$44 Find Cheap Flights from South Carolina to Chicago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Chicago departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from South Carolina to Chicago

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South Carolina to Chicago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South Carolina to Chicago

Thu, Apr 23 - Sun, Apr 26
Frontier Logo
4:19 pm - 5:53 pm
CLT
-
ORD
2h 34mnonstop
Frontier Logo
12:38 pm - 3:46 pm
ORD
-
CLT
2h 08mnonstop
$85Frontier
Thu, Apr 23 - Sun, Apr 26
Frontier Logo
4:19 pm - 5:53 pm
CLT
-
ORD
2h 34mnonstop
Frontier Logo
12:38 pm - 3:46 pm
ORD
-
CLT
2h 08mnonstop
$86Frontier
Sat, Apr 11 - Tue, Apr 14
Multiple Airlines Logo
7:09 pm - 8:39 pm
CLT
-
ORD
2h 30mnonstop
Multiple Airlines Logo
6:01 pm - 11:53 pm
ORD
-
CLT
4h 52m
1 stop
$91Multiple Airlines
Mon, Apr 20 - Sat, Apr 25
Multiple Airlines Logo
5:17 pm - 6:50 pm
CLT
-
ORD
2h 33mnonstop
Multiple Airlines Logo
12:53 pm - 11:44 pm
ORD
-
CLT
9h 51m
1 stop
$94Multiple Airlines
Sat, Apr 18 - Tue, Apr 21
Spirit Airlines Logo
10:20 am - 4:14 pm
MYR
-
ORD
6h 54m
1 stop
Spirit Airlines Logo
2:09 pm - 8:44 am
ORD
-
MYR
17h 35m
1 stop
$156Spirit Airlines
Sat, Apr 18 - Tue, Apr 21
Spirit Airlines Logo
10:20 am - 4:14 pm
MYR
-
ORD
6h 54m
1 stop
Spirit Airlines Logo
2:09 pm - 8:44 am
ORD
-
MYR
17h 35m
1 stop
$164Spirit Airlines
Tue, Mar 31 - Tue, Apr 7
United Airlines Logo
12:33 pm - 1:50 pm
GSP
-
ORD
2h 17mnonstop
United Airlines Logo
8:50 am - 11:54 am
ORD
-
GSP
2h 04mnonstop
$209United Airlines
Thu, Apr 23 - Sun, Apr 26
Delta Logo
7:59 pm - 11:59 pm
GSP
-
ORD
5h 00m
1 stop
Delta Logo
5:15 am - 10:20 am
ORD
-
GSP
4h 05m
1 stop
$213Delta
Fri, Apr 24 - Sat, Apr 25
Delta Logo
5:23 pm - 10:28 pm
GSP
-
MDW
6h 05m
1 stop
Delta Logo
6:00 am - 12:13 pm
MDW
-
GSP
5h 13m
1 stop
$213Delta
Tue, Mar 31 - Tue, Apr 7
United Airlines Logo
10:33 am - 4:49 pm
GSP
-
ORD
7h 16m
1 stop
United Airlines Logo
8:50 am - 11:54 am
ORD
-
GSP
2h 04mnonstop
$219United Airlines
Useful Info

Good to know

Low seasonFebruary
Cheapest flight$44
Most popular time to fly and prices are also 6% lower on average.
Flight from Charlotte to Chicago O'Hare Airport

Flights from South Carolina to Chicago: the best tips from KAYAK users

Insights shared by verified travelers who flew the route from South Carolina to Chicago 
Learn how KAYAK collects reviews and tips from users.
YesicaFlew with United Airlines
CHS
-
ORD
Feb 2026
Utilize the mobile app of your airline it will give you all the updates and information you need
EllenFlew with United Airlines
GSP
-
ORD
May 2024
Greenville airport is small, getting through security won't take too long (particularly if you have Precheck). Be prepared to walk for 10-15 minutes from your arrival gate in O'Hare to your next departure gate, if you have one. Sometimes those gates are really close together, but my experience is that they are typically farther apart and require a solid walk.

FAQs for booking flights from South Carolina to Chicago

  • How does KAYAK find such low prices on flights from South Carolina to Chicago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South Carolina to Chicago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
Saint Joseph
Hammond
Portage
Lansing
Valparaiso
Chesterton
Schererville
Munster
Porter
Monticello
Saint John
Griffith

Everything you need to know for your flight to Chicago

Cabin class types available on flights to South Carolina

Cabin classes available on flights to Chicago. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
First Class flights to Chicagofrom $519
Business Class flights to Chicagofrom $580
Premium Economy Class flights to Chicagofrom $524
Economy Class flights to Chicagofrom $209