$313 Find Cheap Flights from Panama City to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South America departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama City to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá1 stop$513
Guayaquil
Guayaquil2 stops$682
Cusco
Cusco2 stops$1,120
Bogotá
Bogotá1 stop$513
Guayaquil
Guayaquil2 stops$682
Cusco
Cusco2 stops$1,120

Book Cheap Panama City to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South America

Thu, Apr 2 - Mon, Apr 6
Delta Logo
6:00 am - 7:30 pmECP-BOG
13h 30m1 stop
Delta Logo
2:55 pm - 10:42 pmBOG-ECP
7h 47m1 stop
$513Delta
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Fri, Jan 16 - Tue, Jan 27
American Airlines Logo
6:03 pm - 2:15 pmECP-BOG
19h 12m2 stops
American Airlines Logo
11:55 pm - 2:54 pmBOG-ECP
15h 59m1 stop
$540American Airlines
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Thu, Apr 2 - Sun, Apr 5
United Airlines Logo
3:10 pm - 4:54 amECP-BOG
13h 44m1 stop
United Airlines Logo
12:14 am - 2:17 pmBOG-ECP
14h 03m1 stop
$549United Airlines
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Mon, Dec 8 - Mon, Dec 15
American Airlines Logo
3:18 pm - 2:15 pmECP-BOG
21h 57m2 stops
American Airlines Logo
3:15 pm - 11:38 amBOG-ECP
21h 23m2 stops
$568American Airlines
Find Deal
Mon, Dec 8 - Mon, Dec 15
American Airlines Logo
3:18 pm - 2:15 pmECP-BOG
21h 57m2 stops
American Airlines Logo
11:55 pm - 12:21 pmBOG-ECP
13h 26m1 stop
$595American Airlines
Find Deal
Sun, Feb 15 - Tue, Feb 17
American Airlines Logo
4:32 pm - 2:15 pmECP-BOG
20h 43m2 stops
American Airlines Logo
3:15 pm - 9:37 amBOG-ECP
19h 22m2 stops
$600American Airlines
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Fri, Jan 16 - Tue, Jan 27
American Airlines Logo
7:02 am - 11:30 pmECP-BOG
15h 28m1 stop
American Airlines Logo
11:55 pm - 2:54 pmBOG-ECP
15h 59m1 stop
$604American Airlines
Find Deal
Sun, Feb 15 - Tue, Feb 17
American Airlines Logo
12:39 pm - 11:31 pmECP-BOG
9h 52m1 stop
American Airlines Logo
8:00 am - 10:25 pmBOG-ECP
15h 25m2 stops
$610American Airlines
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Thu, Apr 2 - Sun, Apr 5
United Airlines Logo
2:15 pm - 4:54 amECP-BOG
14h 39m2 stops
United Airlines Logo
12:14 am - 12:37 pmBOG-ECP
12h 23m1 stop
$611United Airlines
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Mon, Dec 8 - Mon, Dec 15
Delta Logo
7:30 am - 7:30 pmECP-BOG
11h 00m1 stop
Delta Logo
3:55 pm - 11:06 pmBOG-ECP
8h 11m1 stop
$636Delta
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Booking Insights

KAYAK's insights & trends for Panama City to South America flights

Get data-powered insights and trends into flights from Panama City to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Panama City and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Panama City to South America.

There is just one airline that flies from Panama City to South America direct and that is Delta. The best round-trip deal found from Delta for the route is to Bogotá (BOG) and costs $482.

Which airlines provide the cheapest flights from Panama City to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to South America were found on Delta ($513) and American Airlines ($540).

Good to know

Low seasonMarch
Cheapest flight$343
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from Panama City to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Panama City to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to South America

 
Need help choosing which airline to fly with from Panama City to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8001 reviews
8.5Crew
7.9Comfort
8.2Boarding
7.9Entertainment
7.3Food
Airline reviews

Non stop on long haul is the way to go. Great experience

10.0 ExcellentEric, Oct 2025MCO - ATL
Read more Delta reviews

Non stop on long haul is the way to go. Great experience

The boarding process needs to be refined. Sometimes the gate crew call out the boarding zone, and then flip to the monitor to show which zones are boarding. So unless everyone is gathered around to see the monitor there is usually confusion as wi which zones are boarding.

Passengers need to check in big baggage instead of bringing on the plane. That cause inconvenience for everyone. Otherwise flight was good.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

Quick check in. Everything went smooth. I don't know what can be done about airline food.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

Plane boarded early a quickly, was mostly full. We left close to on time. And landed early.

My experience on this United Airlines flight was highly uncomfortable, primarily due to two issues: Cabin Temperature: The temperature on the Boeing 737 MAX 8 was unacceptably high, feeling consistently around 80 degrees throughout the flight. This made sleeping impossible and significantly detracted from the experience. Seating Arrangement: Being stuck in a middle seat for a six-and-a-half-hour overnight flight compounded the discomfort. Moving forward, I will always purchase a seat assignment to avoid this situation.

Premium Plus is a really good idea for longer flights

7 hours delayed due to operational issues on United’s end. Basically laziness.

Short flight but an "eager to help" crew made the journey more enjoyable!

Flight was delayed only slightly before takeoff due to traffic control. However, the flight arrived early to ORD. Good flight. United has been very reliable for me.

The person I bought the ticket for didn’t make the flight.

The worst landing I have ever had on a domestic flight. Thought we would lose the landing gear on landing in Newark. Then we spent 40 minutes trying to position the plane in the right place to be able to get the jet way to the plane. The plane arrived stopped. The announcer was that we were there. Everybody got up, then we were told to sit back down because they had to have us towed to a different position. We got towed and then everyone stood up and they told us we were in the wrong position to sit back down again, and then we got towed to a different position This did not happen immediately. It was 30 minutes while we wandered around a small section of the tarmac in Newark close to the gate, but apparently not close enough. Horrifying experience The CAB should be investigating that flight

Boarding was organized. Plane seats comfortable and service was attentive. Food options were good.

It is clear that someone knew, and competent, is in charge of food at United Airlines at least for the international flights. I was flying in coach, but the choices of the dinner were excellent. Tasty, and appropriate size. I had the beef, which was a little bit like a shepherds pie, and it was good. Nothing comparable has been served on a United flight in years. It will not be confused with three star food, but it is very good for airline food. Even better was the breakfast choice between a cinnamon roll and a breakfast sandwich. I chose the breakfast sandwich which was absolutely delicious and which I would happily order again at my local Starbucks or Panera. It is clear that someone knew indifferent is in charge of the food and it’s about time.

Everything you need to know for your flight to South America

Information on your arrival and departure airports