STL - TYS

$100 Find Cheap Flights from St. Louis to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 6/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$249
Typical prices: $502-$250
Southwest
Sun 5/31Wed 6/3
STL - TYS • 1 stop
Cheapest one-way
$100
Typical prices: $268-$368
American Airlines
Wed 6/10
STL - TYS • 1 stop
Top airlines
Cheapest • from $249 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between St. Louis and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $281 (round-trip)
Shortest trip • 4h 00m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 18% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Knoxville (STL-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Knoxville

Sun, May 31 - Wed, Jun 3
Southwest Logo
7:35 am - 11:40 am
STL
-
TYS
3h 05m
1 stop
Southwest Logo
8:15 am - 3:15 pm
TYS
-
STL
8h 00m
1 stop
$249Southwest
Sat, Apr 18 - Fri, Apr 24
American Airlines Logo
9:34 am - 6:04 pm
STL
-
TYS
7h 30m
1 stop
American Airlines Logo
6:54 pm - 10:59 pm
TYS
-
STL
5h 05m
1 stop
$255American Airlines
Thu, Apr 16 - Mon, Apr 20
Multiple Airlines Logo
8:06 pm - 5:30 pm
STL
-
TYS
20h 24m
2 stops
Multiple Airlines Logo
1:15 pm - 11:19 pm
TYS
-
STL
11h 04m
1 stop
$263Multiple Airlines
Sun, Apr 19 - Mon, Apr 27
Multiple Airlines Logo
4:59 pm - 5:30 pm
STL
-
TYS
23h 31m
1 stop
Multiple Airlines Logo
1:15 pm - 6:50 am
TYS
-
STL
42h 35m
2 stops
$268Multiple Airlines
Sat, Apr 18 - Fri, Apr 24
Southwest Logo
8:45 am - 6:30 pm
STL
-
TYS
8h 45m
2 stops
Southwest Logo
6:45 pm - 11:15 pm
TYS
-
STL
5h 30m
1 stop
$278Southwest
Thu, Apr 16 - Mon, Apr 20
Multiple Airlines Logo
4:59 pm - 5:30 pm
STL
-
TYS
23h 31m
1 stop
Multiple Airlines Logo
1:15 pm - 11:19 pm
TYS
-
STL
11h 04m
1 stop
$283Multiple Airlines
Sun, May 10 - Fri, May 15
Southwest Logo
8:30 am - 3:15 pm
STL
-
TYS
5h 45m
1 stop
Southwest Logo
6:45 pm - 11:15 pm
TYS
-
STL
5h 30m
1 stop
$286Southwest
Sun, Apr 19 - Wed, Apr 22
Southwest Logo
8:25 am - 2:05 pm
STL
-
TYS
4h 40m
1 stop
Southwest Logo
12:50 pm - 5:15 pm
TYS
-
STL
5h 25m
1 stop
$288Southwest
Sun, May 10 - Fri, May 15
Southwest Logo
2:10 pm - 9:05 pm
STL
-
TYS
5h 55m
2 stops
Southwest Logo
6:45 pm - 11:15 pm
TYS
-
STL
5h 30m
1 stop
$292Southwest
Sun, Apr 19 - Wed, Apr 22
Southwest Logo
5:25 am - 2:05 pm
STL
-
TYS
7h 40m
2 stops
Southwest Logo
5:50 pm - 10:00 pm
TYS
-
STL
5h 10m
1 stop
$293Southwest
Booking Insights

KAYAK's insights & trends for St. Louis to Knoxville flights

Get data-powered insights and trends into flights from St. Louis to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from St. Louis to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from St. Louis to Knoxville departing in May.

What is the cheapest month to fly from St. Louis to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Knoxville is July, where tickets cost $273 (return) on average. On the other hand, the most expensive months are January and October, where the average cost of round-trip tickets is $434 and $378 respectively.

Good to know

Low seasonJanuary
Cheapest flight$100
Best time to beat the crowds but there is an average 29% increase in price.
Most popular time to fly and prices are also 19% lower on average.
Flight from St. Louis to Knoxville

When to book flights from St. Louis to Knoxville

Are your dates flexible? Find out the best times to travel from St. Louis to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Knoxville

  • What is the cheapest flight from St. Louis to Knoxville?

