$86 Find Cheap Flights from Santa Ana to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to South Carolina departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Ana to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Ana to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Santa Ana to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$369
Myrtle Beach
Myrtle Beach2 stops$350
Greenville
Greenville1 stop$388
Columbia
Columbia1 stop$389
Florence
Florence2 stops$932
Charlotte
Charlotte1 stop$236
Charleston
Charleston2 stops$369
Myrtle Beach
Myrtle Beach2 stops$350
Greenville
Greenville1 stop$388
Columbia
Columbia1 stop$389
Florence
Florence2 stops$932
Charlotte
Charlotte1 stop$236

Book Cheap Santa Ana to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to South Carolina

Mon, Apr 20 - Fri, Apr 24
Frontier Logo
11:29 am - 6:54 pm
SNA
-
CLT
28h 25m
1 stop
Frontier Logo
6:30 pm - 11:25 am
CLT
-
SNA
19h 55m
1 stop
$236Frontier
Thu, Apr 16 - Thu, Apr 23
Frontier Logo
7:56 pm - 9:18 am
SNA
-
CLT
10h 22m
2 stops
Frontier Logo
6:18 pm - 10:44 am
CLT
-
SNA
19h 26m
1 stop
$256Frontier
Mon, Apr 13 - Sat, Apr 18
Delta Logo
9:20 pm - 8:51 am
SNA
-
CHS
8h 31m
1 stop
Delta Logo
2:20 pm - 7:47 pm
CHS
-
SNA
8h 27m
1 stop
$377Delta
Wed, May 13 - Wed, Jun 3
Delta Logo
2:00 pm - 11:58 pm
SNA
-
MYR
6h 58m
1 stop
Delta Logo
4:07 pm - 10:29 pm
MYR
-
SNA
9h 22m
1 stop
$383Delta
Sat, Apr 18 - Sat, Apr 25
United Airlines Logo
12:15 pm - 9:59 pm
SNA
-
CHS
6h 44m
1 stop
United Airlines Logo
6:40 am - 11:13 am
CHS
-
SNA
7h 33m
1 stop
$384United Airlines
Sat, Apr 18 - Sat, Apr 25
Southwest Logo
6:45 am - 6:05 pm
SNA
-
CHS
8h 20m
1 stop
Southwest Logo
10:55 am - 5:35 pm
CHS
-
SNA
9h 40m
2 stops
$389Southwest
Sat, May 23 - Sat, May 30
United Airlines Logo
9:14 pm - 8:51 am
SNA
-
CHS
8h 37m
1 stop
United Airlines Logo
6:50 am - 10:59 am
CHS
-
SNA
7h 09m
1 stop
$391United Airlines
Sat, Apr 18 - Sat, Apr 25
Southwest Logo
6:45 am - 6:05 pm
SNA
-
CHS
8h 20m
2 stops
Southwest Logo
10:55 am - 5:35 pm
CHS
-
SNA
9h 40m
2 stops
$394Southwest
Tue, Apr 28 - Sat, May 2
American Airlines Logo
1:23 pm - 10:44 pm
SNA
-
AGS
6h 21m
1 stop
American Airlines Logo
5:08 pm - 10:45 pm
AGS
-
SNA
8h 37m
1 stop
$419American Airlines
Tue, Apr 28 - Sat, May 2
American Airlines Logo
1:23 pm - 10:44 pm
SNA
-
AGS
6h 21m
1 stop
American Airlines Logo
12:54 pm - 8:56 pm
AGS
-
SNA
11h 02m
2 stops
$475American Airlines
Booking Insights

KAYAK's insights & trends for Santa Ana to South Carolina flights

Get data-powered insights and trends into flights from Santa Ana to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Santa Ana to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santa Ana to South Carolina is July, when tickets cost $407 (return) on average. On the other hand, the most expensive months are December and November, when the average cost of round-trip tickets is $587 and $538 respectively.

How far in advance should I book a flight from Santa Ana to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Santa Ana to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Santa Ana to South Carolina, you should book around 3 weeks before departure, which saves you about 45% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 12 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$86
Best time to beat the crowds with an average 7% drop in price.
Most popular time to fly and prices are also 10% lower on average.
Flight from John Wayne (Santa Ana) to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from John Wayne (Santa Ana) to the following destinations at these prices or less: Charlotte $306 one-way - $494 round-trip

Reviews of the top 4 airlines serving from Santa Ana to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Santa Ana to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4324 reviews
8.6Crew
8.1Boarding
8.0Comfort
7.5Entertainment
7.0Food
Airline reviews

Southwest was greaat! The most expensive but the least upsetting for those we were flying to see.

