$343 Find Cheap Flights from John Wayne (Santa Ana) to Spain - Compare and Save

1 adult
1 adult, Economy, 0 bags

Save 25% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Ana to Spain

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Madrid
Madrid2 stops$734
Málaga
Málaga2 stops$877
Valencia
Valencia2 stops$801
Seville
Seville2 stops$1,085
San Sebastian
San Sebastian2 stops$978
Madrid
Madrid2 stops$734
Málaga
Málaga2 stops$877
Valencia
Valencia2 stops$801
Seville
Seville2 stops$1,085
San Sebastian
San Sebastian2 stops$978
Booking Insights

Price, demand and travel trends for Santa Ana to Spain flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Are flights from Santa Ana to Spain cheaper or more expensive than last year?

Fares from Santa Ana to Spain are running about 6% higher than they were around this time last year, averaging $954 round-trip.

What are the cheapest fares from Santa Ana to Spain right now?

Here are the cheapest round-trip fares from Santa Ana to Spain on KAYAK in the last week:

• Madrid Barajas (MAD) from $734
• Bilbao (BIO) from $790
• Valencia (VLC) from $801
• Palma de Mallorca Son Sant Joan (PMI) from $865
• Barcelona-El Prat (BCN) from $876

What’s the cheapest month to fly from Santa Ana to Spain?

February is the cheapest time of year to fly, with average fares of $491. Prices are highest in December, when average flight costs increase to around $1,555.

Which airport in Spain is the cheapest to fly to from Santa Ana?

Based on KAYAK data from the past 12 months, the cheapest airports to fly into Spain are:

• Palma de Mallorca Son Sant Joan (PMI) from $588
• Madrid Barajas (MAD) from $779
• Malaga (AGP) from $867

What’s the cheapest day to fly from Santa Ana to Spain?

Friday tends to be the cheapest day to fly from Santa Ana to Spain, while Tuesday is the most expensive. Fares run about 42% higher that day, based on the past 12 months of KAYAK data.

What's the cheapest time of day to fly from Santa Ana to Spain?

Data from the past 12 months shows it's cheapest to fly to Spain during the night with average prices of $743. The evening is the most expensive time to fly, with average prices of $1,367.

Key details for Santa Ana to Spain flights

Low season

February

Cheapest flight

$343
Beat the crowds with an average 77% drop in travelers.
The most popular month to fly with an average 73% increase in travelers.
One-way flight from Santa Ana to Madrid

Your Santa Ana to Spain flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Santa Ana to Spain?

    Fares from Santa Ana to Spain are around their usual level right now. A round-trip under $727 is considered a good deal, so it's worth keeping an eye out, or setting a Price Alert to catch price changes.

  • How much should I budget for a flight from Santa Ana to Spain?

    Over the past 12 months, round-trip fares from Santa Ana to Spain have ranged from $727 to $1,234.

  • What are the main airports serving Spain?

    Spain has 44 airports. The three busiest are Barcelona-El Prat (BCN) (48% of arrivals), Madrid Barajas (MAD) (25%) and Malaga (AGP) (13%).

  • What airlines fly nonstop from Santa Ana to Spain?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Santa Ana to Spain. One-stop options include:

    • American Airlines
    • United Airlines
    • Delta

  • Which cabin classes are available on flights from Santa Ana to Spain?

    On flights from Santa Ana to Spain you can book Economy Class, Business Class or First Class.

  • What are some popular landmarks in Spain?

    KAYAK travelers' favorite landmarks in Spain include:

    • La Rambla
    • Sagrada Familia
    • Placa de Catalunya
    • Camp Nou

Your guide to booking Santa Ana to Spain flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for February when flights are typically cheapest and avoid December when prices are at their highest.
  • Flying on Friday is usually the cheapest. Flights on Tuesday cost about 42% more on average, so being flexible with your travel dates could help you save.
  • If you're looking to save, Palma de Mallorca Son Sant Joan (PMI) is the cheapest airport to fly into from Santa Ana. If you have onward travel, don't forget to factor in the cost of your journey by train, bus or domestic flight.
  • Start your trip in Barcelona, which is the most popular destination in Spain. From there, it's easy to continue on to other popular destinations such as Madrid, Palma de Mallorca and Seville.

