$211 Find Cheap Flights from Santa Ana to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to South America departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from Santa Ana to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima3 stops$743
Bogotá
Bogotá2 stops$413
Santiago
Santiago1 stop$1,145
Cartagena
Cartagena2 stops$687
Quito
Quito1 stop$697
Guayaquil
Guayaquil2 stops$679
Cali
Cali2 stops$577
Cusco
Cusco2 stops$1,481
Georgetown
Georgetown2 stops$862
Barranquilla
Barranquilla3 stops$674
Lima
Lima3 stops$743
Bogotá
Bogotá2 stops$413
Santiago
Santiago1 stop$1,145
Cartagena
Cartagena2 stops$687
Quito
Quito1 stop$697
Guayaquil
Guayaquil2 stops$679
Cali
Cali2 stops$577
Cusco
Cusco2 stops$1,481
Georgetown
Georgetown2 stops$862
Barranquilla
Barranquilla3 stops$674

Book Cheap Santa Ana to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to South America

Fri, Apr 10 - Mon, Apr 13
Spirit Airlines Logo
2:53 pm - 1:11 pm
SNA
-
BOG
20h 18m
2 stops
Spirit Airlines Logo
2:10 pm - 9:53 am
BOG
-
SNA
21h 43m
2 stops
$413Spirit Airlines
Thu, Apr 9 - Mon, Apr 13
Spirit Airlines Logo
2:53 pm - 1:11 pm
SNA
-
BOG
20h 18m
2 stops
Spirit Airlines Logo
2:10 pm - 9:53 am
BOG
-
SNA
21h 43m
2 stops
$451Spirit Airlines
Fri, Apr 10 - Mon, Apr 13
Multiple Airlines Logo
2:53 pm - 12:21 am
SNA
-
MDE
31h 28m
3 stops
Multiple Airlines Logo
7:00 am - 9:53 am
MDE
-
SNA
28h 53m
3 stops
$521Multiple Airlines
Fri, May 1 - Fri, May 15
Multiple Airlines Logo
4:23 pm - 1:10 pm
SNA
-
MDE
18h 47m
2 stops
Multiple Airlines Logo
2:10 pm - 10:49 am
MDE
-
SNA
22h 39m
2 stops
$524Multiple Airlines
Sat, Apr 11 - Fri, Apr 17
American Airlines Logo
8:17 am - 10:38 pm
SNA
-
BOG
12h 21m
1 stop
American Airlines Logo
12:25 am - 10:08 am
BOG
-
SNA
11h 43m
1 stop
$556American Airlines
Sat, Apr 11 - Fri, Apr 17
American Airlines Logo
9:30 am - 10:38 pm
SNA
-
BOG
11h 08m
1 stop
American Airlines Logo
12:25 am - 3:30 pm
BOG
-
SNA
17h 05m
2 stops
$561American Airlines
Tue, Aug 18 - Fri, Aug 28
United Airlines Logo
8:00 am - 9:10 pm
SNA
-
MDE
11h 10m
1 stop
United Airlines Logo
9:45 am - 9:01 am
MDE
-
SNA
25h 16m
2 stops
$622United Airlines
Tue, Aug 18 - Fri, Aug 28
United Airlines Logo
8:00 am - 9:10 pm
SNA
-
MDE
11h 10m
1 stop
United Airlines Logo
9:45 am - 11:17 am
MDE
-
SNA
27h 32m
1 stop
$630United Airlines
Mon, May 4 - Thu, May 14
Delta Logo
9:20 pm - 6:50 am
SNA
-
SCL
30h 30m
2 stops
Delta Logo
8:40 pm - 9:17 pm
SCL
-
SNA
27h 37m
2 stops
$1,150Delta
Mon, May 4 - Thu, May 14
Delta Logo
6:45 am - 7:15 am
SNA
-
SCL
21h 30m
1 stop
Delta Logo
8:40 pm - 10:29 pm
SCL
-
SNA
28h 49m
1 stop
$1,162Delta
Booking Insights

KAYAK's insights & trends for Santa Ana to South America flights

Get data-powered insights and trends into flights from Santa Ana to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Santa Ana to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santa Ana to South America is February, when tickets cost $645 (return) on average. On the other hand, the most expensive months are January and August, when the average cost of round-trip tickets is $1,921 and $1,496 respectively.

Good to know

Low seasonAugust
Cheapest flight$211
Best time to beat the crowds but there is an average 20% increase in price.
Most popular time to fly with an average 26% increase in price.
Flight from John Wayne (Santa Ana) to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Santa Ana to South America

 
Need help choosing which airline to fly with from Santa Ana to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8288 reviews
7.8Entertainment
7.2Food
8.1Boarding
8.5Crew
7.9Comfort
Airline reviews

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

2.0 MediocreIsabella, Mar 2026
SJC - SLC
Read more Delta reviews

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

The crew, and fellow passengers, were super gracious and kind. There seemed to be plenty of bin space even though the plane was full. It’s nice to get a glass of wine with dinner in Premiere seating, and there was a lot of food.

Everything I mentioned earlier - the airbus was more comfortable indeed and the experience was further enhanced.

The plane was an older model, so it wasn’t as comfortable as others. The flight attendants were not helpful during onboarding. It was a full flight so there was chaos finding space for baggage.

Awesome! On time flight, early arrival, and a complimentary upgrade!

It was nt delta. It was aeromexo. Service was awful. They served a very small drink and NO snack for a 3hr and 35min flight. Then for the first 30 min of the flight is was talk and talk over head interruption the movie/ show i picked to watch.

Delta One is extraordinary. I fly business when somebody hires me. I just wonder why there is such a chasm between business class and the insanely inhumane and nonsensical coach. The seats are not large enough to fit even my tiny wife. We fly 10% of what we did because we don’t want to pay 5-10 k but for $400 it’s unbearable. It seems like the accountants took over and made stupid decisions. Screw in 20 extra seats and make it so unbearