$121 Find Cheap Flights from John Wayne (Santa Ana) to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to South Carolina departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from John Wayne (Santa Ana) to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from John Wayne (Santa Ana) to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Santa Ana to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$337
Myrtle Beach
Myrtle Beach1 stop$363
Greenville
Greenville2 stops$361
Columbia
Columbia1 stop$449
Florence
Florence2 stops$747
Charlotte
Charlotte1 stop$242
Charleston
Charleston2 stops$337
Myrtle Beach
Myrtle Beach1 stop$363
Greenville
Greenville2 stops$361
Columbia
Columbia1 stop$449
Florence
Florence2 stops$747
Charlotte
Charlotte1 stop$242

Book Cheap Santa Ana to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to South Carolina

Thu, Aug 20 - Wed, Aug 26
Frontier Logo
6:38 pm - 11:18 am
SNA
-
CLT
13h 40m
1 stop
Frontier Logo
10:14 pm - 8:09 am
CLT
-
SNA
12h 55m
1 stop
$242Frontier
Sun, Aug 16 - Wed, Aug 26
Frontier Logo
6:39 pm - 11:16 am
SNA
-
CLT
13h 37m
1 stop
Frontier Logo
10:14 pm - 8:09 am
CLT
-
SNA
12h 55m
1 stop
$270Frontier
Tue, Oct 27 - Tue, Nov 3
American Airlines Logo
8:09 am - 5:14 pm
SNA
-
MYR
6h 05m
1 stop
American Airlines Logo
5:21 pm - 10:45 pm
MYR
-
SNA
8h 24m
1 stop
$363American Airlines
Tue, Oct 27 - Tue, Nov 3
American Airlines Logo
8:09 am - 5:14 pm
SNA
-
MYR
6h 05m
1 stop
American Airlines Logo
5:21 pm - 10:45 pm
MYR
-
SNA
8h 24m
1 stop
$364American Airlines
Wed, Aug 12 - Tue, Aug 18
United Airlines Logo
11:10 am - 9:35 pm
SNA
-
CHS
7h 25m
1 stop
United Airlines Logo
4:28 pm - 10:25 pm
CHS
-
SNA
8h 57m
1 stop
$369United Airlines
Wed, Oct 28 - Wed, Nov 11
United Airlines Logo
6:30 pm - 10:20 am
SNA
-
MYR
12h 50m
2 stops
United Airlines Logo
11:30 am - 10:00 pm
MYR
-
SNA
13h 30m
2 stops
$374United Airlines
Tue, Jul 21 - Tue, Jul 28
Southwest Logo
7:00 am - 7:35 pm
SNA
-
CHS
9h 35m
2 stops
Southwest Logo
10:45 am - 2:10 pm
CHS
-
SNA
6h 25m
1 stop
$374Southwest
Wed, Aug 12 - Tue, Aug 18
Southwest Logo
6:45 am - 9:10 pm
SNA
-
CHS
11h 25m
2 stops
Southwest Logo
6:45 am - 2:00 pm
CHS
-
SNA
10h 15m
2 stops
$379Southwest
Sat, Aug 22 - Sat, Aug 29
Delta Logo
12:15 pm - 9:38 pm
SNA
-
SAV
6h 23m
1 stop
Delta Logo
8:17 am - 12:46 pm
SAV
-
SNA
7h 29m
1 stop
$381Delta
Wed, Oct 28 - Wed, Nov 11
Delta Logo
12:20 pm - 11:35 pm
SNA
-
MYR
8h 15m
1 stop
Delta Logo
6:00 am - 12:56 pm
MYR
-
SNA
9h 56m
1 stop
$391Delta
Booking Insights

KAYAK's insights & trends for Santa Ana to South Carolina flights

Get data-powered insights and trends into flights from Santa Ana to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Santa Ana, California to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Santa Ana, California to South Carolina departing in July.

