SNA - GSP

$154 Find Cheap Flights from John Wayne (Santa Ana) to Greenville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Greenville departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Greenville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from John Wayne (Santa Ana) to Greenville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from John Wayne (Santa Ana) to Greenville, as well as popular online travel agencies
Travelers love KAYAK
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Everything you should know

Cheapest round-trip
$358
Typical prices: $650-$872
Multiple Airlines
Thu 7/16Mon 7/20
SNA - GSP • 1 stop
Cheapest one-way
$154
Typical prices: $249-$418
Multiple Airlines
Thu 7/16
SNA - GSP • 1 stop
Top airlines
Cheapest • from $372 (round-trip)
Best reviews • 7.8 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Santa Ana and Greenville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $527 (round-trip)
Shortest trip • 7h 06m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 31% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Greenville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Ana to Greenville (SNA-GSP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Greenville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Greenville

Thu, Jul 16 - Mon, Jul 20
Multiple Airlines Logo
3:22 pm - 11:26 am
SNA
-
GSP
17h 04m
1 stop
Multiple Airlines Logo
8:20 am - 12:15 pm
GSP
-
SNA
30h 55m
1 stop
$358Multiple Airlines
Thu, Jul 16 - Mon, Jul 20
Multiple Airlines Logo
3:22 pm - 11:26 am
SNA
-
GSP
17h 04m
1 stop
Multiple Airlines Logo
8:20 am - 3:28 pm
GSP
-
SNA
34h 08m
2 stops
$362Multiple Airlines
Thu, Dec 3 - Sat, Dec 5
Delta Logo
2:00 pm - 11:37 pm
SNA
-
GSP
6h 37m
1 stop
Delta Logo
7:45 am - 12:56 pm
GSP
-
SNA
8h 11m
1 stop
$372Delta
Thu, Dec 3 - Sat, Dec 5
Southwest Logo
8:55 am - 8:40 pm
SNA
-
GSP
8h 45m
2 stops
Southwest Logo
7:05 am - 2:10 pm
GSP
-
SNA
10h 05m
2 stops
$382Southwest
Wed, Jul 29 - Mon, Aug 3
Multiple Airlines Logo
4:13 pm - 7:30 am
SNA
-
GSP
36h 17m
2 stops
Multiple Airlines Logo
8:45 pm - 12:15 pm
GSP
-
SNA
18h 30m
1 stop
$385Multiple Airlines
Sat, Aug 8 - Sat, Aug 15
United Airlines Logo
7:27 pm - 9:55 am
SNA
-
GSP
11h 28m
2 stops
United Airlines Logo
2:28 pm - 6:51 pm
GSP
-
SNA
7h 23m
1 stop
$399United Airlines
Fri, Aug 7 - Wed, Aug 12
American Airlines Logo
12:01 pm - 10:17 pm
SNA
-
GSP
7h 16m
1 stop
American Airlines Logo
7:00 am - 12:42 pm
GSP
-
SNA
8h 42m
1 stop
$415American Airlines
Fri, Aug 14 - Sat, Aug 22
Southwest Logo
8:55 am - 9:35 pm
SNA
-
GSP
9h 40m
2 stops
Southwest Logo
11:05 am - 6:00 pm
GSP
-
SNA
9h 55m
2 stops
$425Southwest
Fri, Aug 7 - Fri, Aug 14
Multiple Airlines Logo
7:53 pm - 7:28 am
SNA
-
GSP
32h 35m
2 stops
Multiple Airlines Logo
8:45 pm - 12:25 pm
GSP
-
SNA
18h 40m
1 stop
$426Multiple Airlines
Wed, Jul 22 - Wed, Jul 29
American Airlines Logo
12:55 pm - 11:16 pm
SNA
-
GSP
7h 21m
1 stop
American Airlines Logo
7:01 am - 12:05 pm
GSP
-
SNA
8h 04m
1 stop
$431American Airlines
Booking Insights

KAYAK's insights & trends for Santa Ana to Greenville flights

Get data-powered insights and trends into flights from Santa Ana to Greenville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from John Wayne (Santa Ana) to Greenville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Greenville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from John Wayne (Santa Ana) to Greenville is March, where tickets cost $389 (return) on average. On the other hand, the most expensive months are July and December, where the average cost of round-trip tickets is $835 and $678 respectively.

