$576 Find Cheap Flights from South America to Panama City

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight to Panama City departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Cheap Flights from South America to Panama City

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South America to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South America to Panama City

Sat, Sep 27 - Sat, Oct 4
American Airlines Logo
1:50 pm - 9:42 amMDE-ECP
19h 52m2 stops
American Airlines Logo
2:52 pm - 12:50 pmECP-MDE
21h 58m2 stops
$576American Airlines
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Sat, Sep 27 - Sat, Oct 4
United Airlines Logo
9:45 am - 1:10 pmMDE-ECP
27h 25m2 stops
United Airlines Logo
5:08 pm - 9:10 pmECP-MDE
28h 02m1 stop
$594United Airlines
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Fri, Jan 16 - Tue, Jan 20
Delta Logo
10:55 am - 10:42 pmBOG-ECP
12h 47m2 stops
Delta Logo
7:45 am - 8:20 pmECP-BOG
11h 35m2 stops
$654Delta
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Thu, Oct 9 - Mon, Oct 13
American Airlines Logo
12:25 am - 6:44 pmBOG-ECP
18h 19m1 stop
American Airlines Logo
6:32 am - 10:30 pmECP-BOG
15h 58m1 stop
$762American Airlines
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Fri, Nov 7 - Mon, Nov 10
American Airlines Logo
12:45 am - 7:40 pmLIM-ECP
19h 55m2 stops
American Airlines Logo
1:11 pm - 5:10 amECP-LIM
14h 59m2 stops
$795American Airlines
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Tue, Oct 14 - Tue, Oct 21
American Airlines Logo
6:30 am - 10:53 pmLIM-ECP
16h 23m2 stops
American Airlines Logo
11:58 am - 4:10 amECP-LIM
16h 12m2 stops
$805American Airlines
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Tue, Oct 7 - Sat, Oct 18
American Airlines Logo
6:30 am - 10:53 pmLIM-ECP
16h 23m2 stops
American Airlines Logo
5:30 am - 8:30 pmECP-LIM
15h 00m2 stops
$836American Airlines
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Sat, Nov 8 - Mon, Nov 10
Delta Logo
11:40 pm - 10:15 amLIM-ECP
11h 35m1 stop
Delta Logo
11:15 am - 5:00 amECP-LIM
16h 45m1 stop
$848Delta
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Tue, Oct 7 - Sat, Oct 18
 Logo
12:00 pm - 11:10 pmLIM-ECP
11h 10m1 stop
 Logo
5:32 pm - 5:00 amECP-LIM
11h 28m1 stop
Fri, Sep 26 - Wed, Oct 1
United Airlines Logo
12:40 am - 1:10 pmLIM-ECP
36h 30m2 stops
United Airlines Logo
1:55 pm - 11:00 pmECP-LIM
33h 05m2 stops
$901United Airlines
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Good to know

Low seasonOctober
Cheapest flight$576
Best time to beat the crowds with an average 32% drop in price.
Most popular time to fly and prices are also 15% lower on average.
Flight from Medellín to Panama City

FAQs for booking flights from South America to Panama City

  • How does KAYAK find such low prices on flights from South America to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South America to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South America to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to South America with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South America to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from South America to Panama City

 
Need help choosing which airline to fly with from South America to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7980 reviews
8.2Boarding
7.3Food
7.9Entertainment
8.5Crew
7.9Comfort
Airline reviews

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

8.0 ExcellentJeanne, Aug 2025MSY - JFK
Read more Delta reviews

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

Our seats were comfortable with adequate room to stretch out and recline. The food was tasty and served it just the right intervals. Our flight attendant was extra attentive and friendly. Flight arrived early. And the most turbulence. Overall that’s good and experience for an 11 hour flight as can be hoped for

The seats got pretty uncomfortable pretty fast. The armrests are bigger than on other planes, so I had less room in the actual seat. My butt hurt by the end of the flight. :/ comfort was the primary issue. The crew were fantastic!

I believe that a four-hour trip should have a meal. Delta had none.

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

I was uncomfortably cold on the plane. Other than that it was uneventful and therefore as enjoyable as a plane ride can be.

There was supposed to be a meal served, but there wasn’t and the major toilet was out of order

They made us board and then deboard due to mechanical issue which delayed the departure by almost 2 hours and we barely made our connecting flight. These quality checks should've been done before boarding not after.

Having to up charge for a seat assignment is not good. Delta can do better

I liked the friendliness of the staff. The cleanliness of all 3 planes.

For both flights I requested a gluten free meal, they didn’t have one nor were there other options.

Plane was crowded and even when we hit altitude, the plane was hot, not enough air flow.

Flight attendant in first class gave poor service (like he didn't want to be there) and food was awful. We sat waiting for gate upon arrival over 45 mins.

The experience was great, the crew was very polite and hospitable. I will definitely make if my go to airlines.

Inoperable monitor left no entert for 9 hours. Crew was not helpful Food was awful.

Stuck on tarmac for two hours plus a 5.5 hour flight. Rude flight attendant. And no meals, not even for purchase!

Excellent flight. Boarding was efficient and departure was on time. Smooth flight with on time arrival. Deplaning was also efficient.

This flight was perfect. No complaints and only the highest regard for the crew and ground staff and how they executed perfectly. I fly a lot with United and would request predictability and transparency in their operations instead of last minute changes.

This is for UA2274 from Houston to Sacramento. The flight was delayed arriving due to mechanical issues so we left about 3 hours later than scheduled. When boarding the plane the temperature inside was excessive - likely close to 100. Pilot apologized and said it was going to improve at altitude, which it did. But before that I honestly thought there might have been more delays removing passengers made ill from the heat. We were delayed leaving due to another mechanical issue. There was not water on the plane due to a panel that was not secured. They did that quickly, but the combination of mechanical issues was rather disturbing and did not reflect well on United.

1. when we went to check in, our 2 first class seats had been CANCELED and the flight was sold out. This was done without our prior knowledge. It was all we could do to restore one first class seat for my wife and I flew economy. 2, Our flight home was scheduled to leave at 10:30 pm. Due to tsunami warnings, the roads were closed and our flight status was uncertain as to whether it would leave as scheduled. It was announced that it would now leave at 11:20 pm and the roads were now open since the tsunami had come and gone. We made a mad dash to the airport and checked in. Delays were announced at 12:30 pm, 1:30 am, 2:30 am and at 3:30 am it was canceled. Since this was a flight due to natural (tsunami) causes, there was no compensation. We were told to return at 1:00 pm the next day and our baggage would be kept on the plane since the same plane was going to leave at 1:00 pm. We had to return to our hotel for the rest of the night. The same plane did not leave at 1:00 pm and our baggage was gone! All in all, it was a miserable performance by UA. Information was hard to obtain and no one knew what was going on and what was going to happen. Hundreds of passengers slept on the floor, chairs, etc. No food and no water was made available to the passengers. It was a situation where UA could care less what was going on. As a one million mile flyer, I had not experienced anything like this before and it was hugely disappointing!

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