RST - TYS

$278 Find Cheap Flights from Rochester to Knoxville - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$328
Typical prices: $318-$450
American Airlines
Mon 12/24Sun 12/30
RST - TYS • 1 stop
Cheapest one-way
$278
Typical prices: $326-$493
American Airlines
Sun 1/28
RST - TYS • 1 stop
When to travel
September
Cheapest • 21% price drop
April
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Minneapolis St Paul (MSP)
Cheapest • Avg $312 (round-trip)
Chicago O'Hare Intl (ORD)
Shortest trip • 5h 02m (one-way)
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Cheap Flights from Rochester to Knoxville (RST-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Rochester to Knoxville

Thu, Dec 24 - Wed, Dec 30
American Airlines Logo
5:50 pm - 11:50 pmRST  Rochester-TYS Knoxville McGhee Tyson
5h 00m1 stop Chicago O'Hare Intl
American Airlines Logo
6:00 am - 11:15 amTYS  Knoxville McGhee Tyson-RST Rochester
6h 15m1 stop Chicago O'Hare Intl
$328American Airlines
Thu, Jan 7 - Fri, Jan 15
American Airlines Logo
4:28 pm - 11:50 pmRST  Rochester-TYS Knoxville McGhee Tyson
6h 22m1 stop Chicago O'Hare Intl
American Airlines Logo
7:49 am - 12:03 pmTYS  Knoxville McGhee Tyson-RST Rochester
5h 14m1 stop Chicago O'Hare Intl
$328American Airlines
Thu, Jan 7 - Fri, Jan 15
Delta Logo
4:25 pm - 9:37 pmRST  Rochester-TYS Knoxville McGhee Tyson
4h 12m1 stop Minneapolis St Paul
Delta Logo
7:55 am - 11:03 amTYS  Knoxville McGhee Tyson-RST Rochester
4h 08m1 stop Minneapolis St Paul
$328Delta
Thu, Jan 7 - Fri, Jan 15
Delta Logo
4:25 pm - 9:37 pmRST  Rochester-TYS Knoxville McGhee Tyson
4h 12m1 stop Minneapolis St Paul
Delta Logo
8:47 am - 3:43 pmTYS  Knoxville McGhee Tyson-RST Rochester
7h 56m2 stops Atlanta Hartsfield-Jackson Minneapolis St Paul
$334Delta
Thu, Jan 7 - Fri, Jan 15
American Airlines Logo
5:16 am - 11:06 amRST  Rochester-TYS Knoxville McGhee Tyson
4h 50m1 stop Chicago O'Hare Intl
American Airlines Logo
7:02 am - 3:58 pmTYS  Knoxville McGhee Tyson-RST Rochester
9h 56m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$334American Airlines
Thu, Jan 7 - Fri, Jan 15
American Airlines Logo
4:28 pm - 11:50 pmRST  Rochester-TYS Knoxville McGhee Tyson
6h 22m1 stop Chicago O'Hare Intl
American Airlines Logo
7:49 am - 12:03 pmTYS  Knoxville McGhee Tyson-RST Rochester
5h 14m1 stop Chicago O'Hare Intl
$338American Airlines
Thu, Jan 7 - Fri, Jan 15
American Airlines Logo
5:16 am - 6:03 pmRST  Rochester-TYS Knoxville McGhee Tyson
11h 47m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
American Airlines Logo
7:02 am - 3:58 pmTYS  Knoxville McGhee Tyson-RST Rochester
9h 56m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$339American Airlines
Thu, Jan 7 - Fri, Jan 15
Delta Logo
4:25 pm - 11:46 pmRST  Rochester-TYS Knoxville McGhee Tyson
6h 21m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson
Delta Logo
10:05 am - 3:43 pmTYS  Knoxville McGhee Tyson-RST Rochester
6h 38m2 stops Atlanta Hartsfield-Jackson Minneapolis St Paul
$339Delta
Thu, Jan 7 - Fri, Jan 15
American Airlines Logo
5:16 am - 11:06 amRST  Rochester-TYS Knoxville McGhee Tyson
4h 50m1 stop Chicago O'Hare Intl
American Airlines Logo
7:02 am - 3:58 pmTYS  Knoxville McGhee Tyson-RST Rochester
9h 56m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$344American Airlines
Thu, Dec 24 - Wed, Dec 30
American Airlines Logo
5:50 pm - 11:50 pmRST  Rochester-TYS Knoxville McGhee Tyson
5h 00m1 stop Chicago O'Hare Intl
American Airlines Logo
6:00 am - 11:15 amTYS  Knoxville McGhee Tyson-RST Rochester
6h 15m1 stop Chicago O'Hare Intl
$348American Airlines
Booking Insights

