$113 Find Cheap Flights from John Wayne (Santa Ana) to Mississippi - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Mississippi departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Santa Ana to Mississippi

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Jackson
Jackson1 stop$384
Gulfport
Gulfport1 stop$350
Columbus
Columbus1 stop$561
Memphis
Memphis1 stop$280
Jackson
Jackson1 stop$384
Gulfport
Gulfport1 stop$350
Columbus
Columbus1 stop$561
Memphis
Memphis1 stop$280
Booking Insights

KAYAK's insights & trends for Santa Ana to Mississippi flights

Get data-powered insights and trends into flights from Santa Ana to Mississippi to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from John Wayne (Santa Ana) to Mississippi?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Mississippi, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from John Wayne (Santa Ana) to Mississippi is July, when tickets cost $0 (return) on average. On the other hand, the most expensive months are January and May, when the average cost of round-trip tickets is $912 and $849 respectively.

Good to know

Low season

February

Cheapest flight

$113
Most popular time to fly with an average 34% increase in price.
Flight from John Wayne (Santa Ana) to Memphis

FAQs - booking Mississippi flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Mississippi?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Mississippi.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Mississippi?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Mississippi is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Mississippi?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Mississippi with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Mississippi?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Mississippi up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Santa Ana to Mississippi

 
See real verified KAYAK customer reviews for airlines flying from John Wayne (Santa Ana) to Mississippi. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to Mississippi? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11898 reviews
6.4Food
7.5Boarding
7.2Comfort
7.9Crew
6.8Entertainment
Airline reviews

Our experience with American Airlines was extremely disappointing and honestly made an already exhausting international journey much worse. After flying all the way from Melbourne and dealing with significant jet lag, the American Airlines experience at LAX was the last thing we needed. The terminal and boarding area felt very old and uncomfortable, with little to no air conditioning and only old fans running in the area. Boarding was also through outdoor stairs rather than a jet bridge, which felt especially inconvenient after such a long journey. Even though we were traveling First Class, the onboard experience was surprisingly poor. There were no meaningful snack options, no decent coffee available to order, and the aircraft was so small that there was barely enough overhead space for carry-on luggage. The staff experience was also disappointing and lacked the warmth or attentiveness we had experienced on our international flights. To make matters worse, the flight departed late, extending an already very long travel day. Overall, the combination of the outdated terminal, uncomfortable boarding process, limited First Class service, small aircraft, poor staff experience, and delay made this an extremely unpleasant final leg of our journey. It significantly worsened our exhaustion and jet lag rather than making the connection home easier. Unfortunately, this experience was bad enough that I do not plan to travel with American Airlines again in the future.

2.0 MediocreAnonymous, Aug 2026
Read more American Airlines reviews

Our experience with American Airlines was extremely disappointing and honestly made an already exhausting international journey much worse. After flying all the way from Melbourne and dealing with significant jet lag, the American Airlines experience at LAX was the last thing we needed. The terminal and boarding area felt very old and uncomfortable, with little to no air conditioning and only old fans running in the area. Boarding was also through outdoor stairs rather than a jet bridge, which felt especially inconvenient after such a long journey. Even though we were traveling First Class, the onboard experience was surprisingly poor. There were no meaningful snack options, no decent coffee available to order, and the aircraft was so small that there was barely enough overhead space for carry-on luggage. The staff experience was also disappointing and lacked the warmth or attentiveness we had experienced on our international flights. To make matters worse, the flight departed late, extending an already very long travel day. Overall, the combination of the outdated terminal, uncomfortable boarding process, limited First Class service, small aircraft, poor staff experience, and delay made this an extremely unpleasant final leg of our journey. It significantly worsened our exhaustion and jet lag rather than making the connection home easier. Unfortunately, this experience was bad enough that I do not plan to travel with American Airlines again in the future.

The WiFi didn’t work entire flight, couldn’t watch a movie. The recline button didn’t work

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

American was having a problem with their kiosks when I arrived which made the check-in and bag drop process unusually long. Additionally, they only had one person working check-in. Eventually, the kiosks were fixed and everything else went smoothly.

The flight encountered a delay exceeding 4 hours. The food voucher issued was valued at $12, insufficient to cover our meal expenses. Consequently, I was unable to take my medication, leading to a drop in blood sugar levels and exacerbating my anxiety.

Flights were on time. That's the main consideration since I had to change planes. The entertainment was whatever you bring with you and the food (in Economy) is non-existant. Neither of those was a surprise.

The gate crew did try to help, however they lacked the information as to whether the flight will operate or not. Being delayed 6 hours and in a limbo on whether the flight will operate or not is not fun. The airline having staffing issues is not encouraging at all.

The flight was short. However, my bag was delayed and was put on another flight.

Flight was delayed and missed connecting flight. Did not give warning about delay until we showed up at the airport. Not good.

I love to be able to connect my own devices to the entertainment system. It works great!

Everything you need to know for your flight from Santa Ana to Mississippi

Information on your arrival and departure airports