$237 Find Cheap Flights from San Francisco to South America - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from San Francisco to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$632
Bogotá
Bogotá1 stop$433
Medellín
Medellín1 stop$611
Buenos Aires
Buenos Aires1 stop$922
Sao Paulo
Sao Paulo2 stops$823
Rio de Janeiro
Rio de Janeiro2 stops$735
Santiago
Santiago2 stops$675
Cartagena
Cartagena1 stop$461
Quito
Quito1 stop$609
Guayaquil
Guayaquil1 stop$555
Cali
Cali2 stops$588
Cusco
Cusco2 stops$746
Georgetown
Georgetown2 stops$570
Pereira
Pereira2 stops$602
Barranquilla
Barranquilla1 stop$582
Montevideo
Montevideo2 stops$888
Santa Marta
Santa Marta2 stops$604
Asuncion
Asuncion2 stops$991
Lima
Lima2 stops$632
Bogotá
Bogotá1 stop$433
Medellín
Medellín1 stop$611
Buenos Aires
Buenos Aires1 stop$922
Sao Paulo
Sao Paulo2 stops$823
Rio de Janeiro
Rio de Janeiro2 stops$735
Santiago
Santiago2 stops$675
Cartagena
Cartagena1 stop$461
Quito
Quito1 stop$609
Guayaquil
Guayaquil1 stop$555
Cali
Cali2 stops$588
Cusco
Cusco2 stops$746
Georgetown
Georgetown2 stops$570
Pereira
Pereira2 stops$602
Barranquilla
Barranquilla1 stop$582
Montevideo
Montevideo2 stops$888
Santa Marta
Santa Marta2 stops$604
Asuncion
Asuncion2 stops$991

Book Cheap San Francisco to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to South America

Wed, Sep 9 - Mon, Sep 21
United Airlines Logo
4:40 pm - 4:54 am
SFO
-
BOG
10h 14m
1 stop
United Airlines Logo
8:30 am - 12:27 am
BOG
-
SFO
17h 57m
1 stop
$433United Airlines
Sat, Sep 12 - Sun, Sep 20
United Airlines Logo
4:40 pm - 7:20 pm
SFO
-
BOG
24h 40m
1 stop
United Airlines Logo
8:30 am - 12:27 am
BOG
-
SFO
17h 57m
1 stop
$443United Airlines
Wed, Jul 15 - Thu, Jul 23
Avianca Logo
2:15 pm - 2:00 am
SFO
-
BOG
9h 45m
1 stop
Avianca Logo
4:25 am - 12:50 pm
BOG
-
SFO
10h 25m
1 stop
$500Avianca
Thu, Jul 23 - Thu, Jul 30
Avianca Logo
2:15 pm - 2:00 am
SFO
-
BOG
9h 45m
1 stop
Avianca Logo
1:40 pm - 11:55 pm
BOG
-
SFO
12h 15m
1 stop
$508Avianca
Tue, Dec 8 - Wed, Feb 10
American Airlines Logo
6:15 pm - 12:40 pm
SFO
-
BOG
15h 25m
2 stops
American Airlines Logo
8:00 am - 10:33 pm
BOG
-
SFO
17h 33m
2 stops
$513American Airlines
Tue, Sep 15 - Wed, Nov 11
American Airlines Logo
9:35 am - 4:10 am
SFO
-
LIM
16h 35m
1 stop
American Airlines Logo
12:45 am - 9:07 pm
LIM
-
SFO
23h 22m
1 stop
$634American Airlines
Wed, Aug 12 - Tue, Aug 25
LATAM Airlines Logo
4:25 pm - 8:05 am
SFO
-
LIM
13h 40m
1 stop
LATAM Airlines Logo
12:05 pm - 10:17 am
LIM
-
SFO
24h 12m
1 stop
$636LATAM Airlines
Tue, Sep 8 - Tue, Sep 15
LATAM Airlines Logo
7:20 am - 10:10 pm
SFO
-
LIM
12h 50m
1 stop
LATAM Airlines Logo
12:05 pm - 10:28 am
LIM
-
SFO
24h 23m
1 stop
$638LATAM Airlines
Sun, Oct 25 - Tue, Nov 3
Copa Airlines Logo
1:31 am - 11:39 pm
SFO
-
SCL
18h 08m
1 stop
Copa Airlines Logo
1:22 am - 5:25 pm
SCL
-
SFO
21h 03m
1 stop
$723Copa Airlines
Sun, Jul 12 - Tue, Jul 28
Copa Airlines Logo
8:16 pm - 4:05 am
SFO
-
GIG
27h 49m
1 stop
Copa Airlines Logo
5:10 am - 6:00 pm
GIG
-
SFO
16h 50m
1 stop
$738Copa Airlines
Booking Insights

