SNA - GSP

$172 Find Cheap Flights from Santa Ana to Greenville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Greenville departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Greenville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Ana to Greenville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Ana to Greenville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$388
Typical prices: $724-$499
Delta
Wed 5/27Tue 6/2
SNA - GSP • 1 stop
Cheapest one-way
$172
Typical prices: $353-$362
Multiple Airlines
Fri 5/1
SNA - GSP • 2 stops
Top airlines
Cheapest • from $388 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Santa Ana and Greenville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $487 (round-trip)
Shortest trip • 6h 40m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 31% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Greenville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Ana to Greenville (SNA-GSP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Greenville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Greenville

Wed, May 27 - Tue, Jun 2
Delta Logo
2:00 pm - 11:43 pm
SNA
-
GSP
6h 43m
1 stop
Delta Logo
8:45 am - 5:46 pm
GSP
-
SNA
12h 01m
2 stops
$388Delta
Wed, May 27 - Tue, Jun 2
Delta Logo
5:25 pm - 10:55 am
SNA
-
GSP
14h 30m
2 stops
Delta Logo
8:45 am - 5:46 pm
GSP
-
SNA
12h 01m
2 stops
$393Delta
Mon, May 4 - Wed, May 6
United Airlines Logo
9:05 pm - 9:58 am
SNA
-
GSP
9h 53m
2 stops
United Airlines Logo
5:45 pm - 10:35 pm
GSP
-
SNA
7h 50m
1 stop
$396United Airlines
Sat, May 9 - Sat, May 16
American Airlines Logo
7:45 am - 8:01 pm
SNA
-
GSP
9h 16m
1 stop
American Airlines Logo
5:12 pm - 10:39 pm
GSP
-
SNA
8h 27m
1 stop
$399American Airlines
Wed, May 27 - Tue, Jun 2
United Airlines Logo
6:45 am - 5:00 pm
SNA
-
GSP
7h 15m
1 stop
United Airlines Logo
4:15 pm - 8:40 pm
GSP
-
SNA
7h 25m
1 stop
$400United Airlines
Mon, May 4 - Wed, May 6
Delta Logo
7:00 pm - 9:09 am
SNA
-
GSP
11h 09m
2 stops
Delta Logo
5:42 am - 12:09 pm
GSP
-
SNA
9h 27m
2 stops
$401Delta
Mon, May 4 - Wed, May 6
Delta Logo
9:20 pm - 9:09 am
SNA
-
GSP
8h 49m
1 stop
Delta Logo
5:42 am - 12:09 pm
GSP
-
SNA
9h 27m
2 stops
$404Delta
Mon, May 4 - Wed, May 6
Delta Logo
6:58 pm - 10:20 am
SNA
-
GSP
12h 22m
2 stops
Delta Logo
5:42 am - 12:09 pm
GSP
-
SNA
9h 27m
2 stops
$409Delta
Mon, May 4 - Wed, May 6
American Airlines Logo
1:23 pm - 10:40 pm
SNA
-
GSP
6h 17m
1 stop
American Airlines Logo
5:12 pm - 10:45 pm
GSP
-
SNA
8h 33m
1 stop
$418American Airlines
Wed, May 20 - Sun, May 24
American Airlines Logo
1:23 pm - 10:40 pm
SNA
-
GSP
6h 17m
1 stop
American Airlines Logo
6:29 am - 12:11 pm
GSP
-
SNA
8h 42m
1 stop
$425American Airlines
Booking Insights

KAYAK's insights & trends for Santa Ana to Greenville flights

Get data-powered insights and trends into flights from Santa Ana to Greenville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Santa Ana to Greenville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Santa Ana to Greenville departing in May.

What is the cheapest month to fly from Santa Ana to Greenville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Greenville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santa Ana to Greenville is July, where tickets cost $377 (return) on average. On the other hand, the most expensive months are April and February, where the average cost of round-trip tickets is $946 and $638 respectively.

Good to know

Low seasonMarch
Cheapest flight$172
Best time to beat the crowds with an average 29% drop in price.
Most popular time to fly and prices are also 23% lower on average.
Flight from John Wayne (Santa Ana) to Greenville

When to book flights from Santa Ana to Greenville

Are your dates flexible? Find out the best times to travel from Santa Ana to Greenville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from John Wayne (Santa Ana) to Greenville

  • What is the cheapest flight from Santa Ana to Greenville?