Good to know

Low seasonMarch
Cheapest flight$154
Best time to beat the crowds with an average 32% drop in price.
Most popular time to fly with an average 10% increase in price.
Flight from John Wayne (Santa Ana) to Greenville

When to book flights from Santa Ana to Greenville

Are your dates flexible? Find out the best times to travel from Santa Ana to Greenville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from John Wayne (Santa Ana) to Greenville

  • What is the cheapest flight from John Wayne (Santa Ana) to Greenville?

    In the last 5 days, the lowest price for a flight from John Wayne (Santa Ana) to Greenville was $154 for a one-way ticket and $358 for a round-trip.

  • Do I need a passport to fly between John Wayne (Santa Ana) and Greenville?

    A passport is not required to fly from John Wayne (Santa Ana) to Greenville.

  • Which aircraft models fly most regularly from John Wayne (Santa Ana) to Greenville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from John Wayne (Santa Ana) to Greenville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between John Wayne (Santa Ana) and Greenville, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from John Wayne (Santa Ana) to Greenville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from John Wayne (Santa Ana) to Greenville are Delta and United Airlines. With an average price for the route of $464 and an overall rating of 7.8, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $505 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Greenville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Greenville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Greenville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Greenville from John Wayne (Santa Ana) is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Greenville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Greenville with an airline and back to John Wayne (Santa Ana) with another airline. Booking your flights between John Wayne (Santa Ana) and GSP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Greenville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Greenville from John Wayne (Santa Ana) up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Santa Ana to Greenville

 
See real verified KAYAK customer reviews for airlines flying from John Wayne (Santa Ana) to Greenville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to Greenville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8453 reviews
7.8Comfort
7.8Entertainment
7.2Food
8.5Crew
8.1Boarding
Airline reviews

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

6.0 GoodSarah, Jun 2026
LGA - MYR
Read more Delta reviews

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am still at the Airport! Delayed Delayed and Delyaed

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

Flight and seats were great. Food service was average at best. The real main problem we had is that we got cheeseburgers for the kids but the plates was extremely hot. Like ridiculously hot and the stewardess never said anything. Luckily or unluckily my wife touched the plate and was able to deal with it before the kids got burned.

Lost one piece of luggage even though I checked in 2.5 hours before the flight

The boarding process on the departure from LA was rather slow even though I was in Group 1. For first class, I was not expecting to have to pay for Wi-fi but I did and then the wi-fi was spotty. The entree was surprisingly good and so that was a pleasant surprise. However, once I got to Houston, it was terrible. Unfortunately there was bad weather but the constant gate changes for my connecting flight was difficult to manage due to having to navigate back and forth between different terminals.

Service was professional and quick. Premium economy seat was comfortable given the class

The staff was extremely helpful and friendly at all times! They went above and beyond to get us into an earlier flight in San Diego to make our connection in SFO possible, because our original flight did actually not make it! I did so much appreciate the UA team and how they made this possible. We also didn’t have seats together on the long flight to Singapore, but they found us seats together last moment with no additional cost! Nobody sat next to us, so that we were able to sleep! Thanks to UA for improving their service and Underpricer for booking this trip! Please be careful: 1,5 hrs for transfer in San Francisco might not be enough time in the future

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Awful. No counter attendants. No dinner offered due to delays.

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Very poor the plane itself was really old, slight smell that couldn’t be named. I didn’t even get a boarding pass UNTIL AFTER clearing security! Even then, they said when I get to my connected flight I’ll get my 2nd boarding pass there! A bit ridiculous!

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

the head jack on my seat didn't work and the power outlet didn't work for my seat

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

The flight encountered a delay exceeding 4 hours. The food voucher issued was valued at $12, insufficient to cover our meal expenses. Consequently, I was unable to take my medication, leading to a drop in blood sugar levels and exacerbating my anxiety.

Flights were on time. That's the main consideration since I had to change planes. The entertainment was whatever you bring with you and the food (in Economy) is non-existant. Neither of those was a surprise.

The gate crew did try to help, however they lacked the information as to whether the flight will operate or not. Being delayed 6 hours and in a limbo on whether the flight will operate or not is not fun. The airline having staffing issues is not encouraging at all.

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

Flight was delayed and missed connecting flight. Did not give warning about delay until we showed up at the airport. Not good.

In-flight Wi-Fi didn’t work and the flight was 25 minutes late. The Embraer plane I was on was pretty old and the tray table was broken.

I love to be able to connect my own devices to the entertainment system. It works great!

Everything you need to know for your flight from Santa Ana to Greenville

Information on your arrival and departure airports