$313 Find Cheap Flights from Panama City to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South America departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 20% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flights Deals
Useful Info
Flights Deals

Best South America Flight Deals from Panama City

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá1 stop$523
Guayaquil
Guayaquil2 stops$686
Cusco
Cusco2 stops$1,064
Bogotá
Bogotá1 stop$523
Guayaquil
Guayaquil2 stops$686
Cusco
Cusco2 stops$1,064

Cheap Flights from Panama City to South America

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South America

Fri, Oct 31 - Tue, Nov 4
United Airlines Logo
11:05 am - 5:10 amECP-BOG
18h 05m1 stop
United Airlines Logo
1:30 am - 1:57 pmBOG-ECP
13h 27m1 stop
$523United Airlines
Find Deal
Fri, Oct 31 - Tue, Nov 4
Delta Logo
7:45 am - 3:15 amECP-BOG
19h 30m2 stops
Delta Logo
1:35 am - 10:43 pmBOG-ECP
22h 08m2 stops
$527Delta
Find Deal
Wed, Sep 24 - Fri, Sep 26
Delta Logo
11:00 am - 7:15 pmECP-BOG
8h 15m1 stop
Delta Logo
2:55 pm - 11:03 pmBOG-ECP
8h 08m1 stop
$543Delta
Find Deal
Wed, Sep 24 - Thu, Sep 25
Delta Logo
7:00 am - 1:40 pmECP-BOG
6h 40m1 stop
Delta Logo
1:35 am - 5:56 pmBOG-ECP
16h 21m2 stops
$547Delta
Find Deal
Wed, Sep 24 - Fri, Sep 26
United Airlines Logo
6:30 am - 7:20 pmECP-BOG
12h 50m1 stop
United Airlines Logo
8:30 am - 9:52 amBOG-ECP
25h 22m1 stop
$551United Airlines
Find Deal
Wed, Sep 24 - Fri, Sep 26
United Airlines Logo
1:44 pm - 4:54 amECP-BOG
15h 10m2 stops
United Airlines Logo
8:30 am - 9:52 amBOG-ECP
25h 22m1 stop
$556United Airlines
Find Deal
Wed, Sep 24 - Thu, Sep 25
United Airlines Logo
11:09 am - 7:20 pmECP-BOG
8h 11m1 stop
United Airlines Logo
12:14 am - 9:52 amBOG-ECP
9h 38m1 stop
$559United Airlines
Find Deal
Sun, Aug 17 - Sun, Aug 24
American Airlines Logo
7:06 pm - 1:05 pmECP-BOG
17h 59m2 stops
American Airlines Logo
6:30 am - 11:41 pmBOG-ECP
17h 11m2 stops
$562American Airlines
Find Deal
Wed, Sep 24 - Fri, Sep 26
United Airlines Logo
1:44 pm - 4:54 amECP-BOG
15h 10m2 stops
United Airlines Logo
8:30 am - 1:05 pmBOG-ECP
28h 35m2 stops
$563United Airlines
Find Deal
Sun, Aug 17 - Sun, Aug 24
American Airlines Logo
6:35 am - 10:30 pmECP-BOG
15h 55m1 stop
American Airlines Logo
6:30 am - 11:41 pmBOG-ECP
17h 11m2 stops
$572American Airlines
Find Deal
Useful Info

KAYAK's insights & trends for Panama City to South America flights

Get data-powered insights and trends into flights from Panama City to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Panama City to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to South America were found on United Airlines ($523) and Delta ($527).


Good to know

Low seasonApril
High seasonFebruary
Cheapest flight$313
Best time to beat the crowds with an average 2% drop in price.
Most popular time to fly and prices are also 23% lower on average.
Flight from Panama City to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Panama City to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to South America

 
Need help choosing which airline to fly with from Panama City to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7982 reviews
8.2Boarding
8.5Crew
7.9Entertainment
7.9Comfort
7.3Food
Airline reviews

Flight was an hour late, who knows why. It was OK, nothing outstanding.

6.0 GoodJoan, Jun 2025MIA - ATL
Read more Delta reviews

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

The Dekta Rep that checked us in was great. She's very personable, pleasant, and can tell she enjoys her job.

Friendly flight attendants, smooth 8-9 hours flight. Economy seats are small and uncomfortable as usual.

The young man who was our flight attendant in first class was lazy and did not do his job well at all. Never offered drinks upon boarding - actually I take that back... said "are you okay with water" as if I do not want to get you anything else, only passed the snacks around once, got my drink order wrong and then never offered a second round of drinks. He was the worst I have ever seen on Delta and we fly a lot.

Flight left early and arrived early. the whole trip was excellent.

Newer plane, relatively easy boarding, not a full flight and was told that we could not be moved up because of weight and balance issues. Otherwise, a very good experience.

We love united ! We would like to acknowledge Aimee in the lounge near gate 130

Boarded plane and then delayed 1.5 hours while on the plane

Although the flight was delayed the crew and the flight itself were very good. Couldn't fault anything and after the disappointment of being abandoned in the US by BA it was a welcome relief to travel with United

Survey sent before we actually left. Delay after delay. Now a crew problem.

I love flying with United. Unfortunately, I flew on an older plane with minimal upgraded technology (no Bluetooth functionality or handy charging ports). Otherwise, the flight was great and even arrived early.

They changed my seats after I checked in and I was stressed from the time I saw that information until just before boarding, when the gate attendant fixed it, but it shouldn't have happened. And if it couldn't be prevented, then the people on the phone I spoke with should have done something to help, which they did not, nor did they offer me compensation, just meaningless apologies.

online check in was not available so i had to get to airport extra early. The flight was delayed and my luggage was lost. I had an argument with the person behind me who wanted to keep her bag on the floor and not allow my seat to recline on a 9hr plus flight. So overall, lots and lots of areas for improvement.

Horrific. They missed my connecting flight to San Diego. I didn’t get there until Monday at 9am when I had a mandatory court settlement conference scheduled at 6am since we had parties on the east coast. This caused many issues. All because United apparently forgot to hold the doors open until my flight landed that only had a 10 minute delay. This was the last flight to Southern California. So I couldn’t even rent a car to finish the trip. United cannot be trusted when traveling on specific days and times since weather didn’t have anything to do with the delays.

My flight was delayed a very short period of time but they did not hold my connecting flight to San Diego, also through United. So they closed the doors before we got off our plane. They would only have to help the door open for another five to ten minutes. So I missed a court deadline for a manditory mediation settlement conference for my client. I had to get an associate to be there in person and be on the phone with him relaying what he needs to do the entire time. The court was very upset with me and so was my client. United cannot be trusted.

Multiple delays and not straight answer from the United team

Everything you need to know for your flight to South America

Information on your arrival and departure airports

Not what you’re looking for? Find thousands of other hotels, flights, car rentals and package deals with KAYAK.