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Find cheap flights from San Francisco to South America from $142

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to South America departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
sáb. 3/30
sáb. 4/6

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Best South America Flight Deals

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Lima
Lima1 stop$471
Bogotá
Bogotá1 stop$339
Buenos Aires
Buenos Aires3 stops$731
Medellín
Medellín1 stop$348
Sao Paulo
Sao Paulo1 stop$589
Cartagena
Cartagena1 stop$387
Santiago
Santiago1 stop$489
Quito
Quito1 stop$454
Rio de Janeiro
Rio de Janeiro2 stops$725
Guayaquil
Guayaquil2 stops$504
Cali
Cali1 stop$473
Cusco
Cusco2 stops$711
Montevideo
Montevideo2 stops$600
Barranquilla
Barranquilla1 stop$433
Santa Marta
Santa Marta2 stops$526
Pereira
Pereira2 stops$394
San Andrés
San Andrés2 stops$521

Good to know

Low season

August

High season

December

Cheapest flight

$142
Best time to beat the crowds with an average 8% drop in price.
Most popular time to fly with an average 36% increase in price.
Flight from San Francisco to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Francisco to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to South America from San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to South America with an airline and back to San Francisco with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to South America from San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to South America

  • On average*, there is no price difference when choosing to fly in the morning or the evening on this flight route.
*Average of the lowest prices shown in KAYAK’s search results for departures within the next 30 days

Top 5 airlines serving from San Francisco to South America

Need help choosing which airline to fly with from San Francisco to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to KAYAK reviews.
8.0
DeltaOverall score based on 11818 reviews
75food
82boarding
86crew
81overall
81entertainment
79comfort
Airline reviews

Plane was late because of a mechanical malfunction and the food listed as available was not. Flight attendants seem over worked and under paid. They just done seem happy. And that can be seen in their faces.

Read more about Delta

Plane was late because of a mechanical malfunction and the food listed as available was not. Flight attendants seem over worked and under paid. They just done seem happy. And that can be seen in their faces.

Waited 3 hours on a plane to de-ice due to manpower issues. Waited another hour and a half once we landed because of a gate issue. Missed my connections. Created. A total of 13 hours of delay.

Great, on time departure, friendly and accommodating crew, great leg room, Smith flight

Plane was turned around due to fog half way into the flight, Delta did not properly direct passengers to stay on same flight and instead failed to properly rebook on Alaska

Honestly, I didn’t expect that I will experience this long time wait during the check in. There was only one person who was taking care of the passengers for the economy class and it took us to wait about one hour to do our check i. As a result we barely get to the airplane as the gate was at the end of the airport. That is totally not professional where one crue is working at the registration desk with economy and 3-4 crues are helping for the business class.

Like most domestic flights in the US, you are basically on your own with this airline when it comes to food, so be sure to purchase meals and drinks ahead of time or expect to arrive starving and dehydrated (like I was).

You need to be a hacker to get the (Free) WiFi

I guess they don’t serve drinks on planes anymore

The flight was overbooked and the staff at the gate started calling for volunteers to drop out and offering incentives. That delayed the flight

Delta planes have the WORST seat comfort of any plane in history. It's the opposite of ergonomic, in every sense. They also recline minimally, are covered in a vinyl and have no feet rests. Then the disembarking process is chaotic and time consuming (because of the way they load the plane and deal with luggage). Overall, somewhat frustrating but we arrived safely :)

Left my bags in origin city on a business class ticket , spent about 2-3 days in the same clothes plus the flight .

the planes are not modern there are no phone chargers

As usual, the flight with normal legroom was not very comfortable, but the second flight was much better because we had paid for extra legroom. It was very nice to check our bags without an extra fee.

LOCKED MY BAG WITHOUT CONSENT. Had to have my zippers cut upon arrival in Costa Rica.

Pros: "The seats in economy were confortable. The best thing was Copa gave us seats in the second line and my family traveled together."
Cons: "Coffe service could better the experience"
Pros: "The crew was very interested on help and attentive with the passengers. But the seat wasn't comfortable. The design of the cushion is not the best to be seating"
Pros: "You were on time, that is the most important thing in a fly"
Cons: "You could improve your entertainment, you are not a cheap company"
Pros: "That there was seltzer"
Cons: "The management of preparing the flight and plane so that it was ready for the trip!!"
Pros: "Copa was convenient and easy. Very easy boarding process and I appreciated the day flight."
Cons: "This is a business class that is equivalent to a US carrier domestic first class. Good seats, not lay flat but wide on my 737-800. The food and service emulated say American Airlines Domestic 1C as well. Everything was just good enough, and much cheaper that international business on the majors."
Pros: "It was an excellent trip, but the entertainment needs to be improved."
Cons: "More options on entertainment, needs variety."

No air in the middle rows. Had a hard time breathing. Was dying of heat.

