southwest for the route is $230.

Chicago (ORD) is the top choice – 58% of KAYAK users who clicked on 1-stop flights from Pittsburgh to St. Louis picked an itinerary connecting there.

Flights via Nashville (BNA) offer the most affordable fares, with an average round-trip price of $256.

Consider flying via Chicago (MDW) for the shortest journey. The average one-way travel time for flights connecting there is 3h 42m.

If you prefer a quick connection, Chicago (MDW) often has the shortest layovers from Pittsburgh to St. Louis, with an average of 0h 54m.

There is only one cabin class option available for the route, which is Economy. Perform a search on KAYAK to find the latest prices and availability for all cabin fares, which differ across airlines.

Each day, there are between 1 and 2 nonstop flights that take off from Pittsburgh and land in St. Louis, with an average flight time of 1h 40m. The most common departure time is 6:00 am and most flights take off in the morning. Each week, there are 13 flights. The most frequent day of departure is Monday, when 15% of all weekly flights depart. The fewest flights depart on a Saturday.