$109 Find Cheap Flights from Santa Ana to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Missouri departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Ana to Missouri.
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Ana to Missouri.
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Flight Deals

Cheap Flights from Santa Ana to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis1 stop$210
Kansas City
Kansas City1 stop$235
Springfield
Springfield1 stop$349
Columbia
Columbia2 stops$429
Joplin
Joplin1 stop$424
Kirksville
Kirksville2 stops$750
St. Louis
St. Louis1 stop$210
Kansas City
Kansas City1 stop$235
Springfield
Springfield1 stop$349
Columbia
Columbia2 stops$429
Joplin
Joplin1 stop$424
Kirksville
Kirksville2 stops$750

Book Cheap Santa Ana to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Missouri

Thu, Apr 16 - Thu, Apr 23
Frontier Logo
7:56 pm - 9:10 pm
SNA
-
STL
23h 14m
1 stop
Frontier Logo
9:55 pm - 5:56 pm
STL
-
SNA
22h 01m
1 stop
$210Frontier
Thu, May 7 - Sun, May 10
Frontier Logo
8:14 pm - 8:23 pm
SNA
-
STL
22h 09m
1 stop
Frontier Logo
12:16 pm - 12:19 pm
STL
-
SNA
26h 03m
1 stop
$230Frontier
Tue, Apr 7 - Tue, Apr 14
Spirit Airlines Logo
6:45 am - 5:09 pm
SNA
-
MCI
8h 24m
1 stop
Spirit Airlines Logo
6:04 pm - 9:13 pm
MCI
-
SNA
5h 09m
1 stop
$235Spirit Airlines
Thu, Apr 16 - Thu, Apr 23
Multiple Airlines Logo
7:30 am - 9:00 pm
SNA
-
STL
11h 30m
1 stop
Multiple Airlines Logo
8:06 pm - 10:44 am
STL
-
SNA
16h 38m
1 stop
$244Multiple Airlines
Sat, Apr 11 - Mon, Apr 13
Spirit Airlines Logo
6:45 am - 5:09 pm
SNA
-
MCI
8h 24m
1 stop
Spirit Airlines Logo
6:04 pm - 9:13 pm
MCI
-
SNA
5h 09m
1 stop
$249Spirit Airlines
Wed, Aug 26 - Sun, Aug 30
American Airlines Logo
2:29 pm - 10:11 pm
SNA
-
SGF
5h 42m
1 stop
American Airlines Logo
6:00 am - 9:46 am
SGF
-
SNA
5h 46m
1 stop
$349American Airlines
Wed, Aug 26 - Sun, Aug 30
American Airlines Logo
1:45 pm - 11:58 pm
SNA
-
SGF
8h 13m
1 stop
American Airlines Logo
6:00 am - 9:46 am
SGF
-
SNA
5h 46m
1 stop
$369American Airlines
Thu, Apr 23 - Sat, May 2
United Airlines Logo
2:40 pm - 12:36 am
SNA
-
SGF
7h 56m
1 stop
United Airlines Logo
6:00 am - 2:22 pm
SGF
-
SNA
10h 22m
2 stops
$377United Airlines
Wed, Aug 26 - Sun, Aug 30
Delta Logo
12:20 pm - 10:29 pm
SNA
-
SGF
8h 09m
1 stop
Delta Logo
11:40 am - 6:20 pm
SGF
-
SNA
8h 40m
1 stop
$404Delta
Thu, Apr 23 - Tue, Apr 28
United Airlines Logo
7:00 am - 4:26 pm
SNA
-
SGF
7h 26m
1 stop
United Airlines Logo
2:52 pm - 9:45 pm
SGF
-
SNA
8h 53m
1 stop
$421United Airlines
Booking Insights

KAYAK's insights & trends for Santa Ana to Missouri flights

Get data-powered insights and trends into flights from Santa Ana to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Santa Ana to Missouri?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Missouri, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santa Ana to Missouri is October, when tickets cost $326 (return) on average. On the other hand, the most expensive months are March and January, when the average cost of round-trip tickets is $520 and $503 respectively.

Good to know

Low seasonAugust
Cheapest flight$109
Best time to beat the crowds with an average 9% drop in price.
Most popular time to fly and prices are also 15% lower on average.
Flight from John Wayne (Santa Ana) to Kansas City

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from Santa Ana to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Santa Ana to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4324 reviews
7.5Entertainment
8.0Comfort
7.0Food
8.1Boarding
8.6Crew
Airline reviews

Boarding was easy. The seats are small and fairly uncomfortable

8.0 ExcellentNicole, Mar 2026
LGB - OAK
Read more Southwest reviews

Boarding was easy. The seats are small and fairly uncomfortable

The problem with the seat assignments is that there were a lot of rows in the front that were empty but my row at the back was full. Just not so pleasant.

Good but I prefer choose your own seat. With the new assigned seats they should board from the back I see no advantage to this new boarding. Just like every other airline

Flight boarded late after announcing on time boarding. Flight arrived only a little late despite late departure. Had trouble connecting to WiFi

I have not flown Southwest in awhile and had a very pleasant experience. From ticketing to boarding to the flight. The flight left on time and landed ahead of schedule. It won't be so long next time!!

