Which airports can I use when flying from Des Moines to St. Louis?

Flights from Des Moines to St. Louis usually depart from Des Moines (DSM) and arrive at Lambert-St Louis (STL).

What cabin classes can I book on flights from Des Moines to St. Louis?

Only Economy Class is available on flights from Des Moines to St. Louis.

How much can I save by taking a layover when flying from Des Moines to St. Louis?

On this route, nonstop flights are cheaper than layover options on average. Nonstop fares average $261 round-trip, compared to $313 via a layover through Chicago Midway (MDW).

Which aircraft model is used most often on flights from Des Moines to St. Louis?

The Airbus A320-100/200 family is used most often on this route, operated mainly by JetBlue and United Airlines. Other aircraft seen on the route include Airbus A319 variants.

Which airports do connecting flights from Des Moines to St. Louis pass through?

One-stop flights from Des Moines to St. Louis most commonly connect through: • Minneapolis St Paul (MSP) - 48% of one-stop connections • Chicago O'Hare Intl (ORD) - 43% of one-stop connections • Chicago Midway (MDW) - 10% of one-stop connections Minneapolis St Paul (MSP) handles the largest share of one-stop connections on this route.

Can I save money by using flexible dates for flights from Des Moines to St. Louis?

Yes. Being flexible with your travel dates can save you up to 49% on the Des Moines to St. Louis route. Tuesday is the cheapest departure day at $204 round-trip on average, while Saturday is the most expensive at $398, a difference of $194. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

What popular places can I visit in St. Louis?

Some of the most popular sights in St. Louis are Downtown St. Louis, Busch Stadium and Enterprise Center. These are among the most viewed places in St. Louis on KAYAK.

How long is a flight from Des Moines to St. Louis?

There are currently no nonstop flights available from Des Moines to St. Louis. Flights with 1 layover take between 3h 43m and 5h 05m in total, depending on the connection.

Do I need a passport to fly from Des Moines to St. Louis?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from Des Moines to St. Louis changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $235 to $1,079. That means the highest observed fare was about 5x higher than the lowest one.

How are flight prices from Des Moines to St. Louis looking right now?

One-way fares from Des Moines to St. Louis are currently in line with typical prices for this route. Average one-way fares are about $188.

How much time can I save by choosing a different layover airport from Des Moines to St. Louis?

Flying via Minneapolis St Paul (MSP) gives the shortest average 1-stop total travel time at 3h 43m, compared with 4h 09m via Chicago O'Hare Intl (ORD) and 5h 05m via Chicago Midway (MDW).

What car rental options are available at Lambert-St Louis Airport (STL)?

Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates starting from around $31 for economy cars. Top options include: • Hertz • Budget • Alamo • Enterprise Rent-A-Car • Payless

How much should I expect to pay for a Des Moines to St. Louis flight?

Round-trip flights from Des Moines to St. Louis range from $213 to $374, with an average of $297 over the past 12 months. Anything below $213 counts as a good deal.

What is the cheapest airline to fly from Des Moines to St. Louis?

American Airlines ($235) and United Airlines ($235) are the cheapest airlines to fly round-trip from Des Moines to St. Louis according to KAYAK data over the last 5 days.

What is the most popular layover airport when flying from Des Moines to St. Louis?

Minneapolis St Paul (MSP) is the most popular layover for the Des Moines to St. Louis route. 48% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via MSP.

What is the cheapest layover airport when flying from Des Moines to St. Louis?

Flights via Chicago Midway (MDW) offer the most affordable fares, with an average round-trip price of $313. Based on KAYAK data over the past 3 months.

When flying from Des Moines to St. Louis which airport offers the shortest layover?

Minneapolis St Paul (MSP) had the shortest average connection time for Des Moines to St. Louis layovers at 136 minutes over the past 3 months.

$141 CHEAP FLIGHTS from Des Moines to St. Louis (DSM - STL)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$235

Typical prices: $213-$374

American Airlines

Sat 10/20Sun 10/21

DSM - STL • 1 stop

Cheapest one-way

$141

Typical prices: $159-$279

United Airlines

Sun 10/28

DSM - STL • 1 stop

When to travel

October

Cheapest • 16% price drop

March

Most popular

Good to know

Top layover airports

Chicago Midway (MDW)

Cheapest • Avg $313 (round-trip)

Minneapolis St Paul (MSP)

Shortest trip • 3h 43m (one-way)

Insights

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We hope you love your trip to St. Louis!

