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$166 Find cheap flights from San Francisco to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
sáb. 8/24
sáb. 8/31

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Best South America Flight Deals

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Lima
Lima1 stop$505
Bogotá
Bogotá1 stop$371
Buenos Aires
Buenos Aires2 stops$669
Medellín
Medellín1 stop$379
Sao Paulo
Sao Paulo1 stop$615
Cartagena
Cartagena1 stop$379
Santiago
Santiago1 stop$534
Rio de Janeiro
Rio de Janeiro2 stops$802
Quito
Quito1 stop$466
Cali
Cali2 stops$418
Guayaquil
Guayaquil1 stop$380
Cusco
Cusco2 stops$639
Georgetown
Georgetown1 stop$473
Pereira
Pereira2 stops$463
Barranquilla
Barranquilla2 stops$415
Montevideo
Montevideo1 stop$898
Caracas
Caracas3 stops$927
Santa Marta
Santa Marta1 stop$385

Good to know

Low season

May

High season

December

Cheapest flight

$166
Best time to beat the crowds with an average 11% drop in price.
Most popular time to fly with an average 43% increase in price.
Flight from San Francisco to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to South America from San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to South America with an airline and back to San Francisco with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to South America from San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to South America

  • On average*, there is no price difference when choosing to fly in the morning or the evening on this flight route.
*Average of the lowest prices shown in KAYAK’s search results for departures within the next 30 days

Top 5 airlines serving from San Francisco to South America

Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 9630 reviews
7.9Comfort
8.6Crew
8.0Entertainment
7.4Food
8.2Boarding
Airline reviews

My seat was changed at the last minute and I was moved to the last row, right next to the bathroom despite selecting my seat well in advance. I was also made to check my carry on due to space but when I got on the plane there was significant empty overhead space. Picking up my carry on from the luggage carousel added time to my trip which had already been extended due to delay.

2.0 MediocreElizabeth, Jun 2024LAX - JFK
Read more about Delta reviews

My seat was changed at the last minute and I was moved to the last row, right next to the bathroom despite selecting my seat well in advance. I was also made to check my carry on due to space but when I got on the plane there was significant empty overhead space. Picking up my carry on from the luggage carousel added time to my trip which had already been extended due to delay.

There was plenty of overhead room but half of the passengers were told they had to check their carryon bags. My partner and I checked in as early as possible and our seats were split across the aisle.

Flew first class so everything was great. But maybe because the flights were red eye, no meals were served, just chips. I flew Alaska Air 1st class at 9PM (2 hour flight) and they served beef short rib sliders!

There was a loud squeaky sound the whole time we were flying.

I didn’t not like that I could not select my seat and ended up with the worse seat.

The landing was bad and the hostess came two times and i was sleeping but when she served the person that nexts to me I woke up and she didn’t even asked me if I need any drink or snacks two times!!!!

Plane was late because of a mechanical malfunction and the food listed as available was not. Flight attendants seem over worked and under paid. They just done seem happy. And that can be seen in their faces.

Waited 3 hours on a plane to de-ice due to manpower issues. Waited another hour and a half once we landed because of a gate issue. Missed my connections. Created. A total of 13 hours of delay.

Great, on time departure, friendly and accommodating crew, great leg room, Smith flight

Plane was turned around due to fog half way into the flight, Delta did not properly direct passengers to stay on same flight and instead failed to properly rebook on Alaska

This airline doesn’t five and dime you for everything. I do think that a checked bag should be included in every fare.

The seats had plenty of leg room and the staff were very nice.

Copa performed as expected for the amount of money I was willing to spend for the flight; it wasn’t exceptional but it was not bad in any way either. The crew was good; friendly and straightforward. The food was airplane food, so no expectations there and the entertainment was lacking but that was my fault for owning an IPhone with a charging port that’s not compatible with the rest of the world. I’d fly Copa again.

Left my bags in origin city on a business class ticket , spent about 2-3 days in the same clothes plus the flight .

the planes are not modern there are no phone chargers

As usual, the flight with normal legroom was not very comfortable, but the second flight was much better because we had paid for extra legroom. It was very nice to check our bags without an extra fee.

