$176 Find Cheap Flights from San Francisco to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Best South America Flight Deals from San Francisco

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$573
Bogotá
Bogotá2 stops$390
Medellín
Medellín1 stop$400
Buenos Aires
Buenos Aires2 stops$690
Sao Paulo
Sao Paulo1 stop$601
Rio de Janeiro
Rio de Janeiro2 stops$654
Cartagena
Cartagena2 stops$449
Santiago
Santiago1 stop$626
Quito
Quito1 stop$517
Cali
Cali1 stop$443
Guayaquil
Guayaquil1 stop$450
Cusco
Cusco2 stops$694
Georgetown
Georgetown1 stop$507
Pereira
Pereira1 stop$461
Montevideo
Montevideo2 stops$822
Barranquilla
Barranquilla1 stop$449
Santa Marta
Santa Marta2 stops$555
Florianopolis
Florianopolis1 stop$643
Lima
Lima2 stops$573
Bogotá
Bogotá2 stops$390
Medellín
Medellín1 stop$400
Buenos Aires
Buenos Aires2 stops$690
Sao Paulo
Sao Paulo1 stop$601
Rio de Janeiro
Rio de Janeiro2 stops$654
Cartagena
Cartagena2 stops$449
Santiago
Santiago1 stop$626
Quito
Quito1 stop$517
Cali
Cali1 stop$443
Guayaquil
Guayaquil1 stop$450
Cusco
Cusco2 stops$694
Georgetown
Georgetown1 stop$507
Pereira
Pereira1 stop$461
Montevideo
Montevideo2 stops$822
Barranquilla
Barranquilla1 stop$449
Santa Marta
Santa Marta2 stops$555
Florianopolis
Florianopolis1 stop$643

Cheap Flights from San Francisco to South America

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to South America

Tue, Sep 16 - Fri, Sep 26
LATAM Airlines Logo
11:41 am - 10:55 amSFO-BOG
21h 14m2 stops
LATAM Airlines Logo
7:00 am - 6:48 pmBOG-SFO
13h 48m2 stops
$390LATAM Airlines
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Mon, Sep 22 - Sat, Sep 27
Avianca Logo
2:20 pm - 5:27 amSFO-BOG
13h 07m2 stops
Avianca Logo
2:20 pm - 11:55 pmBOG-SFO
11h 35m1 stop
$391Avianca
Find Deal
Sun, Sep 21 - Sat, Sep 27
Avianca Logo
12:05 am - 1:20 pmSFO-BOG
11h 15m1 stop
Avianca Logo
10:13 am - 10:45 pmBOG-SFO
14h 32m2 stops
$392Avianca
Find Deal
Tue, Sep 16 - Fri, Sep 26
LATAM Airlines Logo
11:41 am - 10:55 amSFO-BOG
21h 14m2 stops
LATAM Airlines Logo
7:00 am - 6:48 pmBOG-SFO
13h 48m2 stops
$395LATAM Airlines
Find Deal
Sun, Aug 3 - Thu, Aug 14
Copa Airlines Logo
1:30 am - 5:00 pmSFO-MDE
13h 30m1 stop
Copa Airlines Logo
10:46 am - 11:39 pmMDE-SFO
14h 53m1 stop
$405Copa Airlines
Find Deal
Tue, Sep 2 - Mon, Sep 8
Copa Airlines Logo
1:30 am - 5:07 pmSFO-BOG
13h 37m1 stop
Copa Airlines Logo
12:08 pm - 11:39 pmBOG-SFO
13h 31m1 stop
$405Copa Airlines
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Sun, Jul 27 - Fri, Aug 8
United Airlines Logo
6:55 pm - 9:10 pmSFO-MDE
24h 15m1 stop
United Airlines Logo
12:15 am - 5:45 pmMDE-SFO
19h 30m1 stop
$413United Airlines
Find Deal
Thu, Aug 7 - Wed, Aug 20
United Airlines Logo
7:15 am - 4:54 amSFO-BOG
19h 39m1 stop
United Airlines Logo
8:30 am - 7:00 pmBOG-SFO
12h 30m1 stop
$413United Airlines
Find Deal
Wed, Oct 1 - Fri, Oct 31
American Airlines Logo
11:10 am - 7:19 pmSFO-UIO
30h 09m1 stop
American Airlines Logo
6:30 am - 10:59 pmUIO-SFO
18h 29m1 stop
$530American Airlines
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Mon, Sep 15 - Tue, Oct 7
American Airlines Logo
11:10 am - 7:35 pmSFO-UIO
30h 25m1 stop
American Airlines Logo
6:40 am - 10:44 pmUIO-SFO
18h 04m1 stop
$542American Airlines
Find Deal
Useful Info

KAYAK's insights & trends for San Francisco to South America flights

Get data-powered insights and trends into flights from San Francisco to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to South America is September, when tickets cost $632 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $1,188 and $796 respectively.

What’s the cheapest day of the week to fly from San Francisco to South America?

The average price of all round-trip flights from San Francisco to South America clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from San Francisco to South America, look for departures on Tuesdays and avoid leaving on a Saturday, as it's usually the priciest day. When flying back from South America, Tuesday is the cheapest day to fly and Sunday is the most expensive.

