STL - TYS

$118 Find Cheap Flights from St. Louis to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$235
Typical prices: $353-$472
Delta
Wed 3/4Wed 3/11
STL - TYS • 1 stop
Cheapest one-way
$118
Typical prices: $175-$191
Delta
Mon 4/20
STL - TYS • 1 stop
Top airlines
Delta
Cheapest • from $235 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
July
Cheapest • 19% price drop
July
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Knoxville (STL-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Knoxville

Wed, Mar 4 - Wed, Mar 11
Delta Logo
6:00 am - 11:08 am
STL
-
TYS
4h 08m
1 stop
Delta Logo
5:30 am - 9:05 am
TYS
-
STL
4h 35m
1 stop
$235Delta
Sat, Feb 21 - Mon, Feb 23
American Airlines Logo
6:06 am - 2:29 pm
STL
-
TYS
7h 23m
2 stops
American Airlines Logo
6:38 pm - 11:04 pm
TYS
-
STL
5h 26m
1 stop
$248American Airlines
Thu, Mar 5 - Sun, Mar 8
Southwest Logo
4:45 pm - 10:10 pm
STL
-
TYS
4h 25m
1 stop
Southwest Logo
7:25 pm - 12:15 am
TYS
-
STL
5h 50m
1 stop
$257Southwest
Thu, Mar 5 - Sun, Mar 8
Southwest Logo
2:15 pm - 10:10 pm
STL
-
TYS
6h 55m
2 stops
Southwest Logo
7:25 pm - 12:15 am
TYS
-
STL
5h 50m
1 stop
$262Southwest
Wed, Mar 25 - Sun, Mar 29
Southwest Logo
6:10 am - 1:40 pm
STL
-
TYS
6h 30m
1 stop
Southwest Logo
7:25 pm - 12:15 am
TYS
-
STL
5h 50m
1 stop
$267Southwest
Wed, Mar 25 - Sun, Mar 29
Southwest Logo
10:30 am - 9:10 pm
STL
-
TYS
9h 40m
2 stops
Southwest Logo
7:25 pm - 12:15 am
TYS
-
STL
5h 50m
1 stop
$272Southwest
Fri, Mar 27 - Sun, Mar 29
Southwest Logo
2:35 pm - 9:15 pm
STL
-
TYS
5h 40m
1 stop
Southwest Logo
7:25 pm - 12:15 am
TYS
-
STL
5h 50m
1 stop
$279Southwest
Fri, Mar 27 - Sun, Mar 29
Southwest Logo
12:20 pm - 9:15 pm
STL
-
TYS
7h 55m
2 stops
Southwest Logo
7:25 pm - 12:15 am
TYS
-
STL
5h 50m
1 stop
$284Southwest
Tue, Apr 21 - Sun, Apr 26
Southwest Logo
10:15 am - 5:10 pm
STL
-
TYS
5h 55m
1 stop
Southwest Logo
6:40 am - 9:05 am
TYS
-
STL
3h 25m
1 stop
$286Southwest
Thu, Mar 5 - Sun, Mar 8
Southwest Logo
2:15 pm - 9:15 pm
STL
-
TYS
6h 00m
2 stops
Southwest Logo
2:35 pm - 11:55 pm
TYS
-
STL
10h 20m
2 stops
$287Southwest
Booking Insights

KAYAK's insights & trends for St. Louis to Knoxville flights

Get data-powered insights and trends into flights from St. Louis to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from St. Louis to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from St. Louis to Knoxville departing in March.

What is the cheapest month to fly from St. Louis to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Knoxville is July, where tickets cost $266 (return) on average. On the other hand, the most expensive months are January and March, where the average cost of round-trip tickets is $416 and $402 respectively.

Good to know

Low seasonJanuary
Cheapest flight$118
Best time to beat the crowds but there is an average 27% increase in price.
Most popular time to fly and prices are also 19% lower on average.
Flight from St. Louis to Knoxville

When to book flights from St. Louis to Knoxville

Are your dates flexible? Find out the best times to travel from St. Louis to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Knoxville

  • What is the cheapest flight from St. Louis to Knoxville?

    In the last 3 days, the lowest price for a flight from St. Louis to Knoxville was $140 for a one-way ticket and $235 for a round-trip.

  • Do I need a passport to fly between St. Louis and Knoxville?

    No, a passport isn't needed to fly from St. Louis to Knoxville. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from St. Louis to Knoxville?

