How does KAYAK find such low prices on flights from South Carolina to Chicago?

KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.

How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?

KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

What is the Hacker Fare option on flights from South Carolina to Chicago?

Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.

What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?

Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

$97 CHEAP FLIGHTS from South Carolina to Chicago

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Cheap Flights from South Carolina to Chicago

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Direct

Recent round-trip flight deals from South Carolina to Chicago

Tue, Oct 27 - Thu, Oct 29

3:00 pm - 12:51 pmCHS Charleston-ORD Chicago O'Hare Intl

22h 51m2 stops Orlando Atlanta Hartsfield-Jackson

8:00 am - 4:11 pmORD Chicago O'Hare Intl-CHS Charleston

7h 11m1 stop Fort Lauderdale

$261Multiple Airlines

Thu, Oct 22 - Mon, Oct 26

10:13 pm - 6:31 pmCHS Charleston-ORD Chicago O'Hare Intl

45h 18m2 stops Fort Lauderdale Atlanta Hartsfield-Jackson

8:04 am - 9:01 pmORD Chicago O'Hare Intl-CHS Charleston

11h 57m1 stop Fort Lauderdale

$268Multiple Airlines

Thu, Oct 22 - Mon, Oct 26

7:16 am - 8:59 amCHS Charleston-ORD Chicago O'Hare Intl

2h 43mnonstop

8:40 pm - 11:59 pmORD Chicago O'Hare Intl-CHS Charleston

2h 19mnonstop

$297American Airlines

Tue, Nov 3 - Thu, Nov 5

4:14 pm - 6:01 pmCHS Charleston-ORD Chicago O'Hare Intl

2h 47mnonstop

8:59 pm - 12:15 amORD Chicago O'Hare Intl-CHS Charleston

2h 16mnonstop

$297American Airlines

Sat, Oct 31 - Mon, Nov 2

7:19 pm - 9:00 pmCHS Charleston-ORD Chicago O'Hare Intl

2h 41mnonstop

10:40 am - 1:56 pmORD Chicago O'Hare Intl-CHS Charleston

2h 16mnonstop

$297United Airlines

Thu, Nov 5 - Mon, Nov 9

3:29 pm - 5:05 pmCHS Charleston-ORD Chicago O'Hare Intl

2h 36mnonstop

7:47 am - 11:21 amORD Chicago O'Hare Intl-CHS Charleston

2h 34mnonstop

$297United Airlines

Sat, Oct 31 - Mon, Nov 2

8:20 am - 9:30 amCHS Charleston-MDW Chicago Midway

2h 10mnonstop

12:45 pm - 3:50 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

$297Southwest

Tue, Oct 27 - Wed, Oct 28

7:15 am - 8:25 amCHS Charleston-MDW Chicago Midway

2h 10mnonstop

1:30 pm - 4:40 pmMDW Chicago Midway-CHS Charleston

2h 10mnonstop

$297Southwest

Wed, Dec 9 - Sat, Jan 9

11:24 am - 4:16 pmCHS Charleston-MDW Chicago Midway

5h 52m1 stop Atlanta Hartsfield-Jackson

10:35 am - 3:39 pmMDW Chicago Midway-CHS Charleston

4h 04m1 stop Atlanta Hartsfield-Jackson

$317Delta

Tue, Nov 10 - Thu, Nov 12

5:20 am - 10:24 amCHS Charleston-MDW Chicago Midway

6h 04m1 stop Atlanta Hartsfield-Jackson

1:05 pm - 8:13 pmMDW Chicago Midway-CHS Charleston

6h 08m1 stop Atlanta Hartsfield-Jackson

$317Delta

Recent last minute flight deals from South Carolina to Chicago

Sat, Oct 10 - Sat, Oct 17

1:50 pm - 3:34 pmHHH Hilton Head Island-ORD Chicago O'Hare Intl

2h 44mnonstop

9:55 am - 1:20 pmORD Chicago O'Hare Intl-HHH Hilton Head Island

2h 25mnonstop

$394American Airlines

Thu, Oct 8 - Thu, Oct 15

6:01 am - 7:22 amGSP Greenville-ORD Chicago O'Hare Intl

2h 21mnonstop

7:54 pm - 11:00 pmORD Chicago O'Hare Intl-GSP Greenville

