$176 Find Cheap Flights from San Francisco to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from San Francisco to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$558
Bogotá
Bogotá1 stop$427
Medellín
Medellín1 stop$445
Buenos Aires
Buenos Aires1 stop$1,038
Sao Paulo
Sao Paulo1 stop$617
Rio de Janeiro
Rio de Janeiro2 stops$658
Santiago
Santiago2 stops$477
Cartagena
Cartagena1 stop$414
Quito
Quito1 stop$450
Cali
Cali1 stop$443
Guayaquil
Guayaquil1 stop$451
Cusco
Cusco2 stops$694
Pereira
Pereira1 stop$457
Georgetown
Georgetown1 stop$507
Montevideo
Montevideo2 stops$805
Barranquilla
Barranquilla1 stop$449
Santa Marta
Santa Marta2 stops$470
Florianopolis
Florianopolis2 stops$835
Lima
Lima1 stop$558
Bogotá
Bogotá1 stop$427
Medellín
Medellín1 stop$445
Buenos Aires
Buenos Aires1 stop$1,038
Sao Paulo
Sao Paulo1 stop$617
Rio de Janeiro
Rio de Janeiro2 stops$658
Santiago
Santiago2 stops$477
Cartagena
Cartagena1 stop$414
Quito
Quito1 stop$450
Cali
Cali1 stop$443
Guayaquil
Guayaquil1 stop$451
Cusco
Cusco2 stops$694
Pereira
Pereira1 stop$457
Georgetown
Georgetown1 stop$507
Montevideo
Montevideo2 stops$805
Barranquilla
Barranquilla1 stop$449
Santa Marta
Santa Marta2 stops$470
Florianopolis
Florianopolis2 stops$835

Book Cheap San Francisco to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to South America

lun., nov. 3 - sam., nov. 8
Avianca Logo
1:20 pm - 1:50 amSFO-BOG
9h 30m1 stop
Avianca Logo
1:30 pm - 9:50 pmBOG-SFO
11h 20m1 stop
$427Avianca
Find Deal
mar., déc. 2 - jeu., janv. 29
Avianca Logo
1:35 am - 4:10 pmSFO-BOG
11h 35m1 stop
Avianca Logo
4:00 am - 12:00 pmBOG-SFO
11h 00m1 stop
$428Avianca
Find Deal
ven., oct. 24 - ven., oct. 31
LATAM Airlines Logo
11:00 pm - 1:40 pmSFO-BOG
12h 40m1 stop
LATAM Airlines Logo
8:35 am - 10:30 pmBOG-SFO
15h 55m2 stops
$432LATAM Airlines
Find Deal
mar., nov. 11 - mar., nov. 18
LATAM Airlines Logo
9:30 pm - 4:45 pmSFO-BOG
16h 15m2 stops
LATAM Airlines Logo
7:00 am - 6:14 pmBOG-SFO
14h 14m2 stops
$433LATAM Airlines
Find Deal
dim., oct. 26 - lun., nov. 3
Copa Airlines Logo
1:36 am - 12:32 amSFO-UIO
20h 56m1 stop
Copa Airlines Logo
12:27 pm - 11:17 pmUIO-SFO
13h 50m1 stop
$450Copa Airlines
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mer., déc. 3 - jeu., janv. 29
United Airlines Logo
5:00 am - 10:35 pmSFO-BOG
14h 35m1 stop
United Airlines Logo
1:30 am - 6:50 pmBOG-SFO
20h 20m1 stop
$451United Airlines
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lun., déc. 1 - mar., déc. 9
United Airlines Logo
11:59 pm - 10:35 pmSFO-BOG
19h 36m1 stop
United Airlines Logo
8:15 am - 10:59 pmBOG-SFO
17h 44m1 stop
$459United Airlines
Find Deal
mar., oct. 14 - dim., oct. 19
Copa Airlines Logo
1:31 am - 2:13 pmSFO-UIO
10h 42m1 stop
Copa Airlines Logo
6:03 am - 11:39 pmUIO-SFO
19h 36m1 stop
$470Copa Airlines
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lun., déc. 8 - lun., déc. 15
American Airlines Logo
7:00 am - 7:45 amSFO-SCL
19h 45m1 stop
American Airlines Logo
11:15 pm - 1:33 pmSCL-SFO
19h 18m2 stops
$498American Airlines
Find Deal
jeu., oct. 23 - lun., oct. 27
American Airlines Logo
8:08 am - 10:30 pmSFO-BOG
12h 22m1 stop
American Airlines Logo
6:50 am - 6:58 pmBOG-SFO
14h 08m1 stop
$503American Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for San Francisco to South America flights

Get data-powered insights and trends into flights from San Francisco to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to South America is September, when tickets cost $639 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $1,170 and $804 respectively.

