SAN - TYS

$118 Find Cheap Flights from San Diego to Knoxville - Compare and Save

1 adult
1 adult, Economy, 0 bags

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Everything you should know

Cheapest round-trip
$267
Typical prices: $363-$558
Southwest
Sat 10/27Wed 10/31
SAN - TYS • 1 stop
Cheapest one-way
$118
Typical prices: $200-$358
Multiple Airlines
Sun 11/11
SAN - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between San Diego and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to book
19 weeks
in advance
Our data shows that travelers who book at least 19 weeks in advance save around 45% compared to booking last minute.
Insights
Insights
When to travel
May
Cheapest • 10% price drop
June
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Phoenix Sky Harbor Intl (PHX)
Cheapest • Avg $308 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 6h 45m (one-way)
Insights
Insights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from San Diego to Knoxville (SAN-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Diego to Knoxville

Tue, Oct 27 - Sat, Oct 31
Southwest Logo
6:30 am - 3:40 pmSAN  San Diego-TYS Knoxville McGhee Tyson
6h 10m1 stop Denver Intl
Southwest Logo
8:25 am - 4:15 pmTYS  Knoxville McGhee Tyson-SAN San Diego
10h 50m1 stop Baltimore/Washington
$267Southwest
Wed, Nov 4 - Sun, Nov 8
Multiple Airlines Logo
4:53 pm - 1:19 pmSAN  San Diego-TYS Knoxville McGhee Tyson
17h 26m1 stop Denver Intl
Multiple Airlines Logo
6:30 am - 4:08 pmTYS  Knoxville McGhee Tyson-SAN San Diego
12h 38m1 stop Denver Intl
$325Multiple Airlines
Thu, Oct 29 - Mon, Nov 2
Multiple Airlines Logo
8:32 pm - 9:49 pmSAN  San Diego-TYS Knoxville McGhee Tyson
22h 17m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:42 pm - 6:38 pmTYS  Knoxville McGhee Tyson-SAN San Diego
23h 56m2 stops Las Vegas Harry Reid Intl San Francisco
$325Multiple Airlines
Mon, Nov 2 - Sat, Nov 7
American Airlines Logo
12:28 pm - 11:32 pmSAN  San Diego-TYS Knoxville McGhee Tyson
8h 04m1 stop Dallas/Fort Worth
American Airlines Logo
2:13 pm - 8:46 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 33m1 stop Charlotte Douglas
$337American Airlines
Mon, Nov 9 - Thu, Nov 12
Delta Logo
9:50 pm - 9:55 amSAN  San Diego-TYS Knoxville McGhee Tyson
9h 05m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:00 pm - 9:04 pmTYS  Knoxville McGhee Tyson-SAN San Diego
8h 04m1 stop Atlanta Hartsfield-Jackson
$337Delta
Tue, Nov 10 - Tue, Nov 17
Delta Logo
8:00 am - 8:09 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 09m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:57 am - 12:12 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 15m1 stop Minneapolis St Paul
$337Delta
Tue, Nov 10 - Tue, Nov 17
United Airlines Logo
11:21 am - 11:59 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 38m2 stops Denver Intl Washington, D.C. Dulles Intl
United Airlines Logo
9:00 am - 12:56 pmTYS  Knoxville McGhee Tyson-SAN San Diego
6h 56m1 stop Denver Intl
$342United Airlines
Mon, Nov 2 - Sat, Nov 7
Southwest Logo
6:45 am - 6:45 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 00m2 stops Phoenix Sky Harbor Intl Denver Intl
Southwest Logo
2:50 pm - 8:25 pmTYS  Knoxville McGhee Tyson-SAN San Diego
8h 35m1 stop Nashville Intl
$342Southwest
Fri, Oct 30 - Thu, Nov 5
American Airlines Logo
12:20 pm - 11:18 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 58m1 stop Dallas/Fort Worth
American Airlines Logo
5:32 pm - 11:56 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 24m1 stop Dallas/Fort Worth
$369American Airlines
Fri, Nov 13 - Tue, Nov 17
United Airlines Logo
6:45 am - 4:04 pmSAN  San Diego-TYS Knoxville McGhee Tyson
6h 19m1 stop Denver Intl
United Airlines Logo
1:56 pm - 8:36 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 40m2 stops Chicago O'Hare Intl Denver Intl
$428United Airlines
Booking Insights

Price, demand and travel trends for San Diego to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from San Diego to Knoxville with more confidence.

