$160 Find Cheap Flights from San Francisco to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from San Francisco to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$505
Bogotá
Bogotá1 stop$428
Medellín
Medellín1 stop$474
Buenos Aires
Buenos Aires1 stop$908
Sao Paulo
Sao Paulo1 stop$610
Rio de Janeiro
Rio de Janeiro2 stops$721
Santiago
Santiago1 stop$520
Cartagena
Cartagena1 stop$442
Quito
Quito1 stop$534
Guayaquil
Guayaquil1 stop$418
Cali
Cali1 stop$443
Cusco
Cusco2 stops$688
Pereira
Pereira2 stops$467
Georgetown
Georgetown1 stop$615
Montevideo
Montevideo1 stop$845
Barranquilla
Barranquilla2 stops$464
Santa Marta
Santa Marta2 stops$540
Florianopolis
Florianopolis2 stops$752
Lima
Lima1 stop$505
Bogotá
Bogotá1 stop$428
Medellín
Medellín1 stop$474
Buenos Aires
Buenos Aires1 stop$908
Sao Paulo
Sao Paulo1 stop$610
Rio de Janeiro
Rio de Janeiro2 stops$721
Santiago
Santiago1 stop$520
Cartagena
Cartagena1 stop$442
Quito
Quito1 stop$534
Guayaquil
Guayaquil1 stop$418
Cali
Cali1 stop$443
Cusco
Cusco2 stops$688
Pereira
Pereira2 stops$467
Georgetown
Georgetown1 stop$615
Montevideo
Montevideo1 stop$845
Barranquilla
Barranquilla2 stops$464
Santa Marta
Santa Marta2 stops$540
Florianopolis
Florianopolis2 stops$752

Book Cheap San Francisco to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to South America

Tue, Feb 10 - Wed, Feb 18
Avianca Logo
1:35 am - 4:00 pmSFO-BOG
11h 25m1 stop
Avianca Logo
1:30 pm - 9:50 pmBOG-SFO
11h 20m1 stop
$428Avianca
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Thu, Jan 29 - Sat, Jan 31
Avianca Logo
1:35 am - 4:00 pmSFO-BOG
11h 25m1 stop
Avianca Logo
4:00 am - 12:00 pmBOG-SFO
11h 00m1 stop
$434Avianca
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Thu, Nov 27 - Sun, Dec 7
Copa Airlines Logo
12:36 am - 12:20 amSFO-BOG
20h 44m1 stop
Copa Airlines Logo
7:00 am - 11:17 pmBOG-SFO
19h 17m1 stop
$447Copa Airlines
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Sun, Nov 9 - Thu, Nov 27
United Airlines Logo
12:43 am - 10:35 pmSFO-BOG
18h 52m1 stop
United Airlines Logo
8:15 am - 7:25 pmBOG-SFO
14h 10m1 stop
$449United Airlines
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Sun, Nov 9 - Thu, Nov 27
United Airlines Logo
12:43 am - 10:35 pmSFO-BOG
18h 52m1 stop
United Airlines Logo
8:15 am - 7:25 pmBOG-SFO
14h 10m1 stop
$450United Airlines
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Sun, Nov 16 - Wed, Jan 28
Copa Airlines Logo
12:36 am - 11:07 amSFO-BOG
31h 31m1 stop
Copa Airlines Logo
6:08 pm - 11:20 pmBOG-SFO
32h 12m1 stop
$457Copa Airlines
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Mon, Nov 17 - Wed, Jan 28
LATAM Airlines Logo
10:30 pm - 7:30 pmSFO-BOG
18h 00m1 stop
LATAM Airlines Logo
10:55 am - 11:37 pmBOG-SFO
15h 42m2 stops
$460LATAM Airlines
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Thu, Nov 27 - Fri, Dec 12
LATAM Airlines Logo
9:35 pm - 7:30 pmSFO-BOG
18h 55m1 stop
LATAM Airlines Logo
3:55 pm - 2:36 pmBOG-SFO
25h 41m2 stops
$467LATAM Airlines
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Sun, Nov 9 - Fri, Nov 14
American Airlines Logo
8:00 am - 11:39 pmSFO-MDE
12h 39m1 stop
American Airlines Logo
1:30 am - 11:07 amMDE-SFO
12h 37m1 stop
$503American Airlines
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Sun, Nov 9 - Fri, Nov 14
American Airlines Logo
6:00 am - 11:39 pmSFO-MDE
14h 39m2 stops
American Airlines Logo
1:30 am - 3:03 pmMDE-SFO
16h 33m2 stops
$508American Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for San Francisco to South America flights

