$44 Find Cheap Flights from South Carolina to Chicago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Chicago departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from South Carolina to Chicago

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South Carolina to Chicago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South Carolina to Chicago

Thu, Apr 23 - Sun, Apr 26
Frontier Logo
4:19 pm - 5:53 pm
CLT
-
ORD
2h 34mnonstop
Frontier Logo
12:38 pm - 3:46 pm
ORD
-
CLT
2h 08mnonstop
$85Frontier
Fri, May 8 - Fri, May 15
Frontier Logo
9:26 pm - 10:53 pm
CLT
-
ORD
2h 27mnonstop
Frontier Logo
5:16 pm - 8:31 pm
ORD
-
CLT
2h 15mnonstop
$86Frontier
Sat, Apr 11 - Tue, Apr 14
Multiple Airlines Logo
7:09 pm - 8:39 pm
CLT
-
ORD
2h 30mnonstop
Multiple Airlines Logo
6:01 pm - 11:53 pm
ORD
-
CLT
4h 52m
1 stop
$93Multiple Airlines
Fri, Apr 10 - Tue, Apr 14
Multiple Airlines Logo
10:43 pm - 12:04 am
CLT
-
ORD
2h 21mnonstop
Multiple Airlines Logo
6:01 pm - 11:53 pm
ORD
-
CLT
4h 52m
1 stop
$104Multiple Airlines
Wed, Mar 25 - Tue, Mar 31
Spirit Airlines Logo
6:28 pm - 11:17 pm
MYR
-
ORD
5h 49m
1 stop
Spirit Airlines Logo
5:05 am - 5:33 pm
ORD
-
MYR
11h 28m
1 stop
$170Spirit Airlines
Wed, Mar 25 - Mon, Mar 30
Spirit Airlines Logo
4:50 pm - 12:22 am
SAV
-
ORD
8h 32m
1 stop
Spirit Airlines Logo
6:01 pm - 3:55 pm
ORD
-
SAV
20h 54m
1 stop
$175Spirit Airlines
Tue, Apr 7 - Tue, Apr 14
United Airlines Logo
3:15 pm - 4:46 pm
MYR
-
ORD
2h 31mnonstop
United Airlines Logo
7:00 am - 10:18 am
ORD
-
MYR
2h 18mnonstop
$197United Airlines
Sat, Apr 25 - Sat, May 2
American Airlines Logo
12:36 pm - 2:26 pm
MYR
-
ORD
2h 50mnonstop
American Airlines Logo
10:30 am - 1:53 pm
ORD
-
MYR
2h 23mnonstop
$207American Airlines
Sat, May 23 - Tue, May 26
United Airlines Logo
6:25 am - 7:52 am
CAE
-
ORD
2h 27mnonstop
United Airlines Logo
6:35 am - 9:45 am
ORD
-
CAE
2h 10mnonstop
$229United Airlines
Wed, Apr 22 - Wed, Apr 29
American Airlines Logo
8:16 pm - 9:38 pm
GSP
-
ORD
2h 22mnonstop
American Airlines Logo
8:00 pm - 11:03 pm
ORD
-
GSP
2h 03mnonstop
$231American Airlines
Useful Info

Good to know

Low seasonFebruary
Cheapest flight$44
Best time to beat the crowds but there is an average 2% increase in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from Charlotte to Chicago O'Hare Airport

Flights from South Carolina to Chicago: the best tips from KAYAK users

Insights shared by verified travelers who flew the route from South Carolina to Chicago 
Learn how KAYAK collects reviews and tips from users.
YesicaFlew with United Airlines
CHS
-
ORD
Feb 2026
Utilize the mobile app of your airline it will give you all the updates and information you need
EllenFlew with United Airlines
GSP
-
ORD
May 2024
Greenville airport is small, getting through security won't take too long (particularly if you have Precheck). Be prepared to walk for 10-15 minutes from your arrival gate in O'Hare to your next departure gate, if you have one. Sometimes those gates are really close together, but my experience is that they are typically farther apart and require a solid walk.

FAQs for booking flights from South Carolina to Chicago

  • How does KAYAK find such low prices on flights from South Carolina to Chicago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South Carolina to Chicago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
Saint Joseph
Hammond
Portage
Lansing
Valparaiso
Chesterton
Schererville
Munster
Porter
Monticello
Griffith
Saint John

Everything you need to know for your flight to Chicago

Cabin class types available on flights to South Carolina

Cabin classes available on flights to Chicago. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
First Class flights to Chicagofrom $519
Business Class flights to Chicagofrom $580
Premium Economy Class flights to Chicagofrom $524
Economy Class flights to Chicagofrom $209