KAYAK's insights & trends for San Francisco to South America flights

Get data-powered insights and trends into flights from San Francisco to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to South America is May, when tickets cost $575 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $1,009 and $925 respectively.

How far in advance should I book a flight from San Francisco to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to South America, you should book around 2 weeks before departure, which saves you about 7% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 15 weeks before departure.

Good to know

Low seasonSeptember
Cheapest flight$237
Best time to beat the crowds with an average 11% drop in price.
Most popular time to fly with an average 34% increase in price.
Flight from San Francisco to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Francisco to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Francisco to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Francisco to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from San Francisco to South America

 
Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1569 reviews
6.8Entertainment
7.8Boarding
6.9Food
7.4Comfort
8.1Crew
Airline reviews

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

2.0 MediocreAnonymous, Dec 2025
LAS - PTY
Read more Copa Airlines reviews

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

It would have been better if they don't separate families in seating. We were seated in the aile row in the middle of a family of four. It would have been better if they they seat the family of four together than separated.

It was good, plane is a bit older so seats are somewhat flat

Very good flight and crew Food was a surprise on a short flight

Biggest issue was that they only had two restrooms in the back of the aircraft. Too many people for only two restrooms. The trash was overflowing and there was paper on the floor too. Long lines in the isle to use it. Food was also a bit meh. They don’t offer snacks with drinks, so you might want to buy a snack to hold you off on a longer trip, since the meals are very small.

Everything was smooth and crew was very polite and friendly.

I like that they served a mail, I’m not sure about the in-flight entertainment. I didn’t really check. staff helped me with my luggage. Smooth boarding smooth takeoff smooth flight

The seats had plenty of leg room and the staff were very nice.

Copa performed as expected for the amount of money I was willing to spend for the flight; it wasn’t exceptional but it was not bad in any way either. The crew was good; friendly and straightforward. The food was airplane food, so no expectations there and the entertainment was lacking but that was my fault for owning an IPhone with a charging port that’s not compatible with the rest of the world. I’d fly Copa again.

Left my bags in origin city on a business class ticket , spent about 2-3 days in the same clothes plus the flight .

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Routine and on time flight with pleasant stewards and decent food. Nice experience!

You delayed my trip three days for no reason other than your lack of preparedness, did not offer any compensation, including food or a bed. I couldn’t trust you so I moved up my return flight and lost another day at the end of my trip to hopefully make sure I make my next flight. I will never fly LATAM again. You have the worse accountability and reliability and clearly do not care that your clients have lives and what it cost to fly to another country.

Horrific checkin procedure with neither Delta nor Latam figuring out how to check me in. 4 hrs on customer support with both and both airlines pointing to each other who should do checking. I was not checked in until morning of flight, which for international flight is concerning.

It was a good experience, the flight was a little too long & the food was ok

No extra snacks were available. Meals quality is terrible. Crew was not friendly.

Lost one piece of luggage even though I checked in 2.5 hours before the flight

It was perfect! United Airlines staff was extremely caring, super friendly and professional

United has maintenance issues and can then never recover. No operations ability and simple issues always turn into multiple hours long cascading delays. Worst airline on earth.