Get data-powered insights and trends into flights from San Francisco to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to South America is September, when tickets cost $617 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $1,114 and $807 respectively.

What’s the cheapest day of the week to fly from San Francisco to South America?

The average price of all round-trip flights from San Francisco to South America clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from San Francisco to South America, look for departures on Tuesdays and avoid leaving on a Saturday, as it's usually the priciest day. When flying back from South America, Tuesday is the cheapest day to fly and Sunday is the most expensive.

How far in advance should I book a flight from San Francisco to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to South America, you should book around 2 weeks before departure, which saves you about 14% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Good to know

Low seasonSeptember
Cheapest flight$160
Best time to beat the crowds with an average 13% drop in price.
Most popular time to fly with an average 43% increase in price.
Flight from San Francisco to Medellín

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Francisco to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Francisco to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Francisco to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the morning, when round-trip flights cost $726 on average. Morning departures are around 1% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $738.

Reviews of the top 5 airlines serving from San Francisco to South America

 
Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1563 reviews
7.4Comfort
7.8Boarding
6.8Food
6.8Entertainment
8.1Crew
Airline reviews

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

6.0 GoodZach, Oct 2025DEN - PTY
Read more Copa Airlines reviews

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

the food served was an embarrassment. No connection for charging the cellphone... What a crappy airline.

The flighr attandants were very rude they ignored me didnt offer me anything to drink throughoit the 4 hour flight i feel i was targeted and ignored because i was a darkskin latino man.

Very happy with my flight. I would definitely recommend it.

Did upgrade, travel in business it was great (more room I could sleep)

Placed us in the last rear row of the plane so could not recline seats because of the rear wall, and also made it more of a tight space when the passenger in front reclined their seat. While understand seat assignments, every passenger should be afforded a reclining seat. The odor control scent from the restrooms was overwhelming strong. My wife and I could not deal with it, and she suffered a terrible headache as a result. I kept getting hit by the crew since I was on the ilse seat. No apologies, nothing. They made me feel like I was supposed to take the beating for a 3 hr flight.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor, the airline was not able to help me move flights.

The way the Pilot made all announcements, specially the way he congratulated the entire crew as the best team ever, making a comment that due to them they were able to shorter the delay to the destination. Amazing flight .

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

We were in business class. the angled seats in that class do not have a real window view & the placement of the controls are bad. But we knew that. But the food options were mediocre. The taste was fine, but the size was for a child. It’s just really feels like United is skimping on everything. Even when we were in the Polaris lounge they did not have diet sodas. They said they were out no Coke zero no Diet Coke, etc. I do not think the portion of nuts they serve on the plane could get any smaller. Really a minimal service and offer for what you’re paying for in business.

We had to deboard 2 times due to maintenance issues. They changed the plane, and then we got deviated to LAX due to maibtenance issues on the other plane, had to sleep at LAX and los a full day.

From the first moment you interact with United Airlines, you can expect nothing less but extreme frustration. The baggage handler at the bag drop seems completely unbothered by the presence of customers waiting in line. No help was extended to load the baggage whatsoever. And if any of your bags is overweight by 0.01 pound they will make you re-distribute everything in your suitcase just to play power trip. When it was time to board no help was extended to customers to locate their seats. Moreover. It was a chaotic mess at the gate when it was unclear who should board first and everyone just bunched up, trying to get on the plane. I am sure the crew was doing their best to perform their jobs while being paid their wages however it shouldn’t be that hard to smile once or twice when you’re in the business if serving customers. It is a shame for the United States of America to have a flagship carrier of such low caliber. Our flight was also delayed by about an hour and a half due to further delays prior to our inbound flight. Being someone who has travelled for both business and leisure in Asia, Europe, and South America I have never experienced such poor quality of service.

