$51 Find Cheap Flights from South Carolina to Indiana

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Low seasonJanuary
High seasonJuly
Cheapest flight$51
Best time to beat the crowds but there is an average 2% increase in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from Myrtle Beach to Chicago O'Hare Airport

FAQs for booking flights from South Carolina to Indiana

  • How does KAYAK find such low prices on flights from South Carolina to Indiana?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South Carolina to Indiana.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South Carolina to Indiana?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from South Carolina to Indiana is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South Carolina to Indiana?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from South Carolina to Indiana with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South Carolina to Indiana?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from South Carolina to Indiana up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • Which is the cheapest airport to fly into in Indiana?

    Prices will differ depending on the departure airport, but generally, the cheapest airport to fly to in Indiana is Indianapolis Airport (IND), with an average flight price of $45.

  • What is the cheapest day to fly to Indiana?

    Based on KAYAK data, the cheapest day to fly to Indiana is Saturday where round-trip tickets can be as cheap as $124. On the other hand, the most expensive day to fly is Tuesday, where round-trip prices are $309 on average.

  • What is the cheapest time of day to fly to Indiana?

    The cheapest time of day to fly to Indiana is generally in the evening, when round-trip flights cost $133 on average. Morning departures are around 100% cheaper than evening flights, on average. The most expensive time of day to fly to Indiana is generally at night, which is peak travel time and where the average cost of a ticket is $361.

  • What is the cheapest flight to Indiana?

    The cheapest ticket to Indiana from South Carolina found in the last 72 hours was to Indianapolis, at $88 round-trip. The most popular route is Charleston (CHS) to Indianapolis (IND) and the cheapest round-trip airline ticket found on this route in the last 72 hours was $88.

  • What is the cheapest month to fly from South Carolina to Indiana?

    The cheapest month for flights from South Carolina to Indiana is June, when tickets cost $234 (return) on average. On the other hand, the most expensive months are March and April, when the average cost of round-trip tickets is $756 and $477 respectively.

  • How far in advance should I book a flight from South Carolina to Indiana?

    To get a below average price on the flight from South Carolina to Indiana, you should book around 5 weeks before departure. For the absolute cheapest price, our data suggests you should book 18 weeks before departure.

  • How long is the flight to Indiana?

    An average nonstop flight from South Carolina to Indiana takes 3h 20m, covering a distance of 550 miles. The shortest route is Charlotte (CLT) to Cincinnati (CVG) with an average flight time of 1h 22m.

  • What are the most popular destinations in Indiana?

    Based on KAYAK flight searches, the most popular destination is Chicago (77% of total searches to Indiana). The next most popular destinations are Indianapolis (6%) and Cincinnati (6%). Searches for flights to South Bend (3%), to Louisville (3%) and to Dayton (2%) are also popular.

Top 5 airlines serving from South Carolina to Indiana

 
Need help choosing which airline to fly with from South Carolina to Indiana? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7946 reviews
7.3Food
7.9Entertainment
8.2Boarding
7.9Comfort
8.5Crew
Airline reviews

Great service. Flight was delayed while we sat on the runway for a couple of hours. Weather related. Staff made is very bearable. The steward servicing the first class cabin was exceptional. Thank you! 💗

10.0 ExcellentHartaj, Jun 2025EWR - RDU
Read more Delta reviews

Great service. Flight was delayed while we sat on the runway for a couple of hours. Weather related. Staff made is very bearable. The steward servicing the first class cabin was exceptional. Thank you! 💗

5 hours of delay that could've been much shorter if Delta had taken the 1 hour delay they imposed on the flight before boarding to run any of the plane checks required for flight to find the hydraulic issue that required nearly 3 hours to fix. $24 of meal credit buys a sandwich and a soft drink. Poor communication within the terminal about what gate we'd be re-boarding from and when we'd be re-boarding.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

It would be nice if was given wires ear buds. Overall was a good experience was able to sleep on the plane

My flight was 6 pm 6/6. Every hour they delayed it again - air condition issues then no pilot then the crew had worked too many hours and cancelled the flight at 11 pm. Sent customers to NJ a 45 minutes uber ride to a hotel. Had to be back by 5 am for a 7 am flight and again no pilot etc with another three hours of delays.

