$238 Find Cheap Flights from Panama City to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South America departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 24% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá1 stop$483
Guayaquil
Guayaquil2 stops$632
Bogotá
Bogotá1 stop$483
Guayaquil
Guayaquil2 stops$632

Book Cheap Panama City to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South America

Wed, Feb 4 - Wed, Feb 11
American Airlines Logo
7:02 am - 11:30 pm
ECP
-
BOG
15h 28m1 stop
American Airlines Logo
3:15 pm - 12:45 pm
BOG
-
ECP
22h 30m2 stops
$483American Airlines
Wed, Feb 4 - Wed, Feb 11
Delta Logo
6:00 am - 7:30 pm
ECP
-
BOG
12h 30m1 stop
Delta Logo
9:00 am - 10:38 pm
BOG
-
ECP
14h 38m1 stop
$503Delta
Sat, May 9 - Fri, May 22
Delta Logo
7:45 am - 7:25 pm
ECP
-
BOG
11h 40m1 stop
Delta Logo
2:55 pm - 8:17 am
BOG
-
ECP
17h 22m1 stop
$523Delta
Wed, Mar 25 - Fri, Mar 27
American Airlines Logo
4:34 pm - 11:10 am
ECP
-
BOG
18h 36m2 stops
American Airlines Logo
12:30 pm - 10:06 am
BOG
-
ECP
21h 36m2 stops
$538American Airlines
Sat, May 9 - Fri, May 22
American Airlines Logo
5:00 pm - 12:55 pm
ECP
-
BOG
19h 55m2 stops
American Airlines Logo
2:20 pm - 11:55 am
BOG
-
ECP
21h 35m2 stops
$548American Airlines
Fri, May 8 - Tue, May 12
United Airlines Logo
6:40 am - 7:38 pm
ECP
-
BGA
36h 58m2 stops
United Airlines Logo
6:57 am - 9:56 pm
BGA
-
ECP
14h 59m2 stops
$561United Airlines
Sat, Mar 7 - Sun, Mar 8
American Airlines Logo
6:44 am - 11:27 pm
ECP
-
BOG
15h 43m1 stop
American Airlines Logo
11:55 pm - 9:18 pm
BOG
-
ECP
21h 23m1 stop
$582American Airlines
Fri, May 8 - Tue, May 12
United Airlines Logo
6:40 am - 7:38 pm
ECP
-
BGA
12h 58m2 stops
United Airlines Logo
6:56 pm - 9:56 pm
BGA
-
ECP
27h 00m2 stops
$624United Airlines
Wed, May 13 - Sun, May 17
United Airlines Logo
6:40 am - 5:29 pm
ECP
-
GYE
10h 49m2 stops
United Airlines Logo
8:28 am - 9:56 pm
GYE
-
ECP
37h 28m2 stops
$632United Airlines
Wed, Mar 25 - Thu, Mar 26
United Airlines Logo
6:30 am - 10:35 pm
ECP
-
BOG
16h 05m1 stop
United Airlines Logo
1:30 am - 12:04 pm
BOG
-
ECP
10h 34m1 stop
$640United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South America flights

Get data-powered insights and trends into flights from Panama City to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Panama City and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Panama City to South America.

There is just one airline that flies from Panama City to South America direct and that is Delta. The best round-trip deal found from Delta for the route is to Bogotá (BOG) and costs $482.

Which airlines provide the cheapest flights from Panama City to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to South America were found on American Airlines ($483) and Delta ($503).

Good to know

Low seasonMarch
Cheapest flight$238
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from Panama City to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Panama City to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to South America

 
Need help choosing which airline to fly with from Panama City to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8014 reviews
7.3Food
8.1Boarding
8.5Crew
7.9Comfort
7.9Entertainment
Airline reviews

The food is terrible. The staff is wonderful. Comfort is good.

10.0 ExcellentRonda, Dec 2025
JAX - JFK
Read more Delta reviews

The food is terrible. The staff is wonderful. Comfort is good.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Getting to the flight was arduous and lengthy. The flight itself was good but the food option wasn’t a good selection. I need to do a Kosher option on my return. Flight crew were nice

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

Non stop on long haul is the way to go. Great experience

The boarding process needs to be refined. Sometimes the gate crew call out the boarding zone, and then flip to the monitor to show which zones are boarding. So unless everyone is gathered around to see the monitor there is usually confusion as wi which zones are boarding.

Passengers need to check in big baggage instead of bringing on the plane. That cause inconvenience for everyone. Otherwise flight was good.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

I liked the snacks and the flight attendants were friendly.

Gate agent at Frankfurt was terrible. She denied PRE boarding even as it was printed on the boarding pass. Refused to look at the boarding pass and literally shouting for no reason. Frankfurt airport has horrible and rude staff who avoids trying to answer any question at all. Overall, horrible experience.

The Crew and the food was the worst I ever had in Business Class. First they told us there were no space for carry on. It was plenty of space over our 2 row seats, we had to ask to let us travel with it which was accepted. They were aware that we had to run for the connection due to the previous flight delay. Have us one hour waiting for more customers and not even offer a glass of water. Then started the service and they started to serve other passengers drinks in business and did not offer any drinks until they serve our pre ordered meal and I ask for something to drink. I had to wait until they finished to serve all passengers until Inget something. The crew was the worts I ever had for Business Class in my life.

Very turbulent trip made it pretty bearable, plus the lack of refreshments served and the lack of any air conditioning before takeoff which took an hour or more.

Flight was late - I was downgraded from first class to coach

Not good - outbound flight was delayed and missed my connection even though I got to the gate after running through the airport - the agent would not let me on because the door was closed (flight had not left). There was no notification from United - overall experience was very disappointing. Additionally, I was downgraded from first class to coach on the alternative flight

It was nice to have gotten up upgraded to first class with a meal on a three hour flight

They charged a fee for 1st bag checked. Others in same party were free.

Flight team stood out for perzonal attention, kindness at bright cheery attitudes at 8am. Very helpful.

The worst landing I have ever had on a domestic flight. Thought we would lose the landing gear on landing in Newark. Then we spent 40 minutes trying to position the plane in the right place to be able to get the jet way to the plane. The plane arrived stopped. The announcer was that we were there. Everybody got up, then we were told to sit back down because they had to have us towed to a different position. We got towed and then everyone stood up and they told us we were in the wrong position to sit back down again, and then we got towed to a different position This did not happen immediately. It was 30 minutes while we wandered around a small section of the tarmac in Newark close to the gate, but apparently not close enough. Horrifying experience The CAB should be investigating that flight

Everything you need to know for your flight to South America

Information on your arrival and departure airports