SFO - SCL

$353 Find Cheap Flights from San Francisco to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to Santiago departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Francisco to Santiago.
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Francisco to Santiago.
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Everything you should know

Cheapest round-trip
$635
Typical prices: $872-$681
LATAM Airlines
Mon 9/7Mon 9/21
SFO - SCL • 1 stop
Cheapest one-way
$353
Typical prices: $408-$443
Multiple Airlines
Mon 10/5
SFO - SCL • 3 stops
Top airlines
Cheapest • from $635 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between San Francisco and Santiago. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $945 (round-trip)
Shortest trip • 14h 47m (one-way)
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 4 weeks in advance save around 8% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 19% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from San Francisco to Santiago (SFO-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to Santiago

Mon, Sep 7 - Mon, Sep 21
LATAM Airlines Logo
9:30 am - 5:35 am
SFO
-
SCL
16h 05m
1 stop
LATAM Airlines Logo
11:25 pm - 10:53 am
SCL
-
SFO
15h 28m
1 stop
$635LATAM Airlines
Fri, Aug 21 - Sat, Aug 29
LATAM Airlines Logo
9:30 am - 5:35 am
SFO
-
SCL
17h 05m
1 stop
LATAM Airlines Logo
11:25 pm - 10:49 am
SCL
-
SFO
14h 24m
1 stop
$639LATAM Airlines
Mon, Sep 14 - Sun, Sep 20
LATAM Airlines Logo
7:00 am - 5:35 am
SFO
-
SCL
18h 35m
1 stop
LATAM Airlines Logo
11:25 pm - 3:11 pm
SCL
-
SFO
19h 46m
1 stop
$653LATAM Airlines
Fri, Aug 21 - Sat, Aug 29
LATAM Airlines Logo
11:54 am - 5:35 am
SFO
-
SCL
14h 41m
1 stop
LATAM Airlines Logo
11:25 pm - 10:49 am
SCL
-
SFO
14h 24m
1 stop
$659LATAM Airlines
Mon, Aug 31 - Tue, Sep 29
Copa Airlines Logo
1:12 am - 10:39 pm
SFO
-
SCL
18h 27m
1 stop
Copa Airlines Logo
3:14 am - 11:40 pm
SCL
-
SFO
24h 26m
1 stop
$661Copa Airlines
Tue, Sep 1 - Wed, Sep 30
LATAM Airlines Logo
11:05 am - 5:35 am
SFO
-
SCL
15h 30m
1 stop
LATAM Airlines Logo
6:45 pm - 11:59 am
SCL
-
SFO
21h 14m
2 stops
$662LATAM Airlines
Fri, Aug 21 - Sat, Aug 29
LATAM Airlines Logo
6:50 am - 5:35 am
SFO
-
SCL
19h 45m
1 stop
LATAM Airlines Logo
11:25 pm - 3:50 pm
SCL
-
SFO
19h 25m
1 stop
$663LATAM Airlines
Fri, Aug 21 - Sun, Aug 30
LATAM Airlines Logo
9:30 am - 5:35 am
SFO
-
SCL
17h 05m
1 stop
LATAM Airlines Logo
12:40 am - 7:24 pm
SCL
-
SFO
21h 44m
2 stops
$664LATAM Airlines
Tue, Sep 1 - Wed, Sep 30
LATAM Airlines Logo
6:00 am - 5:35 am
SFO
-
SCL
20h 35m
2 stops
LATAM Airlines Logo
7:50 am - 11:12 pm
SCL
-
SFO
19h 22m
2 stops
$666LATAM Airlines
Mon, Nov 9 - Wed, Dec 9
LATAM Airlines Logo
8:55 am - 5:35 am
SFO
-
SCL
15h 40m
1 stop
LATAM Airlines Logo
7:45 am - 11:11 pm
SCL
-
SFO
20h 26m
2 stops
$668LATAM Airlines
Booking Insights

KAYAK's insights & trends for San Francisco to Santiago flights

Get data-powered insights and trends into flights from San Francisco to Santiago to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from San Francisco to Santiago?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from San Francisco to Santiago departing in September.

What is the cheapest month to fly from San Francisco to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to Santiago is January, where tickets cost $666 (return) on average. On the other hand, the most expensive months are May and April, where the average cost of round-trip tickets is $1,045 and $985 respectively.