LOCKED MY BAG WITHOUT CONSENT. Had to have my zippers cut upon arrival in Costa Rica.

Pros: "The seats in economy were confortable. The best thing was Copa gave us seats in the second line and my family traveled together."
Cons: "Coffe service could better the experience"
Pros: "The crew was very interested on help and attentive with the passengers. But the seat wasn't comfortable. The design of the cushion is not the best to be seating"
Cons: "Copa is trash . Doesn’t accolade passengers with hotels . They except people to wait in the airport for 14 hrs lay over when it’s their fault ! Straight trash . Poor 79 year old lady had to stay at the airport cause her family was 4 hours away ! Trash trash"

You delayed my trip three days for no reason other than your lack of preparedness, did not offer any compensation, including food or a bed. I couldn’t trust you so I moved up my return flight and lost another day at the end of my trip to hopefully make sure I make my next flight. I will never fly LATAM again. You have the worse accountability and reliability and clearly do not care that your clients have lives and what it cost to fly to another country.

They offered food. The crew passed by again offering water. I enjoyed the two seating section. I think is very comfortable instead of the three seat way, unless you seat in the middle; which it's not bad, but I wouldn't prefer. All and all, I think the lay out of the seating rows are better than other airlines so far( I haven't tried many anyways). The lay out makes the getting in and out to use the restroom less uncomfortable and cramped. First time flying with Latam. I will fly with them again

Everything was as you would expect in coach - fine. Flight was close to on time.

I missed my plane because there was a lot of people during the migration process. The airline has the chance to care for their clients and they could get the passengers missing in the flight. I lost a day of work and Montfort transportation to go back home and go to the airport again. Unfortunately the airline doesn’t care about that. I use latam at least 4 times a year, so I guess I need to be treat better. In addition, one on my baggages didyarricw to my destination. So frustrated with this trip.

No air in the middle rows. Had a hard time breathing. Was dying of heat.

Not very good, they nickel & dime you for better seats & pay extra for the checking in bag, bad service all the way around

I loved how polite the crew was even though some of them wasn't the best with English that they still done everything they could to help me with my needs food was amazing

Horrific checkin procedure with neither Delta nor Latam figuring out how to check me in. 4 hrs on customer support with both and both airlines pointing to each other who should do checking. I was not checked in until morning of flight, which for international flight is concerning.

It was a good experience, the flight was a little too long & the food was ok

Awful, horrible customer service. Flight got delayed and had to spend y the night in Bogota as a result. Very poor

I did not enjoy continuously being lied to about the amount of time we would circle Chicago before deciding to redirect to Milwaukee. Then the amount of time we would sit on the ground in Milwaukee waiting for gas, or to take off again. Or the amount of time it would then take to get to Chicago again, or sit on the runway waiting for a gate. The whole time continuously hopefully we would make our connecting flight that kept getting delayed as well. Only to scramble and miss it. Enough with the BS. Tell me the truth. "Sorry, things are backed up and your probably not going to make your flight. You should rebook on the next flight now rather than wait." You'll never hear those words from an airline. Speaking of which. If the flight has been redirected and/or is seriously delayed, how about making the WiFi free for everyone so they get to rebooking and reserving hotel rooms while still in the air. You've inconvenienced me already and now you want me to pay $20 for Internet so I can try to make other plans. Absolutely disgusting!

Excellent. Attendants served preflight drinks and were courteous and nice.

It was great! It’s been awhile since I’ve flown American but this most recent experience reminded me how much I enjoy flying American. Organized. Informative. Efficient. Friendly. Can’t ask for much more, except my luggage got dinged up a bit. But that could have been the airport.

It was the worst experience ever. Cabin temperature cold, for which they did not have any blankets upon my asking. We paid $125 extra for each passenger to get extra space sits; the sits were ridiculously small, tight, and uncomfortable! The flight attendant dropped ice on me and my sister! All in all, American Airlines deserves below zero!