I loved how polite the crew was even though some of them wasn't the best with English that they still done everything they could to help me with my needs food was amazing

Horrific checkin procedure with neither Delta nor Latam figuring out how to check me in. 4 hrs on customer support with both and both airlines pointing to each other who should do checking. I was not checked in until morning of flight, which for international flight is concerning.

Flight from Lima to São Paulo didn’t have USB plug to charge the cellphone.

It was a good experience, the flight was a little too long & the food was ok

Hostile flight attendants. Second flight with Jose so much better. Arrived 1/2 hour early. Thanks.

We had 2 delayed LATAM flights in our trip. We were only given one coffee for 5 hours delay. Also when we were boarding the crew wanted to charge us for our allowed carry on luggage. I got a bit angry and they finally didn’t charge anything. Not flying with LATAM again.

the flight from Boston to Curitiba was on time actually 30 minutes earlier. latam was not able to unload the luggage for custom checkup in Sao Paulo ii took two and half hours . i missed the flight to Curitiba spend the night in hotel and then flying in the morning to Curitiba

Tough flight with turbulence… I was told by a fellow passenger that it is common. Nonetheless, very stressful. Cordial staff.

Very unprofessional staff in the checking and boarding. There was no space for my carry-on bag, which is understandable for a full flight. However, the rudeness in answering my questions about my bag were unnecessary. Shaming and threatening a passenger to be left behind was something I had never experienced (I am 57 years old and a Skymiles member) before. At a minimum, the boarding staff (Krystal Mejia and her manager Dee) should undergo further training on cultural sensitivity and professional skills on speaking with passengers. Krystal, just because I have dark hair and “look Latina” does not mean I can speak Spanish. Your assumption and threatening words until the very ending of my boarding (door of the airplane) were not only unnecessary and stressful but something that a passenger should not experience before boarding.

Very uncomfortable seats and seat backs, and I am only 5’9”. Delayed due to crew issues, spent a long time with no ventilation. Teeny overhead bins. Wifi worked well. Arrived safely.

I was delighted that we were able to get on the 4:40 pm flight rather than our original booking at 6:55 pm!! Other than that, the flight was comfortable and landed early😊

More storage space and leg room, but all-in-all a wonderful experience.

Our flight was delayed many times throughout the day. The final delay was about 8 hours. I spent time in line to speak to someone at their understaffed desk, and also spent time waiting online and then chatting with a service rep. None of the United employees were any help at all. I desperately wanted to go get rest and possibly re-book my trip but I was denied any compensation or voucher for a hotel. I was repeatedly told it was not United's fault and therefore they had no compensation to offer. Overall, a cold and callous experience.

Paid WiFi was only available for a few minutes. Avoid at all costs.

Everything was great, only problem was that flights were delayed

Flight crew and pilots did great. Flight way delayed due to a part needing replacement. Based on what the pilot indicated- the maintenance crew could’ve resolved this more efficiently than replacing whole part- and taken less time

Pretty turbulent, but not anyone’s fault. They got us there. Impressed that they carried on with a drink service.

Please please take consideration when setting cabin temperature. The vents were not functional and it was over 70 degrees in the cabin during the winter months when most people are used to much cooler indoor temperatures. I was down to my white t-shirt and the sweat pants I wore from Auckland to San Francisco and was sweating profusely and there was NO VENT!

For a 17 hour flight, they kept us well feed. The music selection could be better curated. The entertainment selection was about what is expected. The crew was fantastic.

The food at Admirals Club was really great Pijamas were a nice feature The flight attendant was very nice and great attitude The aa.com does not work well specially internet service Overall a very good flight .

Flight was delayed and missed connecting flight. Did not give warning about delay until we showed up at the airport. Not good.

The usual wait at Columbus once you land to get to an open gate (20 minutes) and then the usual 30 minutes for your luggage to appear.

Nothing, flight was supposed to leave at 758 am. My flight didn’t leave until 430 pm. Spent the whole day at the airport.

Everything was very good EXCEPT the food, on a five and a half hour trip. They only gave to us was snacks in first class. They didn't give us pillows or blankets.

It was wonderful upgrading to first. Plane was so cold thou. Crew was great. Wish there was a food option in first for such a long flight. Doesnt matter the time of day. Chintzy.

Do a bit better with n first class offer some real food and pillows

We experienced an involuntary change of schedule. Had 1st class tickets from Fresno to Bonaire, put us in coach from Miami to Bonaire a few days later - terrible flight, try to get a refreshment , water or a meal and air. We will never be subject to that again. I'd rather fly another airline that honors 1st class. Adding insult to injury AA reimbursed my wife's ticket $106.66 for the change in seating, me nothing. Haven't heard back from Customer Service, don't expect to - it's only online, can't speak with a live person. So the difference between 1st class and coach for that portion of the flight is only $106.66? Really? I've flown Delta and United on the same route, will go back to one of them again.

