Which airports can I use when flying from St. Louis to Knoxville?

Flights from St. Louis to Knoxville usually depart from Lambert-St Louis (STL) and arrive at Knoxville McGhee Tyson (TYS).

What cabin classes can I book on flights from St. Louis to Knoxville?

Only Economy Class is available on flights from St. Louis to Knoxville.

Which airports do connecting flights from St. Louis to Knoxville pass through?

One-stop flights from St. Louis to Knoxville most commonly connect through: • Atlanta Hartsfield-Jackson (ATL) - 58% of one-stop connections • Nashville Intl (BNA) - 20% of one-stop connections • Chicago O'Hare Intl (ORD) - 12% of one-stop connections • Charlotte Douglas (CLT) - 7% of one-stop connections

Can I save money by using flexible dates for flights from St. Louis to Knoxville?

Yes. Flexible dates can save you up to 54% on flights from St. Louis to Knoxville. Tuesday is the cheapest departure day at $254 round-trip on average, while Friday is the most expensive at $547, a difference of $293. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

How long is a flight from St. Louis to Knoxville?

A nonstop flight from St. Louis to Knoxville takes 00m, covering 405 miles.

Do I need a passport to fly from St. Louis to Knoxville?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Have flight prices from St. Louis to Knoxville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $205 to $1,032. That means the highest observed fare was about 5x higher than the lowest one.

How are flight prices from St. Louis to Knoxville looking right now?

One-way fares from St. Louis to Knoxville are currently lower than usual. Average one-way flight prices are about $190, which is 38% below the typical average for this route.

How much time can I save by choosing a different layover airport from St. Louis to Knoxville?

Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 11m, compared with 4h 21m via Nashville Intl (BNA) and 4h 29m via Chicago O'Hare Intl (ORD).

What is the time difference between St. Louis and Knoxville?

Knoxville is 1 hour ahead of St. Louis (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include: • Budget • Alamo • Enterprise Rent-A-Car • Thrifty • Avis

How much should I expect to pay for a St. Louis to Knoxville flight?

Round-trip flights from St. Louis to Knoxville range from $279 to $482, with an average of $328 over the past 12 months. Anything below $279 counts as a good deal.

How much is a round-trip flight from St. Louis to Knoxville?

Round-trip flights from St. Louis to Knoxville typically range from $279 to $482. The lowest price found in the past 5 days was $205, on American Airlines.

What's the cheapest day of the week to fly from St. Louis to Knoxville?

Based on deals KAYAK users found in the last 12 months, Tuesday is the cheapest day of the week to fly from St. Louis to Knoxville. It’s 23% cheaper than the average day, while Friday is the most expensive, with prices 66% higher.

What’s the cheapest month to fly from St. Louis to Knoxville?

•August is the cheapest month to fly from St. Louis to Knoxville at $254 round-trip. •June ($634) and January ($547) are the most expensive months. •The price difference between flying in the cheapest and most expensive months is 149% on average. This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Which airline is the cheapest to fly from St. Louis to Knoxville?

American Airlines ($205) and Delta ($213) are the cheapest airlines to fly round-trip from St. Louis to Knoxville according to KAYAK data over the last 5 days.

What’s the most popular layover airport when flying from St. Louis to Knoxville?

Atlanta Hartsfield-Jackson (ATL) is the most popular layover for the St. Louis to Knoxville route. 58% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via ATL.

What is the cheapest layover airport when flying from St. Louis to Knoxville?

Flights via Dallas/Fort Worth (DFW) offer the most affordable fares, with an average round-trip price of $210. Based on KAYAK data over the past 3 months.

When flying from St. Louis to Knoxville which airport offers the shortest layover?

Dallas Love Field (DAL) had the shortest average connection time for St. Louis to Knoxville layovers at 2h 42m over the past 3 months.

$109 CHEAP FLIGHTS from St. Louis to Knoxville (STL - TYS)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$205

Typical prices: $279-$482

American Airlines

Sun 11/4Sun 11/11

STL - TYS • 1 stop

Cheapest one-way

$109

Typical prices: $248-$328

Multiple Airlines

Tue 11/13

STL - TYS • 2 stops

Nonstop flights

Not available

There are currently no direct flights between St. Louis and Knoxville. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

August

Cheapest • 23% price drop

September

Most popular

Good to know

Top layover airports

Dallas/Fort Worth (DFW)

Cheapest • Avg $210 (round-trip)

Atlanta Hartsfield-Jackson (ATL)

Shortest trip • 4h 11m (one-way)

Insights

Start a new search

KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Knoxville!