How far in advance should I book a flight from San Francisco to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to Santiago, you should book around 4 weeks before departure, which saves you about 8% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 25 weeks before departure.

Good to know

Low seasonSeptember
Cheapest flight$353
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly with an average 10% increase in price.
Flight from San Francisco to Santiago

When to book flights from San Francisco to Santiago

Are your dates flexible? Find out the best times to travel from San Francisco to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from San Francisco to Santiago

  • Do I need a visa to fly from San Francisco to Santiago?

    A visa is not one of the mandatory requirements for US citizens traveling to Chile as long as the trip doesn’t exceed 90 days. If so, you will have to visit the Chilean Embassy for further inquiry. You will also need your passport which should be valid up to the point of planned departure from Chile.

  • Which airlines fly directly from San Francisco to Santiago?

    At the moment, there aren’t any airlines flying directly from San Francisco to the city center. Travelers will have to deal with at least one layover during the trip. The most popular layover option for this trip is Los Angeles International Airport which is used by Delta and LATAM Airlines. Other options include Houston when flying with United Airlines and Panama City when flying with Copa Airlines.

  • Is public transport available from Santiago International Airport to the city center?

    The only public transport option available from Santiago International Airport to the city center is the bus service. It runs 24/7 at intervals of 20 minutes during the day and an hour after midnight. The bus connects Santiago Airport to Santiago Central Station although you can disembark at any of the prior stops if it is convenient for you. An alternative to using the bus is getting a taxi from the airport. Although more expensive, it is significantly more convenient and safer than public transport.

  • With which airline should I book a solo ticket for my child?

    LATAM Airlines has an unaccompanied minor service that allows children to fly unaccompanied on international flights. The service is mandatory for children between ages 8 and 12 and only optional for children older than that. With this service, you as the parent can have confidence in the safety of your child as they will have a crew member looking after your child for the whole trip including through immigration and security control.

  • What is the cheapest flight from San Francisco to Santiago?

    In the last 7 days, the lowest price for a flight from San Francisco to Santiago was $353 for a one-way ticket and $635 for a round-trip.

  • Do I need a passport to fly between San Francisco and Santiago?

    Yes

  • Which airports will I be using when flying from San Francisco to Santiago?

    San Francisco and Santiago are both served by 1 main airport. You will leave San Francisco from San Francisco and will be arriving at Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from San Francisco to Santiago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from San Francisco to Santiago?

    SkyTeam, oneworld, and Star Alliance are the airline alliances operating flights between San Francisco and Santiago, with SkyTeam being the most commonly used for this route.

  • What is the most popular layover when flying to Santiago from San Francisco?

    Houston is the most popular layover city among KAYAK users traveling from San Francisco to Santiago.

  • Which is the best airline for flights from San Francisco to Santiago, Delta or Copa Airlines?

    The two airlines most popular with KAYAK users for flights from San Francisco to Santiago are Delta and Copa Airlines. With an average price for the route of $888 and an overall rating of 7.9, Delta is the most popular choice. Copa Airlines is also a great choice for the route, with an average price of $848 and an overall rating of 7.5.

  • How does KAYAK find such low prices on flights from San Francisco to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to San Francisco with another airline. Booking your flights between San Francisco and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from San Francisco to Santiago

  • San Jose Mineta International Airport (SJC) is an alternative for anyone looking for a different departure airport to San Francisco International Airport (SFO). The airport is about 40 miles away from the Bay area and is less busy compared to SFO meaning shorter queues.
  • If you’re looking for a sustainable airline to fly from San Francisco to Santiago (SCL), Delta Air Lines is a great option. They recently invested close to $1 billion over the next decade towards projects that reduce carbon emissions and advance clean air technologies.
  • When booking an economy class ticket with Delta, the main cabin option comes with more privileges. You get the option of advanced seat selection and you are eligible for an upgrade to first class by adding a small charge instead of paying the full amount for First class tickets.
  • LATAM Airlines offers a lot more amenities on its economy cabin compared to any other airline serving the route. They have free Wi-Fi, power outlets, seatback on-demand TV, and a free snack for your flight.
  • The Bay Area Rapid Transit offers a great commuter option to San Francisco International Airport from downtown San Fran. It is especially convenient when Bay Area traffic is a big problem during rush hours.