How far in advance should I book a flight from San Francisco to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to South America, you should book around 2 weeks before departure. For the absolute cheapest price, our data suggests you should book 8 weeks before departure.


Good to know

Low seasonMay
High seasonDecember
Cheapest flight$176
Best time to beat the crowds with an average 15% drop in price.
Most popular time to fly with an average 49% increase in price.
Flight from San Francisco to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Francisco to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Francisco to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Francisco to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the morning, when round-trip flights cost $726 on average. Morning departures are around 1% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $738.

Reviews of the top 5 airlines serving from San Francisco to South America

 
Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1801 reviews
6.7Food
7.4Comfort
7.0Entertainment
8.1Crew
7.6Boarding
Airline reviews

The boarding and new bag drop-off process was confusing and causing massive delays.

2.0 MediocreFernando, Jun 2025GRU - POA
Read more LATAM Airlines reviews

The boarding and new bag drop-off process was confusing and causing massive delays.

Wider seats, better seat cushions, (I felt like there was a board I was sitting on). I had the chicken to eat but It neither tasted nor looked like chicken. The fruit was good.

I was in the last row and they sent me to check in my luggage last minute after boarding. I had to go through the crowd.

I travel often with LATAM, it never disappoints me. The service is great, nice crew, latest and some classic movies. I got 3 small meals, cannot complaint. I’ll definitely travel again with them.

We departed and landed on time, the aircraft was clean and comfortable, the crew were lovely. Online checkin worked well and the self service bag drop at the airport worked well. The a/c was an Airbus A330 and has been fitted with a good entertainment system with lots of choice in many languages. The price I paid for the flight was competitive with other airlines apart from the budget carriers, none of whom I was familiar with so I stuck to an airline I have used in previous visits to South America.

We didn’t have any entertainment. I tried to go online without success. The airplane was extremely cold and they didn’t have blankets.

It was good, however the airplane was really cold. We received snacks and the crew was friendly.

Delta has an outstanding service. They are courteous and punctual most of the time. The flight departed a half hour late but we arrived 15 minutes early.

Although the flight is goof and the crew is good, the way the airline charges you for every service is ridiculous.

They didi not provide wheelchair though we had requested. We had to run around for 40 minutes and arrange it from the airport!

Seats not reclining, no vegetarian food option, no snacks. 7.5 hr flight should have been more comfortable. Luggage limits are unusually small. Will never fly Copa again and will tell friends and family to avoid this airline.

Placed us in the last rear row of the plane so could not recline seats because of the rear wall, and also made it more of a tight space when the passenger in front reclined their seat. While understand seat assignments, every passenger should be afforded a reclining seat. The odor control scent from the restrooms was overwhelming strong. My wife and I could not deal with it, and she suffered a terrible headache as a result. I kept getting hit by the crew since I was on the ilse seat. No apologies, nothing. They made me feel like I was supposed to take the beating for a 3 hr flight.

There was no individual at the front check in when I arrived. I waited for at least 15 minutes and walked around asking security/janitors if they could help and they did not have a solution. So I had to take my checked bag through security and they threw away some of my items. I ended up making it to the gate only a few minutes before it closed due to my waiting for an agent at check in.

The flight was delayed twice and I could not speak with anyone at the airport about checking in. The phone number to Copa - the customer service agents were polite. They are just limited at helping because they are not at the airport

We were in transit from Lima (flight at 1.10am) and we were in stand by in our flight from Panama to Washington. We wait from 4.30 am to 18.30pm in the Airport. The company give us 2 x 15 dollars for eat during the day and a personnal travel voucher of 400 dollars each. Do they buy food one time something in the Airport ??? And one of us live in France so the voucher is not usable. More than 24 hours travel !! And our place were near the toilets, with 8 children around us. The boy behind my seat stamped his feet on my back all the flight. Really Wonder full ! So we are totally unhappy with our travel. Thanks Copa Airlines....

It would have been better if they don't separate families in seating. We were seated in the aile row in the middle of a family of four. It would have been better if they they seat the family of four together than separated.

I upgraded myself to Business Class at the last minute so I had a DREAMS window seat. Seeing as I've never flown Business before everything was novel and fun for me and it made the 7 hour flight much more enjoyable for sure.

No headphones given for inflight entertainment. I missed my flight from the previous day and the customer service agent tried to extort an additional $100.00 US from me for missing my flight. Really?!

The flight was delayed about 4 hours without any explanation. No wifi or entertainment at all on planes. Had to pay for checked bags I was allowed according to reservations.

It was good, plane is a bit older so seats are somewhat flat

Horrific. They missed my connecting flight to San Diego. I didn’t get there until Monday at 9am when I had a mandatory court settlement conference scheduled at 6am since we had parties on the east coast. This caused many issues. All because United apparently forgot to hold the doors open until my flight landed that only had a 10 minute delay. This was the last flight to Southern California. So I couldn’t even rent a car to finish the trip. United cannot be trusted when traveling on specific days and times since weather didn’t have anything to do with the delays.

