$264 Find Cheap Flights from Panama City to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South America departing on 3/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama City to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá1 stop$557
Guayaquil
Guayaquil2 stops$719
Cusco
Cusco2 stops$1,324
Bogotá
Bogotá1 stop$557
Guayaquil
Guayaquil2 stops$719
Cusco
Cusco2 stops$1,324

Book Cheap Panama City to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South America

Sat, May 9 - Fri, May 22
Delta Logo
6:00 am - 1:50 pm
ECP
-
BOG
7h 50m
1 stop
Delta Logo
2:55 pm - 8:29 am
BOG
-
ECP
17h 34m
1 stop
$557Delta
Fri, Apr 17 - Thu, Apr 30
LATAM Airlines Logo
5:49 am - 7:15 pm
ECP
-
BOG
13h 26m
1 stop
LATAM Airlines Logo
2:55 pm - 8:35 am
BOG
-
ECP
17h 40m
1 stop
$565LATAM Airlines
Fri, Apr 17 - Thu, Apr 30
American Airlines Logo
12:33 pm - 10:30 pm
ECP
-
BOG
9h 57m
1 stop
American Airlines Logo
2:10 pm - 1:23 pm
BOG
-
ECP
23h 13m
2 stops
$570American Airlines
Sat, May 9 - Fri, May 22
Delta Logo
6:00 am - 7:25 pm
ECP
-
BOG
13h 25m
1 stop
Delta Logo
2:55 pm - 8:29 am
BOG
-
ECP
17h 34m
1 stop
$577Delta
Sat, May 9 - Fri, May 22
American Airlines Logo
12:26 pm - 10:30 pm
ECP
-
BOG
10h 04m
1 stop
American Airlines Logo
2:10 pm - 10:28 am
BOG
-
ECP
20h 18m
2 stops
$585American Airlines
Mon, Apr 13 - Thu, Apr 16
United Airlines Logo
4:57 pm - 4:54 am
ECP
-
BOG
11h 57m
1 stop
United Airlines Logo
8:30 am - 9:59 pm
BOG
-
ECP
13h 29m
1 stop
$607United Airlines
Mon, Apr 13 - Thu, Apr 16
United Airlines Logo
2:19 pm - 4:54 am
ECP
-
BOG
14h 35m
2 stops
United Airlines Logo
8:30 am - 9:59 pm
BOG
-
ECP
13h 29m
1 stop
$612United Airlines
Fri, Apr 3 - Mon, Apr 6
American Airlines Logo
3:38 pm - 12:40 pm
ECP
-
BOG
21h 02m
2 stops
American Airlines Logo
7:05 am - 11:49 pm
BOG
-
ECP
16h 44m
2 stops
$618American Airlines
Fri, Apr 3 - Sun, Apr 5
American Airlines Logo
12:39 pm - 10:30 pm
ECP
-
BOG
9h 51m
1 stop
American Airlines Logo
12:25 am - 9:18 pm
BOG
-
ECP
20h 53m
1 stop
$622American Airlines
Fri, Apr 3 - Fri, Apr 10
Multiple Airlines Logo
6:43 pm - 8:25 am
ECP
-
CUZ
13h 42m
2 stops
Multiple Airlines Logo
6:50 am - 11:04 pm
CUZ
-
ECP
16h 14m
2 stops
$1,324Multiple Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South America flights

Get data-powered insights and trends into flights from Panama City to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Panama City to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to South America were found on Delta ($557) and LATAM Airlines ($565).

Good to know

Low seasonAugust
Cheapest flight$264
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from Panama City to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Panama City to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to South America

 
Need help choosing which airline to fly with from Panama City to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8212 reviews
7.8Entertainment
7.9Comfort
8.1Boarding
8.5Crew
7.2Food
Airline reviews

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

10.0 ExcellentSoosnata, Feb 2026
MIA - LAX
Read more Delta reviews

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

The flight was great as well as the airline staff

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

I have diamond medallion status and usually we are in comfort plus . We were in main this time ( which was fine ) and my husband wanted wine . I have at least 10 vouchers for drinks that are good for this year and next! The attendant would not take the picture of the voucher as proof and never came back to check as She asked me to pull it up on delta Wi-Fi. Instead my husband just used his Amex to buy the wine . Disappointing!!!

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

it was a very short flight so my expectations were low.

As great a red-eye flight as red-eye flights can be.

Once boarding started it was pretty quick. Food was inedible; cold and salty..

Entertainment kept turning itself off. Gave up on watching a movie.

Plane outlets in my row not working to charge phone. Staff response was, well it should be. Plug into seed for volume not working well. Had to find the sweet spot for plug in or it would shut off and on.

Everything was absolutely wonderful from check in to baggage claim. Staff was very professional and sweet. Will definitely recommend United to family and friends.

Very turbulent trip made it pretty bearable, plus the lack of refreshments served and the lack of any air conditioning before takeoff which took an hour or more.

It was nice to have gotten up upgraded to first class with a meal on a three hour flight

They charged a fee for 1st bag checked. Others in same party were free.

Flight team stood out for perzonal attention, kindness at bright cheery attitudes at 8am. Very helpful.

Everything you need to know for your flight to South America

Information on your arrival and departure airports