SFO - VVI

$299 Find Cheap Flights from San Francisco to Santa Cruz de la Sierra

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to Santa Cruz de la Sierra departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Santa Cruz de la Sierra

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Francisco to Santa Cruz de la Sierra, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Francisco to Santa Cruz de la Sierra, as well as popular online travel agencies
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Flight Deals

Cheap Flights from San Francisco to Santa Cruz de la Sierra (SFO-VVI)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to Santa Cruz de la Sierra that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to Santa Cruz de la Sierra

Wed, Oct 1 - Tue, Oct 7
Avianca Logo
12:05 am - 1:50 amSFO-VVI
22h 45m2 stops
Avianca Logo
2:50 am - 10:45 pmVVI-SFO
22h 55m2 stops
$617Avianca
Find Deal
Wed, Oct 1 - Thu, Oct 9
Avianca Logo
12:05 am - 1:50 amSFO-VVI
22h 45m2 stops
Avianca Logo
2:50 am - 10:45 pmVVI-SFO
22h 55m2 stops
$627Avianca
Find Deal
Thu, Oct 2 - Wed, Oct 8
Multiple Airlines Logo
11:56 pm - 10:40 pmSFO-VVI
43h 44m2 stops
Multiple Airlines Logo
2:50 am - 5:46 pmVVI-SFO
17h 56m2 stops
$636Multiple Airlines
Find Deal
Thu, Nov 13 - Wed, Nov 19
United Airlines Logo
7:10 pm - 10:46 pmSFO-VVI
23h 36m2 stops
United Airlines Logo
1:09 am - 10:59 pmVVI-SFO
25h 50m2 stops
$637United Airlines
Find Deal
Thu, Oct 2 - Tue, Oct 7
United Airlines Logo
11:00 pm - 10:40 pmSFO-VVI
44h 40m2 stops
United Airlines Logo
1:09 am - 11:57 pmVVI-SFO
25h 48m3 stops
$644United Airlines
Find Deal
Wed, Nov 12 - Mon, Nov 24
Copa Airlines Logo
12:36 am - 10:46 pmSFO-VVI
18h 10m1 stop
Copa Airlines Logo
11:40 am - 11:17 pmVVI-SFO
15h 37m1 stop
$671Copa Airlines
Find Deal
Tue, Nov 4 - Sun, Nov 16
Multiple Airlines Logo
12:43 am - 10:46 pmSFO-VVI
42h 03m2 stops
Multiple Airlines Logo
3:40 am - 9:13 pmVVI-SFO
21h 33m2 stops
$673Multiple Airlines
Find Deal
Sun, Sep 28 - Tue, Oct 28
Copa Airlines Logo
1:30 am - 3:36 amSFO-VVI
23h 06m1 stop
Copa Airlines Logo
11:41 am - 11:39 pmVVI-SFO
14h 58m1 stop
$698Copa Airlines
Find Deal
Thu, Nov 13 - Sat, Nov 22
LATAM Airlines Logo
5:55 am - 4:35 amSFO-VVI
18h 40m2 stops
LATAM Airlines Logo
11:15 am - 2:35 pmVVI-SFO
31h 20m2 stops
$929LATAM Airlines
Find Deal
Thu, Oct 2 - Wed, Oct 8
LATAM Airlines Logo
5:55 am - 4:35 amSFO-VVI
19h 40m2 stops
LATAM Airlines Logo
7:27 am - 12:05 amVVI-SFO
43h 38m2 stops
$938LATAM Airlines
Find Deal

Everything you should know

Top airlines
Avianca
Cheapest • from $617 (round-trip)
Copa Airlines
Best reviews • 7.6 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
March
Cheapest • 31% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$617
Typical prices: $688-766
Avianca
Wed 10/1Tue 10/7
SFO - VVI • 2 stops
Cheapest one-way
$299
Overall average: $686
United Airlines
Sun 9/21
SFO - VVI • 2 stops
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santa Cruz de la Sierra!
Booking Insights

KAYAK's insights & trends for San Francisco to Santa Cruz de la Sierra flights

Get data-powered insights and trends into flights from San Francisco to Santa Cruz de la Sierra to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from San Francisco to Santa Cruz de la Sierra?

What’s the cheapest day of the week to fly from San Francisco to Santa Cruz de la Sierra?

