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DSM - BUF

$325 Find Cheap Flights from Des Moines to Buffalo - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$325
Typical prices: $324-$540
American Airlines
Sun 11/11Wed 11/14
DSM - BUF • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Buffalo. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
August
Cheapest • 17% price drop
March
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Detroit Metropolitan Wayne County (DTW)
Cheapest • Avg $374 (round-trip)
Chicago Midway (MDW)
Shortest trip • 4h 14m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Des Moines to Buffalo (DSM-BUF)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Buffalo

Wed, Nov 11 - Sat, Nov 14
American Airlines Logo
6:00 am - 11:40 amDSM  Des Moines-BUF Buffalo
4h 40m1 stop Washington, D.C. Reagan-National
American Airlines Logo
6:46 pm - 12:26 amBUF  Buffalo-DSM Des Moines
6h 40m1 stop Chicago O'Hare Intl
$325American Airlines
Wed, Nov 11 - Fri, Nov 13
United Airlines Logo
1:27 pm - 10:33 pmDSM  Des Moines-BUF Buffalo
8h 06m1 stop Denver Intl
United Airlines Logo
5:58 pm - 10:59 pmBUF  Buffalo-DSM Des Moines
6h 01m1 stop Chicago O'Hare Intl
$325United Airlines
Wed, Nov 11 - Fri, Nov 13
Southwest Logo
6:00 am - 10:40 amDSM  Des Moines-BUF Buffalo
3h 40m1 stop Chicago Midway
Southwest Logo
7:10 pm - 11:05 pmBUF  Buffalo-DSM Des Moines
4h 55m1 stop Chicago Midway
$325Southwest
Wed, Nov 11 - Fri, Nov 13
Southwest Logo
6:00 am - 10:40 amDSM  Des Moines-BUF Buffalo
3h 40m1 stop Chicago Midway
Southwest Logo
12:40 pm - 11:05 pmBUF  Buffalo-DSM Des Moines
11h 25m2 stops Tampa Chicago Midway
$330Southwest
Wed, Nov 11 - Sat, Nov 14
American Airlines Logo
1:58 pm - 9:37 pmDSM  Des Moines-BUF Buffalo
6h 39m1 stop Chicago O'Hare Intl
American Airlines Logo
5:19 pm - 12:26 amBUF  Buffalo-DSM Des Moines
8h 07m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$330American Airlines
Sun, Nov 8 - Tue, Nov 10
United Airlines Logo
1:27 pm - 10:33 pmDSM  Des Moines-BUF Buffalo
8h 06m1 stop Denver Intl
United Airlines Logo
5:58 pm - 9:55 pmBUF  Buffalo-DSM Des Moines
4h 57m1 stop Chicago O'Hare Intl
$333United Airlines
Wed, Nov 11 - Fri, Nov 13
American Airlines Logo
1:58 pm - 11:59 pmDSM  Des Moines-BUF Buffalo
9h 01m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
American Airlines Logo
5:13 am - 1:28 pmBUF  Buffalo-DSM Des Moines
9h 15m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$335American Airlines
Wed, Nov 11 - Fri, Nov 13
Southwest Logo
6:00 am - 4:30 pmDSM  Des Moines-BUF Buffalo
9h 30m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
12:40 pm - 11:05 pmBUF  Buffalo-DSM Des Moines
11h 25m2 stops Tampa Chicago Midway
$335Southwest
Wed, Nov 11 - Sat, Nov 14
American Airlines Logo
1:58 pm - 11:59 pmDSM  Des Moines-BUF Buffalo
9h 01m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
American Airlines Logo
10:20 am - 6:53 pmBUF  Buffalo-DSM Des Moines
9h 33m2 stops Boston Logan Intl Chicago O'Hare Intl
$335American Airlines
Sun, Nov 8 - Tue, Nov 10
Southwest Logo
5:25 am - 10:25 amDSM  Des Moines-BUF Buffalo
4h 00m1 stop Chicago Midway
Southwest Logo
3:55 pm - 10:05 pmBUF  Buffalo-DSM Des Moines
7h 10m2 stops Baltimore/Washington Chicago Midway
$338Southwest
Booking Insights

Price, demand and travel trends for Des Moines to Buffalo flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Des Moines to Buffalo?

Round-trip flights from Des Moines to Buffalo typically range from $324 to $540. The lowest price found in the past 5 days was $325, on American Airlines.

What's the cheapest day of the week to fly from Des Moines to Buffalo?

Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Des Moines to Buffalo. It’s 20% cheaper than the average day, while Sunday is the most expensive, with prices 63% higher.

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Key details for Des Moines to Buffalo flights

Low season

December

Cheapest flight

$325
Beat the crowds with an average 13% drop in travelers.
Round-trip flight from Des Moines to Buffalo

When to book flights from Des Moines to Buffalo

Are your dates flexible? Find out the best times to travel from Des Moines to Buffalo based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Des Moines to Buffalo flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Des Moines to Buffalo?

    Only Economy Class is available on flights from Des Moines to Buffalo.

  • How long is a flight from Des Moines to Buffalo?

    A nonstop flight from Des Moines to Buffalo takes 00m, covering 768 miles.

  • Do I need a passport to fly from Des Moines to Buffalo?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Des Moines to Buffalo flight?

    Round-trip flights from Des Moines to Buffalo range from $324 to $540, with an average of $388 over the past 12 months. Anything below $324 counts as a good deal.

  • Have flight prices from Des Moines to Buffalo changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $325 to $1,181. That means the highest observed fare was about 4x higher than the lowest one.

  • What car rental options are available at Buffalo Airport (BUF)?

    Buffalo Airport (BUF) hosts 5 major car rental companies, with daily rates starting from around $19 for economy cars. Top options include:

    • Dollar
    • Budget
    • Hertz
    • Thrifty
    • Alamo

  • Which airports can I use when flying from Des Moines to Buffalo?

    Flights from Des Moines to Buffalo usually depart from Des Moines (DSM) and arrive at Buffalo (BUF).

  • Which airports do connecting flights from Des Moines to Buffalo pass through?

    One-stop flights from Des Moines to Buffalo most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 64% of one-stop connections
    • Detroit Metropolitan Wayne County (DTW) - 18% of one-stop connections
    • Philadelphia (PHL) - 9% of one-stop connections
    • Charlotte Douglas (CLT) - 5% of one-stop connections

  • Can I save money by using flexible dates for flights from Des Moines to Buffalo?

    Yes. Flexible dates can save you up to 51% on flights from Des Moines to Buffalo. Saturday is the cheapest departure day at $313 round-trip on average, while Sunday is the most expensive at $636, a difference of $323.

    Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • How much time can I save by choosing a different layover airport from Des Moines to Buffalo?

    Flying via Chicago Midway (MDW) gives the shortest average 1-stop total travel time at 4h 14m, compared with 4h 36m via Detroit Metropolitan Wayne County (DTW) and 4h 55m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Des Moines and Buffalo?

    Buffalo is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Des Moines to Buffalo flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Saturday departure and avoid flying on Sunday. On this route, Saturday flights average $313, about $323 less than Sunday fares (51% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Des Moines to Buffalo trip for August. Fares historically average $324 round-trip in that month - typically $412 less than the most expensive month, which is March (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Buffalo Airport.

    • Aloft Buffalo Airport
    • Comfort Inn and Suites Buffalo Airport
    • TownePlace Suites by Marriott Buffalo Airport

More options for your flight from Des Moines to Buffalo

Complete your trip to Buffalo with a hotel stay or car rental

Car rentals in Buffalo
Hotels in Buffalo
Vacations in Buffalo