$104 Find Cheap Flights from Charlotte to Des Moines - Compare and Save

Your flight ticket price will generally be cheaper if you fly to Des Moines on a Tuesday and more expensive on a Sunday. On your return trip to Charlotte, you should consider flying back on a Tuesday, and avoid Mondays for better deals.

The cheapest month for flights from Charlotte to Des Moines is September, where tickets cost $349 (return) on average. On the other hand, the most expensive months are July and June, where the average cost of round-trip tickets is $525 and $515 respectively.

In the past 5 days, the cheapest round-trip tickets from Charlotte to Des Moines were found on Delta ($207) and Southwest ($273).

There is just one airline that flies from Charlotte to Des Moines direct and that is American Airlines. The best round-trip deal found from American Airlines for the route is $335.

Chicago (MDW) is the top choice – 58% of KAYAK users who clicked on 1-stop flights from Charlotte to Des Moines picked an itinerary connecting there.

Flights via Chicago (MDW) offer the most affordable fares, with an average round-trip price of $384.

Consider flying via Detroit (DTW) for the shortest journey. The average one-way travel time for flights connecting there is 4h 38m.

If you prefer a quick connection, Detroit (DTW) often has the shortest layovers from Charlotte to Des Moines, with an average of 0h 52m.

There are 3 cabin class options for the route. These are First, Business and Economy. Perform a search on KAYAK to find the latest prices and availability for all cabin fares, which differ across airlines.

Each day, there are between 2 and 3 nonstop flights that take off from Charlotte and land in Des Moines, with an average flight time of 2h 27m. The most common departure time is 4:00 pm and most flights take off in the morning. Each week, there are 20 flights. The most frequent day of departure is Monday, when 15% of all weekly flights depart. The fewest flights depart on a Saturday.