Flight Deals

Cheap Flights from Des Moines to St. Louis (DSM-STL)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Des Moines to St. Louis

Tue, Oct 20 - Wed, Oct 21

7:31 pm - 12:19 amDSM Des Moines-STL Lambert-St Louis

4h 48m1 stop Chicago O'Hare Intl

5:00 am - 8:56 amSTL Lambert-St Louis-DSM Des Moines

3h 56m1 stop Chicago O'Hare Intl

$235American Airlines

Tue, Oct 20 - Wed, Oct 21

3:11 pm - 9:21 pmDSM Des Moines-STL Lambert-St Louis

6h 10m1 stop Chicago O'Hare Intl

8:00 am - 12:34 pmSTL Lambert-St Louis-DSM Des Moines

4h 34m1 stop Chicago O'Hare Intl

$235United Airlines

Tue, Oct 20 - Wed, Oct 21

6:35 pm - 11:15 pmDSM Des Moines-STL Lambert-St Louis

4h 40m1 stop Denver Intl

2:20 pm - 10:00 pmSTL Lambert-St Louis-DSM Des Moines

7h 40m2 stops Atlanta Hartsfield-Jackson Chicago Midway

$241Southwest

Fri, Oct 23 - Mon, Oct 26

2:00 pm - 11:25 pmDSM Des Moines-STL Lambert-St Louis

9h 25m1 stop Phoenix Sky Harbor Intl

6:10 pm - 11:15 pmSTL Lambert-St Louis-DSM Des Moines

5h 05m1 stop Chicago Midway

$289Southwest

Fri, Oct 23 - Mon, Oct 26

7:10 pm - 11:50 pmDSM Des Moines-STL Lambert-St Louis

4h 40m1 stop Denver Intl

10:20 am - 11:15 pmSTL Lambert-St Louis-DSM Des Moines

12h 55m2 stops Atlanta Hartsfield-Jackson Chicago Midway

$300Southwest

Thu, Oct 15 - Sun, Oct 18

7:31 pm - 12:19 amDSM Des Moines-STL Lambert-St Louis

4h 48m1 stop Chicago O'Hare Intl

5:00 am - 8:56 amSTL Lambert-St Louis-DSM Des Moines

3h 56m1 stop Chicago O'Hare Intl

$312American Airlines

Thu, Oct 1 - Mon, Oct 5

7:05 am - 1:16 pmDSM Des Moines-STL Lambert-St Louis

6h 11m1 stop Chicago O'Hare Intl

5:00 am - 8:56 amSTL Lambert-St Louis-DSM Des Moines

3h 56m1 stop Chicago O'Hare Intl

$330American Airlines

Thu, Oct 15 - Sun, Oct 18

7:31 pm - 12:19 amDSM Des Moines-STL Lambert-St Louis

4h 48m1 stop Chicago O'Hare Intl

5:00 am - 8:56 amSTL Lambert-St Louis-DSM Des Moines

3h 56m1 stop Chicago O'Hare Intl

$344American Airlines

Thu, Oct 29 - Fri, Oct 30

8:00 am - 2:29 pmDSM Des Moines-STL Lambert-St Louis

6h 29m1 stop Chicago O'Hare Intl

6:00 am - 10:32 amSTL Lambert-St Louis-DSM Des Moines

4h 32m1 stop Chicago O'Hare Intl

$351United Airlines

Thu, Oct 1 - Tue, Oct 6

6:55 pm - 10:59 pmDSM Des Moines-STL Lambert-St Louis

4h 04m1 stop Chicago O'Hare Intl

1:29 pm - 5:48 pmSTL Lambert-St Louis-DSM Des Moines

4h 19m1 stop Chicago O'Hare Intl

$352United Airlines

Recent last minute flight deals from Des Moines to St. Louis

Thu, Sep 17 - Sat, Sep 19

2:44 pm - 8:44 pmDSM Des Moines-STL Lambert-St Louis

6h 00m1 stop Chicago O'Hare Intl

11:01 am - 5:27 pmSTL Lambert-St Louis-DSM Des Moines

6h 26m1 stop Chicago O'Hare Intl

$519American Airlines

Fri, Sep 18 - Sun, Sep 20