The average price of all round-trip flights from San Francisco to Santa Cruz de la Sierra clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Santa Cruz de la Sierra on a Friday and more expensive on a Sunday. On your return trip to San Francisco, you should consider flying back on a Tuesday, and avoid Saturdays for better deals.

What is the cheapest month to fly from San Francisco to Santa Cruz de la Sierra?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to Santa Cruz de la Sierra is March, where tickets cost $631 (return) on average. On the other hand, the most expensive months are December and February, where the average cost of round-trip tickets is $1,551 and $1,085 respectively.

Good to know

Low seasonMarch
Cheapest flight$299
Best time to beat the crowds with an average 32% drop in price.
Most popular time to fly with an average 69% increase in price.
Flight from San Francisco to Santa Cruz de la Sierra

When to book flights from San Francisco to Santa Cruz de la Sierra

Are your dates flexible? Find out the best times to travel from San Francisco to Santa Cruz de la Sierra based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from San Francisco to Santa Cruz de la Sierra

  • What is the cheapest flight from San Francisco to Santa Cruz de la Sierra?

    In the last 3 days, the lowest price for a flight from San Francisco to Santa Cruz de la Sierra was $299 for a one-way ticket and $617 for a round-trip.

  • Do I need a passport to fly between San Francisco and Santa Cruz de la Sierra?

    Yes, you’ll need a passport to travel to Santa Cruz de la Sierra from San Francisco.

  • Which aircraft models fly most regularly from San Francisco to Santa Cruz de la Sierra?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from San Francisco to Santa Cruz de la Sierra?

    Star Alliance is the only airline alliance operating flights between San Francisco and Santa Cruz de la Sierra.

  • What is the most popular layover when flying to Santa Cruz de la Sierra from San Francisco?

    Panama City is the most popular layover city among KAYAK users traveling from San Francisco to Santa Cruz de la Sierra.

  • Which is the best airline for flights from San Francisco to Santa Cruz de la Sierra, Copa Airlines or United Airlines?

    The two airlines most popular with KAYAK users for flights from San Francisco to Santa Cruz de la Sierra are Copa Airlines and United Airlines. With an average price for the route of $903 and an overall rating of 7.6, Copa Airlines is the most popular choice. United Airlines is also a great choice for the route, with an average price of $900 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from San Francisco to Santa Cruz de la Sierra?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to Santa Cruz de la Sierra.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to Santa Cruz de la Sierra?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Cruz de la Sierra from San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to Santa Cruz de la Sierra?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Cruz de la Sierra with an airline and back to San Francisco with another airline. Booking your flights between San Francisco and VVI can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to Santa Cruz de la Sierra?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Cruz de la Sierra from San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from San Francisco to Santa Cruz de la Sierra

 
See real verified KAYAK customer reviews for airlines flying from San Francisco to Santa Cruz de la Sierra. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from San Francisco to Santa Cruz de la Sierra? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1531 reviews
6.8Entertainment
8.1Crew
7.8Boarding
6.8Food
7.4Comfort
Airline reviews

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

8.0 ExcellentAnonymous, Aug 2025PTY - ORD
Read more Copa Airlines reviews

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

I selected first class expecting excetional service. It was mediocre at best. The food service was cold, meal choices was poor and on one leg they did provide dessert. I did enjoy the lay day seat but the movies were old and nothing current. Boarding the plane is always hot. So boarding is quite warm until your in the air. I took a small personal air fan. Update the meals and movies.

Very happy with my flight. I would definitely recommend it.

Did upgrade, travel in business it was great (more room I could sleep)

Had to go through security at the gate again. Had to take off shoes and go through the whole thing again even though we have global entry. They asked us to check in items bought at duty free during our layover and since we checked our luggage at the original departure airport, they forced us to check in a small backpack. None of this ever happened with other airlines. In addition, no vegetarian food option and no snacks during a 7 hr flight. Luggage limits are unusually small. This is unacceptable. Will NEVER fly Copa again and will tell friends and family to avoid this airline.

Seats not reclining, no vegetarian food option, no snacks. 7.5 hr flight should have been more comfortable. Luggage limits are unusually small. Will never fly Copa again and will tell friends and family to avoid this airline.

We paid extra with copa for seats near one another The plane was changed and we lost our seats We were all Separated. We have not received a refund for our seats despite emailing and calling.

