$59 Find Cheap Flights from Chicago to Missouri - Compare and Save

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Cheap Flights from Chicago to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Sort by: Cheapest
Kirksville
Kirksville
1h 30mNonstop
from $119per person
St. Louis
1h 10mNonstop
from $149per person
Cape Girardeau
1h 35mNonstop
from $161per person
Joplin
2h 00mNonstop
from $241per person
Kansas City
1h 30mNonstop
from $243per person
Columbia
1h 30mNonstop
from $311per person
Springfield
1h 50mNonstop
from $327per person
Fort Leonard Wood
Fort Leonard Wood
15h 03m3 stops
from $724per person
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Booking Insights

Price, demand and travel trends for Chicago to Missouri flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What are the cheapest fares from Chicago to Missouri recently?

The cheapest fares from Chicago to Missouri on KAYAK in the last week were to Kirksville Cannon Memorial (IRK) from $119 round-trip and to Lambert-St Louis (STL) from $149 round-trip.

How do fares into airports in Missouri compare?

According to KAYAK data from the last 12 months, the cheapest airports to fly into Missouri from Chicago are:

• Kirksville Cannon Memorial (IRK) (avg. price $138)
• Cape Girardeau (CGI) (avg. price $177)
• Fort Leonard Wood Waynesville Regional (TBN) (avg. price $269)

Are flights from Chicago to Missouri cheaper or more expensive than last year?

Fares from Chicago to Missouri are about 3% lower than they were in November last year, averaging $304 round-trip.

What's the cheapest month to fly from Chicago to Missouri?

December is typically the cheapest month to fly from Chicago to Missouri, with round-trip fares averaging $300. June and July are usually the most expensive, averaging $405 and $404, respectively.

How do fares from Chicago to Missouri vary by day of the week?

On average, Saturday is the cheapest day to fly from Chicago to Missouri and Monday is the most expensive. Looking at the past 12 months of KAYAK data, it's 42% more expensive to fly on a Monday compared to Saturday.

What's the best time of day to fly from Chicago to Missouri?

It's cheapest to fly to Missouri in the morning with average prices of $357. The night is the most expensive time to fly, with average prices of $431.

What's the best time to book a flight from Chicago to Missouri?

Book your flights 19 weeks before your trip. KAYAK data collected over the past 12 months shows that booking in this window can save you around 54% compared to booking at the last minute (within 2 weeks of departure).

Key details for Chicago to Missouri flights

Low season

December

Cheapest flight

$59
Beat the crowds with an average 21% drop in travelers.
The most popular month to fly with an average 28% increase in travelers.
One-way flight from Chicago O'Hare Intl Airport to St. Louis

Your Chicago to Missouri flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Chicago to Missouri?

    Yes. Fares from Chicago to Missouri are low right now. As a rule of thumb, a round-trip under $268 (cheaper than most fares this year) is a good deal, so if you spot one at or below that, it's a good time to book.

  • How much should I budget for a flight from Chicago to Missouri?

    Over the past 12 months, round-trip fares from Chicago to Missouri have typically cost between $268 and $488.

  • What are the main airports serving Missouri?

    There are 11 airports in Missouri. 43% of KAYAK users choose Kansas City (MCI) as their arrival airport, while 33% choose Lambert-St Louis (STL).

  • Which airlines fly nonstop from Chicago to Missouri?

    Based on the flight schedule for the next 3 months, 4 airlines offer nonstop flights on this route:

    • United Airlines
    • American Airlines
    • Southwest
    • Contour

  • Which destinations in Missouri can I fly nonstop from Chicago?

    Based on the flight schedule for the next 3 months, you can fly nonstop from Chicago to 7 destinations in Missouri. The most popular among KAYAK travelers are Kansas City, St. Louis and Columbia.

  • Is it cheaper to fly with a layover from Chicago to Missouri?