What is the cheapest month to fly from John Wayne (Santa Ana) to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from John Wayne (Santa Ana) to South Carolina is May, when tickets cost $116 (return) on average. On the other hand, the most expensive months are March and June, when the average cost of round-trip tickets is $381 and $373 respectively.

Good to know

Low seasonJanuary
Cheapest flight$121
Best time to beat the crowds with an average 26% drop in price.
Most popular time to fly with an average 9% increase in price.
Flight from John Wayne (Santa Ana) to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from John Wayne (Santa Ana) to the following destinations at these prices or less: Charlotte $367 one-way - $439 round-trip

Reviews of the top 4 airlines serving from Santa Ana to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from John Wayne (Santa Ana) to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4243 reviews
8.6Crew
8.1Boarding
8.0Comfort
7.0Food
7.5Entertainment
Airline reviews

Flight was delayed, full flight and I had to change gates. Southwest flights are always late later in the day.

4.0 OkaySteven, Jun 2026
ONT - LAS
Read more Southwest reviews

Flight was delayed, full flight and I had to change gates. Southwest flights are always late later in the day.

Was fine, delayed and feels like southwest is always late

I'm glad it wasn't only 75% full because I could get a good seat

The entire experience from boarding to landing was amazing! The crew were very friendly. Will definitely be back.

Delayed flight, lack of information, boarding process is a mess as is the carryon luggage causing issues when leaving the plane….just a poor experience.

Comfortable. Easy. No problems. Just wish they had gf options for snacks.

The crew was very kind and made going to Hawaii relaxing and fun to look forward to! Thank you Southwest for a pleasant flight!

Terrible. Even though there’s assigned seating now, they are still the slowest boarding airline of anyone.

It was good from LAX to Phoenix, But the connection in Phoenix to Tulsa was not that great. The staff on both flights were great. The choice of free entertainment was ok nothing to brag about. The 45 min delay because of some electrical issue wasn't great from Phoenix to Tulsa. We sat there with hardly any air, The seat I had was between windows so the side of the plane pushed in on you. My being a bigger man it then made the seating area uncomfortable. The seats on the plane had no power to connect to recharge your phone or anything. I would recommend that they should look into a slot or clamp to hold your phone to enjoy while watching the entertainment choices hands-free. Also make it possible to raise the inner seat by the window be able to raise the arm rest up to make more room for larger people to set more comfortably. I would also say other then that stop price gouging the airfare or nickel and diming everything. Not fair for people having to fly for emergencies and be paying for higher prices due to the season or holidays. Your making your money either way and the cost of flying is still going to be the same regardless if there's 100 people or 200 people.

Southwest was greaat! The most expensive but the least upsetting for those we were flying to see.

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

Be on time? When not on time a circling for over an hour offer more than 1 bag of chips to the passengers? It was a 7 hour flight by the time we got done.

Flight delayed four separate times. I’m now one hour hours late to landing.

Checkin was good, fllight ws good. Onlly complaint is lack of foot on 6 hour flight from Seattle to Boston. Snacks were flimsy - chips and cookies. could have offered something more substantial for such a long flight. I know you can buy food in airport but for the price you pay for a ticket, they should step up for the passengers.

Long story short, it was one of the better flight experiences I've had in some time when compared with other airlines.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

N Everything was perfect from boarding to assistance to baggage in Tampa

Loved the crew! Sucks that we went from 1 hour and 8 minute layover to a 3 hour layover. But weather sucks like that.

Lost one piece of luggage even though I checked in 2.5 hours before the flight

The boarding process on the departure from LA was rather slow even though I was in Group 1. For first class, I was not expecting to have to pay for Wi-fi but I did and then the wi-fi was spotty. The entree was surprisingly good and so that was a pleasant surprise. However, once I got to Houston, it was terrible. Unfortunately there was bad weather but the constant gate changes for my connecting flight was difficult to manage due to having to navigate back and forth between different terminals.

