DSM - BUF

$327 Find Cheap Flights from Des Moines to Buffalo

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 3/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Buffalo

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Buffalo, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Buffalo, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$327
American Airlines
Fri 3/27Wed 4/1
DSM - BUF • 1 stop
Cheapest one-way
$376
Typical prices: $241-$296
American Airlines
Thu 6/11
DSM - BUF • 1 stop
Top airlines
American Airlines
Cheapest • from $327 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Buffalo. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Detroit (DTW)
Cheapest • Avg $384 (round-trip)
Detroit (DTW)
Shortest trip • 4h 29m (one-way)
Insights
Insights
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Insights
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Buffalo!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Buffalo (DSM-BUF)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Buffalo that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Buffalo

Fri, Mar 27 - Wed, Apr 1
American Airlines Logo
10:04 am - 5:29 pm
DSM
-
BUF
6h 25m
1 stop
American Airlines Logo
5:29 pm - 10:10 pm
BUF
-
DSM
5h 41m
1 stop
$327American Airlines
Fri, Mar 27 - Wed, Apr 1
American Airlines Logo
5:00 am - 11:49 am
DSM
-
BUF
5h 49m
1 stop
American Airlines Logo
5:00 pm - 11:48 pm
BUF
-
DSM
7h 48m
2 stops
$332American Airlines
Fri, Mar 27 - Wed, Apr 1
American Airlines Logo
7:45 am - 3:25 pm
DSM
-
BUF
6h 40m
1 stop
American Airlines Logo
5:00 pm - 11:48 pm
BUF
-
DSM
7h 48m
2 stops
$357American Airlines
Fri, Mar 27 - Wed, Apr 1
American Airlines Logo
6:40 am - 11:49 am
DSM
-
BUF
4h 09m
1 stop
American Airlines Logo
5:29 pm - 10:10 pm
BUF
-
DSM
5h 41m
1 stop
$358American Airlines
Fri, Mar 27 - Wed, Apr 1
American Airlines Logo
5:00 am - 1:42 pm
DSM
-
BUF
7h 42m
2 stops
American Airlines Logo
5:00 pm - 11:48 pm
BUF
-
DSM
7h 48m
2 stops
$372American Airlines
Fri, Mar 27 - Wed, Apr 1
American Airlines Logo
6:40 am - 11:49 am
DSM
-
BUF
4h 09m
1 stop
American Airlines Logo
5:29 pm - 10:10 pm
BUF
-
DSM
5h 41m
1 stop
$383American Airlines
Tue, Jun 9 - Sat, Jun 13
Delta Logo
5:25 pm - 11:03 pm
DSM
-
BUF
4h 38m
1 stop
Delta Logo
6:00 am - 10:14 am
BUF
-
DSM
5h 14m
1 stop
$387Delta
Sat, Jun 6 - Thu, Jun 11
Delta Logo
12:29 pm - 6:56 pm
DSM
-
BUF
5h 27m
1 stop
Delta Logo
6:00 am - 10:14 am
BUF
-
DSM
5h 14m
1 stop
$397Delta
Sat, Aug 1 - Sat, Aug 8
Southwest Logo
5:10 am - 10:20 am
DSM
-
BUF
4h 10m
1 stop
Southwest Logo
7:50 am - 11:30 am
BUF
-
DSM
4h 40m
1 stop
$407Southwest
Sat, Aug 1 - Sat, Aug 8
Southwest Logo
5:10 am - 5:10 pm
DSM
-
BUF
11h 00m
2 stops
Southwest Logo
7:50 am - 11:30 am
BUF
-
DSM
4h 40m
1 stop
$422Southwest
Booking Insights

KAYAK's insights & trends for Des Moines to Buffalo flights

Get data-powered insights and trends into flights from Des Moines to Buffalo to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to Buffalo?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to Buffalo were found on American Airlines ($327) and Delta ($387).

Good to know

Low seasonOctober
Cheapest flight$327
Best time to beat the crowds with an average 41% drop in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from Des Moines to Buffalo

When to book flights from Des Moines to Buffalo

Are your dates flexible? Find out the best times to travel from Des Moines to Buffalo based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Buffalo

  • What is the cheapest flight from Des Moines to Buffalo?

    In the last 3 days, the lowest price for a flight from Des Moines to Buffalo was $376 for a one-way ticket and $327 for a round-trip.

  • Do I need a passport to fly between Des Moines and Buffalo?

    No, a passport isn't needed to fly from Des Moines to Buffalo. However, local authorities might ask for an official ID.

  • Which aircraft models fly most regularly from Des Moines to Buffalo?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Buffalo?

    Star Alliance, oneworld, and SkyTeam are the airline alliances operating flights between Des Moines and Buffalo, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Buffalo, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Buffalo are Delta and United Airlines. With an average price for the route of $332 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $463 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Des Moines to Buffalo?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Buffalo.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Buffalo?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Buffalo from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Buffalo?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Buffalo with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and BUF can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Buffalo?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Buffalo from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Des Moines to Buffalo

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Buffalo. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Buffalo? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8215 reviews
7.8Entertainment
8.1Boarding
8.5Crew
7.2Food
7.9Comfort
Airline reviews

Terrible. Four hour delay because Delta could not find crew to man the aircraft. Terrible communication. Terrible insight into the delays. One of the worst flight experiences I’ve had.