Flight Deals

Cheap Flights from St. Louis to Knoxville (STL-TYS)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from St. Louis to Knoxville

Wed, Nov 4 - Wed, Nov 11

7:24 am - 2:05 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 41m1 stop Dallas/Fort Worth

5:19 pm - 9:51 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 32m1 stop Charlotte Douglas

$205American Airlines

Wed, Nov 4 - Thu, Nov 12

6:00 am - 10:45 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 45m1 stop Atlanta Hartsfield-Jackson

6:10 pm - 11:56 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 46m1 stop Atlanta Hartsfield-Jackson

$213Delta

Mon, Nov 9 - Tue, Nov 10

5:30 pm - 11:59 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 29m1 stop Atlanta Hartsfield-Jackson

6:10 pm - 11:56 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 46m1 stop Atlanta Hartsfield-Jackson

$213Delta

Wed, Nov 4 - Tue, Nov 10

6:00 am - 10:45 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 45m1 stop Atlanta Hartsfield-Jackson

5:40 am - 11:15 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 35m1 stop Atlanta Hartsfield-Jackson

$213Delta

Wed, Nov 4 - Wed, Nov 11

12:40 pm - 8:50 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 10m1 stop Baltimore/Washington

7:55 am - 7:25 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

12h 30m2 stops Baltimore/Washington Pittsburgh

$217Southwest

Tue, Nov 17 - Sat, Nov 21

11:35 am - 4:29 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 54m1 stop Chicago O'Hare Intl

5:30 pm - 10:14 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 44m1 stop Dallas/Fort Worth

$235American Airlines

Fri, Nov 6 - Mon, Nov 16

6:34 pm - 11:23 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

39h 49m2 stops Atlanta Hartsfield-Jackson Washington, D.C. Dulles Intl

9:10 am - 11:16 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

15h 06m1 stop Orlando

$257Multiple Airlines

Wed, Nov 4 - Wed, Nov 11

8:30 am - 7:50 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

10h 20m2 stops Houston Hobby Nashville Intl

7:55 am - 7:25 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

12h 30m2 stops Baltimore/Washington Pittsburgh

$273Southwest

Fri, Oct 30 - Fri, Nov 6

6:44 pm - 6:33 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

46h 49m2 stops Atlanta Hartsfield-Jackson Jacksonville

10:03 pm - 11:16 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

26h 13m1 stop Orlando Sanford Intl

$273Multiple Airlines

Tue, Nov 17 - Sat, Nov 21

5:29 pm - 10:51 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 22m1 stop Chicago O'Hare Intl

6:05 pm - 11:58 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 53m1 stop Charlotte Douglas

$287American Airlines

Recent last minute flight deals from St. Louis to Knoxville

Wed, Oct 7 - Sun, Oct 11

8:00 am - 1:14 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 14m1 stop Chicago O'Hare Intl

6:03 pm - 10:59 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 56m1 stop Chicago O'Hare Intl

$622United Airlines

Fri, Oct 9 - Tue, Oct 13

1:29 pm - 8:49 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 20m1 stop Chicago O'Hare Intl

6:03 pm - 9:21 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 18m1 stop Chicago O'Hare Intl

$622United Airlines

Sat, Oct 10 - Mon, Oct 12

10:05 am - 4:45 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 40m1 stop Orlando

7:25 pm - 11:40 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 15m1 stop Nashville Intl

$623Southwest

Fri, Oct 9 - Tue, Oct 13

3:11 pm - 8:49 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 38m1 stop Chicago O'Hare Intl

7:15 am - 2:10 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 55m1 stop Houston George Bush Intcntl

$625United Airlines

Sat, Oct 10 - Mon, Oct 12

7:20 am - 4:45 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 25m2 stops Nashville Intl Orlando

7:25 pm - 11:40 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 15m1 stop Nashville Intl

$628Southwest

Thu, Oct 8 - Tue, Oct 13

10:27 am - 5:08 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 41m1 stop Chicago O'Hare Intl

6:00 am - 10:48 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 48m1 stop Chicago O'Hare Intl

$628United Airlines

Fri, Oct 9 - Tue, Oct 13

5:00 am - 1:10 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 10m1 stop Orlando

8:20 am - 2:55 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 35m2 stops Baltimore/Washington Nashville Intl

$642Southwest

Thu, Oct 8 - Sun, Oct 11

9:27 am - 3:12 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 45m1 stop Charlotte Douglas

7:15 am - 12:46 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 31m1 stop Washington, D.C. Reagan-National

$663American Airlines

Thu, Oct 8 - Mon, Oct 12

7:16 am - 3:12 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 56m1 stop Charlotte Douglas

6:06 pm - 11:59 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 53m1 stop Charlotte Douglas

$663American Airlines

Fri, Oct 9 - Sun, Oct 11

9:27 am - 5:36 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 09m1 stop Charlotte Douglas

3:56 pm - 10:14 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 18m1 stop Philadelphia

$663American Airlines

Booking Insights

Price, demand and travel trends for St. Louis to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from St. Louis to Knoxville? This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from St. Louis to Knoxville departing in november.
What's the cheapest day of the week to fly from St. Louis to Knoxville?: Based on deals KAYAK users found in the last 12 months, Tuesday is the cheapest day of the week to fly from St. Louis to Knoxville. It’s 23% cheaper than the average day, while Friday is the most expensive, with prices 66% higher.
What’s the cheapest month to fly from St. Louis to Knoxville? KAYAK internal proprietary data takes all prices for each month over the last 12 months for round-trip flights from St. Louis to Knoxville, removes the top 0.1% to account for outliers and then takes the median of all values for each month.: •August is the cheapest month to fly from St. Louis to Knoxville at $254 round-trip.
•June ($634) and January ($547) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 149% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Low season	February
High season	September
Cheapest flight	$109

Beat the crowds with an average 50% drop in travelers.