    Yes, nonstop flights from Chicago to Missouri average $365 over the past 12 months, but flights with a layover can cost less. The most affordable connecting airports are:

    • Minneapolis St Paul (MSP) (avg. price $233)
    • Atlanta Hartsfield-Jackson (ATL) (avg. price $273)
    • Denver Intl (DEN) (avg. price $295)

  • How long is a flight from Chicago to Missouri?

    Nonstop flights from Chicago to Missouri take 1h 42m on average. The fastest scheduled flight takes 1h 10m, flying into Lambert-St Louis (STL).

  • Which cabin classes are available from Chicago to Missouri?

    On flights from Chicago to Missouri you can book Economy Class, Business Class or First Class.

  • What are some popular landmarks around Missouri?

    Missouri is home to many popular sights. KAYAK travelers' favorites include:

    • Busch Stadium
    • Arrowhead Stadium
    • Enterprise Center
    • Kansas City Convention Center

  • What are the earliest and latest flights from Chicago to Missouri?

    The earliest nonstop flight from Chicago to Missouri departs at 12:05 am and the latest leaves at 11:00 pm. Nonstop flights take about 1h 42m.

Your guide to booking Chicago to Missouri flights

Get tips on when to book, when to fly and what to know before your trip.
  • If you can plan ahead, the sweet spot for booking your flight is 19 weeks before your trip. KAYAK data shows fares in this window are around 54% lower than last-minute bookings (made within 2 weeks of departure). Not ready to commit? Set a Price Alert and we'll let you know when prices change.
  • Flexible with your dates? Fly in December to save some money. It's typically the cheapest month on this route, while flights in June will cost you the most.
  • Fly out on a Saturday to get the cheapest fares. Avoid Monday flights, which are about 42% more expensive.
  • If you're watching your budget, fly into Kirksville Cannon Memorial (IRK) which has the lowest average airfare in the region. Just remember to budget for any onward travel by bus, car or domestic flight.
  • Start your trip in St. Louis, the most popular destination in Missouri. From there, it's easy to continue on to other popular spots such as Kansas City, Branson and Springfield.
  • Time or money? If speed matters most, fly from Chicago to Lambert-St Louis (STL). If you're after the lowest fares, Kirksville Cannon Memorial (IRK) is usually your best bet.

Reviews of the top 5 airlines serving from Chicago to Missouri

 
Need help choosing which airline to fly with from Chicago to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4220 reviews
8.6Crew
8.1Boarding
7.5Entertainment
8.0Comfort
7.0Food
Airline reviews

Multiple delays due to weather in Chicago, but the crew did their best to get flights rescheduled and on to their destination. I felt like the crews handled a frustrating situation very well, kudos to them! I was very glad to not have a cancelled flight.

8.0 ExcellentEmmalee, Oct 2026
Read more Southwest reviews

Multiple delays due to weather in Chicago, but the crew did their best to get flights rescheduled and on to their destination. I felt like the crews handled a frustrating situation very well, kudos to them! I was very glad to not have a cancelled flight.

Southwest’s point to point system caused a 2 hour delay due to the crew being late from their inbound flight. Also, the WiFi and entertainment didn’t work on the plane.

A) Checked my luggage at the gate but never got to pre board B) if we are helping with checking our carryon and waiting 40 minutes for it we should have some privileges c) luggage took 40-45 minutes to come.. d) I asked for another snack and was told the plane is full.. seriously a small snack

I like the staff members they were super nice and helpful very sweet people :)

Boarding process of asking for volunteers to check bags goes against the system you had before with 2 bags checked free. This process is more of a guilt trip than a caring attitude toward the customer. In addition bag-size scrutiny has increased which also slows down the process of boarding. My wife said she will not fly on your airline again unless there is no other option.

Overall good, just screaming kids in the area the whole flight.

OKay. I sat in the back of the plane and it was really loud between babies and little kids, and adults who.like to talk a lot and loudly most of the flight.

The first time I flew in the extra legroom section. It was difficult to notice a difference. I had bad luck with my neighbors. The crew was okay. Southwest has reduced the live TV options.