The pilots were late and it made us 1 hour late. The meat was tough and bok choy was also tough.

Stuck on tarmac for two hours plus a 5.5 hour flight. Rude flight attendant. And no meals, not even for purchase!

I learned that seating towards the end of plane that a line forms for the restroom and people use your chair as a hand railing, bumping your seat consistently. I was seated in the aisle. I think that next time if I am towards the back row I would want to sit in the middle or window seat.

The best airline I have ever travel , really good customer service, attention and service !!

Everything was great. Only thing that could’ve made it better was buy on board options for hot food, but the snacks were decent. The flight attendants were great. I had no complaints. I was able to make it to my destination safely

Horrific. They missed my connecting flight to San Diego. I didn’t get there until Monday at 9am when I had a mandatory court settlement conference scheduled at 6am since we had parties on the east coast. This caused many issues. All because United apparently forgot to hold the doors open until my flight landed that only had a 10 minute delay. This was the last flight to Southern California. So I couldn’t even rent a car to finish the trip. United cannot be trusted when traveling on specific days and times since weather didn’t have anything to do with the delays.

The flight was flawless and we even arrived between 20 and 25 minutes early!

Always seated jammed in rear of aircraft Admirals Club food at DFW terminal D was absolute worst food experience and I pay $600/year to eat this dried out junk

Mostly good. Flight was crowded but Airline personnel were very friendly & accommodating. It would be good to have savory snacks rather than just sweet Biscoff cookies.

It was a red eye flight, so no meals were provided, but it was fine with snacks. The seats felt cramped and almost too narrow.

Very crowded flight but what can you expect these days?? Crew was accommodating.

The seats in economy were appeared to be quite thin and lack sufficient cushioning to be comfortable. Perhaps it was my seating position but the plane seemed notably load.

The entertainment package was vast and the selections were very current. Keep updating it was great.

The seat was so hard my tailbone was aching The crew was kind of a b**** because I made a joke that I didn't care if they close the door I total c*** when she was trying to f****** act like she was mad at me because I said that The flight was bumpy. Sure you didnt have control over that.

4 hours late, including over +1 hour waiting in plane to take off. Baggage left behind too.

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Did not fly with Pakistan International Airlines. Have never flown with Pakistan International Airlines.

Boarding, crew were excellent, food was ok and entertainment need to improve

The usb plugs for charging your phone didn’t work, the seats were coarse and hard. Not very comfortable. No inflight WiFi

The seats were uncomfortable and barely reclined at all. Very little leg room despite being business class. The crew was friendly and the food was good. Had to use my own phone for in-flight entertainment.

The check in is the only positive thing in Avianca. The seat is the most uncomfortable I have traveled, the distance is minimal.

Not what it used to be. The sale of food makes them look greedy!

It was horrible. My experience with Avianca. I didn’t know it was Pakistan international Airlines but anyway, whatever it is it is bad horrible you guys need to upgrade everything in those planes. And you guys charge $130 for a carry-on did they wanna let me in with my carry-on that I travel everywhere with the luggage you guys are such a dog thank you

Boarding was excessively slow. They do it by groups in a way that it doesn’t make sense. After business class , ppl that need assistance and any other priority group they should have ppl board from the back to the front. First rows 20+. Then 15+. Then 10, etc. having ppl sitting in the back board last makes no sense. The libe backame long as soon as ppl on rows 10 or so where told to board. The line went all the way up the ramp and tunnel for 25 mins.

Seats are very tight even in Plus, no complimentary snacks or beverage

I receive a service for what I pay, so it is fair.

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