STL - TYS

$119 Find Cheap Flights from St. Louis to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 7/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$237
Typical prices: $253-$427
Delta
Tue 11/10Sat 11/14
STL - TYS • 1 stop
Cheapest one-way
$119
Typical prices: $296-$369
Delta
Tue 7/21
STL - TYS • 1 stop
Top airlines
Cheapest • from $237 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between St. Louis and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $248 (round-trip)
Shortest trip • 4h 02m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 26% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Knoxville (STL-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Knoxville

Tue, Nov 10 - Sat, Nov 14
Delta Logo
4:40 pm - 11:46 pm
STL
-
TYS
6h 06m
1 stop
Delta Logo
12:00 pm - 3:58 pm
TYS
-
STL
4h 58m
1 stop
$237Delta
Wed, Jul 29 - Sat, Aug 1
Southwest Logo
10:20 am - 8:25 pm
STL
-
TYS
9h 05m
2 stops
Southwest Logo
1:35 pm - 7:55 pm
TYS
-
STL
7h 20m
1 stop
$242Southwest
Mon, Jul 20 - Mon, Jul 27
Multiple Airlines Logo
4:09 pm - 11:33 pm
STL
-
TYS
6h 24m
1 stop
Multiple Airlines Logo
12:53 pm - 8:57 am
TYS
-
STL
45h 04m
2 stops
$245Multiple Airlines
Tue, Jul 21 - Fri, Jul 24
Frontier Logo
8:08 pm - 7:24 pm
STL
-
TYS
22h 16m
1 stop
Frontier Logo
8:19 pm - 7:23 pm
TYS
-
STL
24h 04m
1 stop
$247Frontier
Sat, Aug 22 - Mon, Aug 31
Southwest Logo
11:15 am - 7:20 pm
STL
-
TYS
7h 05m
1 stop
Southwest Logo
1:00 pm - 8:00 pm
TYS
-
STL
8h 00m
1 stop
$248Southwest
Tue, Sep 22 - Mon, Sep 28
Southwest Logo
7:15 am - 12:05 pm
STL
-
TYS
3h 50m
1 stop
Southwest Logo
1:00 pm - 7:10 pm
TYS
-
STL
7h 10m
2 stops
$253Southwest
Sat, Aug 22 - Mon, Aug 31
Southwest Logo
8:00 am - 5:40 pm
STL
-
TYS
8h 40m
2 stops
Southwest Logo
8:25 am - 4:20 pm
TYS
-
STL
8h 55m
2 stops
$258Southwest
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
3:50 pm - 9:00 pm
STL
-
TYS
4h 10m
1 stop
Southwest Logo
7:20 pm - 11:40 pm
TYS
-
STL
5h 20m
1 stop
$259Southwest
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
8:30 am - 3:20 pm
STL
-
TYS
5h 50m
1 stop
Southwest Logo
7:10 am - 3:30 pm
TYS
-
STL
9h 20m
2 stops
$264Southwest
Tue, Jul 21 - Sun, Jul 26
Southwest Logo
3:10 pm - 8:25 pm
STL
-
TYS
4h 15m
1 stop
Southwest Logo
7:00 pm - 11:55 pm
TYS
-
STL
5h 55m
1 stop
$268Southwest
Booking Insights

KAYAK's insights & trends for St. Louis to Knoxville flights

Get data-powered insights and trends into flights from St. Louis to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from St. Louis to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from St. Louis to Knoxville departing in November.

What is the cheapest month to fly from St. Louis to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Knoxville is August, where tickets cost $278 (return) on average. On the other hand, the most expensive months are June and January, where the average cost of round-trip tickets is $569 and $547 respectively.

Good to know

Low seasonJanuary
Cheapest flight$119
Best time to beat the crowds but there is an average 45% increase in price.
Most popular time to fly and prices are also 27% lower on average.
Flight from St. Louis to Knoxville

When to book flights from St. Louis to Knoxville

Are your dates flexible? Find out the best times to travel from St. Louis to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Knoxville

  • What is the cheapest flight from St. Louis to Knoxville?

    In the last 5 days, the lowest price for a flight from St. Louis to Knoxville was $119 for a one-way ticket and $237 for a round-trip.

  • Do I need a passport to fly between St. Louis and Knoxville?

    No, a passport isn't needed to fly from St. Louis to Knoxville. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from St. Louis to Knoxville?

    St. Louis airport is called Lambert-St Louis and the only airport in Knoxville is Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from St. Louis to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Knoxville?

    SkyTeam, and oneworld are the airline alliances operating flights between St. Louis and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Knoxville, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from St. Louis to Knoxville are Southwest and Delta. With an average price for the route of $326 and an overall rating of 7.9, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $357 and an overall rating of 7.8.

  • How does KAYAK find such low prices on flights from St. Louis to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from St. Louis to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4243 reviews
8.6Crew
8.1Boarding
7.0Food
8.0Comfort
7.5Entertainment
Airline reviews

Snacks are always pretzels. Why can't you also offer peanuts ?

