$79 Find Cheap Flights from Des Moines to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Missouri departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
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Cheap Flights from Des Moines to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis1 stop$159
Kansas City
Kansas City1 stop$278
St. Louis
St. Louis1 stop$159
Kansas City
Kansas City1 stop$278

Book Cheap Des Moines to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Missouri

Fri, Jan 30 - Fri, Feb 6
Delta Logo
11:26 am - 5:50 pm
DSM
-
STL
6h 24m1 stop
Delta Logo
6:10 am - 10:19 am
STL
-
DSM
4h 09m1 stop
$159Delta
Thu, Jan 22 - Mon, Jan 26
Delta Logo
10:21 am - 4:37 pm
DSM
-
STL
6h 16m1 stop
Delta Logo
6:35 am - 3:41 pm
STL
-
DSM
9h 06m2 stops
$164Delta
Thu, Jan 22 - Mon, Jan 26
Delta Logo
10:59 am - 8:43 pm
DSM
-
STL
9h 44m2 stops
Delta Logo
6:35 am - 3:41 pm
STL
-
DSM
9h 06m2 stops
$169Delta
Thu, Jan 22 - Mon, Jan 26
Delta Logo
6:24 am - 5:50 pm
DSM
-
STL
11h 26m2 stops
Delta Logo
9:59 am - 8:54 pm
STL
-
DSM
10h 55m2 stops
$170Delta
Thu, Jan 22 - Mon, Jan 26
Southwest Logo
3:20 pm - 4:35 pm
DSM
-
STL
1h 15mnonstop
Southwest Logo
10:15 am - 11:25 am
STL
-
DSM
1h 10mnonstop
$171Southwest
Thu, Jan 22 - Mon, Jan 26
Southwest Logo
8:35 am - 1:55 pm
DSM
-
STL
5h 20m1 stop
Southwest Logo
10:15 am - 11:25 am
STL
-
DSM
1h 10mnonstop
$181Southwest
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
3:35 pm - 9:13 pm
DSM
-
STL
5h 38m1 stop
United Airlines Logo
6:00 pm - 11:44 pm
STL
-
DSM
5h 44m1 stop
$241United Airlines
Sun, Jan 25 - Sun, Feb 1
Multiple Airlines Logo
3:53 pm - 8:52 am
DSM
-
MCI
16h 59m1 stop
Multiple Airlines Logo
11:26 am - 10:46 pm
MCI
-
DSM
11h 20m1 stop
$278Multiple Airlines
Sun, Jan 25 - Sun, Feb 1
Multiple Airlines Logo
3:53 pm - 8:52 am
DSM
-
MCI
16h 59m1 stop
Multiple Airlines Logo
11:26 am - 10:19 am
MCI
-
DSM
22h 53m2 stops
$284Multiple Airlines
Sat, Jan 31 - Wed, Feb 4
United Airlines Logo
7:50 am - 9:59 pm
DSM
-
MCI
14h 09m1 stop
United Airlines Logo
8:00 am - 9:50 pm
MCI
-
DSM
13h 50m1 stop
$510United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Missouri flights

Get data-powered insights and trends into flights from Des Moines to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Des Moines to Missouri flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Missouri from Des Moines found in the last 72 hours was to St. Louis, at $232 round-trip. The most popular route is from Des Moines (DSM) to St. Louis (STL), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $232.

Can I save money by flying with a layover from Des Moines to Missouri?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $328, prices are generally cheapest when you fly direct.

What’s the cheapest day of the week to fly from Des Moines to Missouri?

The average price of all round-trip flights from Des Moines to Missouri clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Missouri on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Saturday is the most expensive day to fly from Des Moines to Missouri. For your return ticket, we recommend flying on a Thursday and avoiding Sundays for the best deals.

Good to know

Low seasonSeptember
Cheapest flight$79
Best time to beat the crowds with an average 8% drop in price.
Most popular time to fly and prices are also 7% lower on average.
Flight from Des Moines to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Des Moines to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Missouri?

    The cheapest time of day to fly to Missouri is generally in the evening, when round-trip flights cost $387 on average. Morning departures are around 5% more expensive than evening flights, on average. The most expensive time of day to fly to Missouri is generally in the morning, which is peak travel time and where the average cost of a ticket is $407.