10.0 ExcellentMartie, Mar 2026
LGB - BNA
Read more Southwest reviews

Southwest was greaat! The most expensive but the least upsetting for those we were flying to see.

Boarding was easy. The seats are small and fairly uncomfortable

The problem with the seat assignments is that there were a lot of rows in the front that were empty but my row at the back was full. Just not so pleasant.

Good but I prefer choose your own seat. With the new assigned seats they should board from the back I see no advantage to this new boarding. Just like every other airline

Flight boarded late after announcing on time boarding. Flight arrived only a little late despite late departure. Had trouble connecting to WiFi

The Southwest experience has definitely taken a dive from its early days. You can no longer deferentiate from other airlines. Air travel is too expensive. Southwest is no longer budget friendly. They have lost me as a loyal customer.

The charges were ridiculous for an hour flight and the turbulence was very scary.

The seats are now more narrow. I paid for front row the seats in the front are even more narrow than before.

The wifi on the plane is great. The only issue that I have is that I prefer an aisle seat and on my trips this week, I was either in the middle or window. If we can work to secure aisle seating, I will be thrilled. Nice trip.

Great flight but super high price. Glad it was a business trip and not personal

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

The landing was the worst I’ve experienced with a flight.

The crew, and fellow passengers, were super gracious and kind. There seemed to be plenty of bin space even though the plane was full. It’s nice to get a glass of wine with dinner in Premiere seating, and there was a lot of food.

Everything I mentioned earlier - the airbus was more comfortable indeed and the experience was further enhanced.

The plane was an older model, so it wasn’t as comfortable as others. The flight attendants were not helpful during onboarding. It was a full flight so there was chaos finding space for baggage.

Awesome! On time flight, early arrival, and a complimentary upgrade!

Delta One is extraordinary. I fly business when somebody hires me. I just wonder why there is such a chasm between business class and the insanely inhumane and nonsensical coach. The seats are not large enough to fit even my tiny wife. We fly 10% of what we did because we don’t want to pay 5-10 k but for $400 it’s unbearable. It seems like the accountants took over and made stupid decisions. Screw in 20 extra seats and make it so unbearable that people fly 90% less. Just put the damn price up and put some proper chairs in. But business, yay.

My flight was canceled a few hours before boarding. I was rebooked on Copa airlines and missed an important meeting .

OK, we were delayed and had to de plane and reboard.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Complimentary light meal would be appreciated. But great flight crew service on all legs

Flight delayed for more than 16 hrs and no effort was spent to provide an alternate

Women boarding passengers at the gate was absolutely rude and disrespectful of passengers. The flight attendant was absolutely delightful! Smiling and connected with the passengers. So happy. The seats are cramped and uncomfortable but I guess that’s just the way it is Communication regarding flight was excellent

it was a very short flight so my expectations were low.

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Crew was great (professional, attentive, prompt). Snacks for 4 hrs flight is deplorable.

Terrible planning. And even worse gate agents. Absolutely rude behavior.

Flight was scheduled at 11:26am but they keep Delaying until midnight. They waited at airport restless.

Rough flight No beverage service due to turbulence Bottom Seat cushion was non existent

Not good. One of my luggage is missing. And until now they can’t find it

My 9:50AM flight was delayed to 3:40PM "due to incoming aircraft delay". No aircraft is "delayed" that long. Found out once we did board (after several changes in times) that the aircraft had a maintenance issue and we had to wait for another aircraft. Just tell us that. The aircraft we did get was old and the seats need to be updated. I have been traveling for several weeks with AA and you should refresh your entertainment content as frequent flyers have gone through most of your new content. I have Celiac and a shellfish allergy and continue to have struggles with meals on business and first class flights. Please keep this in mind. Sorry - was a long travel day yesterday and a bit cranky this morning with my experience comments. Still an AA fan.

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

Dloght delayed by 2.5 hrs . Common theme in my last four american floghts

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

My seat was assigned last row behind restrooms No legroom’s I’m very Pettit Still was not comfortable Food choice was excellent

The chicken wrap was tiny ($13 for what looked like a 1/3 of a normal wrap?) and disgusting.

Everything you need to know for your flight from Santa Ana to South Carolina

Information on your arrival and departure airports