Service was professional and quick. Premium economy seat was comfortable given the class

The staff was extremely helpful and friendly at all times! They went above and beyond to get us into an earlier flight in San Diego to make our connection in SFO possible, because our original flight did actually not make it! I did so much appreciate the UA team and how they made this possible. We also didn’t have seats together on the long flight to Singapore, but they found us seats together last moment with no additional cost! Nobody sat next to us, so that we were able to sleep! Thanks to UA for improving their service and Underpricer for booking this trip! Please be careful: 1,5 hrs for transfer in San Francisco might not be enough time in the future

Over 2.5 hour maintenance delay on first morning flight with no acknowledgement, compensation or even gesture of good will. Aircraft had overnighted at airport so issue should have been addressed prior to boarding. Over 3.5 hours before first slow and deliberate beverage service.

Horrifying Almost 2 million miles. Bring your own food and drink. One coffee or drink every three hours. Have to order meals on app more than 24 hours ahead Tiny and dirty bathrooms

Flight was delayed but more than 90 minutes. This caused me to miss my available windows for pick-up by a friend. I had to pay $125 for an uber back home from the airport which was an added expense that I had not budgeted for my trip. Staff was friendly.

Seat pitch is horrible especially on the 15 hour flight. Gate crew at SFO was Outstanding. The flight crew was also great.

My service dog and I were asked to deplane just before they closed the door - clearly very last minute they couldn’t find the documentation that I have filled out many many times before that is for flying service animals. I purposely purchase 3seats (a whole row) since he is large and not all passengers want to sit next to a dog on a cross country flight. The plane departed with my husband on it!!! They made me fill out a hard copy of the same form and had to reschedule me on a later flight where they could find 3 seats together!! I’ve done this so many times before - clearly the error was on their part in a technology glitch - but really people - do better!! Very traumatic - and my husband had to wait for us when he landed ….so bad. Poor pup was confused and tired.

Late plane. Only one crew on the ground so we b had to wait for Denver flight to come in, board, and depart. At 78 yrs of age I was not pleased trying to get my connection. What really made me angry was the notification you sent me to hurry up or I would miss my connection. Why tell me to hurry up when you got me in late. It was not a good way of treating customers.

I was not clear if food was offered or not.

Agency very bad had to cancelled my booking too many changes in the flight changed my flight to 1 week

The gate experience at LAX was abysmal (same for the arrival experience two days prior). Despite the LAX -> SAT schedule of two flights daily, our departure gate was at a smaller hub that we had to be bussed to from Terminal 4. Fortunately, I arrived at LAX extra early and had time to spare, but if I had not known, I might have missed my flight. I looked at the LAX airport map in the AA app and there was no indication of the additional boarding process. Lastly the gate area we were bussed to was crowded with limited food and beverage options. On flight, the fight attendant was hospitable and attentive, the flight was smooth, and AA's free (and working) wifi for AA members were all on the positive side.

Our flight from JFK to Madrid was delayed. We had to go from one side of the Madrid airport (Terminal 4s to the far end of terminal 4 - Gate K98) to our gate in less than 30 minutes. Put passport control and security/baggage check and that’s very hard unless you’re Usain Bolt. I called Iberia Airlines and the telephone customer service told me that I was going to have to pay to re-book. Luckily the help desk in the airport (who was dealing with dozens of people from the same JFK-Madrid flight) did not charge us extra to reschedule to a flight 8 hours later. They also gave us a voucher for breakfast and lunch. Glad the actual person at the airport had some actual sense.

Take-off delayed an hour because of a missing flight officer, so,arrived in Charlotte lates causing many passengers to miss connections. Otherwise a very good flight, safe and comfortable, with an excellent professional crew.

The flight from LA to Chicago was smooth and service was very good overall.

Ontario airport boarding was very easy to park and access, is clean and TSA took 10 minutes total. Check-in was a breeze and cruise was very nice.

Left early arrived early..right amount of talking from pilots..of course had to love the biscuit and water!

Boarding gate at LAX was too crowded—two gates next to one another

On time departure and early arrival. Flight attendant very nice.

Everything you need to know for your flight from Santa Ana to South Carolina

Information on your arrival and departure airports