How does KAYAK find such low prices on flights from South Carolina to Chicago?

KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.

How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?

KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

What is the Hacker Fare option on flights from South Carolina to Chicago?

Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.

What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?

Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

$113 CHEAP FLIGHTS from South Carolina to Chicago

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Cheap Flights from South Carolina to Chicago

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Direct

Recent round-trip flight deals from South Carolina to Chicago

Tue, Nov 24 - Tue, Dec 1

8:22 am - 11:34 pmMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

16h 12m1 stop Fort Lauderdale

3:55 pm - 11:44 amORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

18h 49m2 stops Atlanta Hartsfield-Jackson Tampa

$250Multiple Airlines

Wed, Jan 20 - Tue, Feb 16

2:23 pm - 4:14 pmMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

26h 51m1 stop Fort Lauderdale

8:25 am - 8:33 amORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

23h 08m1 stop Fort Lauderdale

$264Multiple Airlines

Tue, Nov 17 - Wed, Nov 18

5:15 pm - 9:30 pmCHS Charleston-MDW Chicago Midway

5h 15m1 stop Baltimore/Washington

1:25 pm - 4:30 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

$281Southwest

Thu, Feb 11 - Mon, Feb 15

7:00 pm - 12:14 amCHS Charleston-ORD Chicago O'Hare Intl

6h 14m1 stop Charlotte Douglas

8:00 am - 2:30 pmORD Chicago O'Hare Intl-CHS Charleston

5h 30m1 stop Charlotte Douglas

$283American Airlines

Tue, Nov 17 - Tue, Nov 17

8:00 am - 9:15 amCHS Charleston-MDW Chicago Midway

2h 15mnonstop

1:15 pm - 8:05 pmMDW Chicago Midway-CHS Charleston

5h 50m2 stops Richmond Byrd Intl Baltimore/Washington

$286Southwest

Mon, Jan 4 - Thu, Jan 7

6:37 am - 8:16 amCHS Charleston-ORD Chicago O'Hare Intl

2h 39mnonstop

12:06 pm - 3:23 pmORD Chicago O'Hare Intl-CHS Charleston

2h 17mnonstop

$287American Airlines

Thu, Nov 26 - Tue, Dec 1

10:23 am - 2:39 pmCHS Charleston-ORD Chicago O'Hare Intl

5h 16m1 stop Washington, D.C. Dulles Intl

5:59 pm - 9:21 pmORD Chicago O'Hare Intl-CHS Charleston

2h 22mnonstop

$297United Airlines

Wed, Dec 9 - Sat, Jan 9

5:34 pm - 10:54 pmCHS Charleston-MDW Chicago Midway

6h 20m1 stop Atlanta Hartsfield-Jackson

6:00 am - 12:34 pmMDW Chicago Midway-CHS Charleston

5h 34m1 stop Atlanta Hartsfield-Jackson

$301Delta

Fri, Dec 4 - Sun, Dec 6

6:00 am - 7:37 amCHS Charleston-ORD Chicago O'Hare Intl

2h 37mnonstop

7:29 am - 11:02 amORD Chicago O'Hare Intl-CHS Charleston

2h 33mnonstop

$307United Airlines

Wed, Dec 9 - Sat, Jan 9

5:34 pm - 10:54 pmCHS Charleston-MDW Chicago Midway

6h 20m1 stop Atlanta Hartsfield-Jackson

6:00 am - 12:34 pmMDW Chicago Midway-CHS Charleston

5h 34m1 stop Atlanta Hartsfield-Jackson

$307Delta

Recent last minute flight deals from South Carolina to Chicago

Wed, Nov 4 - Mon, Nov 9

5:58 pm - 3:37 pmMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

22h 39m2 stops Tampa Fort Lauderdale

7:55 am - 9:55 amORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

25h 00m1 stop Fort Lauderdale

$348Multiple Airlines

Wed, Nov 4 - Mon, Nov 9

2:42 pm - 3:37 pmMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

25h 55m1 stop Fort Lauderdale

7:55 am - 9:55 amORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

25h 00m1 stop Fort Lauderdale

$349Multiple Airlines

Thu, Nov 5 - Wed, Dec 2

12:18 pm - 1:59 pmCHS Charleston-ORD Chicago O'Hare Intl

2h 41mnonstop

10:38 am - 2:00 pmORD Chicago O'Hare Intl-CHS Charleston

2h 22mnonstop

$357United Airlines

Thu, Nov 5 - Wed, Dec 2

7:10 pm - 8:25 pmCHS Charleston-MDW Chicago Midway