Reviews of the top airlines flying from Santa Ana to Spain

 
Need help choosing which airline to fly with from Santa Ana to Spain? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.3
United AirlinesOverall score based on 10444 reviews
7.7Boarding
8.1Crew
6.7Food
7.3Comfort
7.1Entertainment
Airline reviews

New Max 10, first class seats have been shrunk. End of a 20 hour journey, it was United not Lufthansa, just glad to get home

8.0 ExcellentBernard, Oct 2026
Read more United Airlines reviews

New Max 10, first class seats have been shrunk. End of a 20 hour journey, it was United not Lufthansa, just glad to get home

Seats are uncomfortable and left me in pain in my tailbone area. I got about one hour of sleep.

Delay of two hours due to some mechanical issue. Staff was wonderful and the pilot did let us know what was going on.

Excellent. I had a medical emergency on flight SNA-ORD and the attendants were very helpful.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

The best airline I have ever travel , really good customer service, attention and service !!

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Very poor the plane itself was really old, slight smell that couldn’t be named. I didn’t even get a boarding pass UNTIL AFTER clearing security! Even then, they said when I get to my connected flight I’ll get my 2nd boarding pass there! A bit ridiculous!

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

the head jack on my seat didn't work and the power outlet didn't work for my seat

American Airlines was horrible! The layover flight to DFW was delayed with no clear communication and for us having to stay the whole day which led to staying a night in Dallas was comped with 2 $12 dollar vouchers and a crappy hotel. We missed a whole day in Tokyo for our honeymoon and stressed the whole 24 hours. We were supposed to leave at the same time the following day, but that was delayed hours again. And instead of letting the delayed flight go first, they let the flight that was scheduled ahead of us. American should refund us the day wasted in Dallas that should have been in Tokyo! We had lost out on paid events that we can’t get refunded. When we finally did leave, it was a good flight. You would think that was the only issue with American but we from the LAX layover, we were delayed 6 hours and were given a $12 dollar voucher that covered a drink only. The only communication we were given then was that because they were delayed in a prior flight we were delayed again. I don’t understand why it was only with American that we had such a bad time with! They have definitely left a sour taste in our mouths for our honeymoon! And then they did send an email saying we could have 2K miles…. For what? To be delayed into another day and miss our flight again?

Business class flight attendant was very good. But our flight was delayed two hours for a “mechanical” bathroom issue that literally took 5 minutes to fix. Our plane landed early from its previous flight but still waited for a mechanic to show up to fix an obvious minor issue for almost three hours. This caused us to miss our connecting flight. They put us up in a Days Inn that was 17 miles away from the airport that took a half hour of driving just to get to and this was at 11pm at night. Then when we finally got back on a plane after a full day delay they left our luggage back in the airport. This was an international flight, so no luggage or belongings after flying 8 hours to a different country. We will NEVER fly American Airlines again.

The WiFi didn’t work entire flight, couldn’t watch a movie. The recline button didn’t work

The food was okay and the space in business class was smaller than we had to Singapore.

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

The flight encountered a delay exceeding 4 hours. The food voucher issued was valued at $12, insufficient to cover our meal expenses. Consequently, I was unable to take my medication, leading to a drop in blood sugar levels and exacerbating my anxiety.

Flights were on time. That's the main consideration since I had to change planes. The entertainment was whatever you bring with you and the food (in Economy) is non-existant. Neither of those was a surprise.

The gate crew did try to help, however they lacked the information as to whether the flight will operate or not. Being delayed 6 hours and in a limbo on whether the flight will operate or not is not fun. The airline having staffing issues is not encouraging at all.

Flight was delayed and missed connecting flight. Did not give warning about delay until we showed up at the airport. Not good.

I love to be able to connect my own devices to the entertainment system. It works great!

More options for your flight from Santa Ana to Spain

Complete your trip to Spain with a hotel stay or car rental