$79 Find Cheap Flights from Des Moines to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Missouri departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
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Cheap Flights from Des Moines to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis1 stop$191
Kansas City
Kansas City2 stops$296
St. Louis
St. Louis1 stop$191
Kansas City
Kansas City2 stops$296

Book Cheap Des Moines to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Missouri

Thu, Feb 26 - Sat, Feb 28
American Airlines Logo
7:44 pm - 11:48 pm
DSM
-
STL
4h 04m
1 stop
American Airlines Logo
6:36 pm - 11:40 pm
STL
-
DSM
5h 04m
1 stop
$191American Airlines
Fri, Feb 27 - Fri, Mar 6
Frontier Logo
7:59 pm - 1:56 pm
DSM
-
STL
17h 57m
1 stop
Frontier Logo
8:12 pm - 7:16 pm
STL
-
DSM
23h 04m
1 stop
$193Frontier
Mon, Mar 2 - Thu, Mar 5
Delta Logo
10:57 am - 8:43 pm
DSM
-
STL
9h 46m
2 stops
Delta Logo
6:10 am - 10:17 am
STL
-
DSM
4h 07m
1 stop
$196Delta
Tue, Mar 3 - Wed, Mar 4
United Airlines Logo
3:24 pm - 9:05 pm
DSM
-
STL
5h 41m
1 stop
United Airlines Logo
6:00 pm - 11:43 pm
STL
-
DSM
5h 43m
1 stop
$237United Airlines
Fri, Feb 27 - Fri, Mar 6
Frontier Logo
7:59 pm - 11:59 pm
DSM
-
STL
28h 00m
2 stops
Frontier Logo
8:12 pm - 7:16 pm
STL
-
DSM
23h 04m
1 stop
$251Frontier
Thu, May 14 - Sat, May 16
Delta Logo
6:20 am - 1:17 pm
DSM
-
STL
6h 57m
1 stop
Delta Logo
5:30 pm - 9:17 pm
STL
-
DSM
3h 47m
1 stop
$254Delta
Mon, Mar 2 - Thu, Mar 5
Southwest Logo
5:20 am - 6:40 am
DSM
-
STL
1h 20mnonstop
Southwest Logo
5:30 am - 12:10 pm
STL
-
DSM
6h 40m
1 stop
$266Southwest
Sun, Feb 15 - Thu, Feb 19
Multiple Airlines Logo
9:00 am - 9:53 am
DSM
-
MCI
24h 53m
2 stops
Multiple Airlines Logo
8:28 pm - 6:19 pm
MCI
-
DSM
21h 51m
1 stop
$296Multiple Airlines
Fri, Feb 27 - Sun, Mar 1
Southwest Logo
5:10 am - 11:10 am
DSM
-
MCI
6h 00m
1 stop
Southwest Logo
5:45 am - 10:55 am
MCI
-
DSM
5h 10m
1 stop
$367Southwest
Sun, Feb 22 - Thu, Feb 26
United Airlines Logo
3:24 pm - 3:45 pm
DSM
-
MCI
24h 21m
1 stop
United Airlines Logo
9:12 am - 8:07 pm
MCI
-
DSM
10h 55m
1 stop
$593United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Missouri flights

Get data-powered insights and trends into flights from Des Moines to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Des Moines to Missouri flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Missouri from Des Moines found in the last 72 hours was to St. Louis, at $281 round-trip. The most popular route is from Des Moines (DSM) to St. Louis (STL), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $281.

Can I save money by flying with a layover from Des Moines to Missouri?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $297 on average.

What’s the cheapest day of the week to fly from Des Moines to Missouri?

The average price of all round-trip flights from Des Moines to Missouri clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Missouri on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Sunday is the most expensive day to fly from Des Moines to Missouri. For your return ticket, we recommend flying on a Wednesday and avoiding Sundays for the best deals.

Good to know

Low seasonJune
Cheapest flight$59
Best time to beat the crowds with an average 8% drop in price.
Most popular time to fly and prices are also 7% lower on average.
Flight from Des Moines to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Des Moines to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Missouri?

    The cheapest time of day to fly to Missouri is generally in the evening, when round-trip flights cost $383 on average. Morning departures are around 4% more expensive than evening flights, on average. The most expensive time of day to fly to Missouri is generally in the morning, which is peak travel time and where the average cost of a ticket is $399.

Top tips for finding cheap flights to Missouri

  • Looking for a cheap flight? 25% of our users found tickets from Des Moines to the following destinations at these prices or less: St. Louis $218 one-way - $349 round-trip

Reviews of the top 3 airlines serving from Des Moines to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4273 reviews
7.0Food
7.5Entertainment
8.0Comfort
8.6Crew
8.1Boarding
Airline reviews

Flight attendants very hospitable and friendly. Pilot flew a smooth take off and landing.