Flight a little late. Entertainment system didn’t work for first hour. Toilets dirty after 2 hours. Is there no one assigned to clean them?

Food was very average. And top up drinks offer was absent. For a 11 hour long flight that should be the minimum. The crew didn't want to be there. I understand it was new year day but given they had signed up for it

Book cheap flights from San Francisco to South America

Recent round-trip flight deals

3/10dom.
1 stopJetBlue
10h 28mSFO-BOG
3/13mié.
1 stopJetBlue
13h 34mBOG-SFO
$339
3/11lun.
1 stopJetBlue
10h 28mSFO-BOG
3/14jue.
1 stopJetBlue
13h 34mBOG-SFO
$343
3/12mar.
1 stopCopa Airlines
10h 25mSFO-MDE
5/8mié.
1 stopCopa Airlines
15h 57mMDE-SFO
$348
4/14dom.
1 stopCopa Airlines
29h 14mSFO-MDE
5/1mié.
1 stopCopa Airlines
31h 20mMDE-SFO
$350
3/12mar.
1 stopAmerican Airlines
14h 21mSFO-BOG
4/17mié.
1 stopAmerican Airlines
19h 34mBOG-SFO
$355
3/12mar.
2 stopsAmerican Airlines
13h 25mSFO-BOG
4/17mié.
1 stopAmerican Airlines
19h 34mBOG-SFO
$358
4/22lun.
1 stopLATAM Airlines
11h 00mSFO-CTG
5/2jue.
1 stopLATAM Airlines
11h 03mCTG-SFO
$449
3/10dom.
1 stopDelta
18h 00mSFO-BOG
3/14jue.
1 stopDelta
15h 23mBOG-SFO
$449
3/11lun.
2 stopsLATAM Airlines
14h 32mSFO-BOG
5/6lun.
2 stopsLATAM Airlines
23h 37mBOG-SFO
$454
4/7dom.
1 stopDelta
20h 15mSFO-BOG
4/11jue.
2 stopsDelta
14h 19mBOG-SFO
$455

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Recent one-way flight deals

3/10dom.
1 stopCopa Airlines
13h 36mSFO-BOG
$142
3/10dom.
1 stopJetBlue
10h 28mSFO-BOG
$147
3/12mar.
2 stopsAmerican Airlines
13h 25mSFO-BOG
$154
3/6mié.
1 stopUnited Airlines
10h 15mSFO-BOG
$155
8/27mar.
2 stopsAmerican Airlines
12h 39mSFO-BOG
$159
3/5mar.
1 stopUnited Airlines
17h 24mSFO-BOG
$161
3/10dom.
2 stopsDelta
18h 20mSFO-MDE
$202
3/15vie.
1 stopDelta
20h 15mSFO-BOG
$202
3/10dom.
2 stopsLATAM Airlines
15h 37mSFO-BOG
$221
3/10dom.
1 stopLATAM Airlines
14h 50mSFO-BOG
$230

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Last minute flights from San Francisco to South America

Last minute flight, train and bus deals

3/5mar.
multi-stopAmerican Airlines
9h 45mSFO-CTG
3/12mar.
multi-stopAmerican Airlines
20h 01mCTG-SFO
$387
3/5mar.
multi-stopAmerican Airlines
17h 05mSFO-CTG
3/13mié.
multi-stopAmerican Airlines
16h 58mCTG-SFO
$390
3/3dom.
multi-stopLATAM Airlines
10h 35mSFO-BOG
3/18lun.
multi-stopLATAM Airlines
19h 53mBOG-SFO
$471
3/1vie.
multi-stopUnited Airlines
25h 05mSFO-BOG
3/8vie.
multi-stopUnited Airlines
25h 38mBOG-SFO
$481
3/4lun.
multi-stopCopa Airlines
13h 36mSFO-BOG
3/13mié.
multi-stopCopa Airlines
20h 58mBOG-SFO
$490
3/5mar.
multi-stopDelta
13h 49mSFO-CTG
3/11lun.
multi-stopDelta
24h 42mCTG-SFO
$498
3/5mar.
multi-stopCopa Airlines
11h 28mSFO-BOG
3/21jue.
multi-stopCopa Airlines
10h 29mBOG-SFO
$512
3/1vie.
multi-stopUnited Airlines
32h 14mSFO-BOG
3/9sáb.
multi-stopUnited Airlines
18h 53mBOG-SFO
$539
3/5mar.
multi-stopLATAM Airlines
48h 45mSFO-LIM
3/10dom.
multi-stopLATAM Airlines
24h 28mLIM-SFO
$582
3/3dom.
multi-stopDelta
10h 35mSFO-BOG
3/19mar.
multi-stopDelta
18h 10mBOG-SFO
$633

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