Which airports can I use when flying from St. Louis to Knoxville?

Flights from St. Louis to Knoxville usually depart from Lambert-St Louis (STL) and arrive at Knoxville McGhee Tyson (TYS).

What cabin classes can I book on flights from St. Louis to Knoxville?

Only Economy Class is available on flights from St. Louis to Knoxville.

Which airports do connecting flights from St. Louis to Knoxville pass through?

One-stop flights from St. Louis to Knoxville most commonly connect through: • Atlanta Hartsfield-Jackson (ATL) - 60% of one-stop connections • Nashville Intl (BNA) - 19% of one-stop connections • Charlotte Douglas (CLT) - 12% of one-stop connections • Chicago O'Hare Intl (ORD) - 5% of one-stop connections Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

Can I save money by using flexible dates for flights from St. Louis to Knoxville?

On the St. Louis to Knoxville route, being flexible with your departure day can save you up to 54%. Saturday is the cheapest day at $252 round-trip on average, while Friday is the most expensive at $542: a $290 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

How long is a flight from St. Louis to Knoxville?

A nonstop flight from St. Louis to Knoxville takes 0h 00m, covering 405 miles.

What are the earliest and latest flights from St. Louis to Knoxville?

These are the earliest and latest flight times available from St. Louis to Knoxville: • Earliest: departs at 12:00 am and lands at 12:00 am • Latest: departs at 12:00 am and lands at 12:00 am. The flight takes about 0h 00m.

Do I need a passport to fly from St. Louis to Knoxville?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from St. Louis to Knoxville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $243 to $1,025. That means the highest observed fare was about 4x higher than the lowest one.

How are flight prices from St. Louis to Knoxville looking right now?

One-way fares from St. Louis to Knoxville are currently lower than usual. Average one-way flight prices are about $139, which is 52% below the typical average for this route.

How much time can I save by choosing a different layover airport from St. Louis to Knoxville?

Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 09m, compared with 4h 25m via Nashville Intl (BNA) and 4h 27m via Charlotte Douglas (CLT).

What is the time difference between St. Louis and Knoxville?

Knoxville is 1 hour ahead of St. Louis (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include: · Budget · Alamo · Thrifty · Enterprise Rent-A-Car · Payless

How much should I expect to pay for a St. Louis to Knoxville flight?

Round-trip flights from St. Louis to Knoxville range from $278 to $467, with an average of $331 over the past 12 months. Anything below $278 counts as a good deal.

What is the cheapest airline to fly from St. Louis to Knoxville?

American Airlines ($243) and United Airlines ($243) are the cheapest airlines to fly round-trip from St. Louis to Knoxville according to KAYAK data over the last 5 days.

What is the most popular layover airport when flying from St. Louis to Knoxville?

Atlanta Hartsfield-Jackson (ATL) is the most popular layover for the St. Louis to Knoxville route. 60% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via ATL.

What is the cheapest layover airport when flying from St. Louis to Knoxville?

Flights via Dallas/Fort Worth (DFW) offer the most affordable fares, with an average round-trip price of $210. Based on KAYAK data over the past 3 months.

When flying from St. Louis to Knoxville which airport offers the shortest layover?

Dallas Love Field (DAL) had the shortest average connection time for St. Louis to Knoxville layovers at 162 minutes over the past 3 months.

$122 CHEAP FLIGHTS from St. Louis to Knoxville (STL - TYS)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$243

Typical prices: $278-$467

American Airlines

Wed 9/19Sat 9/22

STL - TYS • 1 stop

Cheapest one-way

$122

Typical prices: $248-$323

United Airlines

Wed 9/5

STL - TYS • 1 stop

Nonstop flights

Not available

There are currently no direct flights between St. Louis and Knoxville. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

August

Cheapest • 16% price drop

November

Most popular

Good to know

Top layover airports

Dallas/Fort Worth (DFW)

Cheapest • Avg $210 (round-trip)

Atlanta Hartsfield-Jackson (ATL)

Shortest trip • 4h 09m (one-way)

Insights

Start a new search

KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Knoxville!

Flight Deals

Cheap Flights from St. Louis to Knoxville (STL-TYS)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from St. Louis to Knoxville

Sat, Sep 19 - Tue, Sep 22

5:18 pm - 10:42 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 24m1 stop Chicago O'Hare Intl

6:06 pm - 10:42 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 36m1 stop Charlotte Douglas

$243American Airlines

Wed, Sep 16 - Wed, Sep 23

5:18 pm - 10:42 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 24m1 stop Chicago O'Hare Intl

6:06 pm - 10:42 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 36m1 stop Charlotte Douglas

$243American Airlines

Tue, Nov 3 - Thu, Nov 5

8:00 am - 2:48 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 48m1 stop Washington, D.C. Dulles Intl

6:45 am - 10:32 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 47m1 stop Chicago O'Hare Intl