Top tips for finding cheap flights to Missouri

  • Looking for a cheap flight? 25% of our users found tickets from Des Moines to the following destinations at these prices or less: St. Louis $203 one-way - $340 round-trip

Reviews of the top 3 airlines serving from Des Moines to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4250 reviews
8.0Comfort
7.5Entertainment
7.0Food
8.1Boarding
8.6Crew
Airline reviews

They sent a notice that they were boarding an hour early. We had to leave the club and run to the gate. They said sorry, that came from corporate and was a mistake. They did not have enough seating because the flight before it had not taken off on time. They moved our gate and delayed it for an hour.

2.0 MediocreRobert, Dec 2025
LAS - TPA
Read more Southwest reviews

They sent a notice that they were boarding an hour early. We had to leave the club and run to the gate. They said sorry, that came from corporate and was a mistake. They did not have enough seating because the flight before it had not taken off on time. They moved our gate and delayed it for an hour.

The boarding and seat assignment system no longer works for me, but I know it is being replaced. Otherwise, I am good with the overall experience.

The lead steward kept singing about "San Francisco" and hotel California---more annoying than humorous....needs work. Flight was smooth and on time.

Still a fan of open seating. Flight was on schedule and arrived on time. The 737 MAX is very comfortable.

Airline travel is always too cramped to really be pleasant, but the cabin crew on this flight did a pretty good job of making up for it by putting on some music during boarding and sprinkling a few funny remarks into the safety briefing and announcements, and just generally being friendly and helpful. It definitely reminded me of why I prefer the in-flight experience on Southwest!

No delays and arrived to destination 30 min early. Staff was super friendly.

San Diego airport is brand new, spacious, airy and very smooth checkin at SW baggage drop.

It was rough. The staff was unprofessional, the choice of on board drinks terrible, it was cramped in space at every airport, they always ran out of overhead bin space so they pressured people to check bags for free or we couldn’t leave on the plane— so I did check my bag to help, and they nearly lost my bag. My bag did not arrive on the luggage belt, another man on my flight and I had to waste our time going to the baggage office to search for our bags. I would only fly southwest again if it was my last choice. Also, my flights were consistently delayed over and over again— at one point they straight up told us we were waiting for the pilot to arrive.

Crew could have been friendlier, maybe I'm spoiled by SW crews. In flight wifi was good. Would be nice to have more food offerings on a 4 plus hour flight

Had to get off plane from prior flight even though I had to reboard same plane to continue to my final destination.

The flight was on time. I generally don’t drink or eat on short flights and the seats were good and the flight attendants were friendly. That’s all I expect

It was nice to have gotten up upgraded to first class with a meal on a three hour flight

United have really come back. Airport and boarding process is clear and good, app and information also very good

Flight was delayed 8 times. We were sitting at the airport for 14 hours. We got 2 hours of sleep (if that) on what was not meant to be a red-eye.

After a delay at the gate, C3, at Ohare on Sunday, I left my Blk ski coat on the bench at the gate, lost! Please review my lob claim, thx.

Very bad! They kept delaying my flight and wouldn’t do anything about it

They brought an empty plane to the gate. Then a flight delay was announced for maintenance and waiting on a part. I was then put on a flight to San Francisco instead with a connecting flight to my final destination. Arrived at my final destination 2 hours late.

The only downside was my cell phone charger wouldn’t work in the charging port but everyone else’s would work in them all. My cell phone cable works fine in my hotel room in Frankfurt.

Flight team stood out for perzonal attention, kindness at bright cheery attitudes at 8am. Very helpful.

Ot was overall fine. Left on time and had basic snacks. Weather was finicky but that’s not the airlines fault.

Gate was overcrowded. Gate agents performed very well. Flight crew was top notch! Efficient & professional & courteous. Both meals not thermalized well. Dinner main dish was actually cold in the center. Almost inedible. Breakfast sandwich was lukewarm.

The boarding was as always, the crew tried their best but not enough. The food was a disaster I had dietary restrictions that were half met because the company did not loaded the food for the flight. The entertainment screen was fine but content was not and also they removed the free messaging option from the flight and they charged 30 dollars for that crappy bandwidth. This flight is not worth the cost and the company is going down on quality.

Awful. They won’t help me with anything. I booked on American but they abdicated to Iberia. The ticket was overpriced. Everything negative

it was fine, decent flight... dont get food besides cookies or pretzels so not sure why you ask about food. same for entertainment..

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

I got sick nothing contagious but distressing enough and the care I received on the flight was astounding.

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

A little late at the start but all worked out well.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

Everything you need to know for your flight from Des Moines to Missouri

Information on your arrival and departure airports