CHS - DSM

$160 Find Cheap Flights from Charleston to Des Moines

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to Des Moines departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Des Moines

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Charleston to Des Moines, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Charleston to Des Moines, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$290
Overall average: $357
Multiple Airlines
Thu 4/23Sun 4/26
CHS - DSM • 1 stop
Cheapest one-way
$160
Typical prices: $148-$213
Delta
Thu 4/30
CHS - DSM • 1 stop
Top airlines
Delta
Cheapest • from $352 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Charleston and Des Moines. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Charlotte (CLT)
Cheapest • Avg $437 (round-trip)
Atlanta (ATL)
Shortest trip • 4h 34m (one-way)
Insights
Insights
Insights
Insights
When to travel
May
Cheapest • 27% price drop
May
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Charleston to Des Moines (CHS-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to Des Moines

Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
7:00 am - 4:00 pm
CHS
-
DSM
10h 00m
1 stop
Multiple Airlines Logo
8:30 am - 9:49 pm
DSM
-
CHS
12h 19m
1 stop
$290Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
7:00 am - 4:00 pm
CHS
-
DSM
10h 00m
1 stop
Multiple Airlines Logo
8:30 am - 9:49 pm
DSM
-
CHS
12h 19m
1 stop
$295Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
6:15 am - 1:09 pm
CHS
-
DSM
31h 54m
2 stops
Multiple Airlines Logo
8:30 am - 9:49 pm
DSM
-
CHS
12h 19m
1 stop
$307Multiple Airlines
Fri, Apr 17 - Sun, Apr 19
Multiple Airlines Logo
7:00 am - 10:57 pm
CHS
-
DSM
16h 57m
2 stops
Multiple Airlines Logo
8:30 am - 9:49 pm
DSM
-
CHS
12h 19m
1 stop
$322Multiple Airlines
Thu, Aug 6 - Mon, Aug 10
Multiple Airlines Logo
7:47 pm - 5:17 pm
CHS
-
DSM
22h 30m
1 stop
Multiple Airlines Logo
6:07 pm - 5:59 pm
DSM
-
CHS
22h 52m
1 stop
$325Multiple Airlines
Fri, Apr 24 - Sun, Apr 26
Multiple Airlines Logo
7:00 am - 10:42 pm
CHS
-
DSM
16h 42m
2 stops
Multiple Airlines Logo
8:30 am - 9:49 pm
DSM
-
CHS
12h 19m
1 stop
$334Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
7:00 am - 4:00 pm
CHS
-
DSM
10h 00m
1 stop
Multiple Airlines Logo
8:30 am - 2:31 pm
DSM
-
CHS
29h 01m
2 stops
$335Multiple Airlines
Fri, Jun 5 - Mon, Jun 8
Multiple Airlines Logo
7:00 am - 11:27 pm
CHS
-
DSM
17h 27m
1 stop
Multiple Airlines Logo
4:07 pm - 11:06 am
DSM
-
CHS
17h 59m
2 stops
$343Multiple Airlines
Tue, Mar 31 - Fri, Apr 3
Delta Logo
4:51 pm - 10:38 pm
CHS
-
DSM
6h 47m
1 stop
Delta Logo
5:20 pm - 12:16 am
DSM
-
CHS
5h 56m
1 stop
$352Delta
Fri, Mar 27 - Tue, Mar 31
United Airlines Logo
8:15 am - 2:24 pm
CHS
-
DSM
7h 09m
1 stop
United Airlines Logo
8:04 am - 1:55 pm
DSM
-
CHS
4h 51m
1 stop
$362United Airlines
Booking Insights

KAYAK's insights & trends for Charleston to Des Moines flights

Get data-powered insights and trends into flights from Charleston to Des Moines to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Charleston to Des Moines?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Charleston to Des Moines, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Charleston to Des Moines is May, where tickets cost $307 (return) on average. On the other hand, the most expensive months are February and November, where the average cost of round-trip tickets is $766 and $537 respectively.

