How does KAYAK find such low prices on flights from South Carolina to Chicago?

KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.

How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?

KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

What is the Hacker Fare option on flights from South Carolina to Chicago?

Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.

What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?

Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

$113 CHEAP FLIGHTS from South Carolina to Chicago

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Cheap Flights from South Carolina to Chicago

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Direct

Recent round-trip flight deals from South Carolina to Chicago

Thu, Dec 3 - Mon, Dec 7

8:10 pm - 1:56 pmMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

18h 46m1 stop Fort Lauderdale

10:37 pm - 11:44 amORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

36h 07m2 stops Atlanta Hartsfield-Jackson Tampa

$264Multiple Airlines

Thu, Jan 28 - Tue, Feb 16

5:06 pm - 10:46 pmMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

6h 40m1 stop Charlotte Douglas

10:00 am - 1:16 pmORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

2h 16mnonstop

$265American Airlines

Thu, Jan 28 - Wed, Feb 17

10:55 am - 4:37 pmMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

6h 42m1 stop Atlanta Hartsfield-Jackson

7:10 am - 1:35 pmORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

5h 25m1 stop Atlanta Hartsfield-Jackson

$275Delta

Wed, Jan 27 - Wed, Feb 17

10:55 am - 4:37 pmMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

6h 42m1 stop Atlanta Hartsfield-Jackson

11:10 am - 5:55 pmORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

5h 45m1 stop Atlanta Hartsfield-Jackson

$275Delta

Thu, Jan 7 - Sat, Jan 9

10:45 am - 4:00 pmMYR Myrtle Beach Intl-MDW Chicago Midway

6h 15m1 stop Nashville Intl

7:50 am - 1:15 pmMDW Chicago Midway-MYR Myrtle Beach Intl

4h 25m1 stop Nashville Intl

$275Southwest

Tue, Jan 5 - Sat, Jan 9

7:05 pm - 10:45 pmMYR Myrtle Beach Intl-MDW Chicago Midway

4h 40m1 stop Nashville Intl

8:00 am - 1:15 pmMDW Chicago Midway-MYR Myrtle Beach Intl

4h 15m1 stop Nashville Intl

$275Southwest

Tue, Dec 29 - Wed, Jan 6

1:03 pm - 12:13 amCHS Charleston-ORD Chicago O'Hare Intl

12h 10m2 stops Columbus Atlanta Hartsfield-Jackson

7:52 pm - 7:30 amORD Chicago O'Hare Intl-CHS Charleston

10h 38m1 stop Tampa

$275Multiple Airlines

Tue, Jan 19 - Tue, Jan 26

6:12 am - 11:03 amMYR Myrtle Beach Intl-ORD Chicago O'Hare Intl

5h 51m1 stop Charlotte Douglas

9:00 am - 4:20 pmORD Chicago O'Hare Intl-MYR Myrtle Beach Intl

6h 20m1 stop Charlotte Douglas

$275American Airlines

Fri, Nov 20 - Wed, Nov 25

3:29 pm - 5:05 pmCHS Charleston-ORD Chicago O'Hare Intl

2h 36mnonstop

6:17 pm - 10:00 pmORD Chicago O'Hare Intl-CHS Charleston

2h 43mnonstop

$280United Airlines

Thu, Nov 26 - Tue, Dec 1

8:30 am - 10:11 amCHS Charleston-ORD Chicago O'Hare Intl

2h 41mnonstop

5:59 pm - 9:21 pmORD Chicago O'Hare Intl-CHS Charleston

2h 22mnonstop

$287United Airlines

Recent last minute flight deals from South Carolina to Chicago

Fri, Oct 30 - Sun, Nov 1

2:49 pm - 3:37 pmGSP Greenville-ORD Chicago O'Hare Intl

25h 48m1 stop Fort Lauderdale

7:55 am - 8:13 amORD Chicago O'Hare Intl-GSP Greenville

23h 18m1 stop Fort Lauderdale

$311Multiple Airlines

Fri, Oct 30 - Sun, Nov 1

8:52 pm - 3:37 pmGSP Greenville-ORD Chicago O'Hare Intl

19h 45m2 stops Tampa Fort Lauderdale

7:55 am - 8:13 amORD Chicago O'Hare Intl-GSP Greenville

23h 18m1 stop Fort Lauderdale

$318Multiple Airlines

Sat, Oct 31 - Sat, Nov 7

6:43 pm - 8:13 pmGSP Greenville-ORD Chicago O'Hare Intl

2h 30mnonstop

8:00 am - 11:07 amORD Chicago O'Hare Intl-GSP Greenville

2h 07mnonstop

$401American Airlines

Sat, Oct 31 - Sat, Nov 7

5:37 pm - 7:00 pmGSP Greenville-ORD Chicago O'Hare Intl

2h 23mnonstop

