$261 Find Cheap Flights from Panama City to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South America departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá1 stop$548
Guayaquil
Guayaquil2 stops$695
Bogotá
Bogotá1 stop$548
Guayaquil
Guayaquil2 stops$695

Book Cheap Panama City to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South America

Wed, Jun 10 - Wed, Jun 17
LATAM Airlines Logo
6:00 am - 7:15 pm
ECP
-
BOG
13h 15m
1 stop
LATAM Airlines Logo
10:05 pm - 10:46 pm
BOG
-
ECP
24h 41m
2 stops
$548LATAM Airlines
Sat, May 9 - Fri, May 22
Delta Logo
6:00 am - 7:25 pm
ECP
-
BOG
13h 25m
1 stop
Delta Logo
2:55 pm - 8:29 am
BOG
-
ECP
17h 34m
1 stop
$557Delta
Thu, Mar 19 - Thu, Mar 26
American Airlines Logo
7:19 am - 10:10 pm
ECP
-
BOG
14h 51m
2 stops
American Airlines Logo
12:40 pm - 10:06 am
BOG
-
ECP
21h 26m
2 stops
$559American Airlines
Sat, May 9 - Fri, May 22
Multiple Airlines Logo
6:00 am - 5:50 pm
ECP
-
BOG
11h 50m
2 stops
Multiple Airlines Logo
10:35 am - 8:29 am
BOG
-
ECP
21h 54m
2 stops
$562Multiple Airlines
Wed, Jun 10 - Wed, Jun 17
United Airlines Logo
9:00 am - 7:20 pm
ECP
-
BOG
10h 20m
1 stop
United Airlines Logo
8:30 am - 9:57 pm
BOG
-
ECP
13h 27m
1 stop
$573United Airlines
Sun, May 10 - Sat, May 16
American Airlines Logo
4:40 pm - 1:05 pm
ECP
-
BOG
20h 25m
2 stops
American Airlines Logo
2:10 pm - 10:03 am
BOG
-
ECP
19h 53m
2 stops
$576American Airlines
Sun, May 10 - Sat, May 16
LATAM Airlines Logo
1:50 pm - 1:50 pm
ECP
-
BOG
24h 00m
1 stop
LATAM Airlines Logo
9:00 am - 6:36 pm
BOG
-
ECP
9h 36m
1 stop
$578LATAM Airlines
Thu, Mar 19 - Thu, Mar 26
Delta Logo
6:00 am - 2:25 pm
ECP
-
BOG
8h 25m
1 stop
Delta Logo
3:55 pm - 8:40 am
BOG
-
ECP
16h 45m
1 stop
$583Delta
Fri, Mar 6 - Sun, Mar 8
American Airlines Logo
6:42 am - 11:30 pm
ECP
-
BOG
15h 48m
1 stop
American Airlines Logo
11:55 pm - 3:08 pm
BOG
-
ECP
15h 13m
1 stop
$603American Airlines
Mon, Apr 13 - Thu, Apr 16
United Airlines Logo
6:30 am - 7:20 pm
ECP
-
BOG
12h 50m
1 stop
United Airlines Logo
8:30 am - 9:59 pm
BOG
-
ECP
13h 29m
1 stop
$607United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South America flights

Get data-powered insights and trends into flights from Panama City to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Panama City to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to South America were found on LATAM Airlines ($548) and Delta ($557).

Good to know

Low seasonMarch
Cheapest flight$261
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from Panama City to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Panama City to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to South America

 
Need help choosing which airline to fly with from Panama City to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8151 reviews
8.5Crew
7.8Entertainment
8.1Boarding
7.2Food
7.9Comfort
Airline reviews

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

10.0 ExcellentG, Feb 2026
FLL - ATL
Read more Delta reviews

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

I have diamond medallion status and usually we are in comfort plus . We were in main this time ( which was fine ) and my husband wanted wine . I have at least 10 vouchers for drinks that are good for this year and next! The attendant would not take the picture of the voucher as proof and never came back to check as She asked me to pull it up on delta Wi-Fi. Instead my husband just used his Amex to buy the wine . Disappointing!!!

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

The only thing nice I can say is the flight crew was really nice and apologetic about the situation. They shared as much information as they had and advised us on what we could do about missing connecting flights. The boarding process was so slow. The gate agent was working by herself and should have had someone working with her. It took almost an hour to board because she was trying to board a full flight of people and provide customer service to everyone who was flying standby and/or had questions. It was really chaotic. This didn't help the fact that we were delayed and folks were missing connections the longer it took.

The food is terrible. The staff is wonderful. Comfort is good.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Getting to the flight was arduous and lengthy. The flight itself was good but the food option wasn’t a good selection. I need to do a Kosher option on my return. Flight crew were nice

Bad food, bad service, cold cabin with no additional blankets when asked for (they told me they don’t provide additional blankets). I’m a frequent traveler and this is one of the worst companies I traveled with (by the way I thought that I booked my ticket with Lufthansa but I didn’t see that the flights were handled by United).

United Airlines is my preferred airlines and I am thankful for Gary who also help support me on the phone to switch my flight literally last min.

Not being stranded in Chicago for her airport to 11:30 tomorrow morning the 3rd

the whole trip was smooth, and as comfortable as flying is these days. flight crew was friendly and very courteous and helpful.

The attendant on board was amazing. She should be doing business/first international long haul.

Although our flight was delayed the overall boarding process was very smooth and the crew was accommodating.

I was fully checked in the prior night and i was unchecked and then didn’t have a seat when I boarded. Instead of an aisle seat, I was out in the middle seat of the very last row of the plane.

Everything was absolutely wonderful from check in to baggage claim. Staff was very professional and sweet. Will definitely recommend United to family and friends.

Very turbulent trip made it pretty bearable, plus the lack of refreshments served and the lack of any air conditioning before takeoff which took an hour or more.

It was nice to have gotten up upgraded to first class with a meal on a three hour flight

Everything you need to know for your flight to South America

Information on your arrival and departure airports