$172 Find Cheap Flights from San Francisco to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from San Francisco to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$531
Bogotá
Bogotá1 stop$473
Medellín
Medellín1 stop$370
Buenos Aires
Buenos Aires3 stops$964
Sao Paulo
Sao Paulo2 stops$718
Rio de Janeiro
Rio de Janeiro2 stops$800
Santiago
Santiago1 stop$692
Cartagena
Cartagena1 stop$393
Quito
Quito2 stops$531
Guayaquil
Guayaquil1 stop$450
Cali
Cali1 stop$537
Cusco
Cusco2 stops$726
Georgetown
Georgetown1 stop$538
Pereira
Pereira2 stops$569
Montevideo
Montevideo2 stops$892
Barranquilla
Barranquilla1 stop$561
Santa Marta
Santa Marta2 stops$548
Asuncion
Asuncion2 stops$950
Lima
Lima1 stop$531
Bogotá
Bogotá1 stop$473
Medellín
Medellín1 stop$370
Buenos Aires
Buenos Aires3 stops$964
Sao Paulo
Sao Paulo2 stops$718
Rio de Janeiro
Rio de Janeiro2 stops$800
Santiago
Santiago1 stop$692
Cartagena
Cartagena1 stop$393
Quito
Quito2 stops$531
Guayaquil
Guayaquil1 stop$450
Cali
Cali1 stop$537
Cusco
Cusco2 stops$726
Georgetown
Georgetown1 stop$538
Pereira
Pereira2 stops$569
Montevideo
Montevideo2 stops$892
Barranquilla
Barranquilla1 stop$561
Santa Marta
Santa Marta2 stops$548
Asuncion
Asuncion2 stops$950

Book Cheap San Francisco to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to South America

Thu, Apr 9 - Tue, Apr 21
Avianca Logo
11:55 pm - 1:10 pm
SFO
-
MDE
11h 15m
1 stop
Avianca Logo
2:10 pm - 11:55 pm
MDE
-
SFO
11h 45m
1 stop
$370Avianca
Thu, Apr 9 - Tue, Apr 21
Avianca Logo
11:55 pm - 1:10 pm
SFO
-
MDE
11h 15m
1 stop
Avianca Logo
10:40 am - 10:35 pm
MDE
-
SFO
13h 55m
2 stops
$374Avianca
Fri, Apr 10 - Sun, Apr 26
Avianca Logo
2:15 pm - 6:20 am
SFO
-
MDE
14h 05m
2 stops
Avianca Logo
2:10 pm - 10:35 pm
MDE
-
SFO
10h 25m
1 stop
$376Avianca
Wed, Apr 15 - Sun, Apr 26
Copa Airlines Logo
8:37 pm - 8:15 am
SFO
-
MDE
9h 38m
1 stop
Copa Airlines Logo
12:40 pm - 11:40 pm
MDE
-
SFO
13h 00m
1 stop
$389Copa Airlines
Mon, May 11 - Thu, May 28
Copa Airlines Logo
1:12 am - 2:15 pm
SFO
-
MDE
11h 03m
1 stop
Copa Airlines Logo
5:00 am - 11:40 pm
MDE
-
SFO
20h 40m
1 stop
$399Copa Airlines
Tue, Apr 28 - Tue, May 5
American Airlines Logo
6:00 am - 9:17 pm
SFO
-
BOG
13h 17m
2 stops
American Airlines Logo
6:30 am - 7:04 pm
BOG
-
SFO
14h 34m
2 stops
$504American Airlines
Fri, Apr 17 - Tue, Apr 21
LATAM Airlines Logo
10:35 pm - 10:00 pm
SFO
-
LIM
21h 25m
2 stops
LATAM Airlines Logo
1:30 pm - 11:59 am
LIM
-
SFO
24h 29m
2 stops
$532LATAM Airlines
Sat, Apr 25 - Wed, May 6
LATAM Airlines Logo
11:59 pm - 9:55 pm
SFO
-
LIM
19h 56m
1 stop
LATAM Airlines Logo
1:30 pm - 11:48 am
LIM
-
SFO
24h 18m
2 stops
$537LATAM Airlines
Tue, Aug 18 - Sun, Aug 30
American Airlines Logo
12:12 pm - 6:50 am
SFO
-
SCL
15h 38m
1 stop
American Airlines Logo
8:30 pm - 7:00 pm
SCL
-
SFO
25h 30m
1 stop
$735American Airlines
Tue, Apr 7 - Sun, May 10
United Airlines Logo
6:55 pm - 6:45 am
SFO
-
GRU
31h 50m
1 stop
United Airlines Logo
10:20 pm - 1:50 am
GRU
-
SFO
31h 30m
1 stop
$740United Airlines
Booking Insights

KAYAK's insights & trends for San Francisco to South America flights

Get data-powered insights and trends into flights from San Francisco to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to South America is February, when tickets cost $612 (return) on average. On the other hand, the most expensive months are December and June, when the average cost of round-trip tickets is $897 and $802 respectively.