The entertainment and wifi mostly didn't work on this flight.

Terrible entertainment system - kept freezing and audio kept cutting out. Snacks were mediocre at best for a 5 hour flight.

The check in and bag drop off for Sky Priority members is slow. The Clear security was also slow - a TSA issue.

I am still upset that my bag was lost on a recent trip to Rome ; we were inconvenienced and out €150 Euros ; delta has refused to reimburse us

I am very bothered by the events today. I can't believe the flight attendants allowed someone to take my seat and made me move. It was embarrassing. I was in the right. The lady just didn't want move. I can't believe delta would allow this to stand and disrespect my rights as a passenger. The lady complained about her leg and that she couldn't move. Firstly somehow she was able to make it to row 24. Not sure how much her leg could have hurt. Secondly, I'm in plenty of pain myself. I just finished chemotherapy a several weeks ago. My body is constantly sore. Yet deltas flight attendants didn't appropriately protect my rights. In the end they found me a seat on the plane but I want to understand how delta can operate this way. They in essence allowed a bully to get their way.

it was so bad. I tried to board my flight from vancouver to saskatoon. And to my surprise they did not board me cause the flight was changed and no email was send to me. and on my boarding pass which i got from seattle says different flight. I did not knew anyone from Vancouver, air canada crew was rude, i asked for today flight but they were rude and i had early morning dental appointment in saskatoon. I was so much in pain and my whole day is wasted today. and i suffered alot. They did provide me hotel but they did not provide me any food. I am really really disappointed first time had so bad experience with air canada. I may think twice to book it again. If i can get any reply or any composition that would be great. Thanks

It was fine, definitely older planes with no charging or anything. There’s no entertainment set up on board, but it is nice that they allow you to access the in flight entertainment from your phone without having to pay for the Wi-Fi and they do offer free texting.

Boarding was mayhem. Late boarding by 15 minutes because of lack of staff (missing 1 flight attendant. We had to wait for an arrival of another plane before we could board). Flight was a little rough, but cannot blame on airlines.

Impressed with the service despite turbulence because of the weather. Both flights arrived before their scheduled times.

Very comfortable (upgraded to business class). The audio on my screen didn’t work, but I managed to play the audio through my phone while watching the screen.

Great experience…left a bit behind schedule but made up fir that in the air and landed 10 minutes early 😁

I was supposed to be on business class at first class from Denver back to Miami due to weather changes. I missed my connection and it’s put on a flight to Fort Lauderdale. Instead of honoring my business class/1st class ticket, they put me in coach, but there were two first class seats open. I think it’s absolutely disgusting that I paid for first class $1300 ticket and they put me in economy and they had to open seats available and I have still not been refunded the difference. I ended up having to eat a snack box instead of the meal I was supposed to get and did not get home till 2 AM so I think that’s a little pathetic that I had to live off crackers for dinner And my poor dog ate some cheese and salami. Oh yes, apparently when they switched me to the new flight they forgot to mention I had a service dog

Excellent service despite turbulence during the flight. Flight attendants were remarkable!

I liked that the flight was nonstop from ORD to CIU for $200 round trip.

Smooth flight, especially take off and landing, and great crew on board. Really loved the stroopwaffles!

Tight! Seats are not designed for those of us who wear extra-large clothes.

The non-stop flight from Grand Rapids was excellent. I neither expected or needed a budget flight and Allegiant made the trip easy and for an affordable price, Arriving at the Mesa Airport (AZA) is a delight compared to the international airport. For our return flight, we were able to arrive 75 minutes before the flight, return the rental car, check our bag and make it to the gate in plenty of time. That would never happen at most airports.

Easiest flights I’ve ever taken. Plane was comfortable without overly crowded seating.

Terrible. Still have not received the refund from them. They sent it to some account that I don't even know. Spoke with costumer service and they are unable to help.

I didn’t like it at all. I miss my second flight because of the delay on Allegiant Air now I m stuck in MCO.

Good, but a bit late on take off after loading. Don't like charging for carry ons!

First time flying with them and will definitely fly again in the future. Crew was so nice and friendly, fought was seamless. They are simple planes, no entertainment, but it’s fine for a short flight or if you have personal devices Rates are competitive, and they did so well with keeping the flight on time after a tropical storm, where other airlines had delays and cancellations.

