STL - TYS

$139 Find Cheap Flights from St. Louis to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$233
Overall average: $293
American Airlines
Tue 4/7Tue 4/7
STL - TYS • 1 stop
Cheapest one-way
$139
Typical prices: $129-$208
American Airlines
Mon 5/4
STL - TYS • 1 stop
Top airlines
Cheapest • from $233 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between St. Louis and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $281 (round-trip)
Shortest trip • 4h 00m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 18% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Knoxville (STL-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Knoxville

Tue, Apr 7 - Tue, Apr 7
American Airlines Logo
6:00 am - 11:18 am
STL
-
TYS
4h 18m
1 stop
American Airlines Logo
6:54 pm - 10:59 pm
TYS
-
STL
5h 05m
1 stop
$233American Airlines
Tue, Apr 7 - Tue, Apr 7
Southwest Logo
5:15 am - 2:20 pm
STL
-
TYS
8h 05m
2 stops
Southwest Logo
5:50 pm - 10:00 pm
TYS
-
STL
5h 10m
1 stop
$238Southwest
Tue, Apr 7 - Fri, Apr 10
Multiple Airlines Logo
11:21 am - 10:36 am
STL
-
TYS
22h 15m
2 stops
Multiple Airlines Logo
4:20 pm - 9:48 am
TYS
-
STL
18h 28m
1 stop
$243Multiple Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
5:51 am - 11:18 am
STL
-
TYS
4h 27m
1 stop
American Airlines Logo
7:50 am - 2:03 pm
TYS
-
STL
7h 13m
1 stop
$245American Airlines
Sat, Apr 25 - Wed, Apr 29
Southwest Logo
6:20 am - 1:20 pm
STL
-
TYS
6h 00m
1 stop
Southwest Logo
7:05 am - 2:50 pm
TYS
-
STL
8h 45m
2 stops
$250Southwest
Sat, Apr 25 - Wed, Apr 29
Southwest Logo
8:45 am - 6:30 pm
STL
-
TYS
8h 45m
2 stops
Southwest Logo
7:05 am - 1:00 pm
TYS
-
STL
6h 55m
2 stops
$255Southwest
Mon, Apr 6 - Thu, Apr 9
American Airlines Logo
6:57 pm - 11:50 pm
STL
-
TYS
3h 53m
1 stop
American Airlines Logo
6:54 pm - 10:59 pm
TYS
-
STL
5h 05m
1 stop
$257American Airlines
Sat, Apr 25 - Sat, May 2
Southwest Logo
2:25 pm - 6:30 pm
STL
-
TYS
3h 05m
1 stop
Southwest Logo
6:40 am - 4:25 pm
TYS
-
STL
10h 45m
2 stops
$262Southwest
Sat, Apr 25 - Sat, May 2
Southwest Logo
8:45 am - 6:30 pm
STL
-
TYS
8h 45m
2 stops
Southwest Logo
6:40 am - 4:25 pm
TYS
-
STL
10h 45m
2 stops
$267Southwest
Mon, Apr 13 - Sun, Apr 19
American Airlines Logo
6:55 pm - 11:55 pm
STL
-
TYS
4h 00m
1 stop
American Airlines Logo
7:00 am - 12:48 pm
TYS
-
STL
6h 48m
1 stop
$268American Airlines
Booking Insights

KAYAK's insights & trends for St. Louis to Knoxville flights

Get data-powered insights and trends into flights from St. Louis to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from St. Louis to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Knoxville is July, where tickets cost $273 (return) on average. On the other hand, the most expensive months are January and October, where the average cost of round-trip tickets is $434 and $378 respectively.

Good to know

Low seasonJanuary
Cheapest flight$139
Best time to beat the crowds but there is an average 29% increase in price.
Most popular time to fly and prices are also 19% lower on average.
Flight from St. Louis to Knoxville

When to book flights from St. Louis to Knoxville

Are your dates flexible? Find out the best times to travel from St. Louis to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Knoxville

  • What is the cheapest flight from St. Louis to Knoxville?

    In the last 3 days, the lowest price for a flight from St. Louis to Knoxville was $139 for a one-way ticket and $233 for a round-trip.

  • Do I need a passport to fly between St. Louis and Knoxville?

    No, a passport isn't needed to fly from St. Louis to Knoxville. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from St. Louis to Knoxville?

    St. Louis airport is called Lambert-St Louis and the only airport in Knoxville is Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from St. Louis to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Knoxville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between St. Louis and Knoxville, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from St. Louis to Knoxville are Delta and American Airlines. With an average price for the route of $323 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $295 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from St. Louis to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from St. Louis to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8293 reviews
7.2Food
8.1Boarding
7.9Comfort
7.8Entertainment
8.5Crew
Airline reviews

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

2.0 MediocreSusan, Mar 2026
JAX - ATL
Read more Delta reviews

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

The WiFi was not working. That made for a long flight.

Absolutely no communication on why there's a delay and multiple flight time reschedules. I would have canceled the flight and drove back home if I known it was going to be rescheduled 3 or 4 times.

Another late night flight and MORE men belligerently drinking and yelling. I had to move from first to economy because they were so obnoxious and disruptive. Crazy to go from a cozy chair to cardboard when you were supposed to be in first. Delta allows was too much drinking which leads to belligerent behavior.

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Love delta smaller commuter plane so no entertainment and paid wifi on MKE-LGA leg was extremely unreliable and slow

Stop changing gates. Stop cancelling flights Stop moving my seat.

Extremely disappointed with Delta. They canceled flight last minute and then I rebooked the other flights and with which were delayed as well

Could not get my connecting flight boarding pass until four hrs before departure! Ver annoying especially since the staff could not explain why!

The flight was flying with 30% capacity. The flight my seat from preferred seating to back of the seat. Even though i can understand that this was to balance the flight weight. The flight attendance decided to do the serving near my seat and in the middle , their noices woke me up from sleep , when i realized that the service has ended and when they were going back asked for a coffee, for which they answered they have completed teh service in my location. That really upset me as they woke me up and also rejected the coffee i asked. I ended up landing with a headache, thanks to the crew that screwed up my travel

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

It would have been nice if American tried to care.

American Airlines did everything they could with the high Spring Break crowd. I was frustrated to be changed from 1st class to a middle seat at the back of the plane. This has happened before, not sure booking 1st class and paying the extra actually works.

I booked 1st class, my flights were changed and I was sitting in the middle at the back of the plane. A far cry from the 1st class I purchased for my flights. I am grateful I arrived on time.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Our flight was delayed 3 times and this is why I am giving such low reviews. Everything else was okay but being in the airport at 4:30pm for my initial flight at 7pm to not leave until after 9:30pm is insane,

Flights were constantly delayed. CRW took 50 minutes to get bags

Flight has been delayed every time I've ever taken it. Seats uncomfortable. Children behind me yelling the entire flight. Some of this is out of their control but overall just consistently not a great experience.

Check in was rough because the check in crew did not know how to manage my international visa documents. Required a long process and 4 people to finally be able to proceed to security. They told us incorrect information several times before acknowledging we did indeed have everything we needed from the start.

Where do I start!! I was delayed with my flight from Dallas to Tampa. On the way back from Tampa to Dallas the flight was delayed over 4 hours+. I was put on another flight that was also delayed but not as long. Traveling on American Airlines is becoming exhausing.

Everything you need to know for your flight from St. Louis to Knoxville

Information on your arrival and departure airports