$430 Find Cheap Flights from Panama City to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South America departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama City to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá2 stops$602
Guayaquil
Guayaquil2 stops$703
Cusco
Cusco2 stops$1,173
Bogotá
Bogotá2 stops$602
Guayaquil
Guayaquil2 stops$703
Cusco
Cusco2 stops$1,173

Book Cheap Panama City to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South America

Tue, Oct 6 - Sat, Mar 6
American Airlines Logo
2:35 pm - 12:51 pm
ECP
-
BOG
22h 16m
2 stops
American Airlines Logo
1:30 pm - 10:06 am
BOG
-
ECP
21h 36m
2 stops
$602American Airlines
Sat, Sep 19 - Sat, Sep 26
American Airlines Logo
7:33 am - 10:30 pm
ECP
-
BOG
14h 57m
1 stop
American Airlines Logo
2:10 pm - 11:42 am
BOG
-
ECP
21h 32m
2 stops
$612American Airlines
Wed, Jul 29 - Wed, Aug 5
American Airlines Logo
4:17 pm - 11:20 am
ECP
-
BOG
19h 03m
2 stops
American Airlines Logo
2:10 pm - 12:45 pm
BOG
-
ECP
22h 35m
2 stops
$615American Airlines
Tue, Sep 8 - Sun, Sep 13
American Airlines Logo
7:32 am - 10:34 pm
ECP
-
BOG
15h 02m
1 stop
American Airlines Logo
2:10 pm - 11:42 am
BOG
-
ECP
21h 32m
2 stops
$626American Airlines
Tue, Oct 6 - Sat, Mar 6
Delta Logo
6:00 am - 1:40 pm
ECP
-
BOG
7h 40m
1 stop
Delta Logo
3:40 pm - 8:17 am
BOG
-
ECP
17h 37m
1 stop
$627Delta
Tue, Sep 8 - Sun, Sep 13
LATAM Airlines Logo
6:00 am - 7:15 pm
ECP
-
BOG
13h 15m
1 stop
LATAM Airlines Logo
2:55 pm - 10:46 pm
BOG
-
ECP
7h 51m
1 stop
$651LATAM Airlines
Mon, Nov 2 - Wed, Nov 4
LATAM Airlines Logo
6:00 am - 7:30 pm
ECP
-
BOG
12h 30m
1 stop
LATAM Airlines Logo
3:55 pm - 8:17 am
BOG
-
ECP
17h 22m
1 stop
$687LATAM Airlines
Mon, Jul 13 - Mon, Jul 20
Copa Airlines Logo
9:00 am - 8:53 pm
ECP
-
GYE
11h 53m
2 stops
Copa Airlines Logo
12:21 pm - 4:23 pm
GYE
-
ECP
28h 02m
2 stops
$703Copa Airlines
Mon, Nov 2 - Thu, Nov 5
United Airlines Logo
11:10 am - 8:56 pm
ECP
-
GYE
32h 46m
2 stops
United Airlines Logo
8:27 am - 8:06 pm
GYE
-
ECP
36h 39m
2 stops
$885United Airlines
Mon, Nov 2 - Thu, Nov 5
United Airlines Logo
6:35 am - 11:40 pm
ECP
-
GYE
16h 05m
2 stops
United Airlines Logo
12:24 pm - 8:06 pm
GYE
-
ECP
32h 42m
2 stops
$927United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South America flights

Get data-powered insights and trends into flights from Panama City to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Panama City to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 5 days, the cheapest round-trip tickets from Panama City to South America were found on American Airlines ($602) and Copa Airlines ($703).

Good to know

Cheapest flight$430
Flight from Panama City to Guayaquil

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Panama City to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to South America

 
Need help choosing which airline to fly with from Panama City to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8410 reviews
8.5Crew
7.8Comfort
7.2Food
7.8Entertainment
8.1Boarding
Airline reviews

Five hour delays every hour, I wish it were all at once

2.0 MediocreAnonymous, Jun 2026
MCO - LGA
Read more Delta reviews

Five hour delays every hour, I wish it were all at once

Got rerouted from a straight flight from Orlando to Atlanta to Knoxville to a flight from Orlando to Detroit to Knoxville! Seriously!! Flight delay out of Detroit! Long day for what should have been a pretty easy travel day!

Left /arrived on time. Decent seat space. Like the wifi/plugs and entertainment. Windows and tray table were kinda gross. Attendants didn't start snack service til 40mins before landing. Two rows before us, captain came on to say there's turbulence and recalled staff to seats. So, no drink/snack. Later, attendants didn't stop to see if we had trash nor even look our way. Felt invisible! Almost all pilot announcements were not only unintelligible, but so quiet. We had no idea what she said.

Gate agent was unhelpful for handicapped boarding. Flight attendant seemed untrained.

Clean planes and not take my comfort class seat away.

Weather caused a long delay, but the efficiency and updates from the pilot were helpful. We were able to make our connection fortunately.

Planes were clean, no water or snacks on either flight.

Aside from a completely packed plane, I really have no complaints.

Much better than Latam, the worse airline company ever. I hope I don't have the need to fly Latam ever in my life again.

The flight was operated by Latam. The aircraft had a technical issue and the flight was delayed for the next day. They grounded other passengers to get their airplane assigned to my flight. Most of he ground staff don't speak English (Orlando Airport), but were very polite.The crew on the other hand could speak English and Portuguese. On board service was good.

Everything you need to know for your flight to South America

Information on your arrival and departure airports