SAN - TYS

$86 Find Cheap Flights from San Diego to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Diego to Knoxville departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Diego to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Diego to Knoxville, as well as popular online travel agencies
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41 299 237 searches in the past 7 days on KAYAK

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Everything you should know

Cheapest round-trip
$221
Typical prices: $593-$372
Frontier
Wed 6/17Wed 6/24
SAN - TYS • 1 stop
Cheapest one-way
$86
Typical prices: $168-$239
Frontier
Mon 5/18
SAN - TYS • 1 stop
Top airlines
Cheapest • from $221 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between San Diego and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $358 (round-trip)
Shortest trip • 5h 40m (one-way)
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 5 weeks in advance save around 27% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 32% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from San Diego to Knoxville (SAN-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Diego to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Diego to Knoxville

Wed, Jun 17 - Wed, Jun 24
Frontier Logo
6:25 am - 7:37 pm
SAN
-
TYS
10h 12m
1 stop
Frontier Logo
8:32 pm - 9:09 am
TYS
-
SAN
15h 37m
1 stop
$221Frontier
Wed, Jun 10 - Wed, Jun 24
Frontier Logo
6:25 am - 7:37 pm
SAN
-
TYS
10h 12m
1 stop
Frontier Logo
8:32 pm - 9:09 am
TYS
-
SAN
15h 37m
1 stop
$241Frontier
Wed, Jun 24 - Sun, Jun 28
Multiple Airlines Logo
6:25 am - 7:37 pm
SAN
-
TYS
10h 12m
1 stop
Multiple Airlines Logo
7:00 am - 9:09 am
TYS
-
SAN
29h 09m
1 stop
$258Multiple Airlines
Fri, May 29 - Fri, Jun 19
Frontier Logo
9:37 am - 7:24 pm
SAN
-
TYS
6h 47m
1 stop
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
$261Frontier
Wed, May 20 - Thu, May 28
Multiple Airlines Logo
6:25 am - 1:59 pm
SAN
-
TYS
28h 34m
1 stop
Multiple Airlines Logo
7:00 am - 11:50 pm
TYS
-
SAN
19h 50m
1 stop
$271Multiple Airlines
Wed, Jun 24 - Sun, Jun 28
Multiple Airlines Logo
6:25 am - 7:37 pm
SAN
-
TYS
10h 12m
1 stop
Multiple Airlines Logo
7:00 am - 9:09 am
TYS
-
SAN
29h 09m
1 stop
$273Multiple Airlines
Wed, Jun 24 - Sun, Jun 28
Multiple Airlines Logo
6:25 am - 7:37 pm
SAN
-
TYS
10h 12m
1 stop
Multiple Airlines Logo
7:00 am - 9:09 am
TYS
-
SAN
29h 09m
1 stop
$276Multiple Airlines
Fri, Aug 7 - Mon, Aug 10
Frontier Logo
6:25 am - 7:36 pm
SAN
-
TYS
10h 11m
1 stop
Frontier Logo
8:32 pm - 9:05 am
TYS
-
SAN
15h 33m
1 stop
$281Frontier
Sat, May 23 - Mon, May 25
Multiple Airlines Logo
6:25 am - 1:59 pm
SAN
-
TYS
28h 34m
1 stop
Multiple Airlines Logo
8:19 pm - 8:42 am
TYS
-
SAN
15h 23m
1 stop
$286Multiple Airlines
Wed, May 20 - Thu, May 28
Multiple Airlines Logo
6:25 am - 1:59 pm
SAN
-
TYS
28h 34m
1 stop
Multiple Airlines Logo
7:00 am - 12:43 pm
TYS
-
SAN
32h 43m
2 stops
$297Multiple Airlines
Booking Insights

KAYAK's insights & trends for San Diego to Knoxville flights

Get data-powered insights and trends into flights from San Diego to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from San Diego to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from San Diego to Knoxville departing in June.

What is the cheapest month to fly from San Diego to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Diego to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Diego to Knoxville is September, where tickets cost $292 (return) on average. On the other hand, the most expensive months are November and October, where the average cost of round-trip tickets is $542 and $482 respectively.

