$90 Find Cheap Flights from Des Moines to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Missouri departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
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Cheap Flights from Des Moines to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis1 stop$244
Kansas City
Kansas City1 stop$296
St. Louis
St. Louis1 stop$244
Kansas City
Kansas City1 stop$296

Book Cheap Des Moines to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Missouri

Mon, Apr 27 - Thu, Apr 30
Frontier Logo
2:04 pm - 7:32 pm
DSM
-
STL
5h 28m
1 stop
Frontier Logo
8:06 pm - 1:09 pm
STL
-
DSM
17h 03m
1 stop
$244Frontier
Tue, Apr 21 - Thu, Apr 23
Southwest Logo
6:30 pm - 11:10 pm
DSM
-
STL
4h 40m
1 stop
Southwest Logo
7:20 am - 11:45 am
STL
-
DSM
4h 25m
1 stop
$275Southwest
Tue, Apr 21 - Thu, Apr 23
Southwest Logo
6:55 am - 1:00 pm
DSM
-
STL
6h 05m
2 stops
Southwest Logo
4:40 pm - 11:05 pm
STL
-
DSM
6h 25m
1 stop
$280Southwest
Mon, Apr 27 - Wed, Apr 29
Southwest Logo
4:20 pm - 12:15 am
DSM
-
STL
7h 55m
2 stops
Southwest Logo
12:40 pm - 9:15 pm
STL
-
DSM
8h 35m
2 stops
$285Southwest
Thu, Apr 23 - Thu, Apr 30
American Airlines Logo
8:03 pm - 11:46 pm
DSM
-
STL
3h 43m
1 stop
American Airlines Logo
7:05 am - 11:30 am
STL
-
DSM
4h 25m
1 stop
$287American Airlines
Sat, Apr 25 - Sat, May 2
Southwest Logo
5:35 am - 10:30 am
DSM
-
STL
4h 55m
1 stop
Southwest Logo
6:10 am - 1:30 pm
STL
-
DSM
7h 20m
2 stops
$292Southwest
Fri, Apr 10 - Sat, Apr 11
United Airlines Logo
3:21 pm - 9:52 pm
DSM
-
STL
6h 31m
1 stop
United Airlines Logo
8:21 am - 12:29 pm
STL
-
DSM
4h 08m
1 stop
$296United Airlines
Mon, Apr 6 - Thu, Apr 9
Multiple Airlines Logo
8:14 pm - 7:58 pm
DSM
-
MCI
23h 44m
1 stop
Multiple Airlines Logo
12:24 pm - 10:06 pm
MCI
-
DSM
9h 42m
1 stop
$296Multiple Airlines
Sat, Apr 25 - Sat, May 2
Southwest Logo
5:35 am - 1:35 pm
DSM
-
STL
8h 00m
2 stops
Southwest Logo
6:10 am - 1:30 pm
STL
-
DSM
7h 20m
2 stops
$297Southwest
Fri, Apr 3 - Wed, Apr 8
Multiple Airlines Logo
8:14 pm - 7:58 pm
DSM
-
MCI
23h 44m
1 stop
Multiple Airlines Logo
12:24 pm - 1:46 pm
MCI
-
DSM
25h 22m
2 stops
$302Multiple Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Missouri flights

Get data-powered insights and trends into flights from Des Moines to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Des Moines to Missouri flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Missouri from Des Moines found in the last 72 hours was to St. Louis, at $412 round-trip. The most popular route is from Des Moines (DSM) to St. Louis (STL), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $412.

What is the cheapest time of day to fly to Missouri?

The average price for all round-trip flights from Des Moines to Missouri depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to Missouri is generally in the evening, when round-trip flights cost $365 on average. Morning departures are around 8% more expensive than evening flights, on average. The most expensive time of day to fly to Missouri is generally in the morning, which is peak travel time and where the average cost of a ticket is $393.

Can I save money by flying with a layover from Des Moines to Missouri?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $286 on average.

What’s the cheapest day of the week to fly from Des Moines to Missouri?

The average price of all round-trip flights from Des Moines to Missouri clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Missouri on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Sunday is the most expensive day to fly from Des Moines to Missouri. For your return ticket, we recommend flying on a Wednesday and avoiding Mondays for the best deals.