10:25 am - 1:21 pmORD Chicago O'Hare Intl-GSP Greenville

1h 56mnonstop

$401United Airlines

Sat, Oct 31 - Sat, Nov 7

6:43 pm - 8:13 pmGSP Greenville-ORD Chicago O'Hare Intl

2h 30mnonstop

8:00 am - 11:07 amORD Chicago O'Hare Intl-GSP Greenville

2h 07mnonstop

$402American Airlines

Sat, Oct 31 - Sat, Nov 7

5:50 am - 11:45 amGSP Greenville-ORD Chicago O'Hare Intl

6h 55m1 stop Newark

5:55 pm - 8:58 pmORD Chicago O'Hare Intl-GSP Greenville

2h 03mnonstop

$411United Airlines

Sat, Oct 31 - Sat, Nov 7

2:00 pm - 5:47 pmGSP Greenville-ORD Chicago O'Hare Intl

4h 47m1 stop Atlanta Hartsfield-Jackson

1:23 pm - 8:21 pmORD Chicago O'Hare Intl-GSP Greenville

5h 58m1 stop Atlanta Hartsfield-Jackson

$421Delta

Sun, Nov 1 - Sun, Nov 8

7:00 am - 10:47 amCAE Columbia Metropolitan-MDW Chicago Midway

4h 47m1 stop Atlanta Hartsfield-Jackson

6:04 am - 10:43 amMDW Chicago Midway-CAE Columbia Metropolitan

3h 39m1 stop Atlanta Hartsfield-Jackson

$434Delta

Wed, Oct 28 - Wed, Nov 4

10:45 am - 1:20 pmGSP Greenville-MDW Chicago Midway

3h 35m1 stop Nashville Intl

12:50 pm - 7:55 pmMDW Chicago Midway-GSP Greenville

6h 05m1 stop Baltimore/Washington

$443Southwest

Wed, Oct 28 - Wed, Nov 4

1:25 pm - 7:30 pmGSP Greenville-MDW Chicago Midway

7h 05m2 stops Baltimore/Washington Greater Rochester Intl

12:45 pm - 6:10 pmMDW Chicago Midway-GSP Greenville

4h 25m1 stop Nashville Intl

$448Southwest

Useful Info

Low season	February
High season	July
Cheapest flight	$113

Best time to beat the crowds with an average 10% drop in price.

Most popular time to fly with an average 17% increase in price.

Flight from Charleston to Chicago O'Hare Airport

Verified travelerFlew with American Airlines-Apr 2026

Chicago has a enormous airport so be ready to walk and transfer to international flights by train via terminal

YesicaFlew with United Airlines-Feb 2026

Utilize the mobile app of your airline it will give you all the updates and information you need

EllenFlew with United Airlines-May 2024

Greenville airport is small, getting through security won't take too long (particularly if you have Precheck). Be prepared to walk for 10-15 minutes from your arrival gate in O'Hare to your next departure gate, if you have one. Sometimes those gates are really close together, but my experience is that they are typically farther apart and require a solid walk.

How does KAYAK find such low prices on flights from South Carolina to Chicago?
KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Chicago.
How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Chicago?
KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.
What is the Hacker Fare option on flights from South Carolina to Chicago?
Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to South Carolina with another airline.
What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Chicago?
Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Merrillville

Hammond

Saint Joseph

Portage

Lansing

Valparaiso

Munster

Chesterton

Schererville

Porter

Monticello

Saint John

Griffith

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$113 Find Cheap Flights from South Carolina to Chicago - Compare and Save

Cheap Flights from South Carolina to Chicago

Recent round-trip flight deals from South Carolina to Chicago

Recent one-way flight deals from South Carolina to Chicago

Recent last minute flight deals from South Carolina to Chicago

Recent direct flight deals from South Carolina to Chicago

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Flights from South Carolina to Chicago: the best tips from KAYAK users

FAQs for booking flights from South Carolina to Chicago

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More options for your flight to Chicago

Complete your trip to Chicago with a hotel stay or car rental

Cabin class types available on flights to South Carolina

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