VVI - ORD

$473 Find Cheap Flights from Santa Cruz de la Sierra to Chicago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Cruz de la Sierra to Chicago departing on 4/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Chicago O'Hare Intl Airport

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Cruz de la Sierra to Chicago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Cruz de la Sierra to Chicago, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$745
Typical prices: $707-$725
Multiple Airlines
Wed 4/8Thu 4/23
VVI - ORD • 2 stops
Cheapest one-way
$477
Multiple Airlines
Sun 4/19
VVI - ORD • 2 stops
Top airlines
Avianca
Cheapest • from $786 (round-trip)
Copa Airlines
Best reviews • 7.5 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Santa Cruz de la Sierra and Chicago. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Chicago!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Cruz de la Sierra to Chicago (VVI-ORD)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Cruz de la Sierra to Chicago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Cruz de la Sierra to Chicago

Wed, Apr 8 - Thu, Apr 23
Multiple Airlines Logo
3:35 am - 11:17 pm
VVI
-
ORD
20h 42m
2 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$745Multiple Airlines
Tue, May 5 - Wed, May 27
Multiple Airlines Logo
3:35 am - 12:27 am
VVI
-
ORD
21h 52m
2 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$755Multiple Airlines
Tue, Apr 7 - Wed, Apr 22
Multiple Airlines Logo
3:35 am - 7:51 pm
VVI
-
ORD
17h 16m
2 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$756Multiple Airlines
Wed, Apr 29 - Fri, May 15
Multiple Airlines Logo
3:35 am - 11:59 pm
VVI
-
ORD
21h 24m
2 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$771Multiple Airlines
Tue, May 5 - Wed, May 27
Multiple Airlines Logo
3:35 am - 5:35 am
VVI
-
ORD
27h 00m
3 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$782Multiple Airlines
Wed, May 6 - Thu, May 28
Multiple Airlines Logo
3:35 am - 10:46 am
VVI
-
ORD
32h 11m
3 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$785Multiple Airlines
Wed, Apr 29 - Fri, May 15
Avianca Logo
3:35 am - 9:20 pm
VVI
-
ORD
18h 45m
1 stop
Avianca Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$786Avianca
Tue, May 5 - Sat, May 23
Multiple Airlines Logo
3:35 am - 12:27 am
VVI
-
ORD
21h 52m
2 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$801Multiple Airlines
Tue, Apr 7 - Wed, Apr 22
Multiple Airlines Logo
3:35 am - 11:17 am
VVI
-
ORD
32h 42m
3 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$816Multiple Airlines
Wed, Apr 29 - Fri, May 15
Multiple Airlines Logo
3:35 am - 12:52 am
VVI
-
ORD
22h 17m
3 stops
Multiple Airlines Logo
11:20 pm - 2:30 am
ORD
-
VVI
26h 10m
1 stop
$826Multiple Airlines
Booking Insights

KAYAK's insights & trends for Santa Cruz de la Sierra to Chicago flights

Get data-powered insights and trends into flights from Santa Cruz de la Sierra to Chicago to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Santa Cruz de la Sierra to Chicago?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Santa Cruz de la Sierra to Chicago were found on Avianca ($786) and United Airlines ($866).

Find deals

Good to know

Low seasonJune
Cheapest flight$477
Best time to beat the crowds with an average 40% drop in price.
Most popular time to fly and prices are also 14% lower on average.
Flight from Santa Cruz de la Sierra to Chicago

When to book flights from Santa Cruz de la Sierra to Chicago

Are your dates flexible? Find out the best times to travel from Santa Cruz de la Sierra to Chicago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking Santa Cruz de la Sierra to Chicago flights

  • What is the cheapest flight from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport?

    In the last 3 days, the lowest price for a flight from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport was $477 for a one-way ticket and $745 for a round-trip.

  • Do I need a passport to fly between Santa Cruz de la Sierra and Chicago?

    A passport is required to fly from Santa Cruz de la Sierra to Chicago.

  • Which airports will I be using when flying from Santa Cruz de la Sierra to Chicago?

    On your way to Chicago, you’ll fly out from Santa Cruz de la Sierra Viru Viru Intl. You’ll be landing at Chicago O'Hare Intl.

  • Which aircraft models fly most regularly from Santa Cruz de la Sierra to Chicago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Santa Cruz de la Sierra to Chicago?

    Star Alliance is the only airline alliance operating flights between Santa Cruz de la Sierra and Chicago.

  • How does KAYAK find such low prices on flights from Santa Cruz de la Sierra to Chicago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santa Cruz de la Sierra to Chicago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santa Cruz de la Sierra to Chicago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from Santa Cruz de la Sierra is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santa Cruz de la Sierra to Chicago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to Santa Cruz de la Sierra with another airline. Booking your flights between Santa Cruz de la Sierra and ORD can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santa Cruz de la Sierra to Chicago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from Santa Cruz de la Sierra up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Santa Cruz de la Sierra to Chicago

 
See real verified KAYAK customer reviews for airlines flying from Santa Cruz de la Sierra to Chicago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Cruz de la Sierra to Chicago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
Copa AirlinesOverall score based on 1577 reviews
8.1Crew
7.4Comfort
6.8Entertainment
6.8Food
7.7Boarding
Airline reviews

Do not book it’s a scam! They stole $1200 from me

2.0 MediocreTalicia, Mar 2026
PTY - RDU
Read more Copa Airlines reviews

Do not book it’s a scam! They stole $1200 from me

Flight got delayed; had to go through security three times.

A lot things happened in this trip.The fly should be less stress.

I always enjoy flying Copa. There are very few airlines where I can enjoy a comfortable sleep in-flight. The snacks weren't the best, but they sufficed. The in-flight entertainment was fantastic, and I crossed another movie off my watch list.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

Simply as follows:- First, there was no vegetarian option for the meal Second, only 2 washrooms for the entire economy class.

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

horrible service, food was an embarrassment, no charging for cellphones, stay away

Everything you need to know for your flight from Santa Cruz de la Sierra to Chicago

Information on your arrival and departure airports

Santa Cruz de la Sierra (VVI)
O'Hare Intl (ORD)