$370 Find Cheap Flights from San Francisco to Santa Cruz de la Sierra - Compare and Save

Flights from San Francisco to Santa Cruz de la Sierra usually depart from San Francisco (SFO) and arrive at Santa Cruz de la Sierra Viru Viru Intl (VVI).

Two cabin classes are available on flights from San Francisco to Santa Cruz de la Sierra:

• Economy Class
• First Class

Most connecting flights from San Francisco to Santa Cruz de la Sierra pass through Panama City Tocumen Intl (PTY), which handles 100% of one-stop traffic on this route. Other layover airports each see under 5%.

Yes. Being flexible with your travel dates can save you up to 43% on the San Francisco to Santa Cruz de la Sierra route. Tuesday is the cheapest departure day at $644 round-trip on average, while Monday is the most expensive at $1,123, a difference of $479. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

A nonstop flight from San Francisco to Santa Cruz de la Sierra takes 0h 00m, covering 5,414 miles.

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $769 to $5,653. That means the highest observed fare was about 7x higher than the lowest one.

One-way fares from San Francisco to Santa Cruz de la Sierra are currently higher than usual. Average one-way flight prices are about $467, which is 35% above the typical average for this route.

Santa Cruz de la Sierra is 3 hours ahead of San Francisco (Bolivia Time vs Pacific Time). Plan for the time shift when scheduling connections or first-day activities.

Round-trip flights from San Francisco to Santa Cruz de la Sierra range from $714 to $1,095, with an average of $919 over the past 12 months. Anything below $714 counts as a good deal.