$243United Airlines

Thu, Sep 10 - Mon, Sep 14

5:30 pm - 10:49 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 19m1 stop Chicago O'Hare Intl

6:02 pm - 9:36 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 34m1 stop Chicago O'Hare Intl

$243United Airlines

Wed, Sep 9 - Thu, Sep 17

10:45 am - 5:36 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 51m1 stop Washington, D.C. Reagan-National

7:18 pm - 10:42 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 24m1 stop Charlotte Douglas

$243American Airlines

Mon, Oct 5 - Thu, Oct 8

1:29 pm - 8:49 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 20m1 stop Chicago O'Hare Intl

10:42 am - 3:43 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 01m1 stop Chicago O'Hare Intl

$243United Airlines

Tue, Nov 3 - Thu, Nov 5

10:55 am - 8:45 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 50m2 stops Chicago Midway Baltimore/Washington

12:50 pm - 6:40 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 50m1 stop Orlando

$248Southwest

Tue, Sep 15 - Tue, Sep 22

7:15 am - 12:05 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 50m1 stop Nashville Intl

12:45 pm - 7:00 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 15m2 stops Orlando Nashville Intl

$248Southwest

Thu, Sep 17 - Mon, Sep 21

6:00 am - 1:21 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 21m1 stop Atlanta Hartsfield-Jackson

6:13 pm - 11:42 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 29m1 stop Atlanta Hartsfield-Jackson

$259Delta

Thu, Sep 17 - Thu, Sep 24

7:05 am - 1:21 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 16m1 stop Atlanta Hartsfield-Jackson

6:13 pm - 11:42 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 29m1 stop Atlanta Hartsfield-Jackson

$259Delta

Recent last minute flight deals from St. Louis to Knoxville

Thu, Aug 20 - Sat, Aug 22

9:30 am - 4:58 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 28m1 stop Chicago O'Hare Intl

7:00 am - 12:03 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 03m1 stop Chicago O'Hare Intl

$609United Airlines

Thu, Aug 20 - Sat, Aug 22

10:10 am - 5:10 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 00m1 stop Orlando

7:50 am - 1:35 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 45m2 stops Baltimore/Washington Norfolk

$614Southwest

Thu, Aug 20 - Sat, Aug 22

9:15 am - 6:35 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 20m2 stops Orlando Nashville Intl

7:50 am - 1:25 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 35m2 stops Baltimore/Washington Cleveland Hopkins Intl

$619Southwest

Thu, Aug 20 - Sun, Aug 23

6:45 pm - 7:05 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

23h 20m2 stops Las Vegas Harry Reid Intl Orlando

7:00 am - 7:13 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

13h 13m1 stop Denver Intl

$641Multiple Airlines

Thu, Aug 20 - Mon, Aug 24

10:22 am - 5:34 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 12m1 stop Charlotte Douglas

1:46 pm - 6:05 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 19m1 stop Dallas/Fort Worth

$643American Airlines

Thu, Aug 20 - Sun, Aug 23

11:22 am - 8:07 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 45m1 stop Philadelphia

5:33 pm - 10:41 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 08m1 stop Dallas/Fort Worth

$643American Airlines

Fri, Aug 21 - Sun, Aug 23

6:54 am - 11:44 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 50m1 stop Charlotte Douglas

7:18 pm - 11:58 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 40m1 stop Chicago O'Hare Intl

$649American Airlines

Thu, Aug 20 - Sun, Aug 23

5:15 am - 12:20 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 05m2 stops Houston Hobby Nashville Intl

2:35 pm - 8:40 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 05m2 stops Dallas Love Field Houston Hobby

$653Southwest

Fri, Aug 21 - Sun, Aug 23

9:15 am - 5:10 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 55m1 stop Orlando

7:35 am - 1:00 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 25m2 stops Nashville Intl Dallas Love Field

$654Southwest

Thu, Aug 20 - Mon, Aug 24

12:59 pm - 8:53 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 54m1 stop Chicago O'Hare Intl

5:45 am - 2:57 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

10h 12m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$833United Airlines

Booking Insights

Price, demand and travel trends for St. Louis to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from St. Louis to Knoxville with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from St. Louis to Knoxville?

Round-trip flights from St. Louis to Knoxville start at $243. Prices are below average for this route right now, with typical round-trip fares ranging from $278 to $467. The lowest price found in the past 5 days was $243 on American Airlines.

What's the cheapest day of the week to fly from St. Louis to Knoxville?

Saturday is the cheapest day of the week to fly from St. Louis to Knoxville, it is 24% cheaper than the average day. Friday is the most expensive day with flight prices 63% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from St. Louis to Knoxville?

August is the cheapest month to fly from St. Louis to Knoxville at $278 round-trip.
June ($634) and January ($547) are the most expensive months.
The price difference between flying in the cheapest and most expensive months is 128% on average.