    St. Louis airport is called Lambert-St Louis and the only airport in Knoxville is Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from St. Louis to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Knoxville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between St. Louis and Knoxville, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Knoxville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from St. Louis to Knoxville are Delta and United Airlines. With an average price for the route of $309 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $315 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from St. Louis to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from St. Louis to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8075 reviews
8.5Crew
8.1Boarding
7.8Entertainment
7.9Comfort
7.2Food
Airline reviews

Probably not the fault of Delta but there was delay after delay after delay and I ended up getting home 4 hours later then I should have at 1:30 in the morning

4.0 Okaybyron, Jan 2026
CWA - MSP
Read more Delta reviews

Probably not the fault of Delta but there was delay after delay after delay and I ended up getting home 4 hours later then I should have at 1:30 in the morning

No in flight service, no explanation - FC got service, C+ did not, unsure about Economy. No turbulence to speak of, so I guess another way to cut cost, or promote health and well being of Delta employees? Also, boarding in MEM combined zones, and with overhead space already full on both flights after Zone 2/ Diamond, presents a huge challenge to find a space for a bag. Delta, other than point A to B, is no longer reasonable to fly - very poor experiences, not even taking into account the chastising at the gate and rude crews, across the board.

It would have been better if the flight wasn't delayed by 2.5 hours

Delta’s staff is unmatched. From the gate agents, to the pilots, to the flight attendants… all top of the industry.

Delta flight Delay for ,more that two hours i.e original flight was 6.30 PM and it starts at 8.45 PM, When we connect Delta team for meal vouchers as it is late arrival in designation,But we did not get it as per delta policy , which is not good for mid night arrival,

Inexperienced boarding crew allowed too many bags on to a full flight and delayed takeoff causing a missed connection and unplanned overnight stay. There was a hotel at the airport but Delta would not pay for it offering only to shuttle me to an area hotel. Never even offerred so much as an apology by anyone working for Delta.

Staff was great! Kind and cordial! Middle seat row 28 seat B has a hump in it. Trays were getting stuck when putting down and up. Good flight

Departure was delayed resulting in me missing my connection. Delta did not autimatically find me another flight.

The seats weren’t reclining even though it wasn’t as exit seat

It was good because we traveled without luggage, carry on only.

I wish there were outlets to charge my iPhone. The crew was great; we had a female pilot who was great with explaining what was happening and delays,

The flight crew where really good. Better then the crew from BNE to SFO

Delayed, toilets did not flush, pilot parked to far away from Gate

Was happy we finally got upgraded in 1st class. The seat getting old. The cushiness need some improvement.

Yet another flight in which beverage and snack service was skipped. Other that that, firmly mediocre. Landed early, to gate late due to congestion at the gates. Airline's fault or airports fault: unknown.

Miserable. They moved my seat, but canceled the next leg of my flight. I resolved the issue at my transfer, but that resulted in lost luggage that has taken days off my schedule with no resolution. Worse, they fail to interface effectively with Lufthansa, forcing me to bounce between two equally useless help desks. The apps are unable to handle the situation, the bag dropped off the tracker, and while the call centers are polite, they do not provide written information to assist with cross-airline communication.

left on time, reasonable boarding process arrived early luggage came out quickly

I like flying first class, and United has a nice one

Teeny tiny bathrooms, crew was not realistic about when we'd arrive.

Check-in, boarding and the flight from Phoenix to Houston was quick and easy. The flight from Houston to Shreveport was delayed 5 hours. It was frustrating but I think United handled it the best they could.

Qatar airways ,boarding arrangements at Hamid international airport could been better

Crew in Columbia was not prepared for landing. It was a bit of a disaster and getting bags took forever.

My seat tv didn’t work the whole trip. And the seat space is too small despite being seated at the front.

The seat cushions were very worn so they were extremely uncomfortable.

Delayed, no updates, had a rewards number but was not working

The seats from lax to DFW was so tight that I could not move my legs . No WiFi and had to pay . Not a good selection of entertainment

AA should improve their in air internet & entertainment options. Seems unreasonable to charge $20/hr and should have some form of free connections. The entertainment options are also pretty limited, movies are outdated and the series only show 3-5 episodes.

We were upgraded to First Class and it was a great flight

Amazing I love American. I’ll never fly anyone else if I can help it.

I love American. I’ll never fly anyone else if I can help it.

Everything you need to know for your flight from St. Louis to Knoxville

Information on your arrival and departure airports