DSM - STL

$105 Find Cheap Flights from Des Moines to St. Louis - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$209
American Airlines
Sat 8/22Sat 8/29
DSM - STL • 1 stop
Cheapest one-way
$105
Typical prices: $104-$144
American Airlines
Thu 8/20
DSM - STL • 1 stop
Top airlines
Cheapest • from $209 (round-trip)
Best reviews • 8.0 score
Airline reviews
Airline reviews
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Airline reviews
Airline reviews
+1
When to travel
Cheapest • 100% price drop
Most popular
Good to know
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+1
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to St. Louis (DSM-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to St. Louis

Sat, Aug 22 - Sat, Aug 29
American Airlines Logo
7:00 am - 12:55 pm
DSM
-
STL
5h 55m
1 stop
American Airlines Logo
8:06 pm - 12:35 am
STL
-
DSM
4h 29m
1 stop
$209American Airlines
Sat, Sep 12 - Sat, Sep 19
American Airlines Logo
2:44 pm - 8:44 pm
DSM
-
STL
6h 00m
1 stop
American Airlines Logo
11:01 am - 5:27 pm
STL
-
DSM
6h 26m
1 stop
$209American Airlines
Tue, Sep 8 - Tue, Sep 15
Southwest Logo
6:10 am - 9:35 am
DSM
-
STL
3h 25m
1 stop
Southwest Logo
6:30 am - 11:50 am
STL
-
DSM
5h 20m
1 stop
$209Southwest
Mon, Nov 2 - Thu, Nov 5
Southwest Logo
5:25 am - 10:05 am
DSM
-
STL
4h 40m
1 stop
Southwest Logo
7:15 pm - 11:00 pm
STL
-
DSM
3h 45m
1 stop
$209Southwest
Tue, Aug 25 - Tue, Sep 1
United Airlines Logo
3:20 pm - 10:00 pm
DSM
-
STL
6h 40m
1 stop
United Airlines Logo
8:30 am - 2:16 pm
STL
-
DSM
5h 46m
1 stop
$209United Airlines
Tue, Sep 8 - Tue, Sep 15
United Airlines Logo
3:22 pm - 10:00 pm
DSM
-
STL
6h 38m
1 stop
United Airlines Logo
8:00 am - 2:20 pm
STL
-
DSM
6h 20m
1 stop
$209United Airlines
Thu, Sep 10 - Thu, Sep 17
Delta Logo
7:00 am - 10:23 am
DSM
-
STL
3h 23m
1 stop
Delta Logo
6:15 am - 10:17 am
STL
-
DSM
4h 02m
1 stop
$209Delta
Thu, Sep 17 - Sat, Sep 19
Southwest Logo
5:40 am - 9:15 am
DSM
-
STL
3h 35m
1 stop
Southwest Logo
8:25 am - 11:30 am
STL
-
DSM
3h 05m
1 stop
$209Southwest
Fri, Sep 4 - Mon, Sep 7
American Airlines Logo
7:49 pm - 12:14 am
DSM
-
STL
4h 25m
1 stop
American Airlines Logo
6:00 am - 10:00 am
STL
-
DSM
4h 00m
1 stop
$253American Airlines
Thu, Aug 20 - Sun, Aug 30
American Airlines Logo
7:49 pm - 12:14 am
DSM
-
STL
4h 25m
1 stop
American Airlines Logo
5:00 am - 9:56 am
STL
-
DSM
4h 56m
1 stop
$282American Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to St. Louis flights

Get data-powered insights and trends into flights from Des Moines to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to St. Louis?

The average price of all round-trip flights from Des Moines to St. Louis clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to St. Louis on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Des Moines to St. Louis. For your return ticket, we recommend flying on a Thursday and avoiding Mondays for the best deals.

What is the cheapest month to fly from Des Moines to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to St. Louis is August, where tickets cost $0 (return) on average. On the other hand, the most expensive months are February and December, where the average cost of round-trip tickets is $635 and $635 respectively.

Can I save money by flying with a layover from Des Moines to St. Louis?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $307 on average.

Good to know

Low season

May

Cheapest flight

$105
Best time to beat the crowds with an average 69% drop in price.
Most popular time to fly and prices are also 38% lower on average.
Flight from Des Moines to St. Louis

When to book flights from Des Moines to St. Louis

Are your dates flexible? Find out the best times to travel from Des Moines to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to St. Louis

  • What is the cheapest flight from Des Moines to St. Louis?

    In the last 5 days, the lowest price for a flight from Des Moines to St. Louis was $105 for a one-way ticket and $209 for a round-trip.

  • Do I need a passport to fly between Des Moines and St. Louis?

    No

  • Which airports will I be using when flying from Des Moines to St. Louis?

    When flying out of Des Moines you will be using Des Moines. You will be landing at St. Louis, also known as Lambert-St Louis.