The flight was delayed two hours, with no information as to why. The gate also changed several times which was aggravating. Would not fly through DFW again.

not enough crew for business class and not great service as a result. underwhelmed overall

The inability to be flexible when you need to change a Basic Economy flight, when your company demands you book through a third party, causes raw feelings about the whole experience. A major airline should realize business and personal plans change all the time. I must save my company money on travel. Even if you have to charge me for the change, I get it. But being so rigid with a policy is not the best customer service.

WiFi was down so no entertainment and I could not work either. The flight was Very turbulent at the end (the last 20 min felt like an eternity) I appreciated the pilot for getting us there safely. The flight attending in first class was kind and attentive to everyone.

The gate crew did try to help, however they lacked the information as to whether the flight will operate or not. Being delayed 6 hours and in a limbo on whether the flight will operate or not is not fun. The airline having staffing issues is not encouraging at all.

From check-in staff to in-flight staff, everyone was wonderfully kind

Our flight from BOS - BOG was delayed 10 hours because they were waiting for a Flight attendant to fly from Miami. They lied and said they would give us food and hotel. That was a straight Lie! It never came! We were in the airport for 13 hours with Two babies. We were on the plane 7 more Hours. When we asked to get diapers from our checked luggage, Jorge in Boston told my wife she should have planned better. Meanwhile, the 10 Avianca Employees Sat there and did nothing for 13 hours. Yes, we planned for 10 hours with the wait and the flight, not 20 hours JORGE! If this was an American company we would have got a refund! But they are not up to American standards. The kicker is they apparently needed the 3rd stewardess to serve the food. Guess what? It was 4AM when they tried to serve the FOOD! Everybody was asleep by then! Ridiculous! Never Again!

My fly was cancelled so i run to the airport and fight for my fly Thank god at the end was good

Terrible. Flight was delayed without explanation, airplane was in poor condition (old, dirty) and crew was not in a good mood.

Definitely my worst experience. We booked a flight JFK - Cartagena with a layover at Bogota. My partner and I were on time for the boarding at 10:55pm. We were about to enter in the plane, literally, when one of the officer from the airline Avianca, took the passport of my partner to apparently « looked at his luggage reservation ». It made no sense, first the luggage was under my name, and then we went through all the controls at the airport. The person went back to the gate inside the airport, I followed my partner. The employees from the airline were rude and disrespectful. They were not explaining us what’s was going on. After 5 minutes of silence treatment. They told us that my partner was intoxicated (it was absolutely not true, they never conducted tests btw) and he couldn’t board in the plane and he will take the next one. They didn’t late us coordinated the trip, and not even let us say goodbye to each other. I was forced to take the plane to bogota and my partner to stay in NYC. It was traumatic. My partner had to wait 6h in the airport (night time) and he had to pay an additional ticket even tho the employees mentioned he was going to take the next flight. We are going to file a complain. It’s unbelievable. First and last time I will ever use this airline. I do not recommend.

Ok, but these people don’t give you nothing no snack no water

No water for a 5 hour flight entertainment not working seats with little room for knees when person in front of me reclined kept bumping my knees.

I don't think anyone actually reads these comments, so I won't spend much time on this submission. If you want to talk, you know how to reach me. The D/FW manager of Avianca (self-identified), Juan Calderon, insisted I buy an onward ticket from San Salvador even though I have diplomatic status in El Salvador and live here. It cost me $1,393 and Mr Calderon would not let me make the ticked flexible so I could get a refund. He went out of his way to be rude to me. He gave me seat 32K -- windowless window seat in the last row and did not offer to let me upgrade even though there were plenty of seats. I have flown well over a million miles in my life and this is the worst experience I have ever had. I would like a refund on the ticket I was forced to buy. Just awful!

This is the Spirit of Latino travel. And don’t even get me started on customer service.

Awful. I checked in online and there was no option to pay for baggage, at the airport when I checked in my baggage was received and Iwas not charged. When I got to LA during the boarding process I was told I didn't pay for baggage, the crew resolved I was let in the plane. When I got to my final destination my baggage was not there. It took me two days to receive my baggage. Bad service ever!

There was no food or drink service, couldn’t even get a glass of water for free. It was a long and expensive flight to not offer food or beverage on the plane.

