DSM - BUF

$157 Find Cheap Flights from Des Moines to Buffalo - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 7/26. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Buffalo

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Buffalo, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Buffalo, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 21% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$335
Typical prices: $332-$341
American Airlines
Sat 8/8Sat 8/15
DSM - BUF • 1 stop
Cheapest one-way
$157
Multiple Airlines
Sun 7/26
DSM - BUF • 2 stops
Top airlines
Cheapest • from $335 (round-trip)
Best reviews • 7.8 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Buffalo. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $335 (round-trip)
Shortest trip • 3h 55m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 100% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Buffalo!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Buffalo (DSM-BUF)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Buffalo that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Buffalo

Sat, Aug 8 - Sat, Aug 15
American Airlines Logo
10:30 am - 5:09 pm
DSM
-
BUF
5h 39m
1 stop
American Airlines Logo
5:49 pm - 12:35 am
BUF
-
DSM
7h 46m
1 stop
$335American Airlines
Sat, Aug 8 - Sat, Aug 15
American Airlines Logo
7:00 am - 4:24 pm
DSM
-
BUF
8h 24m
2 stops
American Airlines Logo
5:49 pm - 12:35 am
BUF
-
DSM
7h 46m
1 stop
$367American Airlines
Mon, Sep 14 - Fri, Sep 18
American Airlines Logo
6:00 am - 12:42 pm
DSM
-
BUF
5h 42m
1 stop
American Airlines Logo
6:56 pm - 12:04 am
BUF
-
DSM
6h 08m
1 stop
$381American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
6:18 pm - 12:15 am
DSM
-
BUF
4h 57m
1 stop
American Airlines Logo
6:59 pm - 11:10 pm
BUF
-
DSM
5h 11m
1 stop
$385American Airlines
Mon, Sep 14 - Fri, Sep 18
United Airlines Logo
6:29 am - 2:18 pm
DSM
-
BUF
6h 49m
2 stops
United Airlines Logo
6:55 am - 10:26 am
BUF
-
DSM
4h 31m
1 stop
$386United Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
6:02 am - 2:19 pm
DSM
-
BUF
7h 17m
1 stop
American Airlines Logo
4:49 pm - 11:10 pm
BUF
-
DSM
7h 21m
1 stop
$388American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
6:02 am - 2:19 pm
DSM
-
BUF
7h 17m
1 stop
American Airlines Logo
4:49 pm - 11:10 pm
BUF
-
DSM
7h 21m
1 stop
$390American Airlines
Tue, Sep 1 - Wed, Sep 2
United Airlines Logo
3:20 pm - 9:07 pm
DSM
-
BUF
4h 47m
1 stop
United Airlines Logo
6:55 am - 12:20 pm
BUF
-
DSM
6h 25m
1 stop
$397United Airlines
Tue, Sep 1 - Wed, Sep 2
United Airlines Logo
5:45 am - 4:56 pm
DSM
-
BUF
10h 11m
2 stops
United Airlines Logo
6:55 am - 10:26 am
BUF
-
DSM
4h 31m
1 stop
$402United Airlines
Tue, Sep 1 - Wed, Sep 2
United Airlines Logo
5:45 am - 4:56 pm
DSM
-
BUF
10h 11m
2 stops
United Airlines Logo
10:30 am - 8:26 pm
BUF
-
DSM
10h 56m
2 stops
$407United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Buffalo flights

Get data-powered insights and trends into flights from Des Moines to Buffalo to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to Buffalo?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Buffalo departing in August.

What is the cheapest month to fly from Des Moines to Buffalo?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Buffalo, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Buffalo is November, where tickets cost $0 (return) on average. On the other hand, the most expensive months are March and May, where the average cost of round-trip tickets is $736 and $654 respectively.

Good to know

Low seasonOctober
Cheapest flight$157
Best time to beat the crowds with an average 43% drop in price.
Most popular time to fly and prices are also 32% lower on average.
Flight from Des Moines to Buffalo

When to book flights from Des Moines to Buffalo

Are your dates flexible? Find out the best times to travel from Des Moines to Buffalo based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Buffalo

  • What is the cheapest flight from Des Moines to Buffalo?

    In the last 5 days, the lowest price for a flight from Des Moines to Buffalo was $157 for a one-way ticket and $335 for a round-trip.

  • Do I need a passport to fly between Des Moines and Buffalo?

    No, a passport isn't needed to fly from Des Moines to Buffalo. However, local authorities might ask for an official ID.

  • Which aircraft models fly most regularly from Des Moines to Buffalo?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Buffalo?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between Des Moines and Buffalo, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Buffalo, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Buffalo are Delta and United Airlines. With an average price for the route of $332 and an overall rating of 7.8, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $436 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Des Moines to Buffalo?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Buffalo.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Buffalo?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Buffalo from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Buffalo?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Buffalo with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and BUF can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Buffalo?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Buffalo from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Des Moines to Buffalo

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Buffalo. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Buffalo? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8455 reviews
7.8Comfort
7.2Food
7.8Entertainment
8.1Boarding
8.5Crew
Airline reviews

The plane was old and thus the seats were not good. No cushion left whatsoever, and it all was a bit worn out.

