STL - TYS

$140 Find Cheap Flights from St. Louis to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
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Flight Deals

Cheap Flights from St. Louis to Knoxville (STL-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Knoxville

Sun, Jan 25 - Wed, Jan 28
Multiple Airlines Logo
5:11 pm - 5:28 pmSTL-TYS
23h 17m1 stop
Multiple Airlines Logo
4:47 pm - 11:01 amTYS-STL
19h 14m1 stop
$228Multiple Airlines
Find Deal
Sun, Jan 25 - Wed, Jan 28
Multiple Airlines Logo
5:11 pm - 10:10 amSTL-TYS
15h 59m1 stop
Multiple Airlines Logo
3:53 pm - 9:47 amTYS-STL
18h 54m2 stops
$231Multiple Airlines
Find Deal
Mon, Nov 17 - Thu, Nov 20
Multiple Airlines Logo
10:25 am - 11:14 pmSTL-TYS
11h 49m1 stop
Multiple Airlines Logo
6:30 am - 11:57 pmTYS-STL
18h 27m2 stops
$236Multiple Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
Delta Logo
9:30 am - 1:44 pmSTL-TYS
3h 14m1 stop
Delta Logo
3:57 pm - 6:33 pmTYS-STL
3h 36m1 stop
$251Delta
Find Deal
Thu, Nov 27 - Wed, Dec 3
American Airlines Logo
6:00 am - 5:42 pmSTL-TYS
10h 42m1 stop
American Airlines Logo
6:18 pm - 10:47 pmTYS-STL
5h 29m1 stop
$263American Airlines
Find Deal
Wed, Dec 3 - Fri, Dec 12
American Airlines Logo
2:11 pm - 9:36 pmSTL-TYS
6h 25m1 stop
American Airlines Logo
5:24 am - 10:36 amTYS-STL
6h 12m1 stop
$265American Airlines
Find Deal
Sat, Nov 15 - Sat, Nov 22
Frontier Logo
7:45 pm - 6:22 pmSTL-TYS
21h 37m1 stop
Frontier Logo
8:05 pm - 6:58 pmTYS-STL
23h 53m1 stop
$283Frontier
Find Deal
Wed, Feb 18 - Sat, Feb 21
Delta Logo
6:35 am - 12:13 pmSTL-TYS
4h 38m1 stop
Delta Logo
5:30 am - 11:04 amTYS-STL
6h 34m1 stop
$285Delta
Find Deal
Tue, Nov 18 - Sat, Nov 22
United Airlines Logo
10:00 am - 5:08 pmSTL-TYS
6h 08m1 stop
United Airlines Logo
5:52 pm - 9:40 pmTYS-STL
4h 48m1 stop
$467United Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
United Airlines Logo
12:55 pm - 7:29 pmSTL-TYS
5h 34m1 stop
United Airlines Logo
9:40 am - 11:42 pmTYS-STL
15h 02m2 stops
$491United Airlines
Find Deal

Everything you should know

Top airlines
Delta
Cheapest • from $251 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
4 weeks
in advance
Our data shows that travelers who book at least 4 weeks in advance save around 17% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
July
Cheapest • 19% price drop
November
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$228
Typical prices: $248-$453
Multiple Airlines
Sun 1/25Wed 1/28
STL - TYS • 1 stop
Cheapest one-way
$107
Typical prices: $228-$320
Frontier
Wed 11/12
STL - TYS • 1 stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Booking Insights

KAYAK's insights & trends for St. Louis to Knoxville flights

Get data-powered insights and trends into flights from St. Louis to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from St. Louis to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from St. Louis to Knoxville departing in January.

What’s the cheapest day of the week to fly from St. Louis to Knoxville?

The average price of all round-trip flights from St. Louis to Knoxville clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Knoxville on a Thursday and more expensive on a Sunday. On your return trip to St. Louis, you should consider flying back on a Wednesday, and avoid Mondays for better deals.

What is the cheapest month to fly from St. Louis to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Knoxville is July, where tickets cost $266 (return) on average. On the other hand, the most expensive months are December and March, where the average cost of round-trip tickets is $432 and $420 respectively.

How far in advance should I book a flight from St. Louis to Knoxville?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to Knoxville, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from St. Louis to Knoxville, you should book around 4 weeks before departure, which saves you about 17% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 13 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$107
Best time to beat the crowds but there is an average 14% increase in price.
Most popular time to fly and prices are also 14% lower on average.
Flight from St. Louis to Knoxville

When to book flights from St. Louis to Knoxville

Are your dates flexible? Find out the best times to travel from St. Louis to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Knoxville

  • What is the cheapest flight from St. Louis to Knoxville?