The most popular month to fly with an average 50% increase in travelers.

One-way flight from St. Louis to Knoxville

When to book flights from St. Louis to Knoxville

Are your dates flexible? Find out the best times to travel from St. Louis to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from St. Louis to Knoxville?
Only Economy Class is available on flights from St. Louis to Knoxville.
How long is a flight from St. Louis to Knoxville?
A nonstop flight from St. Louis to Knoxville takes 00m, covering 405 miles.
Do I need a passport to fly from St. Louis to Knoxville?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.
How much should I expect to pay for a St. Louis to Knoxville flight?
Round-trip flights from St. Louis to Knoxville range from $279 to $482, with an average of $328 over the past 12 months. Anything below $279 counts as a good deal.
Have flight prices from St. Louis to Knoxville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $205 to $1,032. That means the highest observed fare was about 5x higher than the lowest one.
How are flight prices from St. Louis to Knoxville looking right now?
One-way fares from St. Louis to Knoxville are currently lower than usual. Average one-way flight prices are about $190, which is 38% below the typical average for this route.
What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?
Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:

• Budget
• Alamo
• Enterprise Rent-A-Car
• Thrifty
• Avis
Which airports can I use when flying from St. Louis to Knoxville?
Flights from St. Louis to Knoxville usually depart from Lambert-St Louis (STL) and arrive at Knoxville McGhee Tyson (TYS).
Which airports do connecting flights from St. Louis to Knoxville pass through?
One-stop flights from St. Louis to Knoxville most commonly connect through:

• Atlanta Hartsfield-Jackson (ATL) - 58% of one-stop connections
• Nashville Intl (BNA) - 20% of one-stop connections
• Chicago O'Hare Intl (ORD) - 12% of one-stop connections
• Charlotte Douglas (CLT) - 7% of one-stop connections
Can I save money by using flexible dates for flights from St. Louis to Knoxville?
Yes. Flexible dates can save you up to 54% on flights from St. Louis to Knoxville. Tuesday is the cheapest departure day at $254 round-trip on average, while Friday is the most expensive at $547, a difference of $293.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
How much time can I save by choosing a different layover airport from St. Louis to Knoxville?
Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 11m, compared with 4h 21m via Nashville Intl (BNA) and 4h 29m via Chicago O'Hare Intl (ORD).
What is the time difference between St. Louis and Knoxville?
Knoxville is 1 hour ahead of St. Louis (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

If your dates are flexible, aim for a Tuesday departure and avoid flying on Friday. On this route, Tuesday flights average $254, about $293 less than Friday fares (54% savings) based on the last 12 months.
If you can choose when to travel, plan your St. Louis to Knoxville trip for August. Fares historically average $254 round-trip in that month - typically $380 less than the most expensive month, which is June (based on the last 12 months).

More options for your flight from St. Louis to Knoxville

Add a hotel or car rental

Airports

Cabin class

Direct Flights

Origins

Other destinations

Return flight

Complete your trip to Knoxville with a hotel stay or car rental

Car rentals in Knoxville

Hotels in Knoxville

Vacations in Knoxville

STL - TYS

$109 Find Cheap Flights from St. Louis to Knoxville - Compare and Save

Everything you should know

Cheap Flights from St. Louis to Knoxville (STL-TYS)

Recent round-trip flight deals from St. Louis to Knoxville

Recent one-way flight deals from St. Louis to Knoxville

Recent last minute flight deals from St. Louis to Knoxville

Price, demand and travel trends for St. Louis to Knoxville flights

How much is a round-trip flight from St. Louis to Knoxville?

What's the cheapest day of the week to fly from St. Louis to Knoxville?

What’s the cheapest month to fly from St. Louis to Knoxville?

Which airline is the cheapest to fly from St. Louis to Knoxville?

What’s the most popular layover airport when flying from St. Louis to Knoxville?

What is the cheapest layover airport when flying from St. Louis to Knoxville?

When flying from St. Louis to Knoxville which airport offers the shortest layover?

Key details for St. Louis to Knoxville flights

Low season

High season

Cheapest flight

When to book flights from St. Louis to Knoxville

Your St. Louis to Knoxville flight questions, answered

Your guide to booking St. Louis to Knoxville flights

More options for your flight from St. Louis to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from St. Louis to Knoxville

Find direct flights to and from St. Louis and Knoxville

Flights from domestic origins to Knoxville

Flights to other popular destinations

Find deals for your return flight