What’s the cheapest day of the week to fly from San Francisco to South America?

The average price of all round-trip flights from San Francisco to South America clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from San Francisco to South America, look for departures on Tuesdays and avoid leaving on a Saturday, as it's usually the priciest day. When flying back from South America, Tuesday is the cheapest day to fly and Sunday is the most expensive.

How far in advance should I book a flight from San Francisco to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to South America, you should book around 2 weeks before departure, which saves you about 12% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 9 weeks before departure.

Good to know

Low seasonAugust
Cheapest flight$176
Best time to beat the crowds with an average 10% drop in price.
Most popular time to fly with an average 46% increase in price.
Flight from San Francisco to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Francisco to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Francisco to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Francisco to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the morning, when round-trip flights cost $726 on average. Morning departures are around 1% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $738.

Reviews of the top 5 airlines serving from San Francisco to South America

 
Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1849 reviews
7.0Entertainment
8.0Crew
7.6Boarding
6.7Food
7.4Comfort
Airline reviews

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

2.0 MediocreAnonymous, Aug 2025GIG - GRU
Read more LATAM Airlines reviews

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Lost ,y connection due to a mechanical delay, huge line to get new connection and vouchers

Boarding was done by woman who insisted on strict standing in line policy; food was ok; entertainment minimal

entertainment was not good; the shoulder strap on Business class seat did not sit well across the body (more like across the neck); the food was not hot and the special meal promoted by insert in the menu was not available to us

The boarding and new bag drop-off process was confusing and causing massive delays.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

the food served was an embarrassment. No connection for charging the cellphone... What a crappy airline.

The flighr attandants were very rude they ignored me didnt offer me anything to drink throughoit the 4 hour flight i feel i was targeted and ignored because i was a darkskin latino man.

Very happy with my flight. I would definitely recommend it.

Did upgrade, travel in business it was great (more room I could sleep)

Placed us in the last rear row of the plane so could not recline seats because of the rear wall, and also made it more of a tight space when the passenger in front reclined their seat. While understand seat assignments, every passenger should be afforded a reclining seat. The odor control scent from the restrooms was overwhelming strong. My wife and I could not deal with it, and she suffered a terrible headache as a result. I kept getting hit by the crew since I was on the ilse seat. No apologies, nothing. They made me feel like I was supposed to take the beating for a 3 hr flight.

There was no individual at the front check in when I arrived. I waited for at least 15 minutes and walked around asking security/janitors if they could help and they did not have a solution. So I had to take my checked bag through security and they threw away some of my items. I ended up making it to the gate only a few minutes before it closed due to my waiting for an agent at check in.

The flight was delayed twice and I could not speak with anyone at the airport about checking in. The phone number to Copa - the customer service agents were polite. They are just limited at helping because they are not at the airport

We were in transit from Lima (flight at 1.10am) and we were in stand by in our flight from Panama to Washington. We wait from 4.30 am to 18.30pm in the Airport. The company give us 2 x 15 dollars for eat during the day and a personnal travel voucher of 400 dollars each. Do they buy food one time something in the Airport ??? And one of us live in France so the voucher is not usable. More than 24 hours travel !! And our place were near the toilets, with 8 children around us. The boy behind my seat stamped his feet on my back all the flight. Really Wonder full ! So we are totally unhappy with our travel. Thanks Copa Airlines....

We had to deboard 2 times due to maintenance issues. They changed the plane, and then we got deviated to LAX due to maibtenance issues on the other plane, had to sleep at LAX and los a full day.

From the first moment you interact with United Airlines, you can expect nothing less but extreme frustration. The baggage handler at the bag drop seems completely unbothered by the presence of customers waiting in line. No help was extended to load the baggage whatsoever. And if any of your bags is overweight by 0.01 pound they will make you re-distribute everything in your suitcase just to play power trip. When it was time to board no help was extended to customers to locate their seats. Moreover. It was a chaotic mess at the gate when it was unclear who should board first and everyone just bunched up, trying to get on the plane. I am sure the crew was doing their best to perform their jobs while being paid their wages however it shouldn’t be that hard to smile once or twice when you’re in the business if serving customers. It is a shame for the United States of America to have a flagship carrier of such low caliber. Our flight was also delayed by about an hour and a half due to further delays prior to our inbound flight. Being someone who has travelled for both business and leisure in Asia, Europe, and South America I have never experienced such poor quality of service.

