SAT - TYS

$159 Find Cheap Flights from San Antonio to Knoxville - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$317
Typical prices: $313-$476
American Airlines
Sun 11/11Sun 11/18
SAT - TYS • 1 stop
Cheapest one-way
$159
Typical prices: $194-$303
American Airlines
Sun 12/30
SAT - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between San Antonio and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to book
25 weeks
in advance
Our data shows that travelers who book at least 25 weeks in advance save around 54% compared to booking last minute.
Insights
Insights
When to travel
May
Cheapest • 22% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Detroit Metropolitan Wayne County (DTW)
Cheapest • Avg $251 (round-trip)
Dallas Love Field (DAL)
Shortest trip • 4h 41m (one-way)
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Insights
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We hope you love your trip to Knoxville!

Cheap Flights from San Antonio to Knoxville (SAT-TYS)

 

Cheap flights from San Antonio to Knoxville with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Wed, Nov 11 - Wed, Nov 18
American Airlines Logo
9:22 am - 4:42 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
6h 20m1 stop Dallas/Fort Worth
American Airlines Logo
5:32 pm - 9:59 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
5h 27m1 stop Dallas/Fort Worth
$317American Airlines
Fri, Jan 22 - Tue, Jan 26
American Airlines Logo
7:02 am - 1:59 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
5h 57m1 stop Dallas/Fort Worth
American Airlines Logo
8:20 am - 2:50 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
7h 30m1 stop Dallas/Fort Worth
$317American Airlines
Wed, Nov 11 - Wed, Nov 18
Delta Logo
6:30 am - 1:55 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
6h 25m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:10 pm - 10:06 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
4h 56m1 stop Atlanta Hartsfield-Jackson
$317Delta
Mon, Dec 7 - Thu, Dec 10
Delta Logo
6:16 am - 11:27 amSAT  San Antonio-TYS Knoxville McGhee Tyson
4h 11m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:26 pm - 12:35 amTYS  Knoxville McGhee Tyson-SAT San Antonio
6h 09m1 stop Atlanta Hartsfield-Jackson
$317Delta
Tue, Nov 3 - Fri, Nov 6
United Airlines Logo
2:20 pm - 9:57 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
6h 37m1 stop Houston George Bush Intcntl
United Airlines Logo
3:45 pm - 9:26 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
6h 41m1 stop Houston George Bush Intcntl
$317United Airlines
Fri, Jan 22 - Tue, Jan 26
Southwest Logo
7:50 am - 2:00 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
5h 10m1 stop Dallas Love Field
Southwest Logo
2:40 pm - 9:40 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
8h 00m2 stops Dallas Love Field Houston Hobby
$322Southwest
Wed, Nov 11 - Wed, Nov 18
Southwest Logo
7:10 am - 12:20 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
4h 10m1 stop Nashville Intl
Southwest Logo
7:05 am - 1:15 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
7h 10m2 stops Nashville Intl Dallas Love Field
$322Southwest
Sat, Apr 3 - Thu, Apr 15
United Airlines Logo
6:40 am - 1:18 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
5h 38m1 stop Chicago O'Hare Intl
United Airlines Logo
9:15 am - 1:03 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
4h 48m1 stop Houston George Bush Intcntl
$407United Airlines
Wed, Nov 4 - Sun, Nov 8
Multiple Airlines Logo
10:29 pm - 8:43 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
21h 14m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
5:37 pm - 11:58 amTYS  Knoxville McGhee Tyson-SAT San Antonio
19h 21m1 stop Memphis
$475Multiple Airlines
Tue, Nov 24 - Wed, Nov 25
Multiple Airlines Logo
8:28 pm - 10:48 amSAT  San Antonio-TYS Knoxville McGhee Tyson
13h 20m2 stops Denver Intl Orlando
Multiple Airlines Logo
9:55 pm - 3:18 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
18h 23m1 stop Las Vegas Harry Reid Intl
$476Multiple Airlines

Price, demand and travel trends for San Antonio to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from San Antonio to Knoxville?

