$95 Find Cheap Flights from Des Moines to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Missouri departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Missouri, as well as popular online travel agencies
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Flights Deals

Best Missouri Flight Deals from Des Moines

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

St. Louis
St. Louis1 stop$219
Kansas City
Kansas City1 stop$229
St. Louis
St. Louis1 stop$219
Kansas City
Kansas City1 stop$229

Cheap Flights from Des Moines to Missouri

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.

Recent round-trip flight deals from Des Moines to Missouri

Recommended round-trip deals departing in the coming months from the most popular airlines that fly from Des Moines to Missouri.
Discover the best prices for you by selecting your travel dates on KAYAK.
American Airlines Logo
6:13 pm - 11:51 pmDSM-STL
5h 38m1 stop
American Airlines Logo
6:00 am - 11:13 amSTL-DSM
5h 13m1 stop
$219American Airlines
Find Deal
Thu, May 22 - Mon, May 26
American Airlines Logo
5:58 pm - 11:54 pmDSM-STL
5h 56m1 stop
American Airlines Logo
8:05 pm - 11:52 pmSTL-DSM
3h 47m1 stop
$223American Airlines
Find Deal
Fri, Jun 6 - Mon, Jun 9
Southwest Logo
3:40 pm - 11:00 pmDSM-MCI
7h 20m1 stop
Southwest Logo
9:45 am - 4:00 pmMCI-DSM
6h 15m1 stop
$229Southwest
Find Deal
Tue, May 27 - Tue, Jun 3
Southwest Logo
5:40 am - 1:40 pmDSM-MCI
8h 00m2 stops
Southwest Logo
6:55 am - 4:00 pmMCI-DSM
9h 05m1 stop
$234Southwest
Find Deal
Tue, May 27 - Tue, Jun 3
United Airlines Logo
8:00 am - 2:37 pmDSM-STL
6h 37m1 stop
United Airlines Logo
10:00 am - 2:41 pmSTL-DSM
4h 41m1 stop
$252United Airlines
Find Deal
Fri, Aug 15 - Mon, Aug 18
United Airlines Logo
6:45 pm - 10:45 pmDSM-STL
4h 00m1 stop
United Airlines Logo
8:10 am - 2:42 pmSTL-DSM
6h 32m1 stop
$266United Airlines
Find Deal
Thu, Jun 12 - Thu, Jun 19
Delta Logo
1:07 pm - 5:00 pmDSM-STL
3h 53m1 stop
Delta Logo
6:45 am - 5:06 pmSTL-DSM
10h 21m2 stops
$313Delta
Find Deal
Thu, May 22 - Mon, May 26
Delta Logo
5:35 am - 12:04 pmDSM-STL
6h 29m1 stop
Delta Logo
6:45 am - 4:37 pmSTL-DSM
9h 52m2 stops
$344Delta
Find Deal
Tue, May 13 - Fri, Aug 15
 Logo
6:32 pm - 6:41 pmDSM-STL
24h 09m2 stops
 Logo
9:50 am - 10:37 pmSTL-DSM
12h 47m2 stops
Thu, Jun 12 - Thu, Jun 19
 Logo
6:32 pm - 5:04 pmDSM-STL
22h 32m2 stops
 Logo
9:50 am - 10:37 pmSTL-DSM
12h 47m2 stops
Thu, Jun 12 - Thu, Jun 19
Useful Info

KAYAK's insights & trends for Des Moines to Missouri flights

Get data-powered insights and trends into flights from Des Moines to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Des Moines to Missouri flight route?

The cheapest price for flight routes found by users searching on KAYAK in the last 2 weeks for round-trip flights from Des Moines to Missouri.

The cheapest ticket to Missouri from Des Moines found in the last 72 hours was to St. Louis, at $292 round-trip. The most popular route is from Des Moines (DSM) to St. Louis (STL), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $292.

Can I save money by flying with a layover from Des Moines to Missouri?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $216 on average.

What is the cheapest month to fly from Des Moines to Missouri?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Missouri, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Missouri is August, when tickets cost $258 (return) on average. On the other hand, the most expensive months are September and July, when the average cost of round-trip tickets is $664 and $454 respectively.

What’s the cheapest day of the week to fly from Des Moines to Missouri?

The average price of all round-trip flights from Des Moines to Missouri clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Missouri on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Saturday is the most expensive day to fly from Des Moines to Missouri. For your return ticket, we recommend flying on a Saturday and avoiding Thursdays for the best deals.


Good to know

Low seasonJuly
High seasonApril
Cheapest flight$95
Best time to beat the crowds but there is an average 23% increase in price.
Most popular time to fly and prices are also 17% lower on average.
Flight from Des Moines to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Des Moines to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Missouri?

