$338 Find Cheap Flights from Panama City to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South America departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama City to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá2 stops$585
Guayaquil
Guayaquil2 stops$706
Bogotá
Bogotá2 stops$585
Guayaquil
Guayaquil2 stops$706

Book Cheap Panama City to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South America

Wed, May 20 - Wed, May 27
American Airlines Logo
4:00 pm - 11:50 am
ECP
-
BOG
19h 50m
2 stops
American Airlines Logo
2:10 pm - 11:04 am
BOG
-
ECP
20h 54m
2 stops
$585American Airlines
Fri, May 29 - Fri, Jun 5
Delta Logo
6:00 am - 7:15 pm
ECP
-
BOG
13h 15m
1 stop
Delta Logo
9:00 am - 11:28 pm
BOG
-
ECP
14h 28m
1 stop
$587Delta
Sat, May 9 - Fri, May 22
American Airlines Logo
7:00 am - 10:30 pm
ECP
-
BOG
15h 30m
1 stop
American Airlines Logo
2:10 pm - 10:08 am
BOG
-
ECP
19h 58m
2 stops
$605American Airlines
Wed, May 20 - Wed, May 27
Delta Logo
9:19 am - 7:15 pm
ECP
-
BOG
9h 56m
1 stop
Delta Logo
2:55 pm - 11:01 pm
BOG
-
ECP
8h 06m
1 stop
$613Delta
Fri, May 29 - Thu, Jun 4
American Airlines Logo
4:51 pm - 1:05 pm
ECP
-
BOG
20h 14m
2 stops
American Airlines Logo
12:15 am - 10:36 pm
BOG
-
ECP
22h 21m
1 stop
$621American Airlines
Sat, May 9 - Thu, May 21
American Airlines Logo
7:00 am - 10:30 pm
ECP
-
BOG
15h 30m
1 stop
American Airlines Logo
12:15 am - 6:15 pm
BOG
-
ECP
18h 00m
1 stop
$623American Airlines
Fri, May 8 - Fri, May 15
LATAM Airlines Logo
2:50 pm - 12:55 pm
ECP
-
TRU
46h 05m
2 stops
LATAM Airlines Logo
7:00 am - 8:30 am
TRU
-
ECP
25h 30m
2 stops
$1,057LATAM Airlines
Tue, Aug 4 - Tue, Aug 11
LATAM Airlines Logo
11:38 am - 5:45 am
ECP
-
COR
40h 07m
2 stops
LATAM Airlines Logo
7:45 am - 8:15 am
COR
-
ECP
26h 30m
2 stops
$1,107LATAM Airlines
Tue, Jul 7 - Tue, Jul 14
United Airlines Logo
10:25 am - 12:20 am
ECP
-
COR
35h 55m
2 stops
United Airlines Logo
3:32 am - 8:01 pm
COR
-
ECP
42h 29m
2 stops
$1,699United Airlines
Fri, Jul 10 - Wed, Jul 15
United Airlines Logo
6:30 am - 12:20 am
ECP
-
COR
15h 50m
2 stops
United Airlines Logo
3:32 am - 8:01 pm
COR
-
ECP
18h 29m
3 stops
$19,354United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South America flights

Get data-powered insights and trends into flights from Panama City to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Panama City to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to South America were found on Delta ($587) and American Airlines ($591).

Good to know

Cheapest flight$338
Flight from Panama City to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Panama City to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to South America

 
Need help choosing which airline to fly with from Panama City to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8387 reviews
7.9Comfort
7.2Food
7.8Entertainment
8.1Boarding
8.5Crew
Airline reviews

On the return flight, flight attendant Britt went out of her way to inform passengers that several of us had tight connections.

10.0 ExcellentAnonymous, Apr 2026
MIA - DTW
Read more Delta reviews

On the return flight, flight attendant Britt went out of her way to inform passengers that several of us had tight connections.

Too many people are taking up space in the overhead bins with their extra piece of luggage. Since they cannot fit their backpacks or extra luggage piece under the seat in front of them, they store it in the overheads and thus taking up room for other passengers. It wasn’t only one or two persons; more like 12 or 13 passengers.

Kayak botched up the booking, i had to call delta and fix. In the process Delta failed to honor my comfort plus seat assignment that i had previously.

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

The boarding process was straightforward. One pertinent observation regarding all boarding procedures is that if an individual requires assistance or possesses a special status and is part of preboarding, it is advisable to limit the number of passengers who can preboard with them, rather than the entire, sometimes large, companion groups. The seats are uncomfortable, and the entertainment options are significantly inferior compared to other airlines. During the snack service, I requested an additional bag of snacks, but my request was denied. Initially, the flight attendant agreed to my request.becoming a strange accurate moment. The flight duration was four hours.

Flights were on time. Free Wifi on plane. Everything was well organized.

Experience was great - no complaints. Took off on time, landed early. Got to the gate relatively quickly - took a little bit of extra time to deplane but nothing excessive.

Economy plus was so cramped I could not use my laptop. It was beyond bad.

United is one airline which regardless of how many separate United tickets in existence, if one flight breaks down, the airline will take care of all the flights.

Everything was on time and service on the flight was great!

Wifi Bluetooth features for watching in flight movie was horrible. Screen kept blacking out no connection of sound although it said connected. Other than that smooth trip .

The travel company that you have on your site did me so wrong. I don’t know how it happened, but they put my son‘s name on my plane ticket flying to Vietnam. Along with his birthday. They would not have let me fly from Fort Myers to Ho Chi Minh City. I don’t think that I can ever use your service again. I typed my information into the browser along with my passport number and four days before I’m leaving I have to quickly search another ticket to fly out here.

Plane outlets in my row not working to charge phone. Staff response was, well it should be. Plug into seed for volume not working well. Had to find the sweet spot for plug in or it would shut off and on.

Everything was absolutely wonderful from check in to baggage claim. Staff was very professional and sweet. Will definitely recommend United to family and friends.

Everything you need to know for your flight to South America

Information on your arrival and departure airports