Reviews of the top 5 airlines serving from San Francisco to Santiago

 
See real verified KAYAK customer reviews for airlines flying from San Francisco to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from San Francisco to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8428 reviews
7.8Entertainment
7.2Food
8.1Boarding
8.5Crew
7.8Comfort
Airline reviews

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

10.0 ExcellentTeresa, Apr 2026
SMF - LAX
Read more Delta reviews

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

N Everything was perfect from boarding to assistance to baggage in Tampa

Loved the crew! Sucks that we went from 1 hour and 8 minute layover to a 3 hour layover. But weather sucks like that.

Fast, lovely scenery, great info on the Delta flight screen about landmarks we were flying over. Great landing!

Long flight but comfortable and not freezing as I have experienced on Hawaiian flights to the islands. They gave us blankets just in case. Nice touch.

I took seat 15A in anticipation of window seat, there is no window.

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

I had to run from the end of terminal one to the end of terminal two to make the connecting flight....probably a kilometer. No electric carts were available. I'm 76 and literally had to run to make the connection at the last minute. The connecting time was absolutely unrealistic. When Last Call was announced, I tried to get other Copa gate staff to call Gate 221 to let them know I was on my way, but they said no. I came within 1 minute of missing the flight.

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

Boarding was confusing from staff telling going to preboard and than to group 1 Airplane was not cooling at the beginning

Copa staff at PTY and one particular crew member were unhelpful & rude.

Horrible. No TV or any type of entertainment on board. Passwnger listening to/watching stuff on their own phone with no headphones making it noise and uncomfortable for everyone else, little/tiny food portions, old seats, useless wifi (cant access anything). Horrible exlerience especially it was a lomg distance flight with kids.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Easy of boarding, helpfully staff at check in, surprisingly comfortable seating

Lost of requested seat assignments. Lost my husband's meal choice

My service dog and I were asked to deplane just before they closed the door - clearly very last minute they couldn’t find the documentation that I have filled out many many times before that is for flying service animals. I purposely purchase 3seats (a whole row) since he is large and not all passengers want to sit next to a dog on a cross country flight. The plane departed with my husband on it!!! They made me fill out a hard copy of the same form and had to reschedule me on a later flight where they could find 3 seats together!! I’ve done this so many times before - clearly the error was on their part in a technology glitch - but really people - do better!! Very traumatic - and my husband had to wait for us when he landed ….so bad. Poor pup was confused and tired.

My flight time was changed without any notification to me which ruined my time sensitive plans so I ended up completely changing my travel plans and no reimbursement.

No screens or meal options. Freezing cold. Dirty seats. Left late.

I liked that my son and I were reseated next to each other (we had different bookings). I liked that it was a directg flight and mostly on time. I liked that you provided pillows and blankets. Flight attendants were generally courteous. The messaging through wifi did not work well. The food was not good. Seats are very narrow and I felt slightly claustraphobic in the window seat.

Some crew were unfriendly or in some cases just straight up rude.

Outstanding service, efficient & friendly crew, flight was safe, comfortable & on time

United Airline crews were very friendly and very attentive. 12 hours flight was gone like in a shorter one.

Flight itself excellent, but delayed so missed connection & got to destination 2 hrs later

It's a long flight and that is always difficult. I was comfortable and well. The movies available were great and the crew was good.

Premium Economy Good crew, good service, excellent food. Seat back screen just not bright enough.

The crew was very attentive through out the flight. Seats were comfortable, nice flight bag with pillow and blanket. Food was okay, since it was a overnight flight seemed to go by fast.

Left early arrived early..right amount of talking from pilots..of course had to love the biscuit and water!

Boarding gate at LAX was too crowded—two gates next to one another

On time departure and early arrival. Flight attendant very nice.

The business class layout of chairs was weired. You are sitting directly across stranger.,

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

Friendly crew is the only nice thing. Seats uncomfortable. Food and snacks horrible. Movies were the same as the first 10 hour flight two weeks before

Was not able to do a online check-in because the American Airlines system doesn't store our visa or other passport information, allowing us to have a trouble-free check-in. We were forced to have to check-in at the counter which Changes are upgrade status given that we were not able to check in much earlier.

Everything you need to know for your flight from San Francisco to Santiago

Information on your arrival and departure airports