They boarded passengers that sat in the back of the plane first, making boarding very efficient.

I didn't even take this flight. My plans changed and I couldn't get ahold of customer service and the website kept breaking down during the attempt to change the flight. I wound up taking another airline entirely and eating the cost.

The worst flying experience ever 3 delays. No accommodations. Had to deboard the plane after being delayed.

It was one of my worst flight ever. First they were changing the gate for at least 4 times, changing from gate D7 to D12 to D44. Considering the size of the Miami Airport, we are talking about long distance and the train at the airport was not working. Then the flight was delayed around one hour. Then finally we boarded into the plane and when everybody was seated, there was an announcement that there is an issue with one of the tire of the plane, so we all had to get out of the plane with our belongings, to replace the tire. So we had around 2.5-hour delay

Most miserable flight ever. We waited almost 2 hours on the runway because the flight was oversold. American offered $1200 credit. Then there was some nonsense about weight distribution. Ridiculous. No food for 8 plus hours on the flight. I will be writing a letter.

Honestly, I haven’t flown American in years, probably due to the pandemic and my being unable to travel for certain periods in the last two years, but it was a good experience to dig out or obtain a new American Airlines account after many years of traveling for business with American in the past.

The plane was probably full boarding was easy. We were able to check our carry-on luggage for free. It was a return flight through Philly to LA. Never saw a stewardess do a demonstration of emergency Procedures. I think my flight was pretty full

Plane, flight, crew, captain were all great. The first flight had a Chipotle box lunch...delicious.

Plane, flight, crew, captain were all great. The first flight had a Chipotle box lunch...delicious. this return flight not as tasty, but filling.

The flight was 2 hour delayed, otherwise everything was excellent. The delay was due to the hourly limit requirement so given that as a reason, I'm happy with the flight!

Weather delay for 2.5 hours followed by half hour crew delay, did not have ginger ale, uncomfortable seats

So awful Unreliable Unfriendly Bad Mad Mean Smelly Hot Late Overbooked Understaffed Expensive Cramped Narcs If they were a fruit they’d be rotten durian

It’s a great flight. Service is good. Staff is awesome.

Boarding was a breeze, however, two of the flights that I boarded with Spirit did not have Wi-Fi available.

Seats uncomfortable, hard to check luggage, etc. It was like the last flight out of Hanoi

Need screens for tv/movies. Seats are more cramped than any other airlines. Seats are hard. They don’t recline. And in flight time should not be used for sales pitches.

Good experience except for the drunk woman who was with a child. Sad

The ease of booking the flight was very good. Speaking with customer service was also good. However, the crew people are unfriendly and unwelcoming which I found this as unprofessional. As far as comfort it was mediocre. This was my first time flying Spirit and I chose them because of the flight times met my needs and my budget. However, I would be reluctant to fly on Spirit again. In addition, if the crew were more friendly and at least appeared somewhat happy and welcoming personally it would probably make the experience of flying with Spirit better.

Tell them to chose a better, less bumpy route :( my seat had no window all the way at the end 😔

Seats too hard, too much lumbar. Space between rows was extremely tight, so tight hard to place item under seat in front of me. No tv screens. Zero plugs for charging phones. Too many sales pitches

Prepaid for 1 bag but my prior airline did not provide it to me in time to check it with Spirit and I could not get my $75 refunded.

Plane delayed which seems to be the norm with spirt. Everything is an up charge. I had to pay an additional fee because I was late getting back to my car. Will never fly spirit again

It was horrible. We were not allowed on the flight by spirit staff at the gate during boarding because I had a guitar. The same guitar I had at check in which I paid for and they said I can take it on the plane. We missed our flight, lost our luggage, and had to pay another $900 to rebook flights. Worst travel experience ever and spirit staff are the worst staff ever.