    In the last 3 days, the lowest price for a flight from Santa Ana to Greenville was $172 for a one-way ticket and $388 for a round-trip.

  • Do I need a passport to fly between John Wayne (Santa Ana) and Greenville?

    A passport is not required to fly from John Wayne (Santa Ana) to Greenville.

  • Which aircraft models fly most regularly from John Wayne (Santa Ana) to Greenville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from John Wayne (Santa Ana) to Greenville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between John Wayne (Santa Ana) and Greenville, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Santa Ana to Greenville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Santa Ana to Greenville are Delta and United Airlines. With an average price for the route of $462 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $586 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Greenville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Greenville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Greenville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Greenville from John Wayne (Santa Ana) is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Greenville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Greenville with an airline and back to John Wayne (Santa Ana) with another airline. Booking your flights between John Wayne (Santa Ana) and GSP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Greenville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Greenville from John Wayne (Santa Ana) up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Santa Ana to Greenville

 
See real verified KAYAK customer reviews for airlines flying from Santa Ana to Greenville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to Greenville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8408 reviews
7.8Entertainment
8.5Crew
7.9Comfort
8.1Boarding
7.2Food
Airline reviews

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

10.0 ExcellentSarah, Apr 2026
LAX - SFO
Read more Delta reviews

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

N Everything was perfect from boarding to assistance to baggage in Tampa

Loved the crew! Sucks that we went from 1 hour and 8 minute layover to a 3 hour layover. But weather sucks like that.

Fast, lovely scenery, great info on the Delta flight screen about landmarks we were flying over. Great landing!

Long flight but comfortable and not freezing as I have experienced on Hawaiian flights to the islands. They gave us blankets just in case. Nice touch.

I am still at the Airport! Delayed Delayed and Delyaed

I took seat 15A in anticipation of window seat, there is no window.

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

Boarding was again a "free for all". We were boarding group 4, and almost the entire plane was able to board before us. It's a shame that someone who follows the rules, gets the short end of the stick. Not fair.

It was perfect! I've never flown with United before, but I definitely will in the future

I had a cancelled flight because of technical issues going to my destination, and a delayed flight coming home. All told it wasn’t a total bust.

Awful. No counter attendants. No dinner offered due to delays.

They delayed the flight from 9:00 to 11:55 At 11:45 they canceled the flight. I paid a premium price for the tickets with poor service

My flight was canceled a few hours before boarding. I was rebooked on Copa airlines and missed an important meeting .

OK, we were delayed and had to de plane and reboard.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Complimentary light meal would be appreciated. But great flight crew service on all legs

Was not able to do a online check-in because the American Airlines system doesn't store our visa or other passport information, allowing us to have a trouble-free check-in. We were forced to have to check-in at the counter which Changes are upgrade status given that we were not able to check in much earlier.

Good flight, seated and had a water within 5 minutes. Crew was hospitable.

We left at 1030 am pacific from LA and supposed to land at 7 pm Eastern in NY. They made a detour, stopped in Philadelphia and didn’t land till 1130 PM Eastern!!! Worst flight experience with no pilot communication with no explanation as to what was going on. Everyone was very frustrated to say the least.

Flight boarded from Gate 159B, the farthest gate in the LAX Bradley Terminal. While the flight operated on time, the first class cabin attendant made no recognition of my being an Advantage Executive Platinum member.

The flight itself was excellent but the gate attendant made me check my carryon since she said it was an inch too big. I’ve had no problems with this carryon on recent flights on Qantas, Delta, Austrian, Southwest Airlines even though the overhead bins are the same size. there were other carryons in the bins that also looked larger than mine and there was room left in the bins for more. When I picked up my carryon from baggage claim one of the wheels had broken off.

I was in last row so that is never great bc the person in front of me leaned his seat all the way back into me.

The experience at checkin for my American Airlines flight from Sacramento to LAX was very good including the assistance I received in getting my bags checked in and boarding passes printed. Was pleasantly surprised the my bags were checked through all the way to my destination at Clark International Airport in Angeles, Philippines.

Terrible planning. And even worse gate agents. Absolutely rude behavior.

Flight was scheduled at 11:26am but they keep Delaying until midnight. They waited at airport restless.

Rough flight No beverage service due to turbulence Bottom Seat cushion was non existent

Everything you need to know for your flight from Santa Ana to Greenville

Information on your arrival and departure airports