$51 Find Cheap Flights from St. Louis to Jacksonville - Compare and Save

When flying from St. Louis to Jacksonville, you should consider leaving on a Friday and avoid Sundays if you are looking for the best rates. For your return to St. Louis, you’ll find the best rates on Fridays and the most expensive ones on Sundays.

The cheapest month for flights from St. Louis to Jacksonville is October, where tickets cost $275 (return) on average. On the other hand, the most expensive months are July and May, where the average cost of round-trip tickets is $433 and $407 respectively.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $397 on average.

To get a below average price on the flight from St. Louis to Jacksonville, you should book around 4 weeks before departure, which saves you about 50% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 8 weeks before departure.

In the past 5 days, the cheapest round-trip tickets from St. Louis to Jacksonville were found on Frontier ($109) and Southwest ($237).

There are 2 airlines that fly nonstop from St. Louis to Jacksonville. They are JetBlue and Southwest. The cheapest airline for this route is Southwest, with the best round-trip deal found costing $220. On average, the best prices for this route can be found at Southwest.

Atlanta (ATL) is the top choice – 73% of KAYAK users who clicked on 1-stop flights from St. Louis to Jacksonville picked an itinerary connecting there.

Flights via Washington, D.C. (DCA) offer the most affordable fares, with an average round-trip price of $178.

Consider flying via Atlanta (ATL) for the shortest journey. The average one-way travel time for flights connecting there is 4h 03m.

If you prefer a quick connection, Chicago (ORD) often has the shortest layovers from St. Louis to Jacksonville, with an average of 1h 20m.

There is only one cabin class option available for the route, which is Economy. Perform a search on KAYAK to find the latest prices and availability for all cabin fares, which differ across airlines.

Each day, there are between 1 and 2 nonstop flights that take off from St. Louis and land in Jacksonville, with an average flight time of 2h 00m. The most common departure time is 6:00 pm and most flights take off in the morning. Each week, there are 9 flights. The most frequent day of departure is Saturday, when 22% of all weekly flights depart. The fewest flights depart on a Monday.