2.0 MediocreDonna, Feb 2026
DEN - LGA
Read more Delta reviews

Terrible. Four hour delay because Delta could not find crew to man the aircraft. Terrible communication. Terrible insight into the delays. One of the worst flight experiences I’ve had.

The crew, and fellow passengers, were super gracious and kind. There seemed to be plenty of bin space even though the plane was full. It’s nice to get a glass of wine with dinner in Premiere seating, and there was a lot of food.

Good experience and the flight landed early. There was no food I had or entertainment.

bulkhead seat had very little legroom - even in bsiness class.

This was one of the worst flights I’ve been on in years. I upgraded to comfort and had such an uncomfortable experience. The person next to me was oversized - which I understand - however, they took up their space and mine. I could only use about 50% of my seat space to not be physically touching this person the entire flight and there was no spatial awareness. I also could not use the seat outlet because their body was obstructing it. It was very inconvenient. Their body kept touching me repeatedly during the flight and I felt very uncomfortable. To pay more for an upgraded space and then not even being able to use it was highly disappointing.

Delta One is extraordinary. I fly business when somebody hires me. I just wonder why there is such a chasm between business class and the insanely inhumane and nonsensical coach. The seats are not large enough to fit even my tiny wife. We fly 10% of what we did because we don’t want to pay 5-10 k but for $400 it’s unbearable. It seems like the accountants took over and made stupid decisions. Screw in 20 extra seats and make it so unbearable that people fly 90% less. Just put the damn price up and put some proper chairs in. But business, yay.

Air travel sucks. It continues to be awful for all airlines. No shame on delta alone.

Delta canceled our flight and we had to scramble to find another airline to get home. Phoenix is not a delta hub so they didn’t have another plane. It would have been a red eye though Salt Lake City. Getting in at 5am. No bueno.

Flight delays both to Detroits and return flight . The flight to Detroit was associated with mechanical difficulty

The food is terrible. The staff is wonderful. Comfort is good.

Everything was great except for the boarding process. Everyone is lining up all at the same time and it’s hard to tell between the groups as they are way too large.

Women boarding passengers at the gate was absolutely rude and disrespectful of passengers. The flight attendant was absolutely delightful! Smiling and connected with the passengers. So happy. The seats are cramped and uncomfortable but I guess that’s just the way it is Communication regarding flight was excellent

Overall we had a good experience during our flight from San Francisco to Houston.

Airport terminal was outdated, flight was on a small jet with no wifi

We were delayed for about an hour from taking off due to traffic control procedures at the destination airport. But once in the air, the flight went well. The crew members were great and provided cabin service despite moderate turbulence during much of the flight.

it was a very short flight so my expectations were low.

As great a red-eye flight as red-eye flights can be.

Very old flight - time to retire it for newer airplanes

2+ hours delayed Outlet in row 12 did not work Tv monitors did not work Lights kept off the entire flight for at 5pm-7pm flight

Very disappointing given gate agent behavior. Filed a formal complaint with United.

There was free WiFi (definitely a plus), but the flight was delayed 45 minutes waiting on a catering truck that never arrived. The pilot said there would be food vouchers given out at the end of the gangway to make up for the inconvenience, but there was no one offering those. Delay made me late for work!

Overall it was a good flight. Because we traveled on a Saturday we were upgraded to FC since my wife and I are both Executive Platinum. The only areas for improvement we noted are better snack assortment and perhaps a little nicer plane as American is flying some older planes now. Everything else on this flight was excellent, which is frankly not the norm for American since we have had multiple issues on prior AA flights.

The smell from the bathroom kept wafting through the cabin. It made people sick.

The seats are too uncomfortable for anyone over 5ft 8in. I'm 5'10" with a back and hip issue and I was in pai for the full duration of the flight.

Delayed an hour due to operational issues. Minimal apologies or care for the significant inconvenience caused. Landed at nearly 1am and they still couldn’t find ground staff to get us off the plane promptly.

Long delays, lack of information about the status of the flight. The flight was delayed 4 times.

It was good. But the gate team made me check my carry on when there was plenty of space for my luggage on the plane. Otherwise our trip was fine.

Bags took over and hour to come out. Delays due to wind caused rebooking.

Gate was overcrowded. Gate agents performed very well. Flight crew was top notch! Efficient & professional & courteous. Both meals not thermalized well. Dinner main dish was actually cold in the center. Almost inedible. Breakfast sandwich was lukewarm.

RIC Staff was not enough. Elderly passengers had to wait 30 minutes to deplane, so we could board and still had to walk as no chairs were provided. And, passenger in front of my seat assignment rammed seat against my legs entire flight time. Was mildly bruised and left thigh still sore.

Everything you need to know for your flight from Des Moines to Buffalo

Information on your arrival and departure airports