$394 Find Cheap Flights from Panama City to San Francisco - Compare and Save

These are the earliest and latest flight times available from Panama City to San Francisco:

• Earliest: departs at 12:38 pm and lands at 8:21 pm
• Latest: departs at 6:47 pm and lands at 2:30 am.

The flight takes about 7h 43m.

Two cabin classes are available on flights from Panama City to San Francisco:

• Economy Class
• Business Class

A nonstop flight from Panama City to San Francisco takes 7h 43m, covering 3,318 miles.

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Round-trip flights from Panama City to San Francisco range from $693 to $861, with an average of $768 over the past 12 months. Anything below $693 counts as a good deal.

Last-minute fares on this route (booked within two weeks of departure) run 19% above the $768 route average. Book 22 weeks before departure for the lowest fares.

On this route, layover flights are cheaper than nonstop options on average. Layover fares average $677 round-trip via San Salvador El Salvador Intl (SAL), compared to $783 for nonstop.

The Boeing 737 MAX 9 family is used most often on this route, operated mainly by Copa Airlines and United Airlines. Other aircraft seen on the route include Boeing 737 MAX 8 variants.

Afternoon is the busiest departure period on Panama City to San Francisco flights, with 50% of flights leaving in that window. Evening departures account for 50%, morning flights for 0%, and night flights for 0%.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $681 to $4,800. That means the highest observed fare was about 7x higher than the lowest one.

One-way fares from Panama City to San Francisco are currently lower than usual. Average one-way flight prices are about $450, which is 8% below the typical average for this route.

San Francisco Airport (SFO) hosts 5 major car rental companies, with daily rates starting from around $15 for economy cars. Top options include:

• Europcar
• Thrifty
• Dollar
• Hertz
• Fox

Flights from Panama City to San Francisco usually depart from Panama City Tocumen Intl (PTY) and arrive at San Francisco (SFO).

One-stop flights from Panama City to San Francisco most commonly connect through:

• San Salvador El Salvador Intl (SAL) - 66% of one-stop connections
• Houston George Bush Intcntl (IAH) - 28% of one-stop connections
• Miami (MIA) - 2% of one-stop connections
• Atlanta Hartsfield-Jackson (ATL) - 2% of one-stop connections

Yes. Flexible dates can save you up to 7% on flights from Panama City to San Francisco. Thursday is the cheapest departure day at $755 round-trip on average, while Sunday is the most expensive at $809, a difference of $54.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Only Copa Airlines operates flights between Panama City and San Francisco.

Flying via San Salvador El Salvador Intl (SAL) gives the shortest average 1-stop total travel time at 9h 41m, compared with 10h 06m via San José del Cabo Los Cabos (SJD) and 10h 37m via Houston George Bush Intcntl (IAH).

San Francisco is 2 hours behind Panama City (Pacific Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

Some of the most popular sights in San Francisco are Fisherman's Wharf, Union Square and Moscone Center. These are among the most viewed places in San Francisco on KAYAK.

Among airlines operating Panama City to San Francisco flights:

• Copa Airlines: offers extra legroom; offers free seat selection

Extra legroom and free seat selection availability depends on fare class and route.

Here are some options for this route, based on selected ticket types and cabin classes:

• Copa Airlines: a cabin bag and a checked bag in Economy Class

Bag allowance can vary by ticket type, cabin class, route and airline, so always check the fare details before booking.