$97 Find Cheap Flights from South Carolina to Chicago - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Chicago departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from South Carolina to Chicago

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South Carolina to Chicago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South Carolina to Chicago

Wed, Aug 5 - Thu, Aug 6
American Airlines Logo
12:04 pm - 1:37 pm
MYR
-
ORD
2h 33mnonstop
American Airlines Logo
8:15 am - 11:34 am
ORD
-
MYR
2h 19mnonstop
$213American Airlines
Tue, Aug 4 - Tue, Aug 11
Delta Logo
11:43 am - 4:51 pm
MYR
-
ORD
6h 08m
1 stop
Delta Logo
6:40 am - 1:33 pm
ORD
-
MYR
5h 53m
1 stop
$233Delta
Tue, Aug 4 - Tue, Aug 11
United Airlines Logo
10:34 am - 5:02 pm
MYR
-
ORD
7h 28m
1 stop
United Airlines Logo
11:27 am - 2:53 pm
ORD
-
MYR
2h 26mnonstop
$235United Airlines
Mon, Aug 17 - Tue, Aug 18
United Airlines Logo
6:21 pm - 7:56 pm
MYR
-
ORD
2h 35mnonstop
United Airlines Logo
11:27 am - 2:53 pm
ORD
-
MYR
2h 26mnonstop
$250United Airlines
Fri, Aug 7 - Mon, Aug 10
Southwest Logo
6:35 am - 12:15 pm
CLT
-
MDW
6h 40m
2 stops
Southwest Logo
8:00 am - 11:10 am
MDW
-
CLT
2h 10mnonstop
$262Southwest
Tue, Jul 28 - Mon, Aug 3
Multiple Airlines Logo
5:57 pm - 12:49 am
CLT
-
ORD
7h 52m
1 stop
Multiple Airlines Logo
11:30 am - 5:00 pm
ORD
-
CLT
4h 30m
1 stop
$262Multiple Airlines
Sat, Jul 25 - Thu, Jul 30
Frontier Logo
12:01 pm - 5:26 pm
CLT
-
MDW
6h 25m
1 stop
Frontier Logo
9:27 pm - 11:16 am
MDW
-
CLT
12h 49m
1 stop
$263Frontier
Thu, Jul 30 - Sat, Aug 1
Frontier Logo
5:57 pm - 12:49 am
CLT
-
ORD
7h 52m
1 stop
Frontier Logo
8:52 pm - 9:56 am
ORD
-
CLT
12h 04m
1 stop
$263Frontier
Wed, Aug 5 - Mon, Aug 10
Southwest Logo
6:50 am - 10:50 am
CLT
-
MDW
5h 00m
1 stop
Southwest Logo
9:20 am - 9:50 pm
MDW
-
CLT
11h 30m
2 stops
$265Southwest
Thu, Sep 10 - Sun, Sep 20
Multiple Airlines Logo
8:27 am - 12:41 pm
MYR
-
ORD
29h 14m
1 stop
Multiple Airlines Logo
7:45 am - 7:58 am
ORD
-
MYR
23h 13m
1 stop
$265Multiple Airlines
Useful Info

Good to know

Low seasonJanuary
Cheapest flight$97
Best time to beat the crowds with an average 16% drop in price.
Most popular time to fly with an average 9% increase in price.
Flight from Greenville to Chicago Midway Airport

Flights from South Carolina to Chicago: the best tips from KAYAK users

Insights shared by verified travelers who flew the route from South Carolina to Chicago 
Learn how KAYAK collects reviews and tips from users.
Verified travelerFlew with American Airlines
GSP
-
ORD
Apr 2026
Chicago has a enormous airport so be ready to walk and transfer to international flights by train via terminal
YesicaFlew with United Airlines
CHS
-
ORD
Feb 2026
Utilize the mobile app of your airline it will give you all the updates and information you need
EllenFlew with United Airlines
GSP
-
ORD
May 2024
Greenville airport is small, getting through security won't take too long (particularly if you have Precheck). Be prepared to walk for 10-15 minutes from your arrival gate in O'Hare to your next departure gate, if you have one. Sometimes those gates are really close together, but my experience is that they are typically farther apart and require a solid walk.

FAQs for booking flights from South Carolina to Chicago

  • How does KAYAK find such low prices on flights from South Carolina to Chicago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South Carolina to Chicago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Everything you need to know for your flight to Chicago

Cabin class types available on flights to South Carolina

Cabin classes available on flights to Chicago. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
First Class flights to Chicagofrom $554
Business Class flights to Chicagofrom $700
Premium Economy Class flights to Chicagofrom $631
Economy Class flights to Chicagofrom $217