    The cheapest time of day to fly to Missouri is generally in the evening, when round-trip flights cost $406 on average. Morning departures are around 2% more expensive than evening flights, on average. The most expensive time of day to fly to Missouri is generally in the morning, which is peak travel time and where the average cost of a ticket is $415.

Top tips for finding cheap flights to Missouri

  • Looking for a cheap flight? 25% of our users found tickets from Des Moines to the following destinations at these prices or less: St. Louis $167 one-way - $368 round-trip

Top 3 airlines serving from Des Moines to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4294 reviews
8.0Comfort
8.2Boarding
7.6Entertainment
7.1Food
8.6Crew
Airline reviews

It is southwest seat was ok. Not the most comfortable seat

8.0 ExcellentJohn, Apr 2025PVD - FLL
Read more Southwest reviews

It is southwest seat was ok. Not the most comfortable seat

I’ve always loved Southwest. No issues at all. I was flying standby and the gate agent was extremely friendly and helpful. Boarding was smooth and I was able to get a window seat in the emergency exit row. Crew was fantastic! They were very professional and accommodating. We had to divert from our destination due to weather but the flight crew kept everyone at ease and informed us of all pertinent information. Excellent flight

The price of the tickets isn't matching the flight experience. No matter how long the flight is, you're only getting pretzels. The flight attendants looked unkept and over it.

Plz don't take away free bags and free seating

The seats were a bit cramped and worn, but otherwise okay.

I would have liked to arrive on time - not 5 hours late!

After a 3 hour layover in Denver my flight was delayed over 5 hours! No explanation; no assistance; no offer to provide compensation; no one at Southwest was willing to offer any assistance. 8 hours in the Denver airport - ridiculous!

It was a perfect flight in all aspects! Both legs!

Only one drink pass through the cabin for a 4 hour flight. Quite rough and bumpy landing.

Boarding process, crew were good. But the seats were so uncomfortable that was all I could focus on. I literally had to sit forward so that all 3 of us could fit in row. I will try to avoid Southwest in the future for any flights over 60 minutes.

Delta is my preferred airline. I've traveled with them for years. On time in most cases, good communication, easy to use app. Most planes are pretty nice. I was on a CRJ 700/900 however, which was pretty badly aged inside and needed a refresh. No infotainment, unreliable wifi, best to download before boarding or bring a book. Food choices are really just snacks on this flight, nice variety but about what you'd expect. Great staff and prompt in departure and early arrival too. Overall quite satisfied.

Crew was friendly Love the entertainment in the seat head rest.

Delta flight was on time, seats were comfortable, and crew was nice.

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

Delayed take-off. Very small plane so very scary with lots of bumps during the flight. Would never fly Delta on short flights in small 80 seaters plane again! Felt relieved when landed.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

A little bumpy ride . No food was being provided due the the turbulence. That was ok it was a short flight to my standards.

Simply outstanding. Their new lounge for Delta One customers is a cut above the rest.

The Dekta Rep that checked us in was great. She's very personable, pleasant, and can tell she enjoys her job.

The plane was old with small storage areas that had problems closing/latching and not enough storage for everyone, and worn, damaged seats. Service was great but feel a little unsafe on such well used planes.

A bit rush for transit. Food and entertainment are not available

Multiple delays and not straight answer from the United team

Stewardess spilled orange juice on my clothes/seat no help no apology just threw napkins at me to clean the mess up. Not Happy.

Smooth flight. Boarding was chaotic. Could not hear the gate agent over the intercom. People were lined up in the wrong lines. Groups one and two were told to board through line one and group 3 through line 2. All very confusing. Once in the air, the flight was smooth. There was no entertainment option on this aircraft, even though it was a larger aircraft.

The plane pushed back from the gate on time. However, it stopped on the ramp, and we waited for over 20 minutes before the aircraft pulled back to the gate. Apparently, something of importance had to be removed from the aircraft by the gate agent. I found this to be odd. The delay was not significant, but I felt that whatever was on the aircraft that had to be taken off, should’ve been done before we pushed back from the gate.

Electric plugs didn't work. Entertainment system wasn't working

The design of the light switch on the arm rest is ridiculous.

Smooth boarding process. Early departure, smooth flight, early arrival. The entertainment package has very good recent movie options. The flight crew were friendly and professional.

leg space better than expected. two washrooms for one plane isn't enough.

The gate attendant let me walk right by her with a bag too big for the overhead compartment

Everything you need to know for your flight from Des Moines to Missouri

Information on your arrival and departure airports

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