6.0 GoodL, Jun 2026
MSP - JFK
Read more Delta reviews

The plane was old and thus the seats were not good. No cushion left whatsoever, and it all was a bit worn out.

flight was delayed 4+ hours. there was really no understanding of why? weather? the last hour of delay was post boarding. pilot seat was broken. was that the real reason? nonetheless, long day of inconveniences.

Horrible. Faucet in sink not working, wifi not working. Didn’t bring food or snacks

Gate agent showed up 20 minutes before boarding and was not at all friendly. Had to take this flight due to the one on the day before being cancelled and any later options were already full with long standby lists. Despite having paid for Delta Comfort seats, Delta did not allow me (or anyone) to choose their seat. The agent assigned them for everyone just prior to boarding. Self seat selection was allowed on the original flight. Flight staff was great - very friendly.

Be on time? When not on time a circling for over an hour offer more than 1 bag of chips to the passengers? It was a 7 hour flight by the time we got done.

Five hour delays every hour, I wish it were all at once

Left /arrived on time. Decent seat space. Like the wifi/plugs and entertainment. Windows and tray table were kinda gross. Attendants didn't start snack service til 40mins before landing. Two rows before us, captain came on to say there's turbulence and recalled staff to seats. So, no drink/snack. Later, attendants didn't stop to see if we had trash nor even look our way. Felt invisible! Almost all pilot announcements were not only unintelligible, but so quiet. We had no idea what she said.

Gate agent was unhelpful for handicapped boarding. Flight attendant seemed untrained.

Great overall. There was a bit of turbulence so they could only serve water because too much turbulence for the carts. Was glad they prioritized safety though

We flew early evening on New Year's Eve. Our plane was less than half full... Great for the passenger experience -- not so much for the airline lol. Comfortable, spacious, smooth flight -- and early arrival!

It would have been better if the crew has supported my husband's reasons for needing to keep the space clear around his feet, rather than insisting that he put his knapsack in that space.

Very rough getting into denver. my kid threw up it was so rough.

Evidently, my seat had the only broken TV. I couldn’t plug it in, get it to come on, or watch anything, and of course, no one could fix it while we were on the plane. The service was good and the boarding was quick

Delays from united along with Newark air space caused delays. But an average flight! Unfortunately we come to expect delays from the airlines.

Fast checkin with the self serve terminal, good communication at the boarding gate.

The plane’s radio wasn’t working. This delayed the plane for an hour and a half. Then we all broaded and taxied down the runway only to get called back because the radio was still not working. Had to get off the plane and then find another plane making the trip 4 hours delayed. Maybe a different plane should have been chosen sooner?!?!?!

Liked that we left on time for each flight. Snacks not the best, but we're okay.

There was no screens on board AND the WiFi didn’t work. My seat was broken and couldn’t recline so I couldn’t even sleep. The flight attendants didn’t offer anything to make it more comfortable. It was such an old cramped plane, when the person in front of me reclined I couldn’t even open my tray table. All the United ads talk about guaranteeing everyone gets a screen!

The Flight was good, pilot seemed very skillful. My wheel chair sister who could barely walk was allotted the second last seat in the aircraft, with great difficulty she managed to reach on her seat, as she required attendance we were given separate seat, even on request no one cared, so much so there were single passengers who were given twin seats. May not be taken as complaint but a reminder to the checkin staff to keep in mind in future the allottment of wheel chair passengers seats.

For each flight from Key West to Fort Lauderdale to Newark to Buffalo there were at least three delays at each leg of our trip. We were due to arrive home @11:37 but finally arrived @2:25 AM costing us an extra day at the car park. Seats are uncomfortable resulting in need to seek chiropractic care for backache. Upon deplaning my husband discovered someone had taken his clearly identified carryon from the overhead bin. I will not plan on flying again soon and not on United.

This flight moved Gates several times in a short time period, from B to C, which required a substantial walk or rail ride. Then the flight was delayed more than 2 hours and the food was subpar compared to other flights.

Excellent service. Flight attendance like Jessica,, on our flight, is a reason I wouldn’t mind flying through British Airways again. Jessica,, was very courteous and helpful.

Terrible boarding and first class experience. Nice staff but overall disorganized, dirty plane.

I almost missed my flight and they helped me out enormously

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

We liked quick boarding and on time departure. Seats were very uncomfortable.

It was quick, plane was loaded and the service on board was ok

Everything you need to know for your flight from Des Moines to Buffalo

Information on your arrival and departure airports