2h 15mnonstop

1:25 pm - 4:30 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

$357Southwest

Thu, Nov 5 - Wed, Dec 2

10:23 am - 2:38 pmCHS Charleston-ORD Chicago O'Hare Intl

5h 15m1 stop Washington, D.C. Dulles Intl

7:30 am - 11:03 amORD Chicago O'Hare Intl-CHS Charleston

2h 33mnonstop

$367United Airlines

Thu, Nov 5 - Wed, Dec 2

7:40 am - 1:40 pmCHS Charleston-MDW Chicago Midway

7h 00m1 stop Baltimore/Washington

1:25 pm - 4:30 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

$367Southwest

Thu, Nov 5 - Wed, Dec 2

6:00 am - 9:25 amCHS Charleston-ORD Chicago O'Hare Intl

4h 25m1 stop Atlanta Hartsfield-Jackson

5:30 am - 12:59 pmORD Chicago O'Hare Intl-CHS Charleston

6h 29m1 stop Atlanta Hartsfield-Jackson

$377Delta

Wed, Nov 4 - Wed, Nov 11

11:39 am - 12:59 pmGSP Greenville-ORD Chicago O'Hare Intl

2h 20mnonstop

6:55 pm - 9:59 pmORD Chicago O'Hare Intl-GSP Greenville

2h 04mnonstop

$401American Airlines

Tue, Nov 3 - Tue, Nov 10

11:39 am - 12:59 pmGSP Greenville-ORD Chicago O'Hare Intl

2h 20mnonstop

8:00 am - 11:07 amORD Chicago O'Hare Intl-GSP Greenville

2h 07mnonstop

$401American Airlines

Tue, Nov 3 - Tue, Nov 10

7:20 am - 12:59 pmGSP Greenville-ORD Chicago O'Hare Intl

6h 39m1 stop Detroit Metropolitan Wayne County

8:04 am - 1:15 pmORD Chicago O'Hare Intl-GSP Greenville

4h 11m1 stop Atlanta Hartsfield-Jackson

$421Delta

Useful Info

Low season	February
High season	July
Cheapest flight	$113

Best time to beat the crowds with an average 10% drop in price.

Most popular time to fly with an average 17% increase in price.

Flight from Myrtle Beach to Chicago O'Hare Airport

Verified travelerFlew with American Airlines-Apr 2026

Chicago has a enormous airport so be ready to walk and transfer to international flights by train via terminal

YesicaFlew with United Airlines-Feb 2026

Utilize the mobile app of your airline it will give you all the updates and information you need

EllenFlew with United Airlines-May 2024

Greenville airport is small, getting through security won't take too long (particularly if you have Precheck). Be prepared to walk for 10-15 minutes from your arrival gate in O'Hare to your next departure gate, if you have one. Sometimes those gates are really close together, but my experience is that they are typically farther apart and require a solid walk.

How does KAYAK find such low prices on flights from South Carolina to Chicago?
KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.
How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?
KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.
What is the Hacker Fare option on flights from South Carolina to Chicago?
Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.
What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?
Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Merrillville

Hammond

Saint Joseph

Portage

Lansing

Valparaiso

Munster

Chesterton

Schererville

Porter

Monticello

Saint John

Griffith

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$113 Find Cheap Flights from South Carolina to Chicago - Compare and Save

Cheap Flights from South Carolina to Chicago

Recent round-trip flight deals from South Carolina to Chicago

Recent one-way flight deals from South Carolina to Chicago

Recent last minute flight deals from South Carolina to Chicago

Recent direct flight deals from South Carolina to Chicago

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Flights from South Carolina to Chicago: the best tips from KAYAK users

FAQs for booking flights from South Carolina to Chicago

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Complete your trip to Chicago with a hotel stay or car rental

Cabin class types available on flights to South Carolina

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