I flew twice this week on Southwest, was delayed over 2 hours both ways. From Pittsburgh to Chicago it was due to weather but the gate agents, pilot etc were great at updating everyone. Today from Midway to Pittsburgh the plane had come from an international location, kept getting delayed, no information was given until we were delayed for the third time. It was ridiculous, whoever scheduled that plane to fly to Pittsburgh after didn’t consider a lot of things.

Flight was delayed by 12 minutes. Boarding wasn’t fun. The crew was nice though.

The crew was the friendly crew I’ve ever seen. After many many years. They were super friendly. They handed out candy for Halloween. They were just fantastic, which is so rare these days with flying not that other Cruz are not good. It’s just that these folks went above and beyond.

You could have NOT left me and my family high and dry by not completing the reservation changes because they no longer have the contract from Phoenix AZ to Moab Utah. There wasn't even a ticket agent for Contour in Phoenix to talk to. Cost my an additional $1600. to rent a vehicle to get my family to Utah. Now I'm left with trying to have someone make it right financially. I'm not optimistic..........

I’ve flown Contour on 4 different flights in the last couple weeks and every one of the flights were significantly delayed. Like over 2 hours delayed. 3 of the 4 were due to maintenance and one was weather, which is beyond their control. If this continues, I will not fly them anymore. It makes me concerned that they don’t have great maintenance practices. The planes are very old and worn out and the interiors need improvement. I do like the amount of space you have between seats for legroom. They also started charging for bags recently, which I think the did when they partnered up with American Airlines as a codeshare partner. American is also a disaster of an airline so I wish they had some agreement with Delta. I am glad they offer a major airline parternership though. That is certainly giving people more opportunities. I won’t fly Contour unless they have a direct flight to where I am going. If I have to connect then I am going to take Delta. The bus at the DFW airport to get on and off the aircraft is a pain and adds so much extra time to your travel experience. I hope this is temporary while they are building a new terminal, but I don’t know.

Love it. No Frills but better than Spirit No Frills. It's like a simple luxury private plane especially if you've got five or six people on it because then you probably got your own section of the plane.

Not on time. Taxied around the airport for 30 MINUTES! The pilot never said a word. Ai

My luggage is missing and contour is doing a terrible service helping finding it. Unbelievable and the worst experience ever. I would love get my money back.

Flight was fine. I just forgot how smaller planes have more dips and seats in high winds.

It’s the only flight connecting Marion to Chicago, I do appreciate that it was available!

The flight was delayed and then less than 30 mins before boarding they cancelled the flight when clearly they had to have known earlier that they were going to have to cancel. There was only one person there available to talk to and all he could do was tell us to call reservations our self. Due to high call volume I waited 2 hours to even get rebooked on a flight to a different city where I would still have to drive 1 hr to my destination, only option for me. While waiting to talk to reservations people were getting emails with new flight info and the flights were days out and sone even a week out. . I did not get compensated in anyway after having spent all day at the airpot, not even a food voucher. Very disappointed, terrible experience.

Information regarding the delayed flight could have been better, and the Contour airlines app needs some serious updates. But overall, the crew was great and the flight was uneventful.

Very uncomfortable and cramped seats. Everything else was okay, the crew members were nice but nothing was exceptional.

Waited on tarmac for approximately 15-25 minutes before taking off. When landing, the time it took to taxi to our gate was the also 15-25 minutes.

Connection times always good online, but not in reality when first leg is delayed (2 out of 2 times this trip).

It was good flight was smooth, little cold on the plane but other wise good.

Great flight and crew. Need more legroom and DO NOT allow seats to recline.

The guy in front of me was talking constantly, even when the pilot was making announcements. I found this very disrespectful to the pilot and to others.

Essy to get on. The hostess gave very little pop, the plane was late getting in, and we are still waiting for our bags. This sucks. :/

Excellent flight. Smooth, efficient boarding. Quick flight. Arrived early at STL.

