$410 Find Cheap Flights from South America to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Panama City departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$519
Typical prices: $584-$765
Delta
Mon 4/20Wed 4/29
BOG - ECP • 2 stops
Cheapest one-way
$410
American Airlines
Tue 3/24
MDE - ECP • 2 stops
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Flight Deals
Useful Info
Flight Deals

Cheap Flights from South America to Panama City

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South America to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South America to Panama City

Mon, Apr 20 - Wed, Apr 29
Delta Logo
8:40 am - 9:22 pm
BOG
-
ECP
12h 42m
2 stops
Delta Logo
7:05 am - 5:50 pm
ECP
-
BOG
10h 45m
2 stops
$519Delta
Mon, Apr 6 - Thu, Apr 30
LATAM Airlines Logo
2:55 pm - 11:04 pm
BOG
-
ECP
8h 09m
1 stop
LATAM Airlines Logo
7:05 am - 7:15 pm
ECP
-
BOG
12h 10m
1 stop
$528LATAM Airlines
Mon, Apr 6 - Thu, Apr 30
LATAM Airlines Logo
10:35 am - 9:22 pm
BOG
-
ECP
10h 47m
2 stops
LATAM Airlines Logo
7:05 am - 1:40 pm
ECP
-
BOG
6h 35m
1 stop
$532LATAM Airlines
Wed, Apr 8 - Sun, May 17
Delta Logo
9:00 am - 7:47 pm
BOG
-
ECP
10h 47m
1 stop
Delta Logo
6:00 am - 1:50 pm
ECP
-
BOG
7h 50m
1 stop
$546Delta
Mon, Apr 6 - Thu, Apr 30
American Airlines Logo
3:15 pm - 12:54 pm
BOG
-
ECP
21h 39m
2 stops
American Airlines Logo
4:00 pm - 1:05 pm
ECP
-
BOG
21h 05m
2 stops
$563American Airlines
Mon, Mar 30 - Mon, Apr 6
American Airlines Logo
2:10 pm - 9:36 am
MDE
-
ECP
19h 26m
2 stops
American Airlines Logo
4:34 pm - 12:48 pm
ECP
-
MDE
20h 14m
2 stops
$587American Airlines
Fri, Apr 24 - Mon, Apr 27
Delta Logo
9:00 am - 9:22 pm
BOG
-
ECP
12h 22m
1 stop
Delta Logo
5:49 am - 8:10 pm
ECP
-
BOG
14h 21m
2 stops
$595Delta
Fri, Apr 24 - Mon, Apr 27
Delta Logo
9:00 am - 9:22 pm
BOG
-
ECP
12h 22m
1 stop
Delta Logo
5:49 am - 1:40 pm
ECP
-
BOG
7h 51m
1 stop
$596Delta
Thu, Mar 5 - Sun, Mar 8
United Airlines Logo
10:45 am - 9:43 am
MDE
-
ECP
23h 58m
2 stops
United Airlines Logo
5:03 pm - 9:05 pm
ECP
-
MDE
28h 02m
1 stop
$728United Airlines
Thu, Mar 5 - Sun, Mar 8
United Airlines Logo
10:45 am - 9:57 pm
MDE
-
ECP
12h 12m
1 stop
United Airlines Logo
5:03 pm - 9:05 pm
ECP
-
MDE
28h 02m
1 stop
$734United Airlines
Useful Info

Good to know

Low seasonNovember
Cheapest flight$410
Best time to beat the crowds with an average 28% drop in price.
Most popular time to fly and prices are also 12% lower on average.
Flight from Medellín to Panama City

FAQs for booking flights from South America to Panama City

  • How does KAYAK find such low prices on flights from South America to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South America to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South America to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to South America with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South America to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from South America to Panama City

 
Need help choosing which airline to fly with from South America to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9289 reviews
8.1Crew
6.6Food
7.3Comfort
7.7Boarding
7.1Entertainment
Airline reviews

Very disappointing given gate agent behavior. Filed a formal complaint with United.

2.0 MediocreAnnie Caroline, Feb 2026
SFO - LAX
Read more United Airlines reviews

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Do not like the size of the overhead bin. I think staff should monitor the size of suitcases that are being carried on by passengers to ensure they meet the size requirement.

Crew was great (professional, attentive, prompt). Snacks for 4 hrs flight is deplorable.

Flight delayed. WiFi connectivity very poor if not existant. Last minute arrival forced me to run to catch my connection.

Both of my flights arrived early and check in process was smooth

Terrible. No customer service, no food, no drinks on a 6 hour premier economy booking.

Short flight, but no drink/snack service. The flights both going and coming were delayed.

Much better than Spirit. I was please by the easy fast check in and boarding

Crew was great. 2 1/2 hour delay was due to staff needing "rest" was avoidable and self inflicted as United not willing to hire enough crew to keep flight on time.. Ridiculous. The crew and the passengers both suffered due to this.

Horrible Flight significantly delayed. Not due to united issue. But trying to rebook connection flight and get information about overnight accommodation was difficult. Agent did not seem to care or have any interest to help.

Traveling to a place near Panama City?

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Everything you need to know for your flight to Panama City

Information on the airport you'll fly into in Panama City

Panama City (ECP)