$111 Find Cheap Flights from Des Moines to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Missouri departing on 7/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
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Cheap Flights from Des Moines to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis2 stops$227
Kansas City
Kansas City2 stops$316
St. Louis
St. Louis2 stops$227
Kansas City
Kansas City2 stops$316

Book Cheap Des Moines to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Missouri

Thu, Jul 30 - Thu, Aug 6
Multiple Airlines Logo
5:08 pm - 8:57 am
DSM
-
STL
39h 49m
2 stops
Multiple Airlines Logo
7:10 pm - 8:31 pm
STL
-
DSM
25h 21m
1 stop
$227Multiple Airlines
Mon, Jul 20 - Thu, Jul 23
Multiple Airlines Logo
10:01 pm - 6:05 pm
DSM
-
STL
20h 04m
1 stop
Multiple Airlines Logo
7:10 pm - 9:11 pm
STL
-
DSM
26h 01m
1 stop
$260Multiple Airlines
Mon, Jul 6 - Tue, Jul 14
Frontier Logo
2:19 pm - 7:23 pm
DSM
-
STL
5h 04m
1 stop
Frontier Logo
8:08 pm - 1:34 pm
STL
-
DSM
17h 26m
1 stop
$261Frontier
Thu, Jul 30 - Thu, Aug 6
Multiple Airlines Logo
9:33 pm - 6:15 pm
DSM
-
STL
20h 42m
1 stop
Multiple Airlines Logo
7:10 pm - 8:31 pm
STL
-
DSM
25h 21m
1 stop
$271Multiple Airlines
Fri, Jul 3 - Tue, Jul 7
American Airlines Logo
9:02 am - 12:57 pm
DSM
-
STL
3h 55m
1 stop
American Airlines Logo
6:55 am - 1:05 pm
STL
-
DSM
6h 10m
1 stop
$283American Airlines
Mon, Jul 20 - Thu, Jul 23
Multiple Airlines Logo
5:30 pm - 1:21 pm
DSM
-
STL
19h 51m
2 stops
Multiple Airlines Logo
7:10 pm - 9:11 pm
STL
-
DSM
26h 01m
1 stop
$284Multiple Airlines
Mon, Jul 6 - Tue, Jul 14
American Airlines Logo
6:33 pm - 12:16 am
DSM
-
STL
5h 43m
1 stop
American Airlines Logo
5:58 pm - 12:01 am
STL
-
DSM
6h 03m
1 stop
$304American Airlines
Fri, Sep 4 - Mon, Sep 7
United Airlines Logo
6:00 am - 10:12 am
DSM
-
STL
4h 12m
1 stop
United Airlines Logo
8:50 am - 2:16 pm
STL
-
DSM
5h 26m
1 stop
$312United Airlines
Sun, Jul 12 - Sun, Jul 19
Southwest Logo
5:10 am - 9:30 am
DSM
-
MCI
4h 20m
1 stop
Southwest Logo
7:20 pm - 11:50 pm
MCI
-
DSM
4h 30m
1 stop
$347Southwest
Mon, Jul 13 - Sun, Jul 19
Southwest Logo
4:40 pm - 12:15 am
DSM
-
MCI
7h 35m
2 stops
Southwest Logo
5:05 am - 11:25 am
MCI
-
DSM
6h 20m
1 stop
$352Southwest
Booking Insights

KAYAK's insights & trends for Des Moines to Missouri flights

Get data-powered insights and trends into flights from Des Moines to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Des Moines to Missouri flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Missouri from Des Moines found in the last 5 days was to St. Louis, at $414 round-trip. The most popular route is from Des Moines (DSM) to St. Louis (STL), and the cheapest round-trip airline ticket found on this route in the last 5 days was $414.

What is the cheapest time of day to fly to Missouri?

The average price for all round-trip flights from Des Moines to Missouri depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to Missouri is generally in the evening, when round-trip flights cost $355 on average. Morning departures are around 8% more expensive than evening flights, on average. The most expensive time of day to fly to Missouri is generally in the morning, which is peak travel time and where the average cost of a ticket is $384.

Can I save money by flying with a layover from Des Moines to Missouri?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $354, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Des Moines to Missouri?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Missouri, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Missouri is November, when tickets cost $0 (return) on average. On the other hand, the most expensive months are July and February, when the average cost of round-trip tickets is $570 and $310 respectively.

What’s the cheapest day of the week to fly from Des Moines to Missouri?

