Find cheap flights from South Carolina to Chicago

Find cheap flights from South Carolina to Chicago

Round-trip
Economy
Boston (BOS)
Chicago All airports
Tue 8/4
Tue 8/11
Any month
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Search hundreds of travel sites at once for deals on flights to Chicago

Good to know

Low season

September Best time to beat the crowds with an average 4% drop in price.

High season

December Most popular time to fly with an average 16% increase in price.

Average price of a round-trip

$255 (avg. price over the last 2 weeks)

Good deal for a round-trip

$84 or less

FAQs for booking South Carolina to Chicago flights

How does KAYAK find such low prices on flights from South Carolina to Chicago?

How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?

What is the Hacker Fare option on flights from South Carolina to Chicago?

What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?

Top airlines flying from South Carolina to Chicago

Scores according to KAYAK customer reviews

8.2
JetBlue
Overall score based on 19,204 reviews
8.3
Boarding
8.3
Comfort
8.6
Crew
7.9
Entertainment
7.8
Food
Airline reviews
Read more about JetBlue

Book cheap flights from South Carolina to Chicago (round-trip)

Airports
Origin
Charleston
$174
only
$174
Columbia
$166
only
$166
Myrtle Beach
$69
only
$69
Greenville
$118
only
$118
Destination
Chicago
$69
only
$69
$166
only
$166
Tue, Jul 28
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
7h 10m
Fri, Jul 31
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
2h 03m
Trip: 4 days
Based on null reviews
Tue, Jul 28
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
7h 10m
Fri, Jul 31
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
23h 48m
Trip: 4 days
Based on null reviews
Fri, Jul 31
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
7h 10m
Sun, Aug 2
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
2h 03m
Trip: 3 days
Based on null reviews
Sat, Aug 1
CAE
Columbia Metropolitan
ORD
Chicago O'Hare Airport
7h 12m
Wed, Aug 5
ORD
Chicago O'Hare Airport
CAE
Columbia Metropolitan
4h 10m
Trip: 5 days
Based on null reviews
Thu, Aug 27
CHS
Charleston Municipal Airport
ORD
Chicago O'Hare Airport
8h 11m
Mon, Aug 31
ORD
Chicago O'Hare Airport
CHS
Charleston Municipal Airport
7h 36m
Trip: 5 days
Based on null reviews
Thu, Aug 13
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 19m
Sun, Aug 16
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
2h 03m
Trip: 4 days
Based on null reviews
Thu, Aug 13
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 19m
Sun, Aug 16
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
8h 04m
Trip: 4 days
Based on null reviews
Thu, Aug 13
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
4h 24m
Sun, Aug 16
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
5h 04m
Trip: 4 days
Based on null reviews
Fri, Jul 31
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 24m
Sun, Aug 2
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
2h 03m
Trip: 3 days
Based on null reviews
Fri, Jul 31
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
7h 10m
Sun, Aug 2
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
22h 38m
Trip: 3 days
Based on null reviews
Sat, Sep 19
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 23m
Wed, Sep 23
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
2h 09m
Trip: 5 days
Based on null reviews
Fri, Jul 31
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
7h 10m
Thu, Aug 6
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
8h 04m
Trip: 7 days
Based on null reviews
Fri, Sep 25
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 23m
Mon, Sep 28
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
20h 39m
Trip: 4 days
Based on null reviews
Thu, Aug 13
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 19m
Sun, Aug 16
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
18h 51m
Trip: 4 days
Based on null reviews
Sat, Sep 12
CAE
Columbia Metropolitan
MDW
Chicago Midway Airport
6h 40m
Sat, Sep 26
MDW
Chicago Midway Airport
CAE
Columbia Metropolitan
5h 50m
Trip: 15 days
Based on null reviews
Thu, Sep 3
GSP
Greenville
ORD
Chicago O'Hare Airport
11h 44m
Wed, Sep 9
ORD
Chicago O'Hare Airport
GSP
Greenville
10h 37m
Trip: 7 days
Based on null reviews
Sun, Aug 9
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 19m
Tue, Aug 11
ORD
Chicago O'Hare Airport
MYR
Myrtle Beach Metropolitan Area
6h 40m
Trip: 3 days
Based on null reviews
Thu, Aug 6
GSP
Greenville
ORD
Chicago O'Hare Airport
4h 15m
Mon, Aug 10
ORD
Chicago O'Hare Airport
GSP
Greenville
4h 00m
Trip: 5 days
Based on null reviews
Fri, Nov 6
CHS
Charleston Municipal Airport
ORD
Chicago O'Hare Airport
9h 17m
Sun, Nov 8
ORD
Chicago O'Hare Airport
CHS
Charleston Municipal Airport
8h 17m
Trip: 3 days
Based on null reviews
Thu, Jul 30
GSP
Greenville
ORD
Chicago O'Hare Airport
11h 07m
Tue, Aug 4
ORD
Chicago O'Hare Airport
GSP
Greenville
13h 03m
Trip: 6 days
Based on null reviews

