DSM - STL

$79 Find Cheap Flights from Des Moines to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to St. Louis, as well as popular online travel agencies
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41,299,237 searches in the past 7 days on KAYAK

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Everything you should know

Cheapest round-trip
$191
American Airlines
Thu 2/26Sat 2/28
DSM - STL • 1 stop
Cheapest non-stop
$340
Typical prices: $219-$575
Southwest
Thu 2/26Mon 3/2
DSM - STL • Non-stop
Top airlines
American Airlines
Cheapest • from $191 (round-trip)
Southwest
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to St. Louis (DSM-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to St. Louis

Thu, Feb 26 - Sat, Feb 28
American Airlines Logo
7:44 pm - 11:48 pm
DSM
-
STL
4h 04m
1 stop
American Airlines Logo
6:36 pm - 11:40 pm
STL
-
DSM
5h 04m
1 stop
$191American Airlines
Fri, Feb 27 - Fri, Mar 6
Frontier Logo
7:59 pm - 1:56 pm
DSM
-
STL
17h 57m
1 stop
Frontier Logo
8:12 pm - 7:16 pm
STL
-
DSM
23h 04m
1 stop
$193Frontier
Mon, Mar 2 - Thu, Mar 5
Delta Logo
10:57 am - 8:43 pm
DSM
-
STL
9h 46m
2 stops
Delta Logo
6:10 am - 10:17 am
STL
-
DSM
4h 07m
1 stop
$196Delta
Tue, Mar 3 - Wed, Mar 4
United Airlines Logo
3:24 pm - 9:05 pm
DSM
-
STL
5h 41m
1 stop
United Airlines Logo
6:00 pm - 11:43 pm
STL
-
DSM
5h 43m
1 stop
$237United Airlines
Fri, Feb 27 - Fri, Mar 6
Frontier Logo
7:59 pm - 11:59 pm
DSM
-
STL
28h 00m
2 stops
Frontier Logo
8:12 pm - 7:16 pm
STL
-
DSM
23h 04m
1 stop
$251Frontier
Thu, May 14 - Sat, May 16
Delta Logo
6:20 am - 1:17 pm
DSM
-
STL
6h 57m
1 stop
Delta Logo
5:30 pm - 9:17 pm
STL
-
DSM
3h 47m
1 stop
$254Delta
Mon, Mar 2 - Thu, Mar 5
Southwest Logo
5:20 am - 6:40 am
DSM
-
STL
1h 20mnonstop
Southwest Logo
5:30 am - 12:10 pm
STL
-
DSM
6h 40m
1 stop
$266Southwest
Mon, Mar 2 - Thu, Mar 5
Delta Logo
10:57 am - 8:43 pm
DSM
-
STL
9h 46m
2 stops
Delta Logo
6:35 am - 3:40 pm
STL
-
DSM
9h 05m
2 stops
$269Delta
Fri, Feb 27 - Sat, Feb 28
Delta Logo
10:57 am - 4:45 pm
DSM
-
STL
5h 48m
1 stop
Delta Logo
6:10 am - 10:17 am
STL
-
DSM
4h 07m
1 stop
$270Delta
Fri, Feb 27 - Sat, Feb 28
Delta Logo
10:57 am - 8:43 pm
DSM
-
STL
9h 46m
2 stops
Delta Logo
6:10 am - 10:17 am
STL
-
DSM
4h 07m
1 stop
$275Delta
Booking Insights

KAYAK's insights & trends for Des Moines to St. Louis flights

Get data-powered insights and trends into flights from Des Moines to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to St. Louis?

The average price of all round-trip flights from Des Moines to St. Louis clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to St. Louis on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Sunday is the most expensive day to fly from Des Moines to St. Louis. For your return ticket, we recommend flying on a Wednesday and avoiding Sundays for the best deals.

Can I save money by flying with a layover from Des Moines to St. Louis?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $281 on average.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$59
Best time to beat the crowds with an average 46% drop in price.
Most popular time to fly with an average 8% increase in price.
Flight from Des Moines to St. Louis

When to book flights from Des Moines to St. Louis

Are your dates flexible? Find out the best times to travel from Des Moines to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to St. Louis

  • What is the cheapest flight from Des Moines to St. Louis?

    In the last 3 days, the lowest price for a flight from Des Moines to St. Louis was $59 for a one-way ticket and $191 for a round-trip.

  • Do I need a passport to fly between Des Moines and St. Louis?

    No

  • Which airports will I be using when flying from Des Moines to St. Louis?

    When flying out of Des Moines you will be using Des Moines. You will be landing at St. Louis, also known as Lambert-St Louis.

  • Which airlines offer Wi-Fi service onboard planes from Des Moines to St. Louis?

    American Airlines, Delta, and JetBlue offer inflight Wi-Fi service on the Des Moines to St. Louis flight route.

  • Which aircraft models fly most regularly from Des Moines to St. Louis?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Des Moines to St. Louis flight route.

  • On which days can I fly direct from Des Moines to St. Louis?

    There are nonstop flights from Des Moines to St. Louis on a daily basis.

  • How does KAYAK find such low prices on flights from Des Moines to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Des Moines to St. Louis

  • Looking for a cheap flight? 25% of our users found flights on this route for $218 or less one-way and $349 or less round-trip.

Prefer to fly direct from Des Moines to St. Louis?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Des Moines to Lambert-St Louis.
Find which airlines fly direct from Des Moines Airport to Lambert-St Louis Airport, which days they fly and book direct flights.

Direct departures

Des Moines to Lambert-St Louis

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Direct returns

Lambert-St Louis to Des Moines

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Reviews of the top airline flying from Des Moines to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4273 reviews
8.6Crew
8.1Boarding
8.0Comfort
7.5Entertainment
7.0Food
Airline reviews

Flight attendants very hospitable and friendly. Pilot flew a smooth take off and landing.

10.0 ExcellentAnonymous, Feb 2026
MSY - PHX
Read more Southwest reviews

Flight attendants very hospitable and friendly. Pilot flew a smooth take off and landing.

Paid for premium extra leg room but the bin space for rows 1-3 had to go in rows 4-6 and 4-6 had to go to 7-9 because flight attendants have snacks and their luggage upfront. So we pay extra to have to fight thru traffic to get our bags. Only 2nd day of new seating so hope they fix this.

WIFI was great. My selection for seating is an aisle, but during my trip, I never had an aisle seat. If we can get that corrected, I will be thrilled. No snack or drink on this flight.

WIFI was great. My selection for seating is an aisle, but during my trip, I never had an aisle seat. If we can get that corrected, I will be thrilled.

The wifi on the plane is great. The only issue that I have is that I prefer an aisle seat and on my trips this week, I was either in the middle or window. If we can work to secure aisle seating, I will be thrilled. Nice trip.

All good except once again bags took an hour at Midway Airport Happens all the time. Ridiculous

Everything went smoothly and we even arrived a little bit early.

Great vacation. Can't wait till next year for another one.

Great flight but super high price. Glad it was a business trip and not personal

On time. Friendly staff. Took to long to pre bord all the specialty groups. Cramped small plane

Everything you need to know for your flight from Des Moines to St. Louis

Information on your arrival and departure airports

Des Moines (DSM)
St. Louis (STL)