$105 Find Cheap Flights from Des Moines to Missouri - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Missouri departing on 8/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Des Moines to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis1 stop$209
Kansas City
Kansas City2 stops$321
St. Louis
St. Louis1 stop$209
Kansas City
Kansas City2 stops$321

Book Cheap Des Moines to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Missouri

Thu, Aug 20 - Sat, Aug 22
American Airlines Logo
7:49 pm - 12:14 am
DSM
-
STL
4h 25m
1 stop
American Airlines Logo
5:00 am - 10:15 am
STL
-
DSM
5h 15m
1 stop
$209American Airlines
Thu, Aug 27 - Thu, Sep 3
American Airlines Logo
7:49 pm - 12:14 am
DSM
-
STL
4h 25m
1 stop
American Airlines Logo
6:00 am - 10:00 am
STL
-
DSM
4h 00m
1 stop
$209American Airlines
Mon, Nov 2 - Thu, Nov 5
Southwest Logo
5:25 am - 10:05 am
DSM
-
STL
4h 40m
1 stop
Southwest Logo
7:15 pm - 11:00 pm
STL
-
DSM
3h 45m
1 stop
$209Southwest
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
7:10 pm - 11:45 pm
DSM
-
STL
4h 35m
1 stop
Southwest Logo
4:50 pm - 9:55 pm
STL
-
DSM
5h 05m
1 stop
$209Southwest
Thu, Aug 27 - Thu, Sep 3
United Airlines Logo
8:00 am - 12:02 pm
DSM
-
STL
4h 02m
1 stop
United Airlines Logo
8:30 am - 2:16 pm
STL
-
DSM
5h 46m
1 stop
$209United Airlines
Tue, Jan 19 - Thu, Jan 21
United Airlines Logo
6:45 pm - 11:09 pm
DSM
-
STL
4h 24m
1 stop
United Airlines Logo
7:33 am - 2:11 pm
STL
-
DSM
6h 38m
1 stop
$209United Airlines
Wed, Oct 28 - Wed, Oct 28
Southwest Logo
7:05 am - 12:15 pm
DSM
-
STL
5h 10m
1 stop
Southwest Logo
4:05 pm - 9:55 pm
STL
-
DSM
5h 50m
1 stop
$209Southwest
Sat, Sep 12 - Sat, Sep 19
American Airlines Logo
2:44 pm - 8:44 pm
DSM
-
STL
6h 00m
1 stop
American Airlines Logo
11:01 am - 5:27 pm
STL
-
DSM
6h 26m
1 stop
$209American Airlines
Tue, Aug 25 - Tue, Sep 1
United Airlines Logo
3:20 pm - 10:00 pm
DSM
-
STL
6h 40m
1 stop
United Airlines Logo
8:30 am - 2:16 pm
STL
-
DSM
5h 46m
1 stop
$209United Airlines
Fri, Sep 4 - Mon, Sep 7
American Airlines Logo
7:49 pm - 12:14 am
DSM
-
STL
4h 25m
1 stop
American Airlines Logo
6:00 am - 10:00 am
STL
-
DSM
4h 00m
1 stop
$253American Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Missouri flights

Get data-powered insights and trends into flights from Des Moines to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Des Moines to Missouri flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Missouri from Des Moines found in the last 5 days was to St. Louis, at $414 round-trip. The most popular route is from Des Moines (DSM) to St. Louis (STL), and the cheapest round-trip airline ticket found on this route in the last 5 days was $414.

What is the cheapest time of day to fly to Missouri?

The average price for all round-trip flights from Des Moines to Missouri depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to Missouri is generally in the evening, when round-trip flights cost $360 on average. Morning departures are around 10% more expensive than evening flights, on average. The most expensive time of day to fly to Missouri is generally in the morning, which is peak travel time and where the average cost of a ticket is $398.

Can I save money by flying with a layover from Des Moines to Missouri?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $340 on average.

What is the cheapest month to fly from Des Moines to Missouri?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Missouri, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Missouri is August, when tickets cost $0 (return) on average. On the other hand, the most expensive months are February and December, when the average cost of round-trip tickets is $635 and $635 respectively.

What’s the cheapest day of the week to fly from Des Moines to Missouri?

The average price of all round-trip flights from Des Moines to Missouri clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Missouri on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Des Moines to Missouri. For your return ticket, we recommend flying on a Thursday and avoiding Mondays for the best deals.

Good to know

Low season

May

Cheapest flight

$105
Best time to beat the crowds with an average 8% drop in price.
Most popular time to fly and prices are also 38% lower on average.
Flight from Des Moines to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Des Moines to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Des Moines to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4226 reviews
8.1Boarding
7.0Food
8.6Crew
7.5Entertainment
8.0Comfort
Airline reviews

Great job! My family doesnt fly often but we felt safe 100%

10.0 ExcellentK, Jun 2026
AUS - MCI
Read more Southwest reviews

Great job! My family doesnt fly often but we felt safe 100%

Communication about the delayed flight was poor. We were told to move gates three times but that was bad information. We went from gate 128 to gate 126 and then to gate 123 and back to gate 126. Communication about the delay was bad. Ended up being 1 1/2 hour late getting home.

I have roller bag with food and medication told me I couldn't bring on my 2nd flight today. 15 years flying with SW never an issue with that bag.

I have not flown Southwest in awhile and had a very pleasant experience. From ticketing to boarding to the flight. The flight left on time and landed ahead of schedule. It won't be so long next time!!

Everything went smoothly and we even arrived a little bit early.

Boarded on time but once we were ready for take off, the crew determined that, although every seat was taken, somehow someone was on the wrong flight. Delay, delay delay, announcements and ended up with one person checking EVERY ID against their passenger Manifest only to figure out it was a "clerical error." We departed 54 minutes late causing me to run in the St. Louis Airport to make my connection and lose the priority boarding spot I had paid for. Unnecessary delay.

Flight was delayed due to plane not passing inspection And one of the crew had to time out and we had to wait for another one A 3 hour delay

Southwest's seats are the least comfortable I have ever sat in.

It was one and half hour late... Not sure if any other experience matters.

For my birthday trip this was my second time ever flying, this trip was the best.

Flight was 3 hours delayed. They gave our plan to two other routes. Need to knock that off.

We called Kayak for a change due to the TSA situation in Atlanta. What we got was a canceled return flight (in error) and we had to find the mistake. Not happy with Kayak who blamed it on AA.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Boarding delayed 20 minutes for no reason, no wifi, in flight entertainment, or snacks / waters?

This flight captain and crew were amazing, started ahead of time of departure and reached 30 mins before arrival time. Amazing!

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

Improvements in communication and empathy are absolutely necessary for American Airlines staff (top down). It’s like they are numb to the needs of their customers.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Everything you need to know for your flight from Des Moines to Missouri

Information on your arrival and departure airports