Good to know

Low seasonApril
Cheapest flight$160
Best time to beat the crowds with an average 16% drop in price.
Most popular time to fly and prices are also 28% lower on average.
Flight from Charleston to Des Moines

When to book flights from Charleston to Des Moines

Are your dates flexible? Find out the best times to travel from Charleston to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Charleston to Des Moines

  • What is the cheapest flight from Charleston to Des Moines?

    In the last 3 days, the lowest price for a flight from Charleston to Des Moines was $160 for a one-way ticket and $290 for a round-trip.

  • Do I need a passport to fly between Charleston and Des Moines?

    A passport is not required to fly from Charleston to Des Moines.

  • Which aircraft models fly most regularly from Charleston to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Charleston to Des Moines?

    oneworld, and SkyTeam are the airline alliances operating flights between Charleston and Des Moines, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Charleston to Des Moines, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Charleston to Des Moines are Delta and American Airlines. With an average price for the route of $418 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $366 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Charleston to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Charleston is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Charleston with another airline. Booking your flights between Charleston and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Charleston up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Charleston to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Charleston to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Charleston to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8242 reviews
8.1Boarding
7.2Food
7.9Comfort
7.8Entertainment
8.5Crew
Airline reviews

Everything was good except wifi and a leaking drink chiller. The floor was all wet and my bag was soaked. Did not notice until debarking. Have not heard back from Delta. Even though this was leg one of an international flight in first class, they denied access to their Sky Club - very disappointing!

6.0 GoodAnonymous, Feb 2026
RDU - SEA
Read more Delta reviews

Everything was good except wifi and a leaking drink chiller. The floor was all wet and my bag was soaked. Did not notice until debarking. Have not heard back from Delta. Even though this was leg one of an international flight in first class, they denied access to their Sky Club - very disappointing!

The staff was fine. The plane was extremely tight, and I paid for the wifi and it did not work at all. I was actually going to ask for a refund.

two hour delay and the Delta representative on the PA system was unable to understand

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

2+hrs delay without any reason provided and a cramped flight

We waited an hour on the runway to get a gate in Orlando

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

Flight was delayed due to crew being not on time

Flight crew issues delayed my flight by 2 1/2 hours. Causing me to miss my connection.

The staff on board and gate was nice - a welcome change from the usual. We also arrived early, which was a great benefit, given that it takes 30 minutes plus to get bags at SRQ.

Lack of gluten free options in food service. I have Celiac disease and it appears you no longer offer special meals for people with dietary restrictions. I am a frequent flyer traveling into and out of Omaha airport. I have noticed over the course of several months that although our flight typically arrives ahead of schedule (awesome job AA!) - we typically sit on the runway for several minutes waiting for the ground crew to get in place. Not sure if it is a ground crew issue or a gate availability issue (due to construction at this airport). Seems to be more of a ground crew being on time issue.

Arrived early picked up my bag in a few minutes- great trip - thank you

Flight boarded, departed and landed on time. Excellent service from flight attendant in FIRST

Boarding is always an ordeal. Less dogs on flights. I am highly allergic to dogs and cats. Why are there so many animals these days?

Flight to Tampa was delayed taking off due to plane arriving late but no other issues

There was a delay with the plan which cause the flight to leave later and once arrived in Chicago there was another delay and some passengers missed their connecting flights

Massimo, flight attendant was very authentic, attentive - wonderful. Food/wrap was just okay.

Worst experience ever. Flight could not land in Charlotte for what we were told was a ground stop. Had to be diverted to Raleigh to refuel. Strangely during ground stop, our connecting flight had no issue taking off on time causing us to miss our flight. We were told there were no other flights that day to our final destination and that two days out was the next one. The only flights to get us there were from Chicago the next morning. Completely opposite direction but it was a direct flight. So we get flown to Chicago and have to find a hotel in our own dime. The flight in the morning was also delayed. Thankfully only a short time. The non too of all this, our luggage did not arrive by the time we were there. Communication was terrible, through the entire trip. Complete incompetence. Will never fly American again.

I am an AA flyer for a very long time... AA has yet to disappoint.

Flight was delayed. Not much information on when the flight would take off. Eventually we were told it was maintenance. App was not giving updates.

Everything you need to know for your flight from Charleston to Des Moines

Information on your arrival and departure airports