Book cheap flights from South Carolina to Chicago (one-way)

Airports
Origin
Charleston
$73
only
$73
Myrtle Beach
$27
only
$27
Greenville
$60
only
$60
Destination
Chicago
$27
only
$27
$129
only
$129
$83
only
$83
Sat, Aug 1
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
7h 10m
Based on null reviews
Sat, Aug 1
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
23h 49m
Based on null reviews
Thu, Aug 13
CHS
Charleston Municipal Airport
ORD
Chicago O'Hare Airport
8h 11m
Based on null reviews
Sat, Aug 1
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 24m
Based on null reviews
Thu, Sep 17
CHS
Charleston Municipal Airport
MDW
Chicago Midway Airport
6h 37m
Based on null reviews
Sun, Jul 26
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 24m
Based on null reviews
Fri, Aug 14
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 19m
Based on null reviews
Fri, Aug 7
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
2h 19m
Based on null reviews
Fri, Aug 14
GSP
Greenville
ORD
Chicago O'Hare Airport
28h 38m
Based on null reviews
Fri, Aug 14
CHS
Charleston Municipal Airport
RFD
Chicago Greater Rockford
35h 13m
Based on null reviews
Sun, Jul 26
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
23h 09m
Based on null reviews
Fri, Aug 7
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
29h 04m
Based on null reviews
Fri, Aug 7
GSP
Greenville
ORD
Chicago O'Hare Airport
19h 33m
Based on null reviews
Sat, Aug 1
CHS
Charleston Municipal Airport
ORD
Chicago O'Hare Airport
8h 12m
Based on null reviews
Sun, Aug 2
GSP
Greenville
ORD
Chicago O'Hare Airport
11h 10m
Based on null reviews
Sun, Jul 26
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
23h 09m
Based on null reviews
Sun, Aug 16
CHS
Charleston Municipal Airport
ORD
Chicago O'Hare Airport
8h 11m
Based on null reviews
Mon, Aug 3
GSP
Greenville
ORD
Chicago O'Hare Airport
9h 26m
Based on null reviews
Fri, Aug 7
MYR
Myrtle Beach Metropolitan Area
ORD
Chicago O'Hare Airport
24h 56m
Based on null reviews
Sat, Aug 1
CHS
Charleston Municipal Airport
ORD
Chicago O'Hare Airport
8h 55m
Based on null reviews
*
Prices are per person and are for e–tickets and include all taxes & fees in USD.

We attempt to get accurate prices, however, prices are not guaranteed.

Here's why:

We’re not the seller.
At KAYAK we don’t set the prices, so it’s not possible for us to guarantee what other companies are selling.

We compile tonnes of data for you
Our service lets you quickly and easily compare results from hundreds of travel sites at once. In this sense, KAYAK is a search engine and we can't guarantee prices we find.

Why aren’t prices accurate 100% of the time?
Prices on airline seats, hotel rooms and car rentals can change frequently. Several people may also be trying to buy the same travel option simultaneously. As a result, you may find, on occasion, that certain prices are no longer available.

If you have more questions or if you have a bad price to report to us,
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