The pilots were late and it made us 1 hour late. The meat was tough and bok choy was also tough.

Stuck on tarmac for two hours plus a 5.5 hour flight. Rude flight attendant. And no meals, not even for purchase!

I learned that seating towards the end of plane that a line forms for the restroom and people use your chair as a hand railing, bumping your seat consistently. I was seated in the aisle. I think that next time if I am towards the back row I would want to sit in the middle or window seat.

The best airline I have ever travel , really good customer service, attention and service !!

Everything was great. Only thing that could’ve made it better was buy on board options for hot food, but the snacks were decent. The flight attendants were great. I had no complaints. I was able to make it to my destination safely

Horrific. They missed my connecting flight to San Diego. I didn’t get there until Monday at 9am when I had a mandatory court settlement conference scheduled at 6am since we had parties on the east coast. This caused many issues. All because United apparently forgot to hold the doors open until my flight landed that only had a 10 minute delay. This was the last flight to Southern California. So I couldn’t even rent a car to finish the trip. United cannot be trusted when traveling on specific days and times since weather didn’t have anything to do with the delays.

Very comfortable (upgraded to business class). The audio on my screen didn’t work, but I managed to play the audio through my phone while watching the screen.

Flight was late as pilot crew had to land at different airport in their previous flight. Passengers boarded and had to wait for pilots inside plane. Series of incomplete and unnecessary announcements by an annoying voice, rather than complete, informative announcements.

The entertainment package was vast and the selections were very current. Keep updating it was great.

The seat was so hard my tailbone was aching The crew was kind of a b**** because I made a joke that I didn't care if they close the door I total c*** when she was trying to f****** act like she was mad at me because I said that The flight was bumpy. Sure you didnt have control over that.

4 hours late, including over +1 hour waiting in plane to take off. Baggage left behind too.

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Was not able to watch most shows on the entertainment site. They would not load

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

Delayed flight, so I switched fights to SFO to Phoenix , Phoenix to DSM. Excellent service through American Airlines

AA re-routed flight from HNL to LAX due to delay. My group of 3 with reserved seats in row 9 was broken up, with one assigned to a middle seat, another in the last row of the plane. Not happy. No explanation to the delay. No apologies. No compensation. Would have been nice to be offered an Admiral Club admission or a voucher for the extra 3 hours of layover in LAX. Could not hear the boarding gate announcements in LAX. Adjacent gate was boarding at the same time. Loud speakers were competing against each other. Barely made my boarding group.

Almost a 6 hour flight and the only food option is a cheese plate… and chips. Also how is it there are no options for texting on American. I’ll be going back to delta and united.

Bad food, small seats that didn’t recline. I thought I was buying a quantas ticket so I feel like I got scammed

Boarding, crew were excellent, food was ok and entertainment need to improve

The usb plugs for charging your phone didn’t work, the seats were coarse and hard. Not very comfortable. No inflight WiFi

The seats were uncomfortable and barely reclined at all. Very little leg room despite being business class. The crew was friendly and the food was good. Had to use my own phone for in-flight entertainment.

The check in is the only positive thing in Avianca. The seat is the most uncomfortable I have traveled, the distance is minimal.

Not what it used to be. The sale of food makes them look greedy!

Avianca is not what it used to be. So disappointing

It was horrible. My experience with Avianca. I didn’t know it was Pakistan international Airlines but anyway, whatever it is it is bad horrible you guys need to upgrade everything in those planes. And you guys charge $130 for a carry-on did they wanna let me in with my carry-on that I travel everywhere with the luggage you guys are such a dog thank you

Boarding was excessively slow. They do it by groups in a way that it doesn’t make sense. After business class , ppl that need assistance and any other priority group they should have ppl board from the back to the front. First rows 20+. Then 15+. Then 10, etc. having ppl sitting in the back board last makes no sense. The libe backame long as soon as ppl on rows 10 or so where told to board. The line went all the way up the ramp and tunnel for 25 mins.

Seats are very tight even in Plus, no complimentary snacks or beverage

I receive a service for what I pay, so it is fair.

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