How far in advance should I book a flight from San Francisco to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to South America, you should book around 2 weeks before departure, which saves you about 9% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 17 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$172
Most popular time to fly with an average 36% increase in price.
Flight from San Francisco to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Francisco to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Francisco to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Francisco to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from San Francisco to South America

 
Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
Copa AirlinesOverall score based on 1568 reviews
7.8Boarding
7.4Comfort
6.8Food
8.1Crew
6.8Entertainment
Airline reviews

Horrible. No TV or any type of entertainment on board. Passwnger listening to/watching stuff on their own phone with no headphones making it noise and uncomfortable for everyone else, little/tiny food portions, old seats, useless wifi (cant access anything). Horrible exlerience especially it was a lomg distance flight with kids.

2.0 MediocreAnonymous, Dec 2025
PTY - POA
Read more Copa Airlines reviews

Horrible. No TV or any type of entertainment on board. Passwnger listening to/watching stuff on their own phone with no headphones making it noise and uncomfortable for everyone else, little/tiny food portions, old seats, useless wifi (cant access anything). Horrible exlerience especially it was a lomg distance flight with kids.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

Very happy with my flight. I would definitely recommend it.

Did upgrade, travel in business it was great (more room I could sleep)

Enforce the boarding process by group numbers. Tell people to stay seated during the meal/drink distribution. It took forever to get food and drinks because people would not stay out the isle and let the crew do their jobs. Everyone wanted to go to the bathroom forcing the crew to enter and leave the isle constantly so people can pass. Tell people to keep their electronics off speaker mode. No one wants to hear phone conversations and music playing.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

The 777’s economy seat’s legroom was more tolerable than expected. I appreciate the reclining mechanism which slides the seat forward to minimize cannibalizing the space behind. The food was terrible: very salty.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Flight delayed for more than 16 hrs and no effort was spent to provide an alternate

We had turbulence ever 1/2 hr or so and the captains announcements were SOOOO LOUD

it was a very short flight so my expectations were low.

Entertainment kept turning itself off. Gave up on watching a movie.

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Terrible. No customer service, no food, no drinks on a 6 hour premier economy booking.

The flight crew where really good. Better then the crew from BNE to SFO

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

Dloght delayed by 2.5 hrs . Common theme in my last four american floghts

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

My seat was assigned last row behind restrooms No legroom’s I’m very Pettit Still was not comfortable Food choice was excellent

The worst Airline ever. They centered my second flight and leave me in NY. They don’t have any representatives at the airport and they don’t respond to calls. Basically I got stuck. I will never purchase through there again.

The chicken wrap was tiny ($13 for what looked like a 1/3 of a normal wrap?) and disgusting.

Mediocre would be best description. Food bland. Seat biz class uncomfortable to sleep. Crew never dimmed lights completely in an overnight flight to Europe. Would avoid AA if possible.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Massimo, flight attendant was very authentic, attentive - wonderful. Food/wrap was just okay.

Experience was great. The best part is the free Wi-Fi connection which helps me to work on the flight

It was delayed and I lost my connection flight to Cali and I missed my Mom's funeral

I upgraded to businesses class. Because of that the flight was comfortable.

I actually upgraded to the medium level of seats from basic and even doing that it may have been physically the most uncomfortable flight I have ever had. They packed everyone like is a train to death camp. It was a red eye so I hoped to get some sleep but it was physically impossible to find a comfortable way to rest. I met other folks on the same flight and they said the same thing. It was an utterly miserable flight and if I have any other options I will never fly with them again

We found the chairs to be really uncomfortable. It’s also really unacceptable that no form of food or drink is included in a 6+ hour flight

Deplaning was a mess, I sat in business (seats are horrible) and the front door had a problem so we had to deplane from the rear exit. The stairs were not tall enough to reach so there was a large step down from the plane to the top of the stairs.

Staff are the rudest in the industry … awful customer service … will never fly Avianca again

Pros: we leave and arrive on time Cons: the most uncomfortable seats ever. You cant recline at all your seats. No entertainment No TVs flight attendants didn't provide even a glass of water. You have to go to back of the airplane and ask for one. I am Colombian and I remember seeing the flight attendants very neat, elegants which is or was a staple of Avianca.it was one with tennis shoes, no male up, the hair was messy... that was really odd.

Here we have another airline flying to Guatemala but doesn't have a plus or a less, just in the middle. Why? Well, first we don't have even free water Movie selection is poor Seats don't recline in some places Food selection is carb based Forgot to mention, customer service on the web is the worst. Good things; Very reliable on schedule Kind crew

Last seat of Bussines Class it does recline but passenger seating behind kept pushing since they did not have space once my seat was reclined

I handed in my suitcase in perfect condition at SAL Airport. And in MIA Airport I received it with one corner broken and the wheels bent.

Everything you need to know for your flight to South America

Information on your arrival and departure airports