How far in advance should I book a flight from San Diego to Knoxville?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Diego to Knoxville, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Diego to Knoxville, you should book around 5 weeks before departure, which saves you about 27% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 9 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$86
Best time to beat the crowds but there is an average 4% increase in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from San Diego to Knoxville

When to book flights from San Diego to Knoxville

Are your dates flexible? Find out the best times to travel from San Diego to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from San Diego to Knoxville

  • What is the cheapest flight from San Diego to Knoxville?

    In the last 3 days, the lowest price for a flight from San Diego to Knoxville was $86 for a one-way ticket and $221 for a round-trip.

  • Do I need a passport to fly between San Diego and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from San Diego to Knoxville?

    On your way to Knoxville, you’ll fly out from San Diego. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from San Diego to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from San Diego to Knoxville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between San Diego and Knoxville, with Star Alliance being the most commonly used for this route.

  • What is the most popular layover when flying to Knoxville from San Diego?

    Dallas is the most popular layover city among KAYAK users traveling from San Diego to Knoxville.

  • Which is the best airline for flights from San Diego to Knoxville, Delta or Alaska Airlines?

    The two airlines most popular with KAYAK users for flights from San Diego to Knoxville are Delta and Alaska Airlines. With an average price for the route of $422 and an overall rating of 7.9, Delta is the most popular choice. Alaska Airlines is also a great choice for the route, with an average price of $798 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from San Diego to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Diego to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Diego to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from San Diego is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Diego to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to San Diego with another airline. Booking your flights between San Diego and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Diego to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from San Diego up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from San Diego to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from San Diego to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from San Diego to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
Alaska AirlinesOverall score based on 12319 reviews
8.1Boarding
7.8Comfort
8.5Crew
7.1Food
7.0Entertainment
Airline reviews

More efficient with checking lines and boarding/checking bags when needed.

4.0 OkayAnonymous, Apr 2026
SAN - JFK
Read more Alaska Airlines reviews

More efficient with checking lines and boarding/checking bags when needed.

They were really helpful with every question and my kids had never been on a plane and the staff made them feel comfortable

I was on flight #3022 departed from San Diego, California to Medford, Oregon. I had Denise & Damaris as my flight attendants. I didn’t have much interaction with Damaris, but I did with Denise who had, this calm, cool collective voice when she spoke about the emergency exit plans before takeoff. I travel often and I’ve never met a flight attendant that can put you at ease. I felt she respects and takes pride in her position and more airlines need to adopt the integrity and respect that she has for Alaska Airlines. Debbie

All airlines should board planes back to front, instead of catering to higher priced tickets. The boarding groups are inefficient and delay takeoff time

Luggage was severely damaged. Flight was late for several hours

The ticketing counter in SD was a mess. The lady handling the First-Class check-in seemed overwhelmed until a supervisor replaced her. It took almost 20 minutes to get once couple checked in, and then she started walking around the counters while 7 people just stood in line. Once her supervisor arrived, she announced she was going on break, never to engage with customers again.

No outlets, plugs, way to charge the phone or service and no food on one leg o the trip, but other than that, great. Loved WIFI, the flight, the crew, the pilots, the schedule, etc. Great job. My new favorite airline!

I had a problem with my reservation and no one could help me understand what happened. I booked my flight months ago and received a confirmation email. In the confirmation email, it said that the flight would depart at 3:15 p.m. A few hours before the flight, I tried to go online and check in, and suddenly it said that the flight was leaving an hour earlier. I had to rush to get to the airport and almost didn't make it. No one could help me understand why this happened, and I'm really concerned that it might happen in the future. I would appreciate some support in this matter.

It was a super old plane so the first class experience was just not luxurious

Good as usual. Just wished my seat was assigned at online check in. Thanks anyways

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

N Everything was perfect from boarding to assistance to baggage in Tampa

Loved the crew! Sucks that we went from 1 hour and 8 minute layover to a 3 hour layover. But weather sucks like that.

Fast, lovely scenery, great info on the Delta flight screen about landmarks we were flying over. Great landing!

Long flight but comfortable and not freezing as I have experienced on Hawaiian flights to the islands. They gave us blankets just in case. Nice touch.

