$118 Find Cheap Flights from San Francisco to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from San Francisco to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$490
Bogotá
Bogotá1 stop$391
Medellín
Medellín1 stop$322
Buenos Aires
Buenos Aires2 stops$967
Sao Paulo
Sao Paulo1 stop$720
Rio de Janeiro
Rio de Janeiro2 stops$708
Santiago
Santiago3 stops$696
Cartagena
Cartagena1 stop$431
Quito
Quito2 stops$558
Guayaquil
Guayaquil1 stop$483
Cali
Cali3 stops$543
Cusco
Cusco3 stops$664
Georgetown
Georgetown1 stop$578
Pereira
Pereira2 stops$599
Barranquilla
Barranquilla1 stop$561
Montevideo
Montevideo2 stops$893
Santa Marta
Santa Marta1 stop$524
Asuncion
Asuncion2 stops$965
Lima
Lima2 stops$490
Bogotá
Bogotá1 stop$391
Medellín
Medellín1 stop$322
Buenos Aires
Buenos Aires2 stops$967
Sao Paulo
Sao Paulo1 stop$720
Rio de Janeiro
Rio de Janeiro2 stops$708
Santiago
Santiago3 stops$696
Cartagena
Cartagena1 stop$431
Quito
Quito2 stops$558
Guayaquil
Guayaquil1 stop$483
Cali
Cali3 stops$543
Cusco
Cusco3 stops$664
Georgetown
Georgetown1 stop$578
Pereira
Pereira2 stops$599
Barranquilla
Barranquilla1 stop$561
Montevideo
Montevideo2 stops$893
Santa Marta
Santa Marta1 stop$524
Asuncion
Asuncion2 stops$965

Book Cheap San Francisco to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to South America

Thu, May 14 - Wed, May 20
Avianca Logo
11:55 pm - 1:10 pm
SFO
-
MDE
11h 15m
1 stop
Avianca Logo
2:10 pm - 10:35 pm
MDE
-
SFO
10h 25m
1 stop
$322Avianca
Sun, Sep 6 - Sat, Sep 12
Avianca Logo
11:55 pm - 1:10 pm
SFO
-
MDE
11h 15m
1 stop
Avianca Logo
10:40 am - 11:55 pm
MDE
-
SFO
15h 15m
2 stops
$326Avianca
Wed, Jun 3 - Sun, Jun 7
LATAM Airlines Logo
10:55 pm - 8:10 pm
SFO
-
BOG
19h 15m
2 stops
LATAM Airlines Logo
2:55 pm - 1:31 pm
BOG
-
SFO
24h 36m
2 stops
$400LATAM Airlines
Sat, Jun 6 - Wed, Jun 10
United Airlines Logo
6:54 pm - 4:54 am
SFO
-
BOG
32h 00m
1 stop
United Airlines Logo
8:30 am - 12:15 am
BOG
-
SFO
17h 45m
1 stop
$413United Airlines
Wed, Jun 10 - Wed, Jul 15
American Airlines Logo
6:45 am - 10:38 pm
SFO
-
BOG
13h 53m
1 stop
American Airlines Logo
12:25 pm - 11:48 pm
BOG
-
SFO
13h 23m
1 stop
$439American Airlines
Mon, Jun 1 - Sat, Jun 6
American Airlines Logo
9:50 pm - 11:50 am
SFO
-
BOG
12h 00m
1 stop
American Airlines Logo
6:30 am - 11:59 pm
BOG
-
SFO
19h 29m
1 stop
$449American Airlines
Sat, Jun 6 - Wed, Jul 8
United Airlines Logo
6:54 pm - 7:20 pm
SFO
-
BOG
22h 26m
1 stop
United Airlines Logo
8:30 am - 12:15 am
BOG
-
SFO
17h 45m
1 stop
$458United Airlines
Sun, Jun 7 - Mon, Jul 13
LATAM Airlines Logo
11:59 pm - 5:50 pm
SFO
-
BOG
15h 51m
2 stops
LATAM Airlines Logo
11:00 am - 11:45 pm
BOG
-
SFO
14h 45m
2 stops
$460LATAM Airlines
Tue, Apr 21 - Wed, Apr 29
Copa Airlines Logo
1:23 am - 2:09 pm
SFO
-
UIO
10h 46m
1 stop
Copa Airlines Logo
6:01 am - 11:40 pm
UIO
-
SFO
19h 39m
1 stop
$585Copa Airlines
Tue, May 12 - Wed, May 27
Copa Airlines Logo
1:12 am - 12:30 am
SFO
-
GRU
19h 18m
1 stop
Copa Airlines Logo
5:00 am - 6:14 pm
GRU
-
SFO
17h 14m
1 stop
$791Copa Airlines
Booking Insights

KAYAK's insights & trends for San Francisco to South America flights

Get data-powered insights and trends into flights from San Francisco to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to South America is February, when tickets cost $612 (return) on average. On the other hand, the most expensive months are December and June, when the average cost of round-trip tickets is $895 and $793 respectively.

How far in advance should I book a flight from San Francisco to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to South America, you should book around 2 weeks before departure, which saves you about 7% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 17 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$118
Best time to beat the crowds with an average 1% drop in price.
Most popular time to fly with an average 37% increase in price.
Flight from San Francisco to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Francisco to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Francisco to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Francisco to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from San Francisco to South America

 
Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
Copa AirlinesOverall score based on 1575 reviews
7.4Comfort
7.7Boarding
8.1Crew
6.8Food
6.8Entertainment
Airline reviews

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

10.0 ExcellentAnonymous, Apr 2026
DAV - PTY
Read more Copa Airlines reviews

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

Avoid at all costs. My wife had to stay back on a connecting flight as her parents flight was delayed. 10 days later on the way back they cancelled all our flights. We had to rebook all four of us on the next days flight.

