$341 Find Cheap Flights from Panama City to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South America departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Cheap Flights from Panama City to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá1 stop$559
Guayaquil
Guayaquil2 stops$536
Cusco
Cusco2 stops$1,034
Bogotá
Bogotá1 stop$559
Guayaquil
Guayaquil2 stops$536
Cusco
Cusco2 stops$1,034

Book Cheap Panama City to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South America

Wed, Oct 15 - Wed, Oct 22
United Airlines Logo
6:30 am - 1:46 pmECP-GYE
31h 16m2 stops
United Airlines Logo
12:15 pm - 9:48 pmGYE-ECP
33h 33m2 stops
$536United Airlines
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Wed, Feb 25 - Sat, Feb 28
United Airlines Logo
12:55 pm - 10:35 pmECP-BOG
8h 40m1 stop
United Airlines Logo
1:30 am - 11:53 amBOG-ECP
11h 23m1 stop
$559United Airlines
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Fri, Oct 31 - Fri, Nov 7
American Airlines Logo
6:32 am - 11:20 pmECP-BOG
16h 48m1 stop
American Airlines Logo
11:55 pm - 12:41 pmBOG-ECP
13h 46m1 stop
$566American Airlines
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Fri, Feb 20 - Sun, Feb 22
United Airlines Logo
12:55 pm - 10:35 pmECP-BOG
8h 40m1 stop
United Airlines Logo
8:15 am - 9:59 pmBOG-ECP
14h 44m1 stop
$569United Airlines
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Fri, Oct 31 - Fri, Nov 7
American Airlines Logo
6:44 am - 10:10 pmECP-BOG
15h 26m2 stops
American Airlines Logo
1:40 pm - 10:00 amBOG-ECP
21h 20m2 stops
$570American Airlines
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Mon, Sep 29 - Sun, Oct 5
Delta Logo
7:00 am - 1:40 pmECP-BOG
6h 40m1 stop
Delta Logo
2:55 pm - 3:20 pmBOG-ECP
24h 25m1 stop
$585Delta
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Mon, Sep 29 - Mon, Oct 6
Delta Logo
9:13 am - 8:10 pmECP-BOG
10h 57m2 stops
Delta Logo
1:35 am - 12:40 pmBOG-ECP
11h 05m2 stops
$594Delta
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Wed, Oct 15 - Tue, Oct 21
Multiple Airlines Logo
6:30 am - 11:20 pmECP-GYE
40h 50m2 stops
Multiple Airlines Logo
3:35 am - 4:16 pmGYE-ECP
36h 41m2 stops
$645Multiple Airlines
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Fri, Oct 31 - Thu, Nov 6
Air Canada Logo
3:00 pm - 5:10 amECP-BOG
14h 10m1 stop
Air Canada Logo
1:30 am - 9:19 amBOG-ECP
8h 49m1 stop
$770Air Canada
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Thu, Nov 27 - Fri, Nov 28
Multiple Airlines Logo
6:30 am - 10:35 pmECP-BOG
15h 05m1 stop
Multiple Airlines Logo
4:00 am - 9:49 pmBOG-ECP
18h 49m2 stops
$1,032Multiple Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Panama City to South America flights

Get data-powered insights and trends into flights from Panama City to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Panama City to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to South America were found on United Airlines ($536) and American Airlines ($566).

Good to know

Low seasonFebruary
Cheapest flight$341
Best time to beat the crowds with an average 10% drop in price.
Most popular time to fly and prices are also 15% lower on average.
Flight from Panama City to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Panama City to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to South America

 
Need help choosing which airline to fly with from Panama City to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7957 reviews
7.9Comfort
8.2Boarding
7.3Food
8.5Crew
7.9Entertainment
Airline reviews

Passengers need to check in big baggage instead of bringing on the plane. That cause inconvenience for everyone. Otherwise flight was good.

8.0 ExcellentTarun, Sep 2025MCO - LHR
Read more Delta reviews

Passengers need to check in big baggage instead of bringing on the plane. That cause inconvenience for everyone. Otherwise flight was good.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

Quick check in. Everything went smooth. I don't know what can be done about airline food.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

The Dekta Rep that checked us in was great. She's very personable, pleasant, and can tell she enjoys her job.

Terrible. They wouldn't allow me on my flight on the 14th..

We had to deboard 2 times due to maintenance issues. They changed the plane, and then we got deviated to LAX due to maibtenance issues on the other plane, had to sleep at LAX and los a full day.

Everything was good, except the seats in economy were so close together, you could barely get out when the seat in front of your was reclined. If the airlines keep jamming in more and more seats, it will become intolerable. I will look for another airline that considers customer comfort and does not keep adding more rows of seats for more profit.

The newer screen was super cool and had the option to watch many different shows or movies. Crew was polite and helpful. However again, many children screaming bloody murder and kicking my seat, and parents doing nothing about it as usual.

Flight was good and crew was super polite. However, there were around 5 kids screaming the WHOLE 2 hours. I understand kids have to come but parents need to do something to control their children. They make the experience terrible, especially after finishing 16 hour shifts at the hospital I needed some sleep, which I did not get.

IAD with the archaic people movers is just a place to be avoided.

It is clear that someone knew, and competent, is in charge of food at United Airlines at least for the international flights. I was flying in coach, but the choices of the dinner were excellent. Tasty, and appropriate size. I had the beef, which was a little bit like a shepherds pie, and it was good. Nothing comparable has been served on a United flight in years. It will not be confused with three star food, but it is very good for airline food. Even better was the breakfast choice between a cinnamon roll and a breakfast sandwich. I chose the breakfast sandwich which was absolutely delicious and which I would happily order again at my local Starbucks or Panera. It is clear that someone knew indifferent is in charge of the food and it’s about time.

Flight attendant in first class gave poor service (like he didn't want to be there) and food was awful. We sat waiting for gate upon arrival over 45 mins.

This is for UA2274 from Houston to Sacramento. The flight was delayed arriving due to mechanical issues so we left about 3 hours later than scheduled. When boarding the plane the temperature inside was excessive - likely close to 100. Pilot apologized and said it was going to improve at altitude, which it did. But before that I honestly thought there might have been more delays removing passengers made ill from the heat. We were delayed leaving due to another mechanical issue. There was not water on the plane due to a panel that was not secured. They did that quickly, but the combination of mechanical issues was rather disturbing and did not reflect well on United.

Staff members were not helpful they ignored all calls for an attendant.

Everything you need to know for your flight to South America

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