Short flight - no food understandable. Flight was delayed for over an hour. Overall, it was good.

Last minute gate change nearly caused us to miss our flight. Change was not announced or displayed in the main board at the old gate. Terrible communication. When we landed we had to wait 20 minutes because there was another plane at the assigned gate. Not the crew’s fault, but adding 20 minutes to a 45 minute flight sucked.

All good. Flight crew was super friendly at the end of a long day

The food in first class has taken a big downturn

Flight was fine. Just delays leaving due to mechanical issues. But flight crew were kind and professional. Seats were spacious. American doesn't need to have 9 groups for boarding.

Both departure and return flights had mechanical delays. Their planes are antiquated resulting in a two hour flight taking almost four hours to complete.

Crew were helpful, pilot kept us informed about turbulence, snack choice was awesome!

It was one of the worst I have ever had. The plane was over booked, and I did not have a seat. When I questioned why because I had booked this weeks in advance. I was brushed off to be advised they are trying to find someone to give up their seat. Only to be advised I would be boarding last. I had priority boarding in group 1-4. When I asked why I had to be last because that is not what I paid for I was advised it doesn't matter you will get a seat. The ticket person was very rude and unprofessional. The gate changed several times and it was going from one area to another area far away from where we were at. I feel like I should have been compensated in some kind of way because of the way I was treated. The ticket agent acted like it was my fault that the plane was over booked. Not one time was I apologized to for this inconvenience.

I have posted the comments in the first flight leg.

Boarding delayed 20 minutes for no reason, no wifi, in flight entertainment, or snacks / waters?

I had a TERRIBLE experience with the AA crew. I believe it was disability-related. It’s unlikely I will fly AA again.

Flight departed on time. Boarding was easy and efficient. Arrived on time.

Flight was canceled. Most upsetting was message from Kayak, stating that the flight was canceled and click with Kayak for details regarding rebook, refund details. THERE'S NO INFORMATION PROVIDED BY KAYAK EXCEPT THAT FLIGHT IS CANCELED. AND NOW THIS SURVEY TO FIND OUT HOW WAS THE FLIGHT !!!!!!!

Better than expected. Staff were friendly and nice on both flights.

Just know that everything, and I mean everything is “ala cart”. 60$ just to put something in the overhead bin. I will never fly Frontier again nor do I recommend them to anyone else.

Great for the price. No wifi or entertainment, but gate agents and crew were fantastic and we boarded quickly and left on time.

Our flight was canceled for no known reason. We weren’t told until we were checking in at 5:00 am. This was after our last flight with Frontier where we sat on the plane for three hours (not an exaggeration) before we took off because of a mechanical issue. We won’t be flying Frontier again.

I didn’t have enough time to catch my connecting flight and had to use a different Airline. I will be requesting a refund.

I brought a ticket and car rental through Travelocity. There was no where to add a KTN. So I thought i’d add it by looking up ticket on frontier website. I tried 3 times with the frontier chat bot to add my KTN it never updated my boarding pass. So then I tried showing up early to do it in person at the airport. The first employee update my ktn in the system and gave me a new boarding pass. I was sent back by tsa to join regular line. Then I was told to add my Ktn. It would cost me $25 extra. Given the length of the cue I did pay. Congratulations! BUT I will NEVER fly frontier again. Plus the plane was very old. It had actual ashtrays and old looking tray backs. Worst travel experience ever. Im warning my friends and family not to use frontier ever.

It was delayed 9 hours for operational reasons, despite the plane arriving to the airport on time.

Was just ok with over selling I guess. A lot of people in a short space and when we finally arrive i20 minutes, waiting to get out from the plain because we were waiting authorization for out boarding? Something like that.

They changed my flight and did not want to accommodate me or try to help me in any way. They do not care about their customers.

More options for your flight from Chicago to Missouri

Complete your trip to Missouri with a hotel stay or car rental