$233 Find Cheap Flights from San Francisco to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 8/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from San Francisco to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$583
Bogotá
Bogotá1 stop$433
Medellín
Medellín1 stop$601
Buenos Aires
Buenos Aires2 stops$916
Sao Paulo
Sao Paulo1 stop$790
Rio de Janeiro
Rio de Janeiro3 stops$821
Santiago
Santiago1 stop$661
Cartagena
Cartagena1 stop$441
Quito
Quito1 stop$567
Guayaquil
Guayaquil1 stop$512
Cali
Cali1 stop$632
Cusco
Cusco2 stops$784
Georgetown
Georgetown2 stops$570
Pereira
Pereira2 stops$639
Barranquilla
Barranquilla2 stops$543
Montevideo
Montevideo2 stops$893
Santa Marta
Santa Marta2 stops$619
Asuncion
Asuncion2 stops$954
Lima
Lima1 stop$583
Bogotá
Bogotá1 stop$433
Medellín
Medellín1 stop$601
Buenos Aires
Buenos Aires2 stops$916
Sao Paulo
Sao Paulo1 stop$790
Rio de Janeiro
Rio de Janeiro3 stops$821
Santiago
Santiago1 stop$661
Cartagena
Cartagena1 stop$441
Quito
Quito1 stop$567
Guayaquil
Guayaquil1 stop$512
Cali
Cali1 stop$632
Cusco
Cusco2 stops$784
Georgetown
Georgetown2 stops$570
Pereira
Pereira2 stops$639
Barranquilla
Barranquilla2 stops$543
Montevideo
Montevideo2 stops$893
Santa Marta
Santa Marta2 stops$619
Asuncion
Asuncion2 stops$954

Book Cheap San Francisco to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to South America

Thu, Sep 10 - Fri, Sep 25
Delta Logo
11:45 pm - 7:15 pm
SFO
-
BOG
17h 30m
1 stop
Delta Logo
2:55 pm - 10:28 am
BOG
-
SFO
21h 33m
1 stop
$433Delta
Thu, Sep 10 - Fri, Sep 25
Delta Logo
11:45 pm - 8:10 pm
SFO
-
BOG
18h 25m
2 stops
Delta Logo
2:55 pm - 10:17 am
BOG
-
SFO
21h 22m
2 stops
$438Delta
Tue, Aug 25 - Sat, Aug 29
LATAM Airlines Logo
6:00 am - 7:15 pm
SFO
-
BOG
11h 15m
1 stop
LATAM Airlines Logo
2:55 pm - 10:22 am
BOG
-
SFO
21h 27m
1 stop
$464LATAM Airlines
Fri, Jun 26 - Fri, Jul 10
United Airlines Logo
6:54 pm - 4:54 am
SFO
-
BOG
32h 00m
1 stop
United Airlines Logo
12:14 am - 7:22 am
BOG
-
SFO
33h 08m
1 stop
$512United Airlines
Tue, Jul 7 - Tue, Jul 21
Avianca Logo
2:15 pm - 2:00 am
SFO
-
BOG
9h 45m
1 stop
Avianca Logo
4:25 am - 12:50 pm
BOG
-
SFO
10h 25m
1 stop
$553Avianca
Tue, Jul 14 - Mon, Jul 27
Avianca Logo
7:45 am - 2:00 am
SFO
-
BOG
16h 15m
2 stops
Avianca Logo
4:25 am - 12:50 pm
BOG
-
SFO
10h 25m
1 stop
$556Avianca
Sun, Sep 6 - Thu, Sep 24
Copa Airlines Logo
8:21 pm - 12:30 pm
SFO
-
UIO
14h 09m
1 stop
Copa Airlines Logo
6:00 am - 6:10 pm
UIO
-
SFO
14h 10m
1 stop
$567Copa Airlines
Sat, Sep 12 - Mon, Sep 28
United Airlines Logo
12:45 am - 11:25 pm
SFO
-
UIO
20h 40m
1 stop
United Airlines Logo
12:35 am - 5:04 pm
UIO
-
SFO
18h 29m
1 stop
$579United Airlines
Tue, Jun 16 - Wed, Jul 8
LATAM Airlines Logo
10:59 pm - 6:59 pm
SFO
-
UIO
18h 00m
1 stop
LATAM Airlines Logo
12:59 am - 8:05 pm
UIO
-
SFO
21h 06m
1 stop
$589LATAM Airlines
Mon, Aug 31 - Wed, Sep 9
Copa Airlines Logo
1:12 am - 2:07 pm
SFO
-
UIO
10h 55m
1 stop
Copa Airlines Logo
3:09 pm - 11:40 pm
UIO
-
SFO
10h 31m
1 stop
$590Copa Airlines
Booking Insights

KAYAK's insights & trends for San Francisco to South America flights

Get data-powered insights and trends into flights from San Francisco to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to South America is May, when tickets cost $573 (return) on average. On the other hand, the most expensive months are December and June, when the average cost of round-trip tickets is $1,014 and $906 respectively.