Price, demand and travel trends for Rochester to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Rochester to Knoxville with more confidence.

How much is a round-trip flight from Rochester to Knoxville?

Round-trip flights from Rochester to Knoxville start at $328. Prices are typical for this route right now, with typical round-trip fares ranging from $318 to $450. The lowest price found in the past 5 days was $328 on American Airlines.

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Key details for Rochester to Knoxville flights

Low season

January

Cheapest flight

$278
Flight from Rochester to Knoxville

When to book flights from Rochester to Knoxville

Are your dates flexible? Find out the best times to travel from Rochester to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Rochester to Knoxville flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Rochester to Knoxville?

    Flights from Rochester to Knoxville usually depart from Rochester (RST) and arrive at Knoxville McGhee Tyson (TYS).

  • What cabin classes can I book on flights from Rochester to Knoxville?

    Only Economy Class is available on flights from Rochester to Knoxville.

  • Which airports do connecting flights from Rochester to Knoxville pass through?

    Connecting flights from Rochester to Knoxville most commonly pass through:

    • Chicago O'Hare Intl (ORD) - 76% of one-stop connections
    • Minneapolis St Paul (MSP) - 24% of one-stop connections
    Together, these airports account for 100% of one-stop bookings on this route.

  • Can I save money by using flexible dates for flights from Rochester to Knoxville?

    Yes. Being flexible with your travel dates can save you up to 44% on the Rochester to Knoxville route. Friday is the cheapest departure day at $298 round-trip on average, while Wednesday is the most expensive at $523, a difference of $225. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How long is a flight from Rochester to Knoxville?

    There are currently no nonstop flights available from Rochester to Knoxville. Flights with 1 layover take between 5h 02m and 5h 04m in total, depending on the connection.

  • Do I need a passport to fly from Rochester to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Rochester to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $328 to $900. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Rochester to Knoxville looking right now?

    One-way fares from Rochester to Knoxville are currently lower than usual. Average one-way flight prices are about $281, which is 44% below the typical average for this route.

  • How much time can I save by choosing a different layover airport from Rochester to Knoxville?

    Flying via Chicago O'Hare Intl (ORD) gives the shortest average 1-stop total travel time at 5h 02m, compared with 5h 04m via Minneapolis St Paul (MSP).

  • What is the time difference between Rochester and Knoxville?

    Knoxville is 1 hour ahead of Rochester (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    • Budget
    • Alamo
    • Thrifty
    • Enterprise Rent-A-Car
    • Payless

  • How much should I expect to pay for a Rochester to Knoxville flight?

    Round-trip flights from Rochester to Knoxville range from $318 to $450, with an average of $379 over the past 12 months. Anything below $318 counts as a good deal.

Your guide to booking Rochester to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Friday departure instead of Wednesday. On this route, Friday flights average $298 - about $225 less than Wednesday (43% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Rochester to Knoxville trip for September. Fares historically average $298 round-trip in that month - typically $473 less than the most expensive month, which is June (based on the last 12 months).

More options for your flight from Rochester to Knoxville

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