EYW - STL

$142 Find Cheap Flights from Key West to St. Louis - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$321
Typical prices: $338-$477
Multiple Airlines
Thu 11/22Sun 12/2
EYW - STL • 1 stop
Cheapest one-way
$142
Typical prices: $270-$498
Multiple Airlines
Thu 10/11
EYW - STL • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Key West and St. Louis. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
November
Cheapest • 31% price drop
October
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Charlotte Douglas (CLT)
Cheapest • Avg $308 (round-trip)
Miami (MIA)
Shortest trip • 4h 56m (one-way)
Insights
Insights
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Booking Insights
Flight Deals

Cheap Flights from Key West to St. Louis (EYW-STL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to St. Louis

Sun, Nov 22 - Wed, Dec 2
Multiple Airlines Logo
10:59 am - 12:25 pmEYW  Key West-STL Lambert-St Louis
26h 26m1 stop Orlando
Multiple Airlines Logo
2:59 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
42h 20m2 stops Atlanta Hartsfield-Jackson Orlando
$321Multiple Airlines
Tue, Nov 24 - Tue, Dec 1
American Airlines Logo
1:11 pm - 7:50 pmEYW  Key West-STL Lambert-St Louis
7h 39m1 stop Chicago O'Hare Intl
American Airlines Logo
5:00 am - 11:46 amSTL  Lambert-St Louis-EYW Key West
5h 46m1 stop Chicago O'Hare Intl
$323American Airlines
Mon, Nov 23 - Wed, Dec 2
Multiple Airlines Logo
10:59 am - 11:59 pmEYW  Key West-STL Lambert-St Louis
14h 00m1 stop Orlando
Multiple Airlines Logo
2:59 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
42h 20m2 stops Atlanta Hartsfield-Jackson Orlando
$334Multiple Airlines
Tue, Nov 24 - Wed, Dec 2
Multiple Airlines Logo
11:04 am - 11:59 pmEYW  Key West-STL Lambert-St Louis
13h 55m1 stop Orlando
Multiple Airlines Logo
2:59 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
42h 20m2 stops Atlanta Hartsfield-Jackson Orlando
$353Multiple Airlines
Mon, Nov 23 - Thu, Dec 3
Multiple Airlines Logo
10:59 am - 11:59 pmEYW  Key West-STL Lambert-St Louis
14h 00m1 stop Orlando
Multiple Airlines Logo
6:05 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
15h 14m1 stop Orlando
$354Multiple Airlines
Wed, Nov 25 - Wed, Dec 2
Multiple Airlines Logo
10:59 am - 11:59 pmEYW  Key West-STL Lambert-St Louis
14h 00m1 stop Orlando
Multiple Airlines Logo
2:59 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
42h 20m2 stops Atlanta Hartsfield-Jackson Orlando
$360Multiple Airlines
Sun, Nov 22 - Thu, Dec 3
Multiple Airlines Logo
10:59 am - 12:25 pmEYW  Key West-STL Lambert-St Louis
26h 26m1 stop Orlando
Multiple Airlines Logo
6:05 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
15h 14m1 stop Orlando
$362Multiple Airlines
Sun, Nov 22 - Thu, Dec 3
Multiple Airlines Logo
10:59 am - 5:40 pmEYW  Key West-STL Lambert-St Louis
31h 41m2 stops Orlando Atlanta Hartsfield-Jackson
Multiple Airlines Logo
6:05 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
15h 14m1 stop Orlando
$372Multiple Airlines
Mon, Nov 23 - Mon, Nov 30
Multiple Airlines Logo
10:59 am - 11:59 pmEYW  Key West-STL Lambert-St Louis
14h 00m1 stop Orlando
Multiple Airlines Logo
6:35 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
14h 44m2 stops Atlanta Hartsfield-Jackson Orlando
$376Multiple Airlines
Tue, Nov 24 - Wed, Dec 2
Delta Logo
6:05 pm - 11:56 pmEYW  Key West-STL Lambert-St Louis
6h 51m1 stop Atlanta Hartsfield-Jackson
Delta Logo
12:36 pm - 8:02 pmSTL  Lambert-St Louis-EYW Key West
6h 26m1 stop Atlanta Hartsfield-Jackson
$381Delta
Booking Insights

Price, demand and travel trends for Key West to St. Louis flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Key West to St. Louis with more confidence.

What is the cheapest airline to fly from Key West to St. Louis?

American Airlines ($323) and Delta ($381) are the cheapest airlines to fly round-trip from Key West to St. Louis according to KAYAK data over the last 5 days.

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Key details for Key West to St. Louis flights

Low season

January

Cheapest flight

$142
Best time to beat the crowds with an average 26% drop in price.
Most popular time to fly and prices are also 10% lower on average.
Flight from Key West to St. Louis

When to book flights from Key West to St. Louis

Are your dates flexible? Find out the best times to travel from Key West to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Key West to St. Louis flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Key West to St. Louis?

    Flights from Key West to St. Louis usually depart from Key West (EYW) and arrive at Lambert-St Louis (STL).

  • What cabin classes can I book on flights from Key West to St. Louis?

    Only Economy Class is available on flights from Key West to St. Louis.

  • Which airports do connecting flights from Key West to St. Louis pass through?

    One-stop flights from Key West to St. Louis most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 63% of one-stop connections
    • Charlotte Douglas (CLT) - 25% of one-stop connections
    • Miami (MIA) - 13% of one-stop connections

    Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Key West to St. Louis?

    Yes. Being flexible with your travel dates can save you up to 59% on the Key West to St. Louis route. Wednesday is the cheapest departure day at $359 round-trip on average, while Tuesday is the most expensive at $862, a difference of $503. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What popular places can I visit in St. Louis?

    Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.

  • How long is a flight from Key West to St. Louis?

    A nonstop flight from Key West to St. Louis takes 0h 00m, covering 1,102 miles.

  • Do I need a passport to fly from Key West to St. Louis?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Key West to St. Louis changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $321 to $1,410. That means the highest observed fare was about 4x higher than the lowest one.

  • How are flight prices from Key West to St. Louis looking right now?

    One-way fares from Key West to St. Louis are currently lower than usual. Average one-way flight prices are about $288, which is 34% below the typical average for this route.

  • How much time can I save by choosing a different layover airport from Key West to St. Louis?

    Flying via Miami (MIA) gives the shortest average 1-stop total travel time at 4h 56m, compared with 5h 24m via Atlanta Hartsfield-Jackson (ATL) and 5h 27m via Charlotte Douglas (CLT).

  • What is the time difference between Key West and St. Louis?

    St. Louis is 1 hour behind Key West (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Lambert-St Louis Airport (STL)?

    Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates starting from around $31 for economy cars. Top options include:
    • Hertz
    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Payless

  • How much should I expect to pay for a Key West to St. Louis flight?

    Round-trip flights from Key West to St. Louis range from $338 to $477, with an average of $374 over the past 12 months. Anything below $338 counts as a good deal.

Your guide to booking Key West to St. Louis flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Wednesday departure instead of Tuesday. On this route, Wednesday flights average $359 - about $503 less than Tuesday (58% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Key West to St. Louis trip for November. Fares historically average $258 round-trip in that month - typically $604 less than the most expensive month, which is December (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Lambert-St Louis Airport.
    - Drury Inn & Suites St. Louis Airport
    - Renaissance St. Louis Airport Hotel
    - DoubleTree by Hilton St. Louis Airport

More options for your flight from Key West to St. Louis

Complete your trip to St. Louis with a hotel stay or car rental

Car rentals in St. Louis
Hotels in St. Louis
Vacations in St. Louis