2h 06mnonstop

$394American Airlines

Tue, Oct 6 - Tue, Oct 13

12:23 pm - 4:58 pmHHH Hilton Head Island-ORD Chicago O'Hare Intl

5h 35m1 stop Atlanta Hartsfield-Jackson

8:05 am - 3:30 pmORD Chicago O'Hare Intl-HHH Hilton Head Island

6h 25m1 stop Atlanta Hartsfield-Jackson

$414Delta

Wed, Oct 7 - Wed, Oct 14

3:42 pm - 10:59 pmCHS Charleston-ORD Chicago O'Hare Intl

8h 17m1 stop Orlando

8:30 am - 4:11 pmORD Chicago O'Hare Intl-CHS Charleston

30h 41m2 stops Dallas/Fort Worth Fort Lauderdale

$416Multiple Airlines

Tue, Oct 6 - Tue, Oct 13

12:23 pm - 10:17 pmHHH Hilton Head Island-ORD Chicago O'Hare Intl

10h 54m2 stops Atlanta Hartsfield-Jackson New York LaGuardia

8:05 am - 3:30 pmORD Chicago O'Hare Intl-HHH Hilton Head Island

6h 25m1 stop Atlanta Hartsfield-Jackson

$419Delta

Tue, Oct 6 - Wed, Oct 7

7:20 pm - 10:15 pmGSP Greenville-MDW Chicago Midway

3h 55m1 stop Nashville Intl

9:40 am - 6:30 pmMDW Chicago Midway-GSP Greenville

7h 50m2 stops Lambert-St Louis Nashville Intl

$428Southwest

Tue, Oct 6 - Wed, Oct 7

7:00 am - 10:55 amGSP Greenville-MDW Chicago Midway

4h 55m1 stop Nashville Intl

9:30 am - 6:30 pmMDW Chicago Midway-GSP Greenville

8h 00m1 stop Nashville Intl

$428Southwest

Thu, Oct 8 - Mon, Oct 12

6:15 am - 7:46 amCAE Columbia Metropolitan-ORD Chicago O'Hare Intl

2h 31mnonstop

6:29 am - 9:46 amORD Chicago O'Hare Intl-CAE Columbia Metropolitan

2h 17mnonstop

$429United Airlines

Thu, Oct 8 - Sun, Oct 11

5:38 pm - 7:05 pmCAE Columbia Metropolitan-ORD Chicago O'Hare Intl

2h 27mnonstop

1:55 pm - 4:57 pmORD Chicago O'Hare Intl-CAE Columbia Metropolitan

2h 02mnonstop

$429United Airlines

Tue, Oct 6 - Tue, Oct 13

4:03 pm - 11:51 amMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

20h 48m2 stops Fort Lauderdale Atlanta Hartsfield-Jackson

8:04 am - 9:13 amORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

24h 09m1 stop Fort Lauderdale

$435Multiple Airlines

Recent direct flight deals from South Carolina to Chicago

Thu, Oct 22 - Mon, Oct 26

7:16 am - 8:59 amCHS Charleston-ORD Chicago O'Hare Intl

2h 43mnonstop

8:40 pm - 11:59 pmORD Chicago O'Hare Intl-CHS Charleston

2h 19mnonstop

$297American Airlines

Tue, Nov 3 - Thu, Nov 5

4:14 pm - 6:01 pmCHS Charleston-ORD Chicago O'Hare Intl

2h 47mnonstop

8:59 pm - 12:15 amORD Chicago O'Hare Intl-CHS Charleston

2h 16mnonstop

$297American Airlines

Thu, Nov 5 - Mon, Nov 9

3:29 pm - 5:05 pmCHS Charleston-ORD Chicago O'Hare Intl

2h 36mnonstop

7:47 am - 11:21 amORD Chicago O'Hare Intl-CHS Charleston

2h 34mnonstop

$297United Airlines

Sat, Oct 31 - Mon, Nov 2

7:19 pm - 9:00 pmCHS Charleston-ORD Chicago O'Hare Intl

2h 41mnonstop

10:40 am - 1:56 pmORD Chicago O'Hare Intl-CHS Charleston

2h 16mnonstop

$297United Airlines

Sat, Oct 31 - Mon, Nov 2

8:20 am - 9:30 amCHS Charleston-MDW Chicago Midway

2h 10mnonstop

12:45 pm - 3:50 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

$297Southwest

Tue, Oct 27 - Wed, Oct 28

7:15 am - 8:25 amCHS Charleston-MDW Chicago Midway

2h 10mnonstop

1:30 pm - 4:40 pmMDW Chicago Midway-CHS Charleston

2h 10mnonstop

$297Southwest

Mon, Oct 26 - Tue, Oct 27

7:16 am - 8:59 amCHS Charleston-ORD Chicago O'Hare Intl

2h 43mnonstop