    In the last 3 days, the lowest price for a flight from St. Louis to Knoxville was $107 for a one-way ticket and $228 for a round-trip.

  • Do I need a passport to fly between St. Louis and Knoxville?

    No, a passport isn't needed to fly from St. Louis to Knoxville. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from St. Louis to Knoxville?

    St. Louis airport is called Lambert-St Louis and the only airport in Knoxville is Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from St. Louis to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Knoxville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between St. Louis and Knoxville, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Knoxville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from St. Louis to Knoxville are Delta and United Airlines. With an average price for the route of $296 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $378 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from St. Louis to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from St. Louis to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8003 reviews
7.3Food
8.2Boarding
8.5Crew
7.9Comfort
7.9Entertainment
Airline reviews

I truly love flying with Delta. They have always treated me with the upmost respect

10.0 ExcellentMAYRA, Nov 2025JFK - MIA
Read more Delta reviews

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

Everything went well and was good. Nothing exceptional, but no complaints either. Cheap seats are pretty comfortable.

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The customer service before board was very rude and when I expressed my concerns about making the connecting flight she laughed and told me I bought the wrong ticket. I explained once it showed the flight was delayed it no longer let me change seats or anything. I was trying to upgrade to make sure I would get to the next gate on time.

Non stop on long haul is the way to go. Great experience

The flight used a B767 with a very old interior from before 2014. The entertainment system did not work at all during the flight despite attempts to reset the system. It was like they flew this route just to be competitive.

They changed planes and the new plane couldn’t carry enough fuel to fly across the country so we had to stop in Kansas City to refuel. Flight was delayed .

Flight was too crowded and seats are too small, especially since passengrs are getting larger. Having a middle seat is ALWAYS tough! Woman on my left was large & kept creeping in to my space. Flight personnel were great! Have more savory rather than sweet snacks please.

Premium Plus is a really good idea for longer flights

7 hours delayed due to operational issues on United’s end. Basically laziness.

Short flight but an "eager to help" crew made the journey more enjoyable!

Flight was delayed only slightly before takeoff due to traffic control. However, the flight arrived early to ORD. Good flight. United has been very reliable for me.

The person I bought the ticket for didn’t make the flight.

Lately I like the planes have been exceptionally filthy. There’s lines of dust and dirt all across the ceiling in the vents, and the cracks in between the seats are literally full of food. It’s definitely not the quality of service that I was used to with United. I’m also very disappointed with the Wi-Fi! All I wanna do is knock out a few work jobs while I’m trapped in my seat And it spools so bad. They did provide me with a refund, but the process of getting that refund is so complicated. It’s unfortunate.

Another delayed flight. When the delays exceed the duration of the flight, it’s a problem.

Excellent flight. Smooth, efficient boarding. Quick flight. Arrived early at STL.

After boarding the plane in Chicago, the passengers were told that there was a technical problem with the plane. Passengers remained on the plane as they tried to fix the problem. After what was probably an hour passengers were told that there was a need to change planes as the problem was not solved. Passengers disembarked and boarded another plane. After taxing to the runway and waiting for takeoff, passengers were told that owing to the thunderstorm the flight was unable to take off but would try and reroute. After some time passengers were told there wasn't enough fuel for the new route and the plane had to return to the gate for additional fuel. after another log delay the flight got underway. On the plane there was food, drinks, ice or entertainment. We were a glass of water, which appeared rationed. Flight arrived about 5 hours late. The pilot was fantastic and communicated with the passengers throughout the ordeal.

The flight attendants were great, I joked with one I can’t remember her name, a blond, really sweet. I thought it was run well very professional. This was great i survived Spirit, I know for which I speak.

We loved the steward on the plane. He made the night enjoyable

I enjoyed the extra leg room compared to other airlines. The first stewards made my daughter’s birthday special by giving her an extra snack. Then the last one coming home from Chicago to Appleton made our night really enjoyable Thanks for making our trip enjoyable

The flight was smooth, the pilot kept us informed about delays and we arrived more of less on time

Flight delay was communicated before leaving for airport which caused it to be a non-event. Great flight and crew!

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

The flight attendant, a black woman with curly hair who sat near Row 21, was wonderful and kind.

It was good..clean, comfy seat. Friendly warm welcoming crew. Was able to check my cabin luggage at the gate which I was able to pickup in a decent time from baggage claim. The app gave all updates from delays to baggage claim info. Overall smooth flight.

Flight was delayed leaving Dallas. Arrived about 2 hours later than scheduled.

Everything you need to know for your flight from St. Louis to Knoxville

Information on your arrival and departure airports

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