CHS - DSM

$163 Find Cheap Flights from Charleston to Des Moines - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$325
Typical prices: $326-$502
American Airlines
Tue 11/6Tue 11/13
CHS - DSM • 1 stop
Cheapest one-way
$163
Typical prices: $162-$279
Delta
Fri 1/5
CHS - DSM • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Charleston and Des Moines. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
December
Cheapest • 38% price drop
September
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Charlotte Douglas (CLT)
Cheapest • Avg $361 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 50m (one-way)
Insights
Insights
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We hope you love your trip to Des Moines!

Cheap Flights from Charleston to Des Moines (CHS-DSM)

 

Cheap flights from Charleston to Des Moines with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Fri, Nov 6 - Fri, Nov 13
American Airlines Logo
8:32 pm - 11:57 pmCHS  Charleston-DSM Des Moines
4h 25m1 stop Charlotte Douglas
American Airlines Logo
11:28 am - 7:42 pmDSM  Des Moines-CHS Charleston
7h 14m1 stop Charlotte Douglas
$325American Airlines
Tue, Nov 10 - Thu, Nov 12
Delta Logo
4:17 pm - 10:35 pmCHS  Charleston-DSM Des Moines
7h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:52 pm - 11:59 pmDSM  Des Moines-CHS Charleston
4h 07m1 stop Atlanta Hartsfield-Jackson
$325Delta
Fri, Nov 6 - Fri, Nov 13
American Airlines Logo
5:05 am - 10:48 amCHS  Charleston-DSM Des Moines
6h 43m1 stop Charlotte Douglas
American Airlines Logo
1:58 pm - 9:53 pmDSM  Des Moines-CHS Charleston
6h 55m2 stops Chicago O'Hare Intl Charlotte Douglas
$376American Airlines
Tue, Nov 10 - Thu, Nov 12
United Airlines Logo
12:18 pm - 7:16 pmCHS  Charleston-DSM Des Moines
7h 58m1 stop Chicago O'Hare Intl
United Airlines Logo
8:00 am - 1:56 pmDSM  Des Moines-CHS Charleston
4h 56m1 stop Chicago O'Hare Intl
$401United Airlines
Wed, Oct 28 - Fri, Oct 30
Multiple Airlines Logo
6:00 am - 2:42 pmCHS  Charleston-DSM Des Moines
33h 42m2 stops Tampa Philadelphia
Multiple Airlines Logo
9:15 am - 8:38 amDSM  Des Moines-CHS Charleston
22h 23m1 stop Orlando Sanford Intl
$420Multiple Airlines
Tue, Nov 10 - Thu, Nov 12
Southwest Logo
8:00 am - 11:25 amCHS  Charleston-DSM Des Moines
4h 25m1 stop Chicago Midway
Southwest Logo
5:25 am - 6:30 pmDSM  Des Moines-CHS Charleston
12h 05m2 stops Chicago Midway Nashville Intl
$432Southwest
Tue, Nov 10 - Thu, Nov 12
American Airlines Logo
6:10 am - 10:10 amCHS  Charleston-DSM Des Moines
5h 00m1 stop Charlotte Douglas
American Airlines Logo
1:58 pm - 12:17 amDSM  Des Moines-CHS Charleston
9h 19m1 stop Chicago O'Hare Intl
$444American Airlines
Tue, Nov 3 - Wed, Nov 4
American Airlines Logo
12:17 pm - 6:56 pmCHS  Charleston-DSM Des Moines
7h 39m1 stop Chicago O'Hare Intl
American Airlines Logo
7:23 am - 3:24 pmDSM  Des Moines-CHS Charleston
7h 01m1 stop Chicago O'Hare Intl
$446American Airlines
Tue, Oct 27 - Sat, Oct 31
Delta Logo
4:20 pm - 9:43 pmCHS  Charleston-DSM Des Moines
6h 23m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:39 am - 11:04 amDSM  Des Moines-CHS Charleston
4h 25m1 stop Atlanta Hartsfield-Jackson
$517Delta
Wed, Oct 28 - Thu, Oct 29
Delta Logo
6:30 am - 10:42 amCHS  Charleston-DSM Des Moines
5h 12m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:35 am - 1:00 pmDSM  Des Moines-CHS Charleston
6h 25m1 stop Atlanta Hartsfield-Jackson
$537Delta

Price, demand and travel trends for Charleston to Des Moines flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Charleston to Des Moines?