2:29 pm - 8:44 pmDSM Des Moines-STL Lambert-St Louis

6h 15m1 stop Chicago O'Hare Intl

11:01 am - 5:27 pmSTL Lambert-St Louis-DSM Des Moines

6h 26m1 stop Chicago O'Hare Intl

$519American Airlines

Sat, Sep 19 - Sun, Sep 20

8:00 am - 11:57 amDSM Des Moines-STL Lambert-St Louis

3h 57m1 stop Chicago O'Hare Intl

12:59 pm - 5:56 pmSTL Lambert-St Louis-DSM Des Moines

4h 57m1 stop Chicago O'Hare Intl

$519United Airlines

Sat, Sep 19 - Sun, Sep 20

5:30 am - 12:35 pmDSM Des Moines-STL Lambert-St Louis

7h 05m2 stops Chicago Midway Atlanta Hartsfield-Jackson

7:30 pm - 10:55 pmSTL Lambert-St Louis-DSM Des Moines

3h 25m1 stop Chicago Midway

$524Southwest

Thu, Sep 17 - Sat, Sep 19

5:40 am - 10:30 amDSM Des Moines-STL Lambert-St Louis

4h 50m1 stop Chicago Midway

7:50 am - 7:30 pmSTL Lambert-St Louis-DSM Des Moines

11h 40m2 stops Nashville Intl Chicago Midway

$524Southwest

Thu, Sep 17 - Sat, Sep 19

5:40 am - 9:15 amDSM Des Moines-STL Lambert-St Louis

3h 35m1 stop Chicago Midway

7:50 am - 7:30 pmSTL Lambert-St Louis-DSM Des Moines

11h 40m2 stops Nashville Intl Chicago Midway

$530Southwest

Thu, Sep 17 - Sat, Sep 19

5:40 am - 3:20 pmDSM Des Moines-STL Lambert-St Louis

9h 40m2 stops Chicago Midway Atlanta Hartsfield-Jackson

7:50 am - 7:30 pmSTL Lambert-St Louis-DSM Des Moines

11h 40m2 stops Nashville Intl Chicago Midway

$544Southwest

Thu, Sep 17 - Sat, Sep 19

5:40 am - 3:20 pmDSM Des Moines-STL Lambert-St Louis

9h 40m2 stops Chicago Midway Atlanta Hartsfield-Jackson

7:50 am - 7:30 pmSTL Lambert-St Louis-DSM Des Moines

11h 40m2 stops Nashville Intl Chicago Midway

$550Southwest

Fri, Sep 18 - Sun, Sep 20

2:25 pm - 10:00 pmDSM Des Moines-STL Lambert-St Louis

7h 35m1 stop Denver Intl

8:25 am - 3:15 pmSTL Lambert-St Louis-DSM Des Moines

6h 50m2 stops Omaha Eppley Airfield Denver Intl

$569Southwest

Sat, Sep 19 - Sun, Sep 20

12:10 pm - 7:50 pmDSM Des Moines-STL Lambert-St Louis

7h 40m2 stops Chicago Midway Dallas Love Field

8:25 am - 3:15 pmSTL Lambert-St Louis-DSM Des Moines

6h 50m2 stops Omaha Eppley Airfield Denver Intl

$574Southwest

Booking Insights

Price, demand and travel trends for Des Moines to St. Louis flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Des Moines to St. Louis with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Des Moines to St. Louis?

Round-trip flights from Des Moines to St. Louis start at $235. Prices are typical for this route right now, with typical round-trip fares ranging from $213 to $374. The lowest price found in the past 5 days was $235 on American Airlines.

Find deals

Low season	July
High season	March
Cheapest flight	$141

Most popular time to fly with an average 19% increase in price.