Round-trip flights from San Antonio to Knoxville typically range from $313 to $476. The lowest price found in the past 5 days was $317, on American Airlines.

What's the cheapest day of the week to fly from San Antonio to Knoxville?

Based on deals KAYAK users found in the last 12 months, Tuesday is the cheapest day of the week to fly from San Antonio to Knoxville. It’s 15% cheaper than the average day, while Friday is the most expensive, with prices 18% higher.

What’s the cheapest month to fly from San Antonio to Knoxville?

•May is the cheapest month to fly from San Antonio to Knoxville at $292 round-trip.
•March ($518) and April ($478) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 77% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

When are flights from San Antonio to Knoxville the cheapest?

Flights from San Antonio to Knoxville are cheapest 25 weeks before departure. Booking in this window typically costs about 54% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

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Key details for San Antonio to Knoxville flights

Low season

February

Cheapest flight

$159
Beat the crowds with an average 59% drop in travelers.
The most popular month to fly with an average 46% increase in travelers.
One-way flight from San Antonio to Knoxville

When to book flights from San Antonio to Knoxville

Are your dates flexible? Find out the best times to travel from San Antonio to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your San Antonio to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from San Antonio to Knoxville?

    Two cabin classes are available on flights from San Antonio to Knoxville:

    • Economy Class
    • First Class

  • How long is a flight from San Antonio to Knoxville?

    A nonstop flight from San Antonio to Knoxville takes 00m, covering 945 miles.

  • Do I need a passport to fly from San Antonio to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a San Antonio to Knoxville flight?

    Round-trip flights from San Antonio to Knoxville range from $313 to $476, with an average of $375 over the past 12 months. Anything below $313 counts as a good deal.

  • How expensive are last-minute San Antonio to Knoxville flights?

    Last-minute fares on this route (booked within two weeks of departure) run 41% above the $375 route average. Book 25 weeks before departure for the lowest fares.

  • Have flight prices from San Antonio to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $317 to $931. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from San Antonio to Knoxville looking right now?

    One-way fares from San Antonio to Knoxville are currently lower than usual. Average one-way flight prices are about $165, which is 25% below the typical average for this route.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from San Antonio to Knoxville?

    Flights from San Antonio to Knoxville usually depart from San Antonio (SAT) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from San Antonio to Knoxville pass through?

    One-stop flights from San Antonio to Knoxville most commonly connect through:

    • Dallas/Fort Worth (DFW) - 38% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 34% of one-stop connections
    • Nashville Intl (BNA) - 11% of one-stop connections
    • Houston George Bush Intcntl (IAH) - 8% of one-stop connections

  • Can I save money by using flexible dates for flights from San Antonio to Knoxville?

    Yes. Flexible dates can save you up to 28% on flights from San Antonio to Knoxville. Tuesday is the cheapest departure day at $319 round-trip on average, while Friday is the most expensive at $443, a difference of $124.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from San Antonio to Knoxville?

    Flying via Dallas Love Field (DAL) gives the shortest average 1-stop total travel time at 4h 41m, compared with 4h 47m via Nashville Intl (BNA) and 4h 49m via Houston George Bush Intcntl (IAH).

  • What is the time difference between San Antonio and Knoxville?

    Knoxville is 1 hour ahead of San Antonio (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking San Antonio to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Tuesday departure and avoid flying on Friday. On this route, Tuesday flights average $319, about $124 less than Friday fares (28% savings) based on the last 12 months.
  • For the best chance at a low fare, aim to book around 25 weeks before you fly. On this route, that window historically saves about 54% versus last-minute pricing (KAYAK booking data, last 12 months).
  • If you can choose when to travel, plan your San Antonio to Knoxville trip for May. Fares historically average $292 round-trip in that month - typically $226 less than the most expensive month, which is March (based on the last 12 months).

More options for your flight from San Antonio to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Car rentals in Knoxville
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