Book cheap flights from South Carolina to Indiana

Recent round-trip flight deals

7/17Thu
nonstopSpirit Airlines
2h 25mMYR-ORD
7/20Sun
nonstopSpirit Airlines
2h 00mORD-MYR
$104
6/27Fri
nonstopSpirit Airlines
2h 22mMYR-ORD
6/30Mon
nonstopSpirit Airlines
2h 02mORD-MYR
$106
8/30Sat
nonstopAmerican Airlines
2h 10mCLT-ORD
8/30Sat
nonstopAmerican Airlines
2h 18mORD-CLT
$136
8/6Wed
nonstopAmerican Airlines
2h 13mCLT-ORD
8/9Sat
nonstopAmerican Airlines
2h 01mORD-CLT
$141
8/6Wed
nonstopSouthwest
1h 55mCLT-MDW
8/9Sat
nonstopSouthwest
1h 55mMDW-CLT
$141
8/5Tue
nonstopUnited Airlines
2h 15mCLT-ORD
8/6Wed
nonstopUnited Airlines
2h 12mORD-CLT
$149
8/5Tue
nonstopSouthwest
1h 55mCLT-MDW
8/9Sat
nonstopSouthwest
1h 55mMDW-CLT
$149
9/18Thu
nonstopUnited Airlines
2h 20mCLT-ORD
9/22Mon
nonstopUnited Airlines
2h 16mORD-CLT
$157
8/20Wed
1 stopDelta
6h 56mCHS-ORD
8/27Wed
1 stopDelta
5h 45mORD-CHS
$197
8/4Mon
1 stopDelta
6h 06mCLT-MDW
8/12Tue
1 stopDelta
3h 57mMDW-CLT
$197

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Recent one-way flight deals

7/5Sat
nonstopSpirit Airlines
2h 24mMYR-ORD
$51
8/10Sun
nonstopSpirit Airlines
2h 25mMYR-ORD
$53
8/13Wed
nonstopUnited Airlines
2h 36mCLT-ORD
$71
9/4Thu
nonstopAmerican Airlines
2h 16mCLT-ORD
$79
9/23Tue
nonstopUnited Airlines
2h 28mCHS-ORD
$79
8/18Mon
1 stopDelta
4h 57mCHS-ORD
$99
10/8Wed
1 stopDelta
5h 21mCLT-MDW
$99
7/2Wed
1 stopAmerican Airlines
6h 37mCAE-ORD
$100
7/20Sun
2 stopsAllegiant Air
19h 07mGSP-MDW
$136
7/20Sun
2 stopsAllegiant Air
19h 07mGSP-MDW
$138

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Last minute flights from South Carolina to Indiana

Last minute flight, train and bus deals

6/13Fri
nonstopSpirit Airlines
2h 22mMYR-ORD
6/20Fri
nonstopSpirit Airlines
2h 02mORD-MYR
$189
6/14Sat
nonstopSpirit Airlines
2h 24mMYR-ORD
6/20Fri
nonstopSpirit Airlines
2h 02mORD-MYR
$201
6/14Sat
multi-stopAmerican Airlines
6h 23mCAE-ORD
6/21Sat
multi-stopAmerican Airlines
4h 16mORD-CAE
$229
6/14Sat
nonstopAmerican Airlines
2h 08mGSP-ORD
6/17Tue
nonstopAmerican Airlines
1h 53mORD-GSP
$243
6/14Sat
multi-stopDelta
4h 09mGSP-ORD
6/17Tue
multi-stopDelta
7h 38mORD-GSP
$260
6/13Fri
multi-stopDelta
5h 07mGSP-MDW
6/17Tue
multi-stopDelta
6h 14mMDW-GSP
$351
6/14Sat
multi-stopUnited Airlines
4h 41mCAE-ORD
6/21Sat
nonstopUnited Airlines
2h 05mORD-CAE
$359
6/17Tue
multi-stopSouthwest
5h 30mGSP-ORD
6/20Fri
multi-stopSouthwest
7h 10mORD-GSP
$360
6/15Sun
nonstopUnited Airlines
2h 20mCAE-ORD
6/21Sat
nonstopUnited Airlines
2h 05mORD-CAE
$370
6/14Sat
multi-stopSouthwest
10h 05mGSP-ORD
6/17Tue
multi-stopSouthwest
5h 40mORD-GSP
$383

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Everything you need to know for your flight to Indiana

Cabin class types available on flights to South Carolina

Cabin classes available on flights to South Carolina. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.

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