The Southwest experience has definitely taken a dive from its early days. You can no longer deferentiate from other airlines. Air travel is too expensive. Southwest is no longer budget friendly. They have lost me as a loyal customer.

The charges were ridiculous for an hour flight and the turbulence was very scary.

The seats are now more narrow. I paid for front row the seats in the front are even more narrow than before.

The wifi on the plane is great. The only issue that I have is that I prefer an aisle seat and on my trips this week, I was either in the middle or window. If we can work to secure aisle seating, I will be thrilled. Nice trip.

Everything went smoothly and we even arrived a little bit early.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

The crew, and fellow passengers, were super gracious and kind. There seemed to be plenty of bin space even though the plane was full. It’s nice to get a glass of wine with dinner in Premiere seating, and there was a lot of food.

Everything I mentioned earlier - the airbus was more comfortable indeed and the experience was further enhanced.

The plane was an older model, so it wasn’t as comfortable as others. The flight attendants were not helpful during onboarding. It was a full flight so there was chaos finding space for baggage.

Awesome! On time flight, early arrival, and a complimentary upgrade!

We departed early and made up time in the air allowing us to arrive 30 minutes early. Capt was incredibly genuine and thanked every passenger for flying with Delta. Completely humble and professional!

Delta One is extraordinary. I fly business when somebody hires me. I just wonder why there is such a chasm between business class and the insanely inhumane and nonsensical coach. The seats are not large enough to fit even my tiny wife. We fly 10% of what we did because we don’t want to pay 5-10 k but for $400 it’s unbearable. It seems like the accountants took over and made stupid decisions. Screw in 20 extra seats and make it so unbearable that people fly 90% less. Just put the damn price up and put some proper chairs in. But business, yay.

Delta’s staff is unmatched. From the gate agents, to the pilots, to the flight attendants… all top of the industry.

OK, we were delayed and had to de plane and reboard.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Complimentary light meal would be appreciated. But great flight crew service on all legs

Flight delayed for more than 16 hrs and no effort was spent to provide an alternate

Women boarding passengers at the gate was absolutely rude and disrespectful of passengers. The flight attendant was absolutely delightful! Smiling and connected with the passengers. So happy. The seats are cramped and uncomfortable but I guess that’s just the way it is Communication regarding flight was excellent

Airport terminal was outdated, flight was on a small jet with no wifi

it was a very short flight so my expectations were low.

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Crew was great (professional, attentive, prompt). Snacks for 4 hrs flight is deplorable.

Not good. One of my luggage is missing. And until now they can’t find it

My 9:50AM flight was delayed to 3:40PM "due to incoming aircraft delay". No aircraft is "delayed" that long. Found out once we did board (after several changes in times) that the aircraft had a maintenance issue and we had to wait for another aircraft. Just tell us that. The aircraft we did get was old and the seats need to be updated. I have been traveling for several weeks with AA and you should refresh your entertainment content as frequent flyers have gone through most of your new content. I have Celiac and a shellfish allergy and continue to have struggles with meals on business and first class flights. Please keep this in mind. Sorry - was a long travel day yesterday and a bit cranky this morning with my experience comments. Still an AA fan.

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

Dloght delayed by 2.5 hrs . Common theme in my last four american floghts

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

My seat was assigned last row behind restrooms No legroom’s I’m very Pettit Still was not comfortable Food choice was excellent

The chicken wrap was tiny ($13 for what looked like a 1/3 of a normal wrap?) and disgusting.

Mediocre would be best description. Food bland. Seat biz class uncomfortable to sleep. Crew never dimmed lights completely in an overnight flight to Europe. Would avoid AA if possible.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Massimo, flight attendant was very authentic, attentive - wonderful. Food/wrap was just okay.

My flight was delayed by over an hour and the turbulance was horrible.

I was double booked for my ticket- they have record of it and admitted to their error but wouldn’t let me board until I paid once again for the fare- have documentation of their mistake -

I cannot effectively rate the food and drink as I had not. Otherwise, the trip was fine. The seats were nice, the crew was fine. They could smile once in a while. They all look like they were mad.

Flight out was great but this flight was canceled and nothing was available for 2 days after this so I had to purchase an expensive ticket from another airline so I could go home. The flight cancellation was said to be a crew issue, it wasn’t weather or maintenance.

They cancelled the flight due to crew unavailability. The next day they cancelled the flight again.

For the price of the fare, there really isn’t much to complain about.

A Spirit agent caused me to miss my flight. The company has not responded for request of refund. Stay away from Spirit.

I arrived two hours early, and at 9:20 I was still queuing for security.

Got to LAX at 3:20 am, the counter personnel did not start to check in bags till 3:40 am. I patiently waited at the priority check in line as they started to take people from the general line. After about 15 minutes of waiting, I approached the lady exactly in front of the priority line and asked her if they would be taking people from the priority line or if I would need to switch to waiting in the general line. She responded “yes”, I then asked her yes to what? And she yelled back at me loudly “I SAID YES!” Needless to say, I waited at the end of the line of the general line. I could have been told the priority line would not be called upon and could have queued in the general line ahead of many people that arrived to cue after I did

Terrible they canceled the flight very sheepishly and ended up costing me 1200 dollars and kayak and xcover are doing nothing

Everything you need to know for your flight from Santa Ana to Missouri

Information on your arrival and departure airports