6.0 GoodAnonymous, Mar 2026
STL - HOU
Read more Southwest reviews

Snacks are always pretzels. Why can't you also offer peanuts ?

Only downside was the legroom and seat width, which is always a problem unless I spend more for a premium seat.

Very good. Sad to learn Southwest is going start to charge for bags

Exceptional crew! Friendly and professional. Pleasant attitude and treated everyone with respect.

The flight was promptly on schedule and Southwest delivered everything they promised. No excuses for any shortfalls just 100% ownership of their responsibilities and business. The boarding and seating policy is a complete shambles. What started out as a great idea when Southwest first hit the market has been turned into a disaster due to the lack of integrity in many of the people who fly Southwest and take advantage of Southwest generosity at the expense of their fellow passengers.

Crew was excellent - Plane was fine. Media was good, could use more kid shows; Not a fan of the brownie brittle -- snack could be slightly better.

Left on time and arrived early. Brand new plane and no parts missing. Comfortable seats. The actual Captain spoke prior to the flight and reassured everyone about safety. Crew was so nice and fun. Perfect flight!

Everything went smoothly and the plane wasn’t full. It was delayed though. The delay was increased due to a crew change which was frustrating.

Love Southwest! Always a good trip with a happy crew who goes out of their way to be kind and fun.

friendly staff for the most part. they thought we were going to have bad turbulence so no drink service. there wasn't any turbulence. Iwish you had a choice of snacks

The flights are constantly late anymore, and they won't even give you a glass of water on the plane. For years, they were able to do a service on this flight from Atlanta to Knoxville and Knoxville Atlanta now they say it's too short of a flight. You can't even get a quick drink of water.

From checking to boarding, it was a seamless experience. The service agents were so helpful. The flight crew was so pleasant.

Should never have had to go to Detroit from Orlando back to Tennessee!

Smallest leg room I've ever had on a plane.

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

My flight was canceled after being rescheduled for four days canceling my trip. Kayak and everyone affiliated with it I.e the airlines, and just fly have been excruciating to deal with. My trip to visit family had to be canceled as there was no way to make it. I am furious at all of you.

They delayed our flight because of bad weather in NY which was completely understandable. Then they cancelled our flight and a later flight that evening. The earliest we could fly was the next morning. We ended up buying last minute tickets on another airline and made it home slightly delayed but safely that evening. Delta kept saying it was weather related but if that was the case how did we make it back on another airline? The weather in NY was cloudy but not bad.

Very frustrated with boarding gate crew. She announced the plane was small and they would be limiting us to one item to carry on. Not a problem for me as I understand the tiny planes have limited space!! Not the case here! It was a rather large plane and had plenty of room for bags! So because I don’t want to be one of “those people” who ignores the request to check a carry on I did so asking if I would be able to pick it up at the bottom of the ramp on arrival in Knoxville to which she responded “yes”! Then I watched as every other passenger held onto their 2 items and boarded!! Then when we arrived in Knoxville our 2 carry ons had been put with all the other luggage and we had to go to baggage pick up and wait for all the big checked bags to come off the carousel! So she lied!! Frustrating. Next time I won’t be so nice!

The plane smelled like a sewer. Multiple passengers complained. It’s a safety and quality issue to clean these planes.

We were delayed 2 hours leaving STL. I had 20 mins from when we landed in SLC terminal A to make it to SLC terminal B. I had to actually run! thankfully I made my flight but 3/4 legs were delayed to some capacity.

American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.

Delays experienced in boarding/take off due to incoming plane delayed. However, the boarding time/depart time in the app was significantly delayed in providing these updates. Usually not updated until an hour after we should have already boarded. Poorly managed.

Good crew and flight was on time. It’s a small plane with limited overhead luggage space. They said the overhead space was full and I had to check my bag. There was still space when I got on. Waiting for my checked luggage added 30 minutes to my trip. Not the end of the world but also not great.

Trip delayed for 2 hours because of rain. We boarded and have to get down the flight and reboard again.

No enough space plus only allowing one laggage instead of two like other airlines.

Qatar airways ,boarding arrangements at Hamid international airport could been better

Plane was delayed for 6 hours, at first by weather, which is understandable, but was further delayed with NO given reason for 2 1/2 hours more. We had no clue when we were going to depart actually until they opened the ramp. VERY POOR to ZERO COMMUNICATION!!!

At least it was a short flight. Greyhound with wings.

Two flight changes before the scheduled flight. On the day of the flight, the flight was delayed, which caused the connecting flight to be missed. Then, I was directed to another airport (CUN) and traveled to Tulum. American gave a $12 voucher for lunch. The least expensive item on the menu at a Mexican restaurant was $9.99. Driving to Tulum was a bad auto crash, and traffic was delayed two-plus hours. The bottom line is that we should have been at the hotel at noon, but it ended up at 11:30 PM.

Our flight got changed and/or delayed 8 times before we boarded.

Everything you need to know for your flight from St. Louis to Knoxville

Information on your arrival and departure airports