Very comfortable (upgraded to business class). The audio on my screen didn’t work, but I managed to play the audio through my phone while watching the screen.

Flight was late as pilot crew had to land at different airport in their previous flight. Passengers boarded and had to wait for pilots inside plane. Series of incomplete and unnecessary announcements by an annoying voice, rather than complete, informative announcements.

Breakfast was not loaded at SFO due to catering company change. Seems like a major airline at a major hub would have thought of something else or warned passengers to pick up food before boarding a 3 hour flight.

Boarding seemed to be organized bedlam. For what ever reason, preboarding took longer than 20 minutes. Made the plane 20 minutes late taking off. Luckily we arrived on time. Flight crew seemed very friendly. Only slight turbulence.

They hired a new catering company the same day of my flight. They botched the job by not delivering the right carts and after THREE HOURS waiting, the flight crew timed out (flight was 19 hours long and FAA rules state crew can’t work more than 14 hours long). So they CANCELED OUR FLIGHT!! Worst experience ever. Avoid UAL at all costs.

The personnel were professional and friendly. The Boeing 737 Max 9 is too claustrophobic and was very warm at both airport gates, and still warm in the air.

While the staff was pleasant and helpful, the following observations are for your awareness. There was some delay on the tarmac on take off and landing. The paid lunch/food offerings were limited. Entertainment was only available on WiFi at a cost.

get E+, a must for 5 hours flight if you are tall

Liked fold flat bed. Didn’t like having no window. Didn’t like poor choice of food and being served dinner very late, hours after take off of a 7:40pm flight. Servers not friendly. Food horrible in business class.

Almost a 6 hour flight and the only food option is a cheese plate… and chips. Also how is it there are no options for texting on American. I’ll be going back to delta and united.

Bad food, small seats that didn’t recline. I thought I was buying a quantas ticket so I feel like I got scammed

The chair cushions may need an upgrade. I have been noticing they are so worn out, thin so you’d sit in a dip 😄. Other than that, all was an enjoyable trip. Thanks AA!

Cramped seats. FAA should make airlines have more legroom, for even short people complain

Flight was full, and would have preferred an aisle seat, but due to getting a late ticket ,the seat I had was adequate. The flight crew were very help full and hard working. Food and drink were excellent for the 11hr flight. Overall I was pleased with flight, and would recommend British Airways again.

Eventless. It was a good flight and good crew. Can’t complaint.

Very helpful ground crew after an earlier flight delay and being rebooked on a different flight.

British Airways staff are very polite and willing to help.

The plane was late and then sat on the runway for almost 45 minutes before taking off.

We kept being told that the flight was full and that all overhead compartments were full and therefore had to check in our hand luggage. We were some of the last people to board and noticed that there was still sufficient space in the overhead compartments. We were obliged to check in hand luggage when there was space and so had to wait at luggage retrieval which took a while to then noticed damage to our luggage - not a great experience!

Boarding was excessively slow. They do it by groups in a way that it doesn’t make sense. After business class , ppl that need assistance and any other priority group they should have ppl board from the back to the front. First rows 20+. Then 15+. Then 10, etc. having ppl sitting in the back board last makes no sense. The libe backame long as soon as ppl on rows 10 or so where told to board. The line went all the way up the ramp and tunnel for 25 mins.

Seats are very tight even in Plus, no complimentary snacks or beverage

Flight to Bogotá delayed by 3 h Missed connection from Bogotá to Guayaquil. Avianca unable to bring us to Baltra on time Overall delay 36h. We missed boat departure from galagos. Overall 10 day trip needed to be cancelled. Avianca was completely un-professional.

I receive a service for what I pay, so it is fair.

i think the flight was late because they were so strict about measuring everyone's personal items to try and charge them $119. It was really petty and made us late.

There isn't much space in-between seats and even water needs to be paid for during the flight.

We did not know about the bag fees until check in. They are way too high. It’s insane. We also had a huge delay and everything costed extra which was very annoying.

Lounge for business was closed. Boarding was rush and stand by. Seat for business is just the middle seat blocked and some more leg room.

Flew with our two children. Paid $380 to check two bags (one was overweight). They then left the bags behind on Sunday, December 21st, with all our family’s clothes and family Christmas presents. When we arrived at our destination they told us the bags had not arrived, and they thought (but didn’t know) they were still in Boston, but that there’d be a flight the next day and the bags would arrive the next day. The next day we found out there was no flight, now we’re hoping we get our bags before we fly back out. Meanwhile, trying to get any engagement or accurate information is a waste of time. The folks at the call center are just gatekeepers, who can’t connect with any departments that actually do things to solve a problem. Getting information is made deliberately difficult. My biggest regret is that I’ve had a number of awful experiences with Avianca traveling between the US and Colombia, and still let myself get suckered into buying these tickets because the schedule was great. Never again.

We were not aware carry-on bags cost extra until we arrived at the airport so, we were charged $240.00 for two small carry- on bags! There was a substantial fee for drinks and snacks. No wifi, or other entertainment was available. Waiting areas were crowded and uncomfortable.

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