$141 Find Cheap Flights from John Wayne (Santa Ana) to South Carolina - Compare and Save

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Cheap Flights from Santa Ana to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Sort by: Cheapest
Charleston
6h 44m2 stops
from $277per person
Savannah
6h 16m2 stops
from $305per person
Myrtle Beach
6h 40m2 stops
from $332per person
Charlotte
4h 38mNonstop
from $339per person
Greenville
6h 37m2 stops
from $349per person
Columbia
6h 47m2 stops
from $390per person
Hilton Head Island
6h 53m2 stops
from $447per person
Augusta
6h 48m2 stops
from $549per person
Booking Insights

KAYAK's insights & trends for Santa Ana to South Carolina flights

Get data-powered insights and trends into flights from Santa Ana to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Santa Ana, California to South Carolina?

Flight prices are below average for this route right now.

Flights to South Carolina from Santa Ana, California usually cost between $442 and $726 in October.
The lowest price found in the past 5 days was $377 on United Airlines (Oct 17-Oct 20).

What is the cheapest month to fly from John Wayne (Santa Ana) to South Carolina?

The cheapest month for flights from John Wayne (Santa Ana) to South Carolina is February, when tickets cost $452 (return) on average. On the other hand, the most expensive months are November and December, when the average cost of round-trip tickets is $756 and $676 respectively.

Good to know

Low season

January

Cheapest flight

$141
Best time to beat the crowds with an average 23% drop in price.
Most popular time to fly with an average 3% increase in price.
Flight from John Wayne (Santa Ana) to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from John Wayne (Santa Ana) to the following destinations at these prices or less: Charlotte $259 one-way - $548 round-trip

Reviews of the top 4 airlines serving from Santa Ana to South Carolina

 
Need help choosing which airline to fly with from Santa Ana to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4193 reviews
8.6Crew
7.5Entertainment
8.1Boarding
8.0Comfort
7.0Food
Airline reviews

Southwest has been a nightmare. Delayed flights, missed connections, systems down. Never again am I flying southwest.

2.0 MediocrePhilip, Sep 2026
Read more Southwest reviews

Southwest has been a nightmare. Delayed flights, missed connections, systems down. Never again am I flying southwest.

had to check bag at gate when there was still overhead bin space. As usual the WIFI didn't really work.

Nice managed … it was a smaller plane, so the seating wasn’t as comfortable.

The Southwest airline was ok. A big thank you to Kayak team (David), who worked with me on Sunday afternoon to rebook my travel from Burbank, CA, to CVG. My original flight on Sunday was delayed, so I had to cancel Sunday flight and rebook my travel to Monday. Could not have done it without help from David from Kayak team. Ante Soda GE Aerospace

Seated at front bulkhead for a smidge extra leg room away from home and on flight back home. Away crew was very proactive about assuring our carryons had space close behind us (because no seat in front of us our personal items had to be in a small bin overhead). They actively required passengers place overhead luggage on its side so more items could fit in bins. Home crew made no such efforts. I had to struggle back rows to get overhead bags upon landing, no crew help then either, and some disgruntled passengers as I and others retrieved our bags. There was a system that worked pretty well. The home bound crew just didn't feel like working.

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Great flight, 47 passengers on a 180 seat plane. Stewardess was pleasant and cheerful.

The 700 model seating is too tight both seat size & leg room

Flight team was great and we even arrived ahead of plan!

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am still at the Airport! Delayed Delayed and Delyaed

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

All good on Delta's part. Passengers could be a little more courteous to each other.

Flight and seats were great. Food service was average at best. The real main problem we had is that we got cheeseburgers for the kids but the plates was extremely hot. Like ridiculously hot and the stewardess never said anything. Luckily or unluckily my wife touched the plate and was able to deal with it before the kids got burned.

awesome team work seen since on board till off plane in my destination. thanks you so much.

Flight was on time, clean, etc. Despite connecting to your wi fi I was unable to use your app to watch entertainment.

Boarding, time to take off, in flight offerings, and staff were all great. I recommend using UA for this short flight.

This was an auto-rebook due to being delayed from an earlier UA connecting flight. The boarding was fine, but they sat me in a middle seat when my original booking was a window seat. Overall, the flight was fine as it still got me to my final destination.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Awful. No counter attendants. No dinner offered due to delays.

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Very poor the plane itself was really old, slight smell that couldn’t be named. I didn’t even get a boarding pass UNTIL AFTER clearing security! Even then, they said when I get to my connected flight I’ll get my 2nd boarding pass there! A bit ridiculous!

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

the head jack on my seat didn't work and the power outlet didn't work for my seat

The WiFi didn’t work entire flight, couldn’t watch a movie. The recline button didn’t work

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

The flight encountered a delay exceeding 4 hours. The food voucher issued was valued at $12, insufficient to cover our meal expenses. Consequently, I was unable to take my medication, leading to a drop in blood sugar levels and exacerbating my anxiety.

Flights were on time. That's the main consideration since I had to change planes. The entertainment was whatever you bring with you and the food (in Economy) is non-existant. Neither of those was a surprise.

The gate crew did try to help, however they lacked the information as to whether the flight will operate or not. Being delayed 6 hours and in a limbo on whether the flight will operate or not is not fun. The airline having staffing issues is not encouraging at all.

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

Flight was delayed and missed connecting flight. Did not give warning about delay until we showed up at the airport. Not good.

I love to be able to connect my own devices to the entertainment system. It works great!

More options for your flight from Santa Ana to South Carolina

Complete your trip to South Carolina with a hotel stay or car rental