DSM - BUF
$199 Find Cheap Flights from Des Moines to Buffalo - Compare and Save
This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 12/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
Everything you should know
Cheapest round-trip
$325
Typical prices: $317-$463
Southwest
Sun 11/11Wed 11/14
DSM - BUF • 1 stop
Cheapest one-way
$199
Typical prices: $209-$313
Southwest
Sat 12/22
DSM - BUF • 1 stop
Flight Deals
Cheap Flights from Des Moines to Buffalo (DSM-BUF)
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Buffalo that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.
Recent round-trip flight deals from Des Moines to Buffalo
Wed, Nov 11 - Sat, Nov 14
3:30 pm - 8:55 pmDSM Des Moines-BUF Buffalo
4h 25m1 stop Chicago Midway
4:35 pm - 7:45 pmBUF Buffalo-DSM Des Moines
4h 10m1 stop Chicago Midway
$325Southwest
Sat, Oct 31 - Mon, Nov 2
9:26 am - 5:08 pmDSM Des Moines-BUF Buffalo
6h 42m1 stop Chicago O'Hare Intl
4:16 pm - 12:26 amBUF Buffalo-DSM Des Moines
9h 10m2 stops Boston Logan Intl Chicago O'Hare Intl
$330American Airlines
Wed, Nov 11 - Sat, Nov 14
7:23 am - 5:26 pmDSM Des Moines-BUF Buffalo
9h 03m2 stops Chicago O'Hare Intl New York LaGuardia
7:57 am - 1:28 pmBUF Buffalo-DSM Des Moines
6h 31m1 stop Chicago O'Hare Intl
$330American Airlines
Sat, Oct 31 - Mon, Nov 2
7:29 am - 5:56 pmDSM Des Moines-BUF Buffalo
9h 27m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
4:16 pm - 12:26 amBUF Buffalo-DSM Des Moines
9h 10m2 stops Boston Logan Intl Chicago O'Hare Intl
$335American Airlines
Wed, Nov 11 - Sat, Nov 14
7:23 am - 5:26 pmDSM Des Moines-BUF Buffalo
9h 03m2 stops Chicago O'Hare Intl New York LaGuardia
10:20 am - 6:53 pmBUF Buffalo-DSM Des Moines
9h 33m2 stops Boston Logan Intl Chicago O'Hare Intl
$335American Airlines
Wed, Nov 11 - Fri, Nov 13
1:27 pm - 10:33 pmDSM Des Moines-BUF Buffalo
8h 06m1 stop Denver Intl
5:58 pm - 10:59 pmBUF Buffalo-DSM Des Moines
6h 01m1 stop Chicago O'Hare Intl
$350United Airlines
Sat, Oct 31 - Mon, Nov 2
3:01 pm - 9:29 pmDSM Des Moines-BUF Buffalo
5h 28m1 stop Washington, D.C. Reagan-National
6:46 pm - 12:26 amBUF Buffalo-DSM Des Moines
6h 40m1 stop Chicago O'Hare Intl
$350American Airlines
Wed, Nov 11 - Fri, Nov 13
7:23 am - 5:26 pmDSM Des Moines-BUF Buffalo
9h 03m2 stops Chicago O'Hare Intl New York LaGuardia
4:16 pm - 12:26 amBUF Buffalo-DSM Des Moines
9h 10m2 stops Boston Logan Intl Chicago O'Hare Intl
$360American Airlines
Fri, Oct 30 - Mon, Nov 2
6:05 am - 2:27 pmDSM Des Moines-BUF Buffalo
7h 22m1 stop Philadelphia
4:16 pm - 12:26 amBUF Buffalo-DSM Des Moines
9h 10m2 stops Boston Logan Intl Chicago O'Hare Intl
$376American Airlines
Wed, Nov 11 - Fri, Nov 13
6:00 am - 10:40 amDSM Des Moines-BUF Buffalo
3h 40m1 stop Chicago Midway
7:10 pm - 11:05 pmBUF Buffalo-DSM Des Moines
4h 55m1 stop Chicago Midway
$397Southwest
Recent one-way flight deals from Des Moines to Buffalo
Tue, Dec 22
5:10 am - 10:05 amDSM Des Moines-BUF Buffalo
3h 55m1 stop Chicago Midway
$199Southwest
Tue, Dec 22
5:10 am - 2:50 pmDSM Des Moines-BUF Buffalo
8h 40m2 stops Chicago Midway Baltimore/Washington
$204Southwest
Wed, Dec 23
6:15 am - 11:27 amDSM Des Moines-BUF Buffalo
4h 12m1 stop Detroit Metropolitan Wayne County
$209Delta
Wed, Dec 23
9:53 am - 10:07 pmDSM Des Moines-BUF Buffalo
11h 14m2 stops Chicago O'Hare Intl New York LaGuardia
$258American Airlines
Wed, Dec 23
