$91 Find Cheap Flights from South Carolina to Chicago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Chicago departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from South Carolina to Chicago

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South Carolina to Chicago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South Carolina to Chicago

Tue, Jun 9 - Tue, Jun 16
Frontier Logo
10:01 am - 12:48 am
CLT
-
ORD
15h 47m
1 stop
Frontier Logo
4:59 pm - 11:34 am
ORD
-
CLT
17h 35m
1 stop
$190Frontier
Tue, Aug 11 - Tue, Aug 18
Frontier Logo
5:57 pm - 12:49 am
CLT
-
ORD
7h 52m
1 stop
Frontier Logo
12:29 am - 12:33 pm
ORD
-
CLT
11h 04m
1 stop
$195Frontier
Tue, Jun 30 - Tue, Jul 7
American Airlines Logo
12:23 pm - 2:03 pm
MYR
-
ORD
2h 40mnonstop
American Airlines Logo
9:00 am - 12:26 pm
ORD
-
MYR
2h 26mnonstop
$217American Airlines
Tue, Jun 30 - Tue, Jul 7
Delta Logo
6:00 am - 10:13 am
MYR
-
ORD
5h 13m
1 stop
Delta Logo
8:03 am - 3:27 pm
ORD
-
MYR
6h 24m
1 stop
$237Delta
Thu, Jun 4 - Tue, Jun 9
American Airlines Logo
12:22 pm - 1:54 pm
MYR
-
ORD
2h 32mnonstop
American Airlines Logo
8:30 am - 11:53 am
ORD
-
MYR
2h 23mnonstop
$244American Airlines
Wed, Jun 10 - Tue, Jun 16
United Airlines Logo
10:34 am - 2:29 pm
MYR
-
ORD
4h 55m
1 stop
United Airlines Logo
7:03 am - 10:36 am
ORD
-
MYR
2h 33mnonstop
$248United Airlines
Tue, Jun 30 - Tue, Jul 7
United Airlines Logo
10:34 am - 2:29 pm
MYR
-
ORD
4h 55m
1 stop
United Airlines Logo
11:00 am - 2:19 pm
ORD
-
MYR
2h 19mnonstop
$255United Airlines
Thu, Aug 27 - Wed, Sep 2
Multiple Airlines Logo
10:05 am - 12:25 pm
SAV
-
ORD
27h 20m
1 stop
Multiple Airlines Logo
7:55 am - 5:55 pm
ORD
-
SAV
9h 00m
1 stop
$257Multiple Airlines
Wed, Jun 10 - Tue, Jun 16
Delta Logo
7:57 pm - 11:59 pm
MYR
-
ORD
5h 02m
1 stop
Delta Logo
6:22 pm - 11:59 pm
ORD
-
MYR
4h 37m
1 stop
$264Delta
Thu, Aug 27 - Wed, Sep 2
Multiple Airlines Logo
10:05 am - 12:25 pm
SAV
-
ORD
27h 20m
1 stop
Multiple Airlines Logo
1:50 pm - 1:55 pm
ORD
-
SAV
23h 05m
2 stops
$269Multiple Airlines
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Good to know

Low seasonFebruary
Cheapest flight$91
Best time to beat the crowds but there is an average 1% increase in price.
Most popular time to fly and prices are also 6% lower on average.
Flight from Charlotte to Chicago O'Hare Airport

Flights from South Carolina to Chicago: the best tips from KAYAK users

Insights shared by verified travelers who flew the route from South Carolina to Chicago 
Verified travelerFlew with American Airlines
GSP
-
ORD
Apr 2026
Chicago has a enormous airport so be ready to walk and transfer to international flights by train via terminal
YesicaFlew with United Airlines
CHS
-
ORD
Feb 2026
Utilize the mobile app of your airline it will give you all the updates and information you need
EllenFlew with United Airlines
GSP
-
ORD
May 2024
Greenville airport is small, getting through security won't take too long (particularly if you have Precheck). Be prepared to walk for 10-15 minutes from your arrival gate in O'Hare to your next departure gate, if you have one. Sometimes those gates are really close together, but my experience is that they are typically farther apart and require a solid walk.

FAQs for booking flights from South Carolina to Chicago

  • How does KAYAK find such low prices on flights from South Carolina to Chicago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South Carolina to Chicago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
Saint Joseph
Hammond
Portage
Lansing
Valparaiso
Schererville
Chesterton
Munster
Porter
Monticello
Saint John
Griffith

Everything you need to know for your flight to Chicago

Cabin class types available on flights to South Carolina

Cabin classes available on flights to Chicago. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.