Good to know

Low seasonSeptember
Cheapest flight$90
Best time to beat the crowds with an average 9% drop in price.
Most popular time to fly and prices are also 12% lower on average.
Flight from Des Moines to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Des Moines to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Des Moines to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4318 reviews
8.0Comfort
7.0Food
8.6Crew
8.1Boarding
7.5Entertainment
Airline reviews

Long layover between flights to Long Island from BWI - need better coordination between flights

4.0 OkayKenny, Mar 2026
TPA - BWI
Read more Southwest reviews

Long layover between flights to Long Island from BWI - need better coordination between flights

I elected to pay for the upgrades and found very little difference

The new seating arrangement is so over priced for what you get.

The problem with the seat assignments is that there were a lot of rows in the front that were empty but my row at the back was full. Just not so pleasant.

No food or entertainment, just a quick 40 minute flight. A little bumpy due to Santa Ana winds but pilot has no control over that. Good flight and landing!

Good but I prefer choose your own seat. With the new assigned seats they should board from the back I see no advantage to this new boarding. Just like every other airline

I realize they are still working out kinks with the new boarding process, but by the time I boarded in group 5, most of the bins were full. All airlines should better enforce small bags and jackets going under the seats until everyone has boarded.

WiFi was not working and didn’t have a beverage service

Snacks are always pretzels. Why can't you also offer peanuts ?

Flight boarded late after announcing on time boarding. Flight arrived only a little late despite late departure. Had trouble connecting to WiFi

Both my flight where delayed Had 25min to make it to my transfer flight

Everything was on time and service on the flight was great!

Wifi Bluetooth features for watching in flight movie was horrible. Screen kept blacking out no connection of sound although it said connected. Other than that smooth trip .

The travel company that you have on your site did me so wrong. I don’t know how it happened, but they put my son‘s name on my plane ticket flying to Vietnam. Along with his birthday. They would not have let me fly from Fort Myers to Ho Chi Minh City. I don’t think that I can ever use your service again. I typed my information into the browser along with my passport number and four days before I’m leaving I have to quickly search another ticket to fly out here.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

The flight was delayed so we were dead tired, and after that the turbulence was horrible. I was very scared.

It’s always a great time flying with united airlines.

Good flight. Efficient boarding and competent flight crew. No problems until we arrived at our destination gate. We were early so there was an aircraft at the gate that had to move before we could pull in. Then, due to the type of aircraft we flew, the cabin door could not be opened until some luggage from the cargo bay was offloaded to preserve center of gravity characteristics. So, that further delayed deplaning. Despite being 20 minutes early on landing, we ended up being 5 to 10 minutes late after all the delays.

Everything went well except the turbulence what no one have a control of but pilot and crew handled very good!

There was no WiFi available, there were mechanical problems with the plane and we landed at C 124, then the gate was switched to A 26, then all the way back to C126! For a 75 yo woman traveling alone, this was a difficult journey, indeed!

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

It would have been nice if American tried to care.

American Airlines did everything they could with the high Spring Break crowd. I was frustrated to be changed from 1st class to a middle seat at the back of the plane. This has happened before, not sure booking 1st class and paying the extra actually works.

I booked 1st class, my flights were changed and I was sitting in the middle at the back of the plane. A far cry from the 1st class I purchased for my flights. I am grateful I arrived on time.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Our flight was delayed 3 times and this is why I am giving such low reviews. Everything else was okay but being in the airport at 4:30pm for my initial flight at 7pm to not leave until after 9:30pm is insane,

Flights were constantly delayed. CRW took 50 minutes to get bags

Flight has been delayed every time I've ever taken it. Seats uncomfortable. Children behind me yelling the entire flight. Some of this is out of their control but overall just consistently not a great experience.

Check in was rough because the check in crew did not know how to manage my international visa documents. Required a long process and 4 people to finally be able to proceed to security. They told us incorrect information several times before acknowledging we did indeed have everything we needed from the start.

Everything you need to know for your flight from Des Moines to Missouri

Information on your arrival and departure airports