Horrible. No TV or any type of entertainment on board. Passwnger listening to/watching stuff on their own phone with no headphones making it noise and uncomfortable for everyone else, little/tiny food portions, old seats, useless wifi (cant access anything). Horrible exlerience especially it was a lomg distance flight with kids.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

Very happy with my flight. I would definitely recommend it.

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Boarding was again a "free for all". We were boarding group 4, and almost the entire plane was able to board before us. It's a shame that someone who follows the rules, gets the short end of the stick. Not fair.

It was perfect! I've never flown with United before, but I definitely will in the future

the entire flight felt off. The crew seemed uninterested and disengaged. The food service was really bad - overcooked, bland, weird food service. They actually woke us up to serve chicken wraps in the middle of the night, after dinner and before breakfast. Made no sense. Ultimately, I was glad they did though, because the breakfast had been held for so long it was inedible. Eggs, potatoes, sausage - all disgusting. We were asked to "honor" the lavatories for premium customers and stay in our own cabin: this was also strange. So people in economy didn't pay enough to use the closest toilet to them??? It's a toilet. All in all, not the experience I have come to expect from United Airlines. The return flight from Paris to SFO was better, btw.

They delayed the flight from 9:00 to 11:55 At 11:45 they canceled the flight. I paid a premium price for the tickets with poor service

The 777’s economy seat’s legroom was more tolerable than expected. I appreciate the reclining mechanism which slides the seat forward to minimize cannibalizing the space behind. The food was terrible: very salty.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Flight delayed for more than 16 hrs and no effort was spent to provide an alternate

We had turbulence ever 1/2 hr or so and the captains announcements were SOOOO LOUD

it was a very short flight so my expectations were low.

Good flight, seated and had a water within 5 minutes. Crew was hospitable.

We left at 1030 am pacific from LA and supposed to land at 7 pm Eastern in NY. They made a detour, stopped in Philadelphia and didn’t land till 1130 PM Eastern!!! Worst flight experience with no pilot communication with no explanation as to what was going on. Everyone was very frustrated to say the least.

I cancelled my ticket less than 24 hours deadline but I didn’t get refunded.

Flight boarded from Gate 159B, the farthest gate in the LAX Bradley Terminal. While the flight operated on time, the first class cabin attendant made no recognition of my being an Advantage Executive Platinum member.

The flight itself was excellent but the gate attendant made me check my carryon since she said it was an inch too big. I’ve had no problems with this carryon on recent flights on Qantas, Delta, Austrian, Southwest Airlines even though the overhead bins are the same size. there were other carryons in the bins that also looked larger than mine and there was room left in the bins for more. When I picked up my carryon from baggage claim one of the wheels had broken off.

I was in last row so that is never great bc the person in front of me leaned his seat all the way back into me.

The experience at checkin for my American Airlines flight from Sacramento to LAX was very good including the assistance I received in getting my bags checked in and boarding passes printed. Was pleasantly surprised the my bags were checked through all the way to my destination at Clark International Airport in Angeles, Philippines.

Terrible planning. And even worse gate agents. Absolutely rude behavior.

Flight was scheduled at 11:26am but they keep Delaying until midnight. They waited at airport restless.

Rough flight No beverage service due to turbulence Bottom Seat cushion was non existent

The worst experience I've ever had because the "people" @ Avianca wouldn't let me fly because they said I needed a round trip ticket

Seating was tight. Seats don't recline. Initial flight was cancelled. Lost two days of vacation.

It was delayed and I lost my connection flight to Cali and I missed my Mom's funeral

I upgraded to businesses class. Because of that the flight was comfortable.

I actually upgraded to the medium level of seats from basic and even doing that it may have been physically the most uncomfortable flight I have ever had. They packed everyone like is a train to death camp. It was a red eye so I hoped to get some sleep but it was physically impossible to find a comfortable way to rest. I met other folks on the same flight and they said the same thing. It was an utterly miserable flight and if I have any other options I will never fly with them again

We found the chairs to be really uncomfortable. It’s also really unacceptable that no form of food or drink is included in a 6+ hour flight

Deplaning was a mess, I sat in business (seats are horrible) and the front door had a problem so we had to deplane from the rear exit. The stairs were not tall enough to reach so there was a large step down from the plane to the top of the stairs.

Staff are the rudest in the industry … awful customer service … will never fly Avianca again

Pros: we leave and arrive on time Cons: the most uncomfortable seats ever. You cant recline at all your seats. No entertainment No TVs flight attendants didn't provide even a glass of water. You have to go to back of the airplane and ask for one. I am Colombian and I remember seeing the flight attendants very neat, elegants which is or was a staple of Avianca.it was one with tennis shoes, no male up, the hair was messy... that was really odd.

Here we have another airline flying to Guatemala but doesn't have a plus or a less, just in the middle. Why? Well, first we don't have even free water Movie selection is poor Seats don't recline in some places Food selection is carb based Forgot to mention, customer service on the web is the worst. Good things; Very reliable on schedule Kind crew

Everything you need to know for your flight to South America

Information on your arrival and departure airports