SFO - VVI

$320 Find Cheap Flights from San Francisco to Santa Cruz de la Sierra

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to Santa Cruz de la Sierra departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santa Cruz de la Sierra

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Francisco to Santa Cruz de la Sierra, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Francisco to Santa Cruz de la Sierra, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$664
Overall average: $749
Copa Airlines
Tue 4/7Wed 4/22
SFO - VVI • 1 stop
Cheapest one-way
$325
Typical prices: $349-$789
United Airlines
Fri 2/27
SFO - VVI • 2 stops
Top airlines
Copa Airlines
Cheapest • from $664 (round-trip)
Copa Airlines
Best reviews • 7.5 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
September
Cheapest • 30% price drop
April
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santa Cruz de la Sierra!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from San Francisco to Santa Cruz de la Sierra (SFO-VVI)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to Santa Cruz de la Sierra that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to Santa Cruz de la Sierra

Tue, Apr 7 - Wed, Apr 22
Copa Airlines Logo
1:23 am - 3:40 am
SFO
-
VVI
23h 17m
1 stop
Copa Airlines Logo
1:15 am - 6:25 pm
VVI
-
SFO
20h 10m
1 stop
$664Copa Airlines
Wed, Mar 4 - Thu, Mar 19
United Airlines Logo
11:20 pm - 10:50 pm
SFO
-
VVI
43h 30m
2 stops
United Airlines Logo
11:54 am - 9:26 pm
VVI
-
SFO
36h 32m
2 stops
$679United Airlines
Tue, Mar 3 - Thu, Mar 19
United Airlines Logo
12:43 am - 10:50 pm
SFO
-
VVI
42h 07m
3 stops
United Airlines Logo
11:54 am - 5:05 pm
VVI
-
SFO
56h 11m
2 stops
$685United Airlines
Tue, Apr 14 - Sat, Apr 18
United Airlines Logo
1:55 pm - 10:42 pm
SFO
-
VVI
29h 47m
2 stops
United Airlines Logo
11:48 am - 7:05 am
VVI
-
SFO
46h 17m
2 stops
$689United Airlines
Thu, Mar 5 - Thu, Mar 19
United Airlines Logo
6:44 pm - 10:50 pm
SFO
-
VVI
24h 06m
2 stops
United Airlines Logo
11:54 am - 1:28 am
VVI
-
SFO
40h 34m
2 stops
$691United Airlines
Mon, Mar 2 - Mon, Mar 16
Copa Airlines Logo
12:54 am - 10:50 pm
SFO
-
VVI
17h 56m
1 stop
Copa Airlines Logo
1:14 am - 11:40 pm
VVI
-
SFO
25h 26m
1 stop
$706Copa Airlines
Wed, Mar 4 - Wed, Mar 18
Copa Airlines Logo
12:54 am - 10:50 pm
SFO
-
VVI
17h 56m
1 stop
Copa Airlines Logo
1:14 am - 6:28 pm
VVI
-
SFO
20h 14m
1 stop
$712Copa Airlines
Tue, Mar 3 - Thu, Mar 19
United Airlines Logo
12:43 am - 3:31 am
SFO
-
VVI
22h 48m
3 stops
United Airlines Logo
11:54 am - 7:34 pm
VVI
-
SFO
34h 40m
3 stops
$716United Airlines
Mon, Mar 2 - Tue, Mar 10
Copa Airlines Logo
12:54 am - 10:50 pm
SFO
-
VVI
17h 56m
1 stop
Copa Airlines Logo
1:14 am - 11:40 pm
VVI
-
SFO
25h 26m
1 stop
$719Copa Airlines
Sat, Mar 7 - Sat, Mar 14
United Airlines Logo
6:56 pm - 3:31 am
SFO
-
VVI
28h 35m
2 stops
United Airlines Logo
11:54 am - 12:06 pm
VVI
-
SFO
51h 12m
2 stops
$728United Airlines
Booking Insights

KAYAK's insights & trends for San Francisco to Santa Cruz de la Sierra flights

Get data-powered insights and trends into flights from San Francisco to Santa Cruz de la Sierra to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to Santa Cruz de la Sierra?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to Santa Cruz de la Sierra is September, where tickets cost $644 (return) on average. On the other hand, the most expensive months are December and May, where the average cost of round-trip tickets is $1,592 and $1,115 respectively.

Good to know

Low seasonMarch
Cheapest flight$325
Best time to beat the crowds with an average 27% drop in price.
Most popular time to fly and prices are also 19% lower on average.
Flight from San Francisco to Santa Cruz de la Sierra

When to book flights from San Francisco to Santa Cruz de la Sierra

Are your dates flexible? Find out the best times to travel from San Francisco to Santa Cruz de la Sierra based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from San Francisco to Santa Cruz de la Sierra

  • What is the cheapest flight from San Francisco to Santa Cruz de la Sierra?

    In the last 3 days, the lowest price for a flight from San Francisco to Santa Cruz de la Sierra was $320 for a one-way ticket and $664 for a round-trip.

  • Do I need a passport to fly between San Francisco and Santa Cruz de la Sierra?

    Yes, you’ll need a passport to travel to Santa Cruz de la Sierra from San Francisco.

  • Which aircraft models fly most regularly from San Francisco to Santa Cruz de la Sierra?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from San Francisco to Santa Cruz de la Sierra?

    Star Alliance is the only airline alliance operating flights between San Francisco and Santa Cruz de la Sierra.

  • Which is the best airline for flights from San Francisco to Santa Cruz de la Sierra, Copa Airlines or United Airlines?

