Find Cheap Flights from Des Moines to Buffalo (DSM - BUF)

Depart
Return
1 adult
Adults
18-64
Seniors
65+
Youths
12-17
Children
2-11
Seat Infants
under 2
Lap Infants
under 2
The price shown for each flight will be the average for all passengers including any infants.
Compare vs. KAYAK all | none
Browse Origins:
Browse Destinations:

Dates flexible? Here are the best fares found in the past 48 hours...

Book cheap flights from Des Moines to Buffalo

(Round-trip)
Depart: Tue Aug 15 2017 Return: Tue Aug 22 2017 Trip spans 8 days
American Airlines
American Airlines
DSM
11:20a
BUF
6:57p
7h 37m
1 stop
BUF
2:20a
DSM
10:07a
7h 47m
1 stop
Depart: Sat Aug 12 2017 Return: Tue Aug 22 2017 Trip spans 11 days
United
United
DSM
2:25p
BUF
6:59p
4h 34m
1 stop
BUF
10:00a
DSM
3:50p
5h 50m
1 stop
Depart: Wed Aug 16 2017 Return: Tue Aug 22 2017 Trip spans 7 days
Delta
Delta
DSM
2:00a
BUF
7:30a
5h 30m
1 stop
BUF
1:20p
DSM
5:36p
4h 16m
1 stop
Depart: Fri May 5 2017 Return: Sun May 7 2017 Trip spans 3 days
Major Airline
Major Airline
DSM
1:00a
BUF
1:32a
0h 32m
nonstop
BUF
9:00a
DSM
11:32a
2h 32m
nonstop
Depart: Mon Aug 14 2017 Return: Tue Aug 22 2017 Trip spans 9 days
American Airlines
American Airlines
DSM
3:31p
BUF
7:15p
3h 44m
1 stop
BUF
2:20a
DSM
10:07a
7h 47m
1 stop
Depart: Fri Aug 18 2017 Return: Tue Aug 22 2017 Trip spans 5 days
Delta
Delta
DSM
3:35a
BUF
10:21a
6h 46m
1 stop
BUF
1:20p
DSM
7:58p
6h 38m
1 stop
Depart: Thu Oct 19 2017 Return: Sun Oct 22 2017 Trip spans 4 days
United
United
DSM
4:09a
BUF
8:29a
4h 20m
1 stop
BUF
3:20a
DSM
7:20a
4h 00m
1 stop
Depart: Sat May 13 2017 Return: Tue May 16 2017 Trip spans 4 days
American Airlines
American Airlines
DSM
2:08a
BUF
6:14a
4h 06m
1 stop
BUF
12:58p
DSM
6:16p
5h 18m
1 stop
Depart: Sun Aug 13 2017 Return: Tue Aug 22 2017 Trip spans 10 days
Delta
Delta
DSM
2:30a
BUF
6:09a
3h 39m
1 stop
BUF
2:25a
DSM
8:01a
5h 36m
1 stop
Depart: Fri May 19 2017 Return: Sun May 28 2017 Trip spans 10 days
United
United
DSM
1:18a
BUF
5:04a
3h 46m
1 stop
BUF
6:45a
DSM
10:52a
4h 07m
1 stop
Depart: Tue Jul 11 2017 Return: Fri Jul 14 2017 Trip spans 4 days
American Airlines
American Airlines
DSM
11:25a
BUF
6:57p
7h 32m
1 stop
BUF
1:30a
DSM
5:39a
4h 09m
1 stop
Depart: Thu Aug 17 2017 Return: Tue Aug 22 2017 Trip spans 6 days
United
United
DSM
4:05a
BUF
8:29a
4h 24m
1 stop
BUF
10:00a
DSM
3:50p
5h 50m
1 stop
Depart: Fri May 12 2017 Return: Mon May 15 2017 Trip spans 4 days
Delta
Delta
DSM
7:30a
BUF
1:23p
5h 53m
1 stop
BUF
12:35p
DSM
8:00p
7h 25m
1 stop
Depart: Thu Jun 22 2017 Return: Mon Jun 26 2017 Trip spans 5 days
Major Airline
Major Airline
DSM
2:00a
BUF
2:32a
0h 32m
1 stop
BUF
2:00a
DSM
4:32a
2h 32m
1 stop
Depart: Fri May 26 2017 Return: Mon May 29 2017 Trip spans 4 days
Delta
Delta
DSM
2:30a
BUF
6:13a
3h 43m
1 stop
BUF
2:30a
DSM
6:36a
4h 06m
1 stop
Depart: Thu Jul 13 2017 Return: Tue Jul 18 2017 Trip spans 6 days
American Airlines
American Airlines
DSM
11:25a
BUF
6:57p
7h 32m
1 stop
BUF
4:40a
DSM
11:48a
7h 08m
1 stop
Depart: Tue May 9 2017 Return: Mon May 15 2017 Trip spans 7 days
Delta
Delta
DSM
6:17a
BUF
11:58a
5h 41m
1 stop
BUF
12:35p
DSM
8:00p
7h 25m
1 stop
Depart: Thu May 18 2017 Return: Sun May 21 2017 Trip spans 4 days
Delta
Delta
DSM
1:45a
BUF
7:55a
6h 10m
1 stop
BUF
2:00a
DSM
6:36a
4h 36m
1 stop
* Prices are per person and are for e–tickets and include all taxes & fees in USD.

We attempt to get accurate prices, however, prices are not guaranteed.

Here's why:

We’re not the seller.
At KAYAK we don’t set the prices, so it’s not possible for us to guarantee what other companies are selling.

We compile tonnes of data for you
Our service lets you quickly and easily compare results from hundreds of travel sites at once. In this sense, KAYAK is a search engine and we can't guarantee prices we find.

Why aren’t prices accurate 100% of the time?
Prices on airline seats, hotel rooms and car rentals can change frequently. Several people may also be trying to buy the same travel option simultaneously. As a result, you may find, on occasion, that certain prices are no longer available.

If you have more questions or if you have a bad price to report to us,
please send us an email and someone from our team will get back to you promptly.

Airports
Origin

Des Moines
$337
Destination

Buffalo
$337