SNA - GSP

$187 Find Cheap Flights from John Wayne (Santa Ana) to Greenville - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$369
Typical prices: $469-$643
American Airlines
Wed 11/14Sat 11/17
SNA - GSP • 1 stop
Cheapest one-way
$187
Typical prices: $260-$549
Multiple Airlines
Mon 11/12
SNA - GSP • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Santa Ana and Greenville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
May
Cheapest • 26% price drop
June
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Atlanta Hartsfield-Jackson (ATL)
Cheapest • Avg $518 (round-trip)
Dallas/Fort Worth (DFW)
Shortest trip • 7h 19m (one-way)
Insights
Insights
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We hope you love your trip to Greenville!

Cheap Flights from Santa Ana to Greenville (SNA-GSP)

 

Cheap flights from Santa Ana to Greenville with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Sat, Nov 14 - Tue, Nov 17
American Airlines Logo
10:45 am - 9:58 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
8h 13m1 stop Dallas/Fort Worth
American Airlines Logo
5:16 pm - 10:32 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
8h 16m1 stop Charlotte Douglas
$369American Airlines
Fri, Dec 11 - Tue, Dec 15
Delta Logo
2:30 pm - 11:47 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
6h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 11:48 amGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
9h 08m1 stop Atlanta Hartsfield-Jackson
$369Delta
Mon, Nov 9 - Wed, Nov 11
United Airlines Logo
9:10 pm - 11:17 amSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
11h 07m1 stop Newark
United Airlines Logo
4:29 pm - 9:19 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
7h 50m1 stop Denver Intl
$369United Airlines
Wed, Nov 11 - Mon, Nov 16
United Airlines Logo
10:47 am - 8:58 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
7h 11m1 stop Chicago O'Hare Intl
United Airlines Logo
4:29 pm - 10:00 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
8h 31m1 stop Denver Intl
$369United Airlines
Wed, Dec 2 - Wed, Dec 16
United Airlines Logo
11:34 am - 9:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
7h 25m1 stop Houston George Bush Intcntl
United Airlines Logo
4:18 pm - 10:15 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
8h 57m1 stop Denver Intl
$369United Airlines
Fri, Dec 11 - Tue, Dec 15
Southwest Logo
9:10 am - 8:10 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
8h 00m2 stops Austin Bergstrom Nashville Intl
Southwest Logo
2:50 pm - 9:45 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
9h 55m2 stops Baltimore/Washington Denver Intl
$379Southwest
Wed, Dec 2 - Wed, Dec 16
Southwest Logo
7:45 am - 8:50 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
10h 05m2 stops Dallas Love Field Nashville Intl
Southwest Logo
2:50 pm - 9:45 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
9h 55m2 stops Baltimore/Washington Denver Intl
$379Southwest
Mon, Nov 9 - Wed, Nov 11
Southwest Logo
8:15 am - 8:10 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
8h 55m2 stops San Jose Nashville Intl
Southwest Logo
7:05 am - 2:00 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
9h 55m2 stops Nashville Intl Denver Intl
$411Southwest
Fri, Dec 11 - Tue, Dec 15
American Airlines Logo
12:10 pm - 9:52 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
6h 42m1 stop Dallas/Fort Worth
American Airlines Logo
7:45 am - 3:42 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
10h 57m2 stops Dallas/Fort Worth Phoenix Sky Harbor Intl
$425American Airlines
Sat, Nov 14 - Tue, Nov 17
American Airlines Logo
8:00 am - 8:31 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
9h 31m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
7:51 am - 2:03 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
9h 12m1 stop Dallas/Fort Worth
$425American Airlines

Price, demand and travel trends for Santa Ana to Greenville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Santa Ana to Greenville?

Round-trip flights from Santa Ana to Greenville typically range from $469 to $643. The lowest price found in the past 5 days was $369, on American Airlines.

What's the cheapest day of the week to fly from Santa Ana to Greenville?

Based on deals KAYAK users found in the last 12 months, Friday is the cheapest day of the week to fly from Santa Ana to Greenville. It’s 23% cheaper than the average day, while Monday is the most expensive, with prices 6% higher.

What’s the cheapest month to fly from Santa Ana to Greenville?

•May is the cheapest month to fly from Santa Ana to Greenville at $433 round-trip.
•February ($887) and December ($746) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 104% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Santa Ana to Greenville flights

Low season

March

Cheapest flight

$187
Beat the crowds with an average 59% drop in travelers.
The most popular month to fly with an average 118% increase in travelers.
One-way flight from Santa Ana to Greenville

When to book flights from Santa Ana to Greenville

Are your dates flexible? Find out the best times to travel from Santa Ana to Greenville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Santa Ana to Greenville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Santa Ana to Greenville?

    Only Economy Class is available on flights from Santa Ana to Greenville.

  • How long is a flight from Santa Ana to Greenville?

    A nonstop flight from Santa Ana to Greenville takes 00m, covering 2,025 miles.

  • Do I need a passport to fly from Santa Ana to Greenville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Santa Ana to Greenville flight?

    Round-trip flights from Santa Ana to Greenville range from $469 to $643, with an average of $586 over the past 12 months. Anything below $469 counts as a good deal.

  • Have flight prices from Santa Ana to Greenville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $369 to $3,499. That means the highest observed fare was about 9x higher than the lowest one.

  • How are flight prices from Santa Ana to Greenville looking right now?

    One-way fares from Santa Ana to Greenville are currently lower than usual. Average one-way flight prices are about $252, which is 31% below the typical average for this route.

  • What car rental options are available at Greenville Airport (GSP)?

    Greenville Airport (GSP) hosts 5 major car rental companies, with daily rates starting from around $30 for economy cars. Top options include:

    • Budget
    • Alamo
    • Thrifty
    • Enterprise Rent-A-Car
    • Avis

  • Which airports can I use when flying from Santa Ana to Greenville?

    Flights from Santa Ana to Greenville usually depart from Santa Ana J. Wayne/Orange Cnty (SNA) and arrive at Greenville (GSP).

  • Which airports do connecting flights from Santa Ana to Greenville pass through?

    One-stop flights from Santa Ana to Greenville most commonly connect through:

    • Dallas/Fort Worth (DFW) - 73% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 15% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 13% of one-stop connections

  • Can I save money by using flexible dates for flights from Santa Ana to Greenville?

    Yes. Flexible dates can save you up to 28% on flights from Santa Ana to Greenville. Friday is the cheapest departure day at $452 round-trip on average, while Monday is the most expensive at $622, a difference of $170.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Santa Ana to Greenville?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 7h 18m, compared with 7h 19m via Dallas/Fort Worth (DFW) and 7h 52m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Santa Ana and Greenville?

    Greenville is 3 hours ahead of Santa Ana (Eastern Time vs Pacific Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Santa Ana to Greenville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Friday departure and avoid flying on Monday. On this route, Friday flights average $452, about $170 less than Monday fares (27% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Santa Ana to Greenville trip for May. Fares historically average $433 round-trip in that month - typically $454 less than the most expensive month, which is February (based on the last 12 months).

More options for your flight from Santa Ana to Greenville

Complete your trip to Greenville with a hotel stay or car rental

Car rentals in Greenville
Hotels in Greenville
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