10.0 ExcellentAnonymous, Feb 2026
MSY - PHX
Read more Southwest reviews

Flight attendants very hospitable and friendly. Pilot flew a smooth take off and landing.

Paid for premium extra leg room but the bin space for rows 1-3 had to go in rows 4-6 and 4-6 had to go to 7-9 because flight attendants have snacks and their luggage upfront. So we pay extra to have to fight thru traffic to get our bags. Only 2nd day of new seating so hope they fix this.

WIFI was great. My selection for seating is an aisle, but during my trip, I never had an aisle seat. If we can get that corrected, I will be thrilled. No snack or drink on this flight.

WIFI was great. My selection for seating is an aisle, but during my trip, I never had an aisle seat. If we can get that corrected, I will be thrilled.

The wifi on the plane is great. The only issue that I have is that I prefer an aisle seat and on my trips this week, I was either in the middle or window. If we can work to secure aisle seating, I will be thrilled. Nice trip.

All good except once again bags took an hour at Midway Airport Happens all the time. Ridiculous

Everything went smoothly and we even arrived a little bit early.

Great vacation. Can't wait till next year for another one.

Great flight but super high price. Glad it was a business trip and not personal

On time. Friendly staff. Took to long to pre bord all the specialty groups. Cramped small plane

The attendant on board was amazing. She should be doing business/first international long haul.

I was fully checked in the prior night and i was unchecked and then didn’t have a seat when I boarded. Instead of an aisle seat, I was out in the middle seat of the very last row of the plane.

In overall it was a good experience, the only down point was that the entertainment screen was working properly.

HORRIBLE, my initial flight was cancelled, they made me pay $200 extra dollars and that got cancelled as well! After 6 cancellations I decided to get a refund because I needed to get home to my babies. Out of $1000+ dollars they offered me only $40 in refund! Totally unacceptable! The flight that they cancelled I was able to fly it on another airline. I had to spend $400 on one way tickets just to get home! I’m still getting the runaround.

First class ticket gets you a choice of chips or nuts. . Just like economy Southwest. Also no screen in the seats. This is first class???!

Seated dude next to me even though lots of empty rows. But main thing was we sat on the tarmac after landing for 30 minutes because of, in the words of the dude who sat next to me, “operational incompetence”. We got changing directions about where to pick up gate checked bags. Pilot and flight attendant were awesome though.

It was a pretty standard flight... until the almost hour and a half spent on the taxi way. I get that the weather has been poor but the delay had nothing to do with the weather and more to do with a plane with several issues tying up the gate. I get that that happens from time to time but this has been EVERY flight I've been on for the past 5 years and I fly 3 to 5 times a year. This isn't just United... it's American, it's Delta. It's an issue with the entire industry. I work for UPS and packages on a cargo plane get better service than people do these days. Anymore I HATE flying.

Flight arrived 30 min early and bag was waiting at the baggage pickup. United Club HNL was one of the nicest in the system

Unfortunately weather delayed our flight waiting for our plane to arrive and due to a little snow time was needed to deice the plane so departure was very delayed and I missed the connecting flight

Very good. Because of the delays with my previous flight, I missed my connection, but I was able to book another flight through the United app easily.

Update to handle the delay was very bad, crews no smiles or welcome or thanks. Don’t care attitude

It would be nice to have some low carb options in the snacks.

I was trying to take 2 one and a half hour one way trips and I experienced almost 20 delays over the course of those two trips. Only a few of them were due to weather the rest was disorganization

No gates avail at DFW so our incoming had to wait 30 mins for a plane to push back because they Had mechanical. We boarded 90 mins delayed and then we had a mechanical. Come on American…do better. Also at my seat the tray table had not been cleaned. Floor had not been cleaned. But captain and flight Att were very picture and apologetic.

Crew was helpful and cheerful especially when they had no refreshments to work with. The plane was never serviced and had nothing but limited water and coffee onboard. For the price point, a concern of services.

Flight was smooth, quick and felt safe. The 2 delays not happening would have been better but I guess that happens in the airline industry

Flight was canceled. I asked to be rerouted to OKC and then took an Uber.

AA did not allow to board a flight because my connecting flight from DFW had been canceled. I got on another flight to another city. No service on the plane and I did not use their entertainment system.

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

Don't change gate multiple times make people run across the airport. Announce delays in a timely manner. Have maintenance crew ready. Don't delay and keep passengers on the plane for 3 hrs. on tarmac.

Everything you need to know for your flight from Des Moines to Missouri

Information on your arrival and departure airports