11:38 am - 2:55 pmORD Chicago O'Hare Intl-CHS Charleston

2h 17mnonstop

$297American Airlines

Tue, Dec 22 - Wed, Dec 23

6:37 am - 8:16 amCHS Charleston-ORD Chicago O'Hare Intl

2h 39mnonstop

8:58 pm - 12:20 amORD Chicago O'Hare Intl-CHS Charleston

2h 22mnonstop

$297American Airlines

Tue, Nov 3 - Mon, Nov 9

8:00 am - 9:15 amCHS Charleston-MDW Chicago Midway

2h 15mnonstop

12:45 pm - 3:50 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

$297Southwest

Sat, Dec 12 - Sun, Dec 13

5:45 pm - 7:05 pmCAE Columbia Metropolitan-ORD Chicago O'Hare Intl

2h 20mnonstop

10:37 am - 1:54 pmORD Chicago O'Hare Intl-CAE Columbia Metropolitan

2h 17mnonstop

$319United Airlines

Useful Info

Low season	February
High season	July
Cheapest flight	$97

Best time to beat the crowds with an average 10% drop in price.

Most popular time to fly with an average 16% increase in price.

Flight from Greenville to Chicago O'Hare Airport

Verified travelerFlew with American Airlines-Apr 2026

Chicago has a enormous airport so be ready to walk and transfer to international flights by train via terminal

YesicaFlew with United Airlines-Feb 2026

Utilize the mobile app of your airline it will give you all the updates and information you need

EllenFlew with United Airlines-May 2024

Greenville airport is small, getting through security won't take too long (particularly if you have Precheck). Be prepared to walk for 10-15 minutes from your arrival gate in O'Hare to your next departure gate, if you have one. Sometimes those gates are really close together, but my experience is that they are typically farther apart and require a solid walk.

How does KAYAK find such low prices on flights from South Carolina to Chicago?
KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.
How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?
KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.
What is the Hacker Fare option on flights from South Carolina to Chicago?
Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.
What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?
Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Merrillville

Hammond

Saint Joseph

Portage

Lansing

Valparaiso

Schererville

Munster

Chesterton

Porter

Monticello

Saint John

Griffith

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$97 Find Cheap Flights from South Carolina to Chicago - Compare and Save

Cheap Flights from South Carolina to Chicago

Recent round-trip flight deals from South Carolina to Chicago

Recent one-way flight deals from South Carolina to Chicago

Recent last minute flight deals from South Carolina to Chicago

Recent direct flight deals from South Carolina to Chicago

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Flights from South Carolina to Chicago: the best tips from KAYAK users

FAQs for booking flights from South Carolina to Chicago

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More options for your flight to Chicago

Complete your trip to Chicago with a hotel stay or car rental

Cabin class types available on flights to South Carolina

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Flights from domestic origins to Chicago

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Find deals for your return flight