Flight from Des Moines to St. Louis

When to book flights from Des Moines to St. Louis

Are your dates flexible? Find out the best times to travel from Des Moines to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Des Moines to St. Louis?
Flights from Des Moines to St. Louis usually depart from Des Moines (DSM) and arrive at Lambert-St Louis (STL).
What cabin classes can I book on flights from Des Moines to St. Louis?
Only Economy Class is available on flights from Des Moines to St. Louis.
How much can I save by taking a layover when flying from Des Moines to St. Louis?
On this route, nonstop flights are cheaper than layover options on average. Nonstop fares average $261 round-trip, compared to $313 via a layover through Chicago Midway (MDW).
Which aircraft model is used most often on flights from Des Moines to St. Louis?
The Airbus A320-100/200 family is used most often on this route, operated mainly by JetBlue and United Airlines. Other aircraft seen on the route include Airbus A319 variants.
Which airports do connecting flights from Des Moines to St. Louis pass through?
One-stop flights from Des Moines to St. Louis most commonly connect through:

• Minneapolis St Paul (MSP) - 48% of one-stop connections
• Chicago O'Hare Intl (ORD) - 43% of one-stop connections
• Chicago Midway (MDW) - 10% of one-stop connections

Minneapolis St Paul (MSP) handles the largest share of one-stop connections on this route.
Can I save money by using flexible dates for flights from Des Moines to St. Louis?
Yes. Being flexible with your travel dates can save you up to 49% on the Des Moines to St. Louis route. Tuesday is the cheapest departure day at $204 round-trip on average, while Saturday is the most expensive at $398, a difference of $194. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
What popular places can I visit in St. Louis?
Some of the most popular sights in St. Louis are Downtown St. Louis, Busch Stadium and Enterprise Center. These are among the most viewed places in St. Louis on KAYAK.
How long is a flight from Des Moines to St. Louis?
There are currently no nonstop flights available from Des Moines to St. Louis. Flights with 1 layover take between 3h 43m and 5h 05m in total, depending on the connection.
Do I need a passport to fly from Des Moines to St. Louis?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from Des Moines to St. Louis changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $235 to $1,079. That means the highest observed fare was about 5x higher than the lowest one.
How are flight prices from Des Moines to St. Louis looking right now?
One-way fares from Des Moines to St. Louis are currently in line with typical prices for this route. Average one-way fares are about $188.
How much time can I save by choosing a different layover airport from Des Moines to St. Louis?
Flying via Minneapolis St Paul (MSP) gives the shortest average 1-stop total travel time at 3h 43m, compared with 4h 09m via Chicago O'Hare Intl (ORD) and 5h 05m via Chicago Midway (MDW).
What car rental options are available at Lambert-St Louis Airport (STL)?
Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates starting from around $31 for economy cars. Top options include:
• Hertz
• Budget
• Alamo
• Enterprise Rent-A-Car
• Payless
How much should I expect to pay for a Des Moines to St. Louis flight?
Round-trip flights from Des Moines to St. Louis range from $213 to $374, with an average of $297 over the past 12 months. Anything below $213 counts as a good deal.

If your dates can be flexible, aim for a Tuesday departure instead of Saturday. On this route, Tuesday flights average $204 - about $194 less than Saturday (49% savings) based on the last 12 months.
If you can choose when to travel, plan your Des Moines to St. Louis trip for October. Fares historically average $250 round-trip in that month - typically $385 less than the most expensive month, which is February (based on the last 12 months).
If you're arriving late at night and need somewhere to stay, check out these hotels close to Lambert-St Louis Airport.
- Drury Inn & Suites St. Louis Airport
- Renaissance St. Louis Airport Hotel
- DoubleTree by Hilton St. Louis Airport

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DSM - STL

$141 Find Cheap Flights from Des Moines to St. Louis - Compare and Save

Everything you should know

Cheap Flights from Des Moines to St. Louis (DSM-STL)

Recent round-trip flight deals from Des Moines to St. Louis

Recent one-way flight deals from Des Moines to St. Louis

Recent last minute flight deals from Des Moines to St. Louis

Price, demand and travel trends for Des Moines to St. Louis flights

How much is a round-trip flight from Des Moines to St. Louis?

What is the cheapest airline to fly from Des Moines to St. Louis?

What is the most popular layover airport when flying from Des Moines to St. Louis?

What is the cheapest layover airport when flying from Des Moines to St. Louis?

When flying from Des Moines to St. Louis which airport offers the shortest layover?

Key details for Des Moines to St. Louis flights

Low season

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Cheapest flight

When to book flights from Des Moines to St. Louis

Your Des Moines to St. Louis flight questions, answered

Your guide to booking Des Moines to St. Louis flights

More options for your flight from Des Moines to St. Louis

Complete your trip to St. Louis with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Des Moines to St. Louis

Find direct flights to and from Des Moines and St. Louis

Flights from domestic origins to St. Louis

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