4:19 pm - 5:33 pmDSM Des Moines-BUF Buffalo
48h 14m3 stops Nashville Intl Orlando Atlanta Hartsfield-Jackson
$291Multiple Airlines
Tue, Dec 22
7:30 am - 4:46 pmDSM Des Moines-BUF Buffalo
32h 16m3 stops Austin Bergstrom Atlanta Hartsfield-Jackson Tampa
$327Multiple Airlines
Recent last minute flight deals from Des Moines to Buffalo
Sat, Oct 10 - Tue, Oct 13
9:00 am - 11:58 amDSM Des Moines-BUF Buffalo
25h 58m2 stops Orlando Sanford Intl Raleigh-Durham
6:51 pm - 11:55 amBUF Buffalo-DSM Des Moines
18h 04m1 stop Orlando
$635Multiple Airlines
Sat, Oct 10 - Tue, Oct 13
9:26 am - 5:08 pmDSM Des Moines-BUF Buffalo
6h 42m1 stop Chicago O'Hare Intl
4:24 pm - 9:24 pmBUF Buffalo-DSM Des Moines
6h 00m1 stop Charlotte Douglas
$807American Airlines
Sat, Oct 10 - Tue, Oct 13
8:00 am - 7:07 pmDSM Des Moines-BUF Buffalo
10h 07m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
3:05 pm - 9:23 pmBUF Buffalo-DSM Des Moines
7h 18m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
$817United Airlines
Sat, Oct 10 - Tue, Oct 13
8:00 am - 7:12 pmDSM Des Moines-BUF Buffalo
10h 12m3 stops Chicago O'Hare Intl Washington, D.C. Reagan-National Newark
6:30 am - 5:48 pmBUF Buffalo-DSM Des Moines
12h 18m2 stops Newark Chicago O'Hare Intl
$1,103United Airlines
Booking Insights
Price, demand and travel trends for Des Moines to Buffalo flights
Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.
Prices
Airlines
Layovers
How much is a round-trip flight from Des Moines to Buffalo?
This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Buffalo departing in november.
Round-trip flights from Des Moines to Buffalo typically range from $317 to $463. The lowest price found in the past 5 days was $325, on Southwest.
What’s the most popular layover airport when flying from Des Moines to Buffalo?
KAYAK data for 1-stop round-trips over the past 3 months. Only counts itineraries with the same layover on both legs.Chicago O'Hare Intl (ORD) is the most popular layover for the Des Moines to Buffalo route. 53% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via ORD.
What is the cheapest layover airport when flying from Des Moines to Buffalo?
Flights via Detroit Metropolitan Wayne County (DTW) offer the most affordable fares, with an average round-trip price of $343. Based on KAYAK data over the past 3 months.
Key details for Des Moines to Buffalo flights
Low season | February |
|---|---|
High season | August |
Cheapest flight | $199 |
When to book flights from Des Moines to Buffalo
Are your dates flexible? Find out the best times to travel from Des Moines to Buffalo based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.
Your Des Moines to Buffalo flight questions, answered
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Your guide to booking Des Moines to Buffalo flights
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Cabin class types available on flights from Des Moines to Buffalo
Cabin classes available on flights from Des Moines to Buffalo. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
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Flights from domestic origins to Buffalo
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Flights to other popular destinations
The most popular flights on KAYAK according to clicks in the last 2 weeks. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.