I took seat 15A in anticipation of window seat, there is no window.

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Outstanding service, efficient & friendly crew, flight was safe, comfortable & on time

It was a red-eye, but the flight felt surprisingly quick. The seats were very comfortable, and that made resting much easier. I also want to thank the gentleman seated next to me, who graciously moved so my mom could sit beside me. We slept almost the entire way. The cabin crew was respectful in not disturbing us, while also being courteous and professional throughout. Thank you, United.

Poor communication, flight was delayed for preventable reasons. I missed my connection.

Boarding was again a "free for all". We were boarding group 4, and almost the entire plane was able to board before us. It's a shame that someone who follows the rules, gets the short end of the stick. Not fair.

It was perfect! I've never flown with United before, but I definitely will in the future

I had a cancelled flight because of technical issues going to my destination, and a delayed flight coming home. All told it wasn’t a total bust.

They delayed the flight from 9:00 to 11:55 At 11:45 they canceled the flight. I paid a premium price for the tickets with poor service

We had excellent customer service despite the chaos at George Bush airport in Houston!

My flight was canceled a few hours before boarding. I was rebooked on Copa airlines and missed an important meeting .

Left early arrived early..right amount of talking from pilots..of course had to love the biscuit and water!

Boarding gate at LAX was too crowded—two gates next to one another

Flying in the United States with the major airlines has become so underwhelming. A 2-3hr flight in most other parts of the world with the major carriers of the area comes with newer, CLEANER aircraft and significantly better in flight service in terms of both staff attitude and a actual meal service.

On time departure and early arrival. Flight attendant very nice.

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

Was not able to do a online check-in because the American Airlines system doesn't store our visa or other passport information, allowing us to have a trouble-free check-in. We were forced to have to check-in at the counter which Changes are upgrade status given that we were not able to check in much earlier.

Good flight, seated and had a water within 5 minutes. Crew was hospitable.

Delays experienced in boarding/take off due to incoming plane delayed. However, the boarding time/depart time in the app was significantly delayed in providing these updates. Usually not updated until an hour after we should have already boarded. Poorly managed.

We left at 1030 am pacific from LA and supposed to land at 7 pm Eastern in NY. They made a detour, stopped in Philadelphia and didn’t land till 1130 PM Eastern!!! Worst flight experience with no pilot communication with no explanation as to what was going on. Everyone was very frustrated to say the least.

Flight boarded from Gate 159B, the farthest gate in the LAX Bradley Terminal. While the flight operated on time, the first class cabin attendant made no recognition of my being an Advantage Executive Platinum member.

Plane was hot and miserable and the crew was rude!

12 hour delay required getting on and off plane 3 times - would have at least liked to have been offered a snack or drink

They didn’t offer a water, even after I asked

They switched our terminal 3 times and we were delayed for four plus hours!!!

It was an early flight and most people napped/slept and the crew let us which was nice.

The crew acted like they had never done this and kept barking passive aggressive orders at people. + the security line + the delay + sitting on the tarmac for 2 hours + none of the apps or signage updating with correct times

Remind customers of the need to have passport or new ID for boarding.

The flight never took off and we spent 7 hours at the airport

It was ok. It was expensive to check 2 bags ($75.00 per bag), and then it took a long time to wait for shuttle to take us from one terminal to the terminal where the plane was taking off at LAX. And all of this for a flight where we had to pay for any food or drink that was not water.

When I wanted to check in 3 hours prior to boarding time, the employees mentioned “a little over an hour delay” so I waited for an hour then I went to go look for food in the terminal and most people from that flight were in the same area looking for food. Finally I decided after food to check to see if it’s anytime closer and now it’s 2 mins until boarding closes?! What are you kidding me? I didn’t receive anything via sms about boarding now nor via email or on the intercom. I luckily made it through, barely, and then there’s no room for my carry on mind you I’m in the very first row so I had to place my purse in one further row back and my carry on sections down. Not sure who pays for better seats to get your stuff placed all over the plane but that was the worst experience I’ve ever had flying with anyone.

Everything you need to know for your flight from San Diego to Knoxville

Information on your arrival and departure airports