It was ok. However, the food was quite poor since I don't eat pasta.

Tell people to remain in their seats during the meal/beverage distribution. Enforce boarding by group numbers. No one was checking. Tell people to turn their electronics speakers off. Bigger cups for drinks.

Enforce the boarding process by group numbers. Tell people to stay seated during the meal/drink distribution. It took forever to get food and drinks because people would not stay out the isle and let the crew do their jobs. Everyone wanted to go to the bathroom forcing the crew to enter and leave the isle constantly so people can pass. Tell people to keep their electronics off speaker mode. No one wants to hear phone conversations and music playing.

We had to deboard 2 times due to maintenance issues. They changed the plane, and then we got deviated to LAX due to maibtenance issues on the other plane, had to sleep at LAX and los a full day.

From the first moment you interact with United Airlines, you can expect nothing less but extreme frustration. The baggage handler at the bag drop seems completely unbothered by the presence of customers waiting in line. No help was extended to load the baggage whatsoever. And if any of your bags is overweight by 0.01 pound they will make you re-distribute everything in your suitcase just to play power trip. When it was time to board no help was extended to customers to locate their seats. Moreover. It was a chaotic mess at the gate when it was unclear who should board first and everyone just bunched up, trying to get on the plane. I am sure the crew was doing their best to perform their jobs while being paid their wages however it shouldn’t be that hard to smile once or twice when you’re in the business if serving customers. It is a shame for the United States of America to have a flagship carrier of such low caliber. Our flight was also delayed by about an hour and a half due to further delays prior to our inbound flight. Being someone who has travelled for both business and leisure in Asia, Europe, and South America I have never experienced such poor quality of service.

The pilots were late and it made us 1 hour late. The meat was tough and bok choy was also tough.

Stuck on tarmac for two hours plus a 5.5 hour flight. Rude flight attendant. And no meals, not even for purchase!

I learned that seating towards the end of plane that a line forms for the restroom and people use your chair as a hand railing, bumping your seat consistently. I was seated in the aisle. I think that next time if I am towards the back row I would want to sit in the middle or window seat.

The best airline I have ever travel , really good customer service, attention and service !!

Everything was great. Only thing that could’ve made it better was buy on board options for hot food, but the snacks were decent. The flight attendants were great. I had no complaints. I was able to make it to my destination safely

Horrific. They missed my connecting flight to San Diego. I didn’t get there until Monday at 9am when I had a mandatory court settlement conference scheduled at 6am since we had parties on the east coast. This caused many issues. All because United apparently forgot to hold the doors open until my flight landed that only had a 10 minute delay. This was the last flight to Southern California. So I couldn’t even rent a car to finish the trip. United cannot be trusted when traveling on specific days and times since weather didn’t have anything to do with the delays.

Very comfortable (upgraded to business class). The audio on my screen didn’t work, but I managed to play the audio through my phone while watching the screen.

Flight was late as pilot crew had to land at different airport in their previous flight. Passengers boarded and had to wait for pilots inside plane. Series of incomplete and unnecessary announcements by an annoying voice, rather than complete, informative announcements.

Boarding, crew were excellent, food was ok and entertainment need to improve

Luggage lost and nowhere to be found, no response from either airline regarding my bag

The seats were uncomfortable and barely reclined at all. Very little leg room despite being business class. The crew was friendly and the food was good. Had to use my own phone for in-flight entertainment.

Avianca is not what it used to be. So disappointing

Boarding was excessively slow. They do it by groups in a way that it doesn’t make sense. After business class , ppl that need assistance and any other priority group they should have ppl board from the back to the front. First rows 20+. Then 15+. Then 10, etc. having ppl sitting in the back board last makes no sense. The libe backame long as soon as ppl on rows 10 or so where told to board. The line went all the way up the ramp and tunnel for 25 mins.

Seats are very tight even in Plus, no complimentary snacks or beverage

I receive a service for what I pay, so it is fair.

i think the flight was late because they were so strict about measuring everyone's personal items to try and charge them $119. It was really petty and made us late.

There isn't much space in-between seats and even water needs to be paid for during the flight.

We did not know about the bag fees until check in. They are way too high. It’s insane. We also had a huge delay and everything costed extra which was very annoying.

Everything you need to know for your flight from San Francisco to Santa Cruz de la Sierra

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