How far in advance should I book a flight from San Francisco to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to South America, you should book around 2 weeks before departure, which saves you about 6% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 15 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$233
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly with an average 35% increase in price.
Flight from San Francisco to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Francisco to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Francisco to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Francisco to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from San Francisco to South America

 
Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1573 reviews
7.4Comfort
6.9Food
7.8Boarding
6.8Entertainment
8.1Crew
Airline reviews

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

10.0 ExcellentAnonymous, Apr 2026
DAV - PTY
Read more Copa Airlines reviews

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

Avoid at all costs. My wife had to stay back on a connecting flight as her parents flight was delayed. 10 days later on the way back they cancelled all our flights. We had to rebook all four of us on the next days flight.

Horrible. No TV or any type of entertainment on board. Passwnger listening to/watching stuff on their own phone with no headphones making it noise and uncomfortable for everyone else, little/tiny food portions, old seats, useless wifi (cant access anything). Horrible exlerience especially it was a lomg distance flight with kids.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

Very happy with my flight. I would definitely recommend it.

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

Easy of boarding, helpfully staff at check in, surprisingly comfortable seating

Lost of requested seat assignments. Lost my husband's meal choice

My service dog and I were asked to deplane just before they closed the door - clearly very last minute they couldn’t find the documentation that I have filled out many many times before that is for flying service animals. I purposely purchase 3seats (a whole row) since he is large and not all passengers want to sit next to a dog on a cross country flight. The plane departed with my husband on it!!! They made me fill out a hard copy of the same form and had to reschedule me on a later flight where they could find 3 seats together!! I’ve done this so many times before - clearly the error was on their part in a technology glitch - but really people - do better!! Very traumatic - and my husband had to wait for us when he landed ….so bad. Poor pup was confused and tired.

My flight time was changed without any notification to me which ruined my time sensitive plans so I ended up completely changing my travel plans and no reimbursement.

No screens or meal options. Freezing cold. Dirty seats. Left late.

I liked that my son and I were reseated next to each other (we had different bookings). I liked that it was a directg flight and mostly on time. I liked that you provided pillows and blankets. Flight attendants were generally courteous. The messaging through wifi did not work well. The food was not good. Seats are very narrow and I felt slightly claustraphobic in the window seat.

Some crew were unfriendly or in some cases just straight up rude.

Outstanding service, efficient & friendly crew, flight was safe, comfortable & on time

United Airline crews were very friendly and very attentive. 12 hours flight was gone like in a shorter one.

Flight itself excellent, but delayed so missed connection & got to destination 2 hrs later

Ontario airport boarding was very easy to park and access, is clean and TSA took 10 minutes total. Check-in was a breeze and cruise was very nice.

It's a long flight and that is always difficult. I was comfortable and well. The movies available were great and the crew was good.

Premium Economy Good crew, good service, excellent food. Seat back screen just not bright enough.

The crew was very attentive through out the flight. Seats were comfortable, nice flight bag with pillow and blanket. Food was okay, since it was a overnight flight seemed to go by fast.

Left early arrived early..right amount of talking from pilots..of course had to love the biscuit and water!

Boarding gate at LAX was too crowded—two gates next to one another

On time departure and early arrival. Flight attendant very nice.

The business class layout of chairs was weired. You are sitting directly across stranger.,

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

Friendly crew is the only nice thing. Seats uncomfortable. Food and snacks horrible. Movies were the same as the first 10 hour flight two weeks before

The worst experience I've ever had because the "people" @ Avianca wouldn't let me fly because they said I needed a round trip ticket

Seating was tight. Seats don't recline. Initial flight was cancelled. Lost two days of vacation.

It was delayed and I lost my connection flight to Cali and I missed my Mom's funeral

I upgraded to businesses class. Because of that the flight was comfortable.

I actually upgraded to the medium level of seats from basic and even doing that it may have been physically the most uncomfortable flight I have ever had. They packed everyone like is a train to death camp. It was a red eye so I hoped to get some sleep but it was physically impossible to find a comfortable way to rest. I met other folks on the same flight and they said the same thing. It was an utterly miserable flight and if I have any other options I will never fly with them again

We found the chairs to be really uncomfortable. It’s also really unacceptable that no form of food or drink is included in a 6+ hour flight

Deplaning was a mess, I sat in business (seats are horrible) and the front door had a problem so we had to deplane from the rear exit. The stairs were not tall enough to reach so there was a large step down from the plane to the top of the stairs.

Staff are the rudest in the industry … awful customer service … will never fly Avianca again

Pros: we leave and arrive on time Cons: the most uncomfortable seats ever. You cant recline at all your seats. No entertainment No TVs flight attendants didn't provide even a glass of water. You have to go to back of the airplane and ask for one. I am Colombian and I remember seeing the flight attendants very neat, elegants which is or was a staple of Avianca.it was one with tennis shoes, no male up, the hair was messy... that was really odd.

Here we have another airline flying to Guatemala but doesn't have a plus or a less, just in the middle. Why? Well, first we don't have even free water Movie selection is poor Seats don't recline in some places Food selection is carb based Forgot to mention, customer service on the web is the worst. Good things; Very reliable on schedule Kind crew

Everything you need to know for your flight to South America

Information on your arrival and departure airports