Round-trip flights from Charleston to Des Moines typically range from $326 to $502. The lowest price found in the past 5 days was $325, on American Airlines.

What's the cheapest day of the week to fly from Charleston to Des Moines?

Based on deals KAYAK users found in the last 12 months, Wednesday is the cheapest day of the week to fly from Charleston to Des Moines. It’s 34% cheaper than the average day, while Saturday is the most expensive, with prices 63% higher.

What’s the cheapest month to fly from Charleston to Des Moines?

•December is the cheapest month to fly from Charleston to Des Moines at $233 round-trip.
•June ($618) and October ($418) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 165% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

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Key details for Charleston to Des Moines flights

Low season

March

Cheapest flight

$163
Beat the crowds with an average 62% drop in travelers.
The most popular month to fly with an average 75% increase in travelers.
One-way flight from Charleston to Des Moines

When to book flights from Charleston to Des Moines

Are your dates flexible? Find out the best times to travel from Charleston to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Charleston to Des Moines flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Charleston to Des Moines?

    Only Economy Class is available on flights from Charleston to Des Moines.

  • How long is a flight from Charleston to Des Moines?

    A nonstop flight from Charleston to Des Moines takes 00m, covering 956 miles.

  • Do I need a passport to fly from Charleston to Des Moines?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Charleston to Des Moines flight?

    Round-trip flights from Charleston to Des Moines range from $326 to $502, with an average of $378 over the past 12 months. Anything below $326 counts as a good deal.

  • Have flight prices from Charleston to Des Moines changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $325 to $1,763. That means the highest observed fare was about 5x higher than the lowest one.

  • How are flight prices from Charleston to Des Moines looking right now?

    One-way fares from Charleston to Des Moines are currently lower than usual. Average one-way flight prices are about $188, which is 12% below the typical average for this route.

  • What car rental options are available at Des Moines Airport (DSM)?

    Des Moines Airport (DSM) hosts 5 major car rental companies, with daily rates starting from around $32 for economy cars. Top options include:

    • Hertz
    • Payless
    • Budget
    • Alamo
    • Avis

  • Which airports can I use when flying from Charleston to Des Moines?

    Flights from Charleston to Des Moines usually depart from Charleston (CHS) and arrive at Des Moines (DSM).

  • Which airports do connecting flights from Charleston to Des Moines pass through?

    One-stop flights from Charleston to Des Moines most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 43% of one-stop connections
    • Charlotte Douglas (CLT) - 43% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 7% of one-stop connections
    • Detroit Metropolitan Wayne County (DTW) - 4% of one-stop connections

  • Can I save money by using flexible dates for flights from Charleston to Des Moines?

    Yes. Flexible dates can save you up to 60% on flights from Charleston to Des Moines. Wednesday is the cheapest departure day at $250 round-trip on average, while Saturday is the most expensive at $618, a difference of $368.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Charleston to Des Moines?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 50m, compared with 4h 50m via Charlotte Douglas (CLT) and 4h 55m via Chicago Midway (MDW).

  • What is the time difference between Charleston and Des Moines?

    Des Moines is 1 hour behind Charleston (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Des Moines?

    Some of the most popular sights in Des Moines are UnityPoint Health - Des Moines, Science Center of Iowa and Hy Vee Hall. These are among the most viewed places in Des Moines on KAYAK.

Your guide to booking Charleston to Des Moines flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Wednesday departure and avoid flying on Saturday. On this route, Wednesday flights average $250, about $368 less than Saturday fares (60% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Charleston to Des Moines trip for December. Fares historically average $233 round-trip in that month - typically $385 less than the most expensive month, which is June (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Des Moines Airport.

    • Days Inn & Suites by Wyndham Des Moines Airport
    • Holiday Inn Des Moines-Airport/Conf Center By IHG
    • Homewood Suites by Hilton - Des Moines Airport

More options for your flight from Charleston to Des Moines

Complete your trip to Des Moines with a hotel stay or car rental

Car rentals in Des Moines
Hotels in Des Moines
Vacations in Des Moines