How much is a round-trip flight from San Diego to Knoxville?

Round-trip flights from San Diego to Knoxville start at $267. Prices are below average for this route right now, with typical round-trip fares ranging from $363 to $558. The lowest price found in the past 5 days was $267 on Southwest.

What's the cheapest day of the week to fly from San Diego to Knoxville?

Tuesday is the cheapest day of the week to fly from San Diego to Knoxville, it is 7% cheaper than the average day. Sunday is the most expensive day with flight prices 16% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from San Diego to Knoxville?

  • May is the cheapest month to fly from San Diego to Knoxville at $414 round-trip.
  • December ($516) and November ($516) are the most expensive months.
  • The price difference between flying in the cheapest and most expensive months is 24% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

When are prices from San Diego to Knoxville the cheapest?

Flights from San Diego to Knoxville are cheapest 19 weeks before departure. Booking in this window typically costs about 45% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

Find deals

Key details for San Diego to Knoxville flights

Low season

February

Cheapest flight

$118
Best time to beat the crowds but there is an average 3% increase in price.
Most popular time to fly with an average 4% increase in price.
Flight from San Diego to Knoxville

When to book flights from San Diego to Knoxville

Are your dates flexible? Find out the best times to travel from San Diego to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your San Diego to Knoxville flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from San Diego to Knoxville?

    Flights from San Diego to Knoxville usually depart from San Diego (SAN) and arrive at Knoxville McGhee Tyson (TYS).

  • What cabin classes can I book on flights from San Diego to Knoxville?

    Two cabin classes are available on flights from San Diego to Knoxville:

    • Economy Class
    • First Class

  • Which airports do connecting flights from San Diego to Knoxville pass through?

    One-stop flights from San Diego to Knoxville most commonly connect through:

    • Dallas/Fort Worth (DFW) - 55% of one-stop connections
    • Denver Intl (DEN) - 17% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 14% of one-stop connections
    • Detroit Metropolitan Wayne County (DTW) - 3% of one-stop connections

    Dallas/Fort Worth (DFW) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from San Diego to Knoxville?

    Yes. Being flexible with your travel dates can save you up to 21% on the San Diego to Knoxville route. Tuesday is the cheapest departure day at $428 round-trip on average, while Sunday is the most expensive at $536, a difference of $108. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How expensive are last-minute San Diego to Knoxville flights?

    Last-minute fares on this route - booked within 2 weeks of departure - run 39% above the route average of $459. Book 19 weeks before departure for the lowest fares.

  • How long is a flight from San Diego to Knoxville?

    A nonstop flight from San Diego to Knoxville takes 0h 00m, covering 1,897 miles.

  • Do I need a passport to fly from San Diego to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from San Diego to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $267 to $1,880. That means the highest observed fare was about 7x higher than the lowest one.

  • How are flight prices from San Diego to Knoxville looking right now?

    One-way fares from San Diego to Knoxville are currently lower than usual. Average one-way flight prices are about $172, which is 36% below the typical average for this route.

  • How much time can I save by choosing a different layover airport from San Diego to Knoxville?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 6h 45m, compared with 6h 50m via Dallas/Fort Worth (DFW) and 6h 50m via Nashville Intl (BNA).

  • What is the time difference between San Diego and Knoxville?

    Knoxville is 3 hours ahead of San Diego (Eastern Time vs Pacific Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    • Budget
    • Alamo
    • Thrifty
    • Enterprise Rent-A-Car
    • Payless

  • How much should I expect to pay for a San Diego to Knoxville flight?

    Round-trip flights from San Diego to Knoxville range from $363 to $558, with an average of $459 over the past 12 months. Anything below $363 counts as a good deal.

Your guide to booking San Diego to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Tuesday departure instead of Sunday. On this route, Tuesday flights average $428 - about $108 less than Sunday (20% savings) based on the last 12 months.
  • For the best chance at a low fare, aim to book around 19 weeks before you fly. On this route, that window historically saves about 45% versus last-minute pricing (KAYAK booking data, last 12 months).
  • If you can choose when to travel, plan your San Diego to Knoxville trip for May. Fares historically average $414 round-trip in that month - typically $102 less than the most expensive month, which is November (based on the last 12 months).

More options for your flight from San Diego to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Car rentals in Knoxville
Hotels in Knoxville
Vacations in Knoxville