This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Low season	February
High season	November
Cheapest flight	$122

Best time to beat the crowds but there is an average 13% increase in price.

Most popular time to fly with an average 2% increase in price.

Flight from St. Louis to Knoxville

When to book flights from St. Louis to Knoxville

Are your dates flexible? Find out the best times to travel from St. Louis to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from St. Louis to Knoxville?
Flights from St. Louis to Knoxville usually depart from Lambert-St Louis (STL) and arrive at Knoxville McGhee Tyson (TYS).
What cabin classes can I book on flights from St. Louis to Knoxville?
Only Economy Class is available on flights from St. Louis to Knoxville.
Which airports do connecting flights from St. Louis to Knoxville pass through?
One-stop flights from St. Louis to Knoxville most commonly connect through:

• Atlanta Hartsfield-Jackson (ATL) - 60% of one-stop connections
• Nashville Intl (BNA) - 19% of one-stop connections
• Charlotte Douglas (CLT) - 12% of one-stop connections
• Chicago O'Hare Intl (ORD) - 5% of one-stop connections

Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.
Can I save money by using flexible dates for flights from St. Louis to Knoxville?
On the St. Louis to Knoxville route, being flexible with your departure day can save you up to 54%. Saturday is the cheapest day at $252 round-trip on average, while Friday is the most expensive at $542: a $290 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.
How long is a flight from St. Louis to Knoxville?
A nonstop flight from St. Louis to Knoxville takes 0h 00m, covering 405 miles.
What are the earliest and latest flights from St. Louis to Knoxville?
These are the earliest and latest flight times available from St. Louis to Knoxville:

• Earliest: departs at 12:00 am and lands at 12:00 am
• Latest: departs at 12:00 am and lands at 12:00 am.

The flight takes about 0h 00m.
Do I need a passport to fly from St. Louis to Knoxville?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from St. Louis to Knoxville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $243 to $1,025. That means the highest observed fare was about 4x higher than the lowest one.
How are flight prices from St. Louis to Knoxville looking right now?
One-way fares from St. Louis to Knoxville are currently lower than usual. Average one-way flight prices are about $139, which is 52% below the typical average for this route.
How much time can I save by choosing a different layover airport from St. Louis to Knoxville?
Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 09m, compared with 4h 25m via Nashville Intl (BNA) and 4h 27m via Charlotte Douglas (CLT).
What is the time difference between St. Louis and Knoxville?
Knoxville is 1 hour ahead of St. Louis (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.
What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?
Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
· Budget
· Alamo
· Thrifty
· Enterprise Rent-A-Car
· Payless
How much should I expect to pay for a St. Louis to Knoxville flight?
Round-trip flights from St. Louis to Knoxville range from $278 to $467, with an average of $331 over the past 12 months. Anything below $278 counts as a good deal.

If your dates can be flexible, aim for a Saturday departure instead of Friday. On this route, Saturday flights average $252 - about $290 less than Friday (54% savings) based on the last 12 months.
If you can choose when to travel, plan your St. Louis to Knoxville trip for August. Fares historically average $278 round-trip in that month - typically $356 less than the most expensive month, which is June (based on the last 12 months).

Everything you need to know for your flight from St. Louis to Knoxville

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Complete your trip

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Information on your arrival and departure airports

St. Louis (STL)

Knoxville (TYS)

STL - TYS

$122 Find Cheap Flights from St. Louis to Knoxville - Compare and Save

Everything you should know

Cheap Flights from St. Louis to Knoxville (STL-TYS)

Recent round-trip flight deals from St. Louis to Knoxville

Recent one-way flight deals from St. Louis to Knoxville

Recent last minute flight deals from St. Louis to Knoxville

Price, demand and travel trends for St. Louis to Knoxville flights

How much is a round-trip flight from St. Louis to Knoxville?

What's the cheapest day of the week to fly from St. Louis to Knoxville?

What is the cheapest month to fly from St. Louis to Knoxville?

What is the cheapest airline to fly from St. Louis to Knoxville?

What is the most popular layover airport when flying from St. Louis to Knoxville?

What is the cheapest layover airport when flying from St. Louis to Knoxville?

When flying from St. Louis to Knoxville which airport offers the shortest layover?

Key details for St. Louis to Knoxville flights

Low season

High season

Cheapest flight

When to book flights from St. Louis to Knoxville

Your St. Louis to Knoxville flight questions, answered

Your guide to booking St. Louis to Knoxville flights

Everything you need to know for your flight from St. Louis to Knoxville

Information on your arrival and departure airports

Cabin class types available on flights from St. Louis to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Find direct flights to and from St. Louis and Knoxville

Flights to other popular destinations

Flights from domestic origins to Knoxville

Choose which airport to fly into in Knoxville

Find deals for your return flight