  • Which airlines offer Wi-Fi service onboard planes from Des Moines to St. Louis?

    JetBlue, Delta, and American Airlines offer inflight Wi-Fi service on the Des Moines to St. Louis flight route.

  • Which aircraft models fly most regularly from Des Moines to St. Louis?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Des Moines to St. Louis flight route.

  • Which airline alliances offer flights from Des Moines to St. Louis?

    oneworld is the only airline alliance operating flights between Des Moines and St. Louis.

  • Which is the best airline for flights from Des Moines to St. Louis, Southwest or American Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to St. Louis are Southwest and American Airlines. With an average price for the route of $250 and an overall rating of 8.0, Southwest is the most popular choice. American Airlines is also a great choice for the route, with an average price of $398 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Des Moines to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Des Moines to St. Louis

  • Looking for a cheap flight? 25% of our users found flights on this route for $462 or less round-trip.

Reviews of the top airlines flying from Des Moines to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4227 reviews
8.6Crew
7.5Entertainment
7.0Food
8.0Comfort
8.1Boarding
Airline reviews

I have roller bag with food and medication told me I couldn't bring on my 2nd flight today. 15 years flying with SW never an issue with that bag.

2.0 MediocreStuart, Mar 2026
HOU - STL
Read more Southwest reviews

I have roller bag with food and medication told me I couldn't bring on my 2nd flight today. 15 years flying with SW never an issue with that bag.

I have not flown Southwest in awhile and had a very pleasant experience. From ticketing to boarding to the flight. The flight left on time and landed ahead of schedule. It won't be so long next time!!

Everything went smoothly and we even arrived a little bit early.

Boarded on time but once we were ready for take off, the crew determined that, although every seat was taken, somehow someone was on the wrong flight. Delay, delay delay, announcements and ended up with one person checking EVERY ID against their passenger Manifest only to figure out it was a "clerical error." We departed 54 minutes late causing me to run in the St. Louis Airport to make my connection and lose the priority boarding spot I had paid for. Unnecessary delay.

Southwest's seats are the least comfortable I have ever sat in.

For my birthday trip this was my second time ever flying, this trip was the best.

Crew was great flight was great baggage claim was a failure. It took over 1 hour for bags to arrive. Poor communication poor effort when I spoke to the supervisor about the delay

Everything was great except the food. The pretzels are really crappy.

I had a front row middle. I am not a big person and I barely fit in between that seat! No place to put my arms, even though the guys on each side were not taking over the arm rests. It felt like a frontier flight (if that tells you everything )

Overall is was a pretty good flight. However we were 15 mins late taking off and no one told us anything. We were all in our seats just sitting there for 15mins and all the sudden the pilot stayed we are leaving now. I think they should have at least said something after our take off time passed. Everyone was wondering what was going on. I will say the pilot did increase the speed of the plane so we arrived in time. So we weren't late.

We called Kayak for a change due to the TSA situation in Atlanta. What we got was a canceled return flight (in error) and we had to find the mistake. Not happy with Kayak who blamed it on AA.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Boarding delayed 20 minutes for no reason, no wifi, in flight entertainment, or snacks / waters?

This flight captain and crew were amazing, started ahead of time of departure and reached 30 mins before arrival time. Amazing!

Improvements in communication and empathy are absolutely necessary for American Airlines staff (top down). It’s like they are numb to the needs of their customers.

I like the speed of boarding and deplaning and the fact that everything was on time. The crew (attendants) were probably quite new and did not begin the in cabin service until 30 min before landing even though there was little to no air turbulence for the last 1.5 hours of the flight. It made for a mad scramble at the end to get trash collected and carts stowed before touch down.

The flights was delayed by hours and it was the firmest landing I have experienced in my life. My back is still sore.

I did like the employee's, they are very friendly and all smiled most of the time, Overall, from checking in bags to getting on plane, not enough employees to be able to get all on the plane, therefore I was not able to get on the plane, due to no one wea there for me to check in my bag, so I decided to go thru the security point and by the time they were done with my bags, I was told that my bag cannot be checked in, and then found out that the lady that does the check in was boarding the customers onto the plane, she said that she was going back and fourth, there for was not able to get on the plane, which changed all my flights by the time I got to Dallas, I was on standby 3 times, and wasn't sure about being able to get on the fourth plane, so ended up buying another plane ticket, so I could make my destination on time.

Not sure about entertainment as I didn't use any, so maybe there should be an NA option on this survey. Otherwise everything was just as it should be. Of course I wish planes were more comfortable and had seats that would tilt back further.

American Airlines “Randy” questioned why I needed preboarding and denied my request for same. Then Randy attempted to berate me when I boarded with my group. I was seated in an exit roll with a young man with a disability that exhibited difficulty controlling and settling himself. But Tandy questioned my disability. The flight was horrible. It was overpacked.

Everything you need to know for your flight from Des Moines to St. Louis

Information on your arrival and departure airports