The average price of all round-trip flights from Des Moines to Missouri clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Missouri on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Des Moines to Missouri. For your return ticket, we recommend flying on a Thursday and avoiding Mondays for the best deals.

Good to know

Low seasonMay
Cheapest flight$111
Best time to beat the crowds with an average 10% drop in price.
Most popular time to fly and prices are also 32% lower on average.
Flight from Des Moines to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Des Moines to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Des Moines to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4235 reviews
7.5Entertainment
7.0Food
8.0Comfort
8.6Crew
8.1Boarding
Airline reviews

Flight was delayed over 3 hours. Planes were dirty. Staff indifferent. And they serve vegan pretzels as snacks.

2.0 MediocreMatthew, Jun 2026
CVG - MDW
Read more Southwest reviews

Flight was delayed over 3 hours. Planes were dirty. Staff indifferent. And they serve vegan pretzels as snacks.

It was great. The gate staff were very helpful in Portland when my son forgot his rolling bag and had to go back to get it just in time to make it on the plane. We really appreciate that. Great job!

Airline is not very senior friendly. Flights are late, forcing us to run to the connecting flight. Food is awful. Wish they would go back to pretzels and peanuts. During flight, pressurization isn’t quite right and all of our ears get plugged. Everything is nickel and dime, charging for boarding, seat selection and legroom. While a screen at the desk in the gate area says check your roll on bag now for free due to space limitation, the employee at the desk will not check the bag without a $100 fee. Insane.

Kayak could’ve posted the correct gate number. Almost missed my flight.

Slow boarding, limited food and drink portions. Bad delays and turbulence

there were two flight attendants that were up front...that were the best! They get KUDOs for making my trip only fantastic. Tell them Jeff said that!

OKay. I sat in the back of the plane and it was really loud between babies and little kids, and adults who.like to talk a lot and loudly most of the flight.

Flight coming out of Buffalo was delayed, so we had to be rescheduled on another flight from Baltimore to Phoenix which means we had a long layover and got home 3.5 hours late. Shuttle to parking stopped at 10pm, so we had to pay for an Uber to the parking lot and got charged an extra day of parking since it was after midnight. Not the best experience. Long day!

Was fine, delayed and feels like southwest is always late

I don't know why flying out of Sarasota requires two plane changes.

We sat on plane at gate delayed without communication as to why we were just sitting there

Agency very bad had to cancelled my booking too many changes in the flight changed my flight to 1 week

Trash. Sat on the runway for 40 mins…missed connecting flight because of it now I’m stuck. Thanks…a whole fkn lot.

The flight was delayed significantly and we sat on runway after landing for awhile. Best thing was the flight attendant, Jenny, in first class, who was very professional and attentive. She was excellent - the rest of the flight was not.

Awfully rude American worker at door when we started boarding flight. Then, walk into a blazing hot airplane with no air conditioning until twenty minutes into the flight. Free entertainment was non existent! My husband, along with the fellow passenger in our row, and I could not get entertainment to work, no WIFI! Really?? Been flying American a long time. Was very disappointed.

Flight was delayed by 6 hours... the level of incompetence was truly astounding. I won't be flying American Airlines again. I don't care if AA is direct and there is a layover with another airline, I'll take the layover.

Leave on time. We waited on the plane for hour hours and it was hot and smelly

Two hours delay, probably one hour because they didn’t bring catering and they had to bring water in board. There a change of aircraft. But delays galore at CLT so it must be a CLT and/or AA operation issue. The 1 hr additional delays because nobody could bring 2 packs of water sooner is probably the best example of this airline operates

Flight was delayed 5 hours. Initial reason for delay was 'maintenance' - which makes sense. Then, the additional 2 hours continued to say it was maintenance - when I know EWR had a 2 hour delay. AA did not say that. Additionally, when boarding, there was only one agent at the counter for a long time - until another came to help. After boarding, we had to wait another 45 minutes due to 'no catering'. So while we waited for catering, AA continued to board additional passengers - which seemed odd - and raised questions about what really was going on. I sat in First Class. During the flight, the flight crew allowed a significant number of non-First Class passengers to use the front bathroom - which created a very crowded environment in First Class which was uncomfortable. This also delayed First Class passengers from using the bathroom. Overall, horrible experience.

The Charleston, WV airport was cute. Very good staff and small enough to feel comfortable. The plane had more leg room than bigger planes. Much more comfortable.

Everything you need to know for your flight from Des Moines to Missouri

Information on your arrival and departure airports