    The two airlines most popular with KAYAK users for flights from San Francisco to Santa Cruz de la Sierra are Copa Airlines and United Airlines. With an average price for the route of $898 and an overall rating of 7.5, Copa Airlines is the most popular choice. United Airlines is also a great choice for the route, with an average price of $902 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from San Francisco to Santa Cruz de la Sierra?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to Santa Cruz de la Sierra.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to Santa Cruz de la Sierra?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Cruz de la Sierra from San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to Santa Cruz de la Sierra?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Cruz de la Sierra with an airline and back to San Francisco with another airline. Booking your flights between San Francisco and VVI can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to Santa Cruz de la Sierra?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Cruz de la Sierra from San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from San Francisco to Santa Cruz de la Sierra

 
See real verified KAYAK customer reviews for airlines flying from San Francisco to Santa Cruz de la Sierra. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from San Francisco to Santa Cruz de la Sierra? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
Copa AirlinesOverall score based on 1557 reviews
8.1Crew
6.8Entertainment
6.8Food
7.8Boarding
7.4Comfort
Airline reviews

Seats were awful. Media should have been included for such a long flight.

4.0 OkayPaul, Jan 2026
LIM - PTY
Read more Copa Airlines reviews

Seats were awful. Media should have been included for such a long flight.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

The flight was good overall. Everything went smoothly, although the landing was a bit rough. Still, it was a pleasant experience

I always enjoy flying Copa. There are very few airlines where I can enjoy a comfortable sleep in-flight. The snacks weren't the best, but they sufficed. The in-flight entertainment was fantastic, and I crossed another movie off my watch list.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

I selected first class expecting excetional service. It was mediocre at best. The food service was cold, meal choices was poor and on one leg they did provide dessert. I did enjoy the lay day seat but the movies were old and nothing current. Boarding the plane is always hot. So boarding is quite warm until your in the air. I took a small personal air fan. Update the meals and movies.

Very happy with my flight. I would definitely recommend it.

Did upgrade, travel in business it was great (more room I could sleep)

The flight crew where really good. Better then the crew from BNE to SFO

Food should be changed in menu Many muslims travels in this airlime they need to add one Halal meal

left on time, reasonable boarding process arrived early luggage came out quickly

Some flight attendants were great others were cranky. Seats were very tight and sitting on an aisle was very hard as the carts and people walking constantly bumped shoulder and arm.

Pushed back only to get deplaned due to a tire damaged by ground crew. They did at least go pretty fast. The bathrooms should be banned under the Geneva convention. No room to even sit straight on the toilet. The under-seat entertainment units block what little leg room there is.

United airlines has the best customer experience from booking to arrival. I always fly United airlines. The mileage program is excellent

from SFO-> FRA flight, AVML meal was significantly less compared to regular meal, especially no Desert, no Bread, no sides.

This was an older airplane. The cabin was constantly warm to hot throughout the 10 hour flight and there were no vents to personalize air flow. Also since it was an older plane, the material and comfort of the chairs were very uncomfortable. I left my flight with major soreness on my tailbone.

Older aircraft, no meal, only food was for purchase. Not impressed United.

Not pleasant trip cross country when the entertainment and WiFi system not working. No entertainment for entirety of route. Staff was rather nonchalant in that they dismissed the problem due to age of plane. It would have been nice to know this up front so I could have come prepared to read or download movies before boarding Coincidentally or not, there was a similar issue with the entertainment system on my previous flight I took on my fist leg of the trip. There are no seat TVs, so you must rely on the app when it works. United can do better. Also, what use it it to pay for boarding group 2 when half of the passengers are in the same line as you?

It was delayed and I lost my connection flight to Cali and I missed my Mom's funeral

I actually upgraded to the medium level of seats from basic and even doing that it may have been physically the most uncomfortable flight I have ever had. They packed everyone like is a train to death camp. It was a red eye so I hoped to get some sleep but it was physically impossible to find a comfortable way to rest. I met other folks on the same flight and they said the same thing. It was an utterly miserable flight and if I have any other options I will never fly with them again

Deplaning was a mess, I sat in business (seats are horrible) and the front door had a problem so we had to deplane from the rear exit. The stairs were not tall enough to reach so there was a large step down from the plane to the top of the stairs.

Staff are the rudest in the industry … awful customer service … will never fly Avianca again

Pros: we leave and arrive on time Cons: the most uncomfortable seats ever. You cant recline at all your seats. No entertainment No TVs flight attendants didn't provide even a glass of water. You have to go to back of the airplane and ask for one. I am Colombian and I remember seeing the flight attendants very neat, elegants which is or was a staple of Avianca.it was one with tennis shoes, no male up, the hair was messy... that was really odd.

Here we have another airline flying to Guatemala but doesn't have a plus or a less, just in the middle. Why? Well, first we don't have even free water Movie selection is poor Seats don't recline in some places Food selection is carb based Forgot to mention, customer service on the web is the worst. Good things; Very reliable on schedule Kind crew

Last seat of Bussines Class it does recline but passenger seating behind kept pushing since they did not have space once my seat was reclined

We waited for one hour to deboard the plane after landing. That could be better

I like the crew members they're very friendly. Clean plane. The flight was on time. I dont like the comfort my car seat its better that the plane seats. They charge for everything. This airline was very good. Now it's a low cost airline

I like the crew they're very friendly. I don't like. on five hour flight they not offered snacks. Any drink. Not even coffee

Everything you need to know for your flight from San Francisco to Santa Cruz de la Sierra

Information on your arrival and departure airports