Book cheap flights from San Francisco to South America

Recent round-trip flight deals

8/15jue.
1 stopDelta
20h 27mSFO-BOG
8/30vie.
2 stopsDelta
19h 04mBOG-SFO
$371
8/26lun.
1 stopJetBlue
12h 24mSFO-MDE
9/13vie.
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8/22jue.
1 stopCopa Airlines
12h 29mSFO-CTG
8/29jue.
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1/18sáb.
1 stopAmerican Airlines
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1/22mié.
1 stopAmerican Airlines
16h 50mCTG-SFO
$391
8/21mié.
1 stopAmerican Airlines
11h 25mSFO-BOG
9/9lun.
2 stopsAmerican Airlines
15h 59mBOG-SFO
$392
9/3mar.
1 stopCopa Airlines
10h 36mSFO-CTG
9/9lun.
1 stopCopa Airlines
18h 58mCTG-SFO
$393
11/5mar.
1 stopLATAM Airlines
10h 30mSFO-BOG
1/15mié.
1 stopLATAM Airlines
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11/5mar.
2 stopsLATAM Airlines
18h 35mSFO-BOG
1/15mié.
2 stopsLATAM Airlines
17h 27mBOG-SFO
$406
9/15dom.
1 stopAvianca
11h 05mSFO-LIM
9/21sáb.
1 stopAvianca
13h 10mLIM-SFO
$505
9/10mar.
2 stopsAvianca
15h 40mSFO-LIM
9/17mar.
1 stopAvianca
13h 10mLIM-SFO
$506

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9/7sáb.
1 stopJetBlue
11h 55mSFO-MDE
$166
8/23vie.
1 stopUnited Airlines
19h 05mSFO-BOG
$166
8/25dom.
1 stopAmerican Airlines
12h 37mSFO-CTG
$167
9/2lun.
2 stopsDelta
19h 17mSFO-BOG
$167
9/13vie.
1 stopCopa Airlines
10h 32mSFO-CTG
$168
8/24sáb.
2 stopsAmerican Airlines
14h 25mSFO-BOG
$171
8/26lun.
2 stopsDelta
17h 26mSFO-BOG
$172
8/21mié.
1 stopCopa Airlines
10h 31mSFO-CTG
$182
9/10mar.
2 stopsLATAM Airlines
15h 37mSFO-BOG
$183
8/1jue.
2 stopsLATAM Airlines
18h 15mSFO-BOG
$188

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Last minute flights from San Francisco to South America

Last minute flight, train and bus deals

7/26vie.
multi-stopAmerican Airlines
18h 33mSFO-CTG
8/4dom.
multi-stopAmerican Airlines
21h 13mCTG-SFO
$486
7/26vie.
multi-stopAmerican Airlines
22h 48mSFO-BOG
7/29lun.
multi-stopAmerican Airlines
11h 23mBOG-SFO
$498
7/30mar.
multi-stopCopa Airlines
10h 22mSFO-CTG
9/18mié.
multi-stopCopa Airlines
16h 12mCTG-SFO
$689
7/29lun.
multi-stopAvianca
11h 15mSFO-LIM
8/18dom.
multi-stopAvianca
32h 00mLIM-SFO
$744
7/27sáb.
multi-stopAvianca
15h 35mSFO-BOG
8/11dom.
multi-stopAvianca
15h 35mBOG-SFO
$744
7/26vie.
multi-stopCopa Airlines
29h 05mSFO-CTG
8/1jue.
multi-stopCopa Airlines
18h 52mCTG-SFO
$831
7/29lun.
multi-stopLATAM Airlines
19h 01mSFO-CTG
8/1jue.
multi-stopLATAM Airlines
20h 12mCTG-SFO
$943
7/29lun.
multi-stopLATAM Airlines
18h 30mSFO-SCL
8/12lun.
multi-stopLATAM Airlines
31h 42mSCL-SFO
$967
7/29lun.
multi-stopDelta
20h 25mSFO-SCL
8/4dom.
multi-stopDelta
16h 36mSCL-SFO
$977
7/27sáb.
multi-stopDelta
20h 45mSFO-SCL
8/10sáb.
multi-stopDelta
20h 57mSCL-SFO
$982

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San Francisco - South America Flights