    In the last 3 days, the lowest price for a flight from St. Louis to Knoxville was $100 for a one-way ticket and $249 for a round-trip.

  • Do I need a passport to fly between St. Louis and Knoxville?

    No, a passport isn't needed to fly from St. Louis to Knoxville. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from St. Louis to Knoxville?

    St. Louis airport is called Lambert-St Louis and the only airport in Knoxville is Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from St. Louis to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Knoxville?

    SkyTeam, and oneworld are the airline alliances operating flights between St. Louis and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from St. Louis to Knoxville are Delta and American Airlines. With an average price for the route of $321 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $294 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from St. Louis to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from St. Louis to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8341 reviews
7.2Food
7.8Entertainment
8.5Crew
7.9Comfort
8.1Boarding
Airline reviews

Delta is always a wonderful experience. A clean plane and the crew is really friendly.

10.0 ExcellentCharlean, Mar 2026
LAS - ATL
Read more Delta reviews

Delta is always a wonderful experience. A clean plane and the crew is really friendly.

Too many people are taking up space in the overhead bins with their extra piece of luggage. Since they cannot fit their backpacks or extra luggage piece under the seat in front of them, they store it in the overheads and thus taking up room for other passengers. It wasn’t only one or two persons; more like 12 or 13 passengers.

This was the worse experience. They delayed our flight twice and we still had to find another flight to get home sooner which was alos delayed. Also, the flight attendant named Ginny on DL9890 leaving at 4:13pm on 3/23/26 was extremely rude.

I love Delta the flight attendants were personable and the flight arrived 1/2 earlier thanks expected. All a plus. The gate agent was a bit flustered but even with that I still had a good experience. Her supervisor assisted me.

Got to fly my favorite plane, the Boeing 767-400ER, to Milan. The soft blush pink mood lighting during meal service was very beautiful and gorgeous. The service was top-notch, and our flights were on time. I highly recommend Delta.

I am still at the Airport! Delayed Delayed and Delyaed

I took seat 15A in anticipation of window seat, there is no window.

The first class flight attendant was awful to everyone. Very rude; no customer service. She should not be working in first class.

Snacks and included beverages were appreciated. Boarding went smoothly. Plenty of overhead bin space. Seats get very uncomfortable after a couple of hours. After waiting 10 painful minutes for my walker, a very nice Delta guest agent pushed me in a wheelchair to the gate. It was finally delivered to me after another 15 minutes . Our checked bag was on the carousel long b4 I was able to retrieve it. Fortunately it was still there but somewhere along the way the straps we used to secure it were removed and and were not reattached. Wish I had made note of the agents name.

It was fine. 55 minute flight. No snacks or beverage service offered. Boarding went smoothly and my walker was waiting for me on the jet way.

The flight changed gates multiple times and flight had to be delayed multiple times

We called Kayak for a change due to the TSA situation in Atlanta. What we got was a canceled return flight (in error) and we had to find the mistake. Not happy with Kayak who blamed it on AA.

I was in last row so that is never great bc the person in front of me leaned his seat all the way back into me.

Delayed for mechanical and no updates on what was happening and how long the delay might be.

My flight from LGA was cancelled and my rebooked flight from JFK was delayed numerous times. I will now be getting home after 2am.

Flight was delayed half hour before boarding, but when I checked flight aware the plane that would Pick us up had a delay of more than an hour. AA should let us know in advance to avoid waiting several hours in the airport

On the return flight, arriving in Denver we sat on the tarmac in Denver for over 20 minutes.

Typical AA - late by 90+ mn. Gate changed twice... Changed the departure time 6 times No explanation, no communication on reasons for delay I travel with AA twice a year... and it is consistently very poor.. I will continue to use AA only when i have to.

The flight attendant in business class was excellent! Professional, friendly and attentive.

Delays with no explanation. It could have been handled better.

Everything you need to know for your flight from St. Louis to Knoxville

Information on your arrival and departure airports