I paid for a confirmed upgraded aisle seat and was moved to a center seat in the back of the plane at the last minute.

Horrifying Almost 2 million miles. Bring your own food and drink. One coffee or drink every three hours. Have to order meals on app more than 24 hours ahead Tiny and dirty bathrooms

Easy of boarding, helpfully staff at check in, surprisingly comfortable seating

Lost of requested seat assignments. Lost my husband's meal choice

My service dog and I were asked to deplane just before they closed the door - clearly very last minute they couldn’t find the documentation that I have filled out many many times before that is for flying service animals. I purposely purchase 3seats (a whole row) since he is large and not all passengers want to sit next to a dog on a cross country flight. The plane departed with my husband on it!!! They made me fill out a hard copy of the same form and had to reschedule me on a later flight where they could find 3 seats together!! I’ve done this so many times before - clearly the error was on their part in a technology glitch - but really people - do better!! Very traumatic - and my husband had to wait for us when he landed ….so bad. Poor pup was confused and tired.

My flight time was changed without any notification to me which ruined my time sensitive plans so I ended up completely changing my travel plans and no reimbursement.

Flight was delayed multiple times without giving any particular reason and the only thing that was communicated was that 'Aircraft is getting ready'. I was stuck at SFO airport for 15 hours and finally took Southwest Airlines flight back home to Dallas.

I was not clear if food was offered or not.

Agency very bad had to cancelled my booking too many changes in the flight changed my flight to 1 week

Take-off delayed an hour because of a missing flight officer, so,arrived in Charlotte lates causing many passengers to miss connections. Otherwise a very good flight, safe and comfortable, with an excellent professional crew.

B-class on an old plane with antiquated amenities and poor service. Landed in Rome w/o bag that didn’t make the connection (plenty of time in London). Bag will come to hotel NOT the day it lands but the following night!! Still waiting for bag…BA had nothing to offer in support and couldn’t even tell me their comp, told to submit receipts and then I’ll learn what is or isn’t covered.

Premium Economy Good crew, good service, excellent food. Seat back screen just not bright enough.

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

Not good. One of my luggage is missing. And until now they can’t find it

Dloght delayed by 2.5 hrs . Common theme in my last four american floghts

The worst Airline ever. They centered my second flight and leave me in NY. They don’t have any representatives at the airport and they don’t respond to calls. Basically I got stuck. I will never purchase through there again.

Staff are the rudest in the industry … awful customer service … will never fly Avianca again

Here we have another airline flying to Guatemala but doesn't have a plus or a less, just in the middle. Why? Well, first we don't have even free water Movie selection is poor Seats don't recline in some places Food selection is carb based Forgot to mention, customer service on the web is the worst. Good things; Very reliable on schedule Kind crew

I had to go to the boarding counter for them to enter my return flight as it’s not with Avianca. There was a long queue as there were lots of people being called to the counter.

Boarding, crew were excellent, food was ok and entertainment need to improve

There isn't much space in-between seats and even water needs to be paid for during the flight.

We were not aware carry-on bags cost extra until we arrived at the airport so, we were charged $240.00 for two small carry- on bags! There was a substantial fee for drinks and snacks. No wifi, or other entertainment was available. Waiting areas were crowded and uncomfortable.

Ok, but these people don’t give you nothing no snack no water

No water for a 5 hour flight entertainment not working seats with little room for knees when person in front of me reclined kept bumping my knees.

Awful. I checked in online and there was no option to pay for baggage, at the airport when I checked in my baggage was received and Iwas not charged. When I got to LA during the boarding process I was told I didn't pay for baggage, the crew resolved I was let in the plane. When I got to my final destination my baggage was not there. It took me two days to receive my baggage. Bad service ever!

Wasn’t able to take the trip and no one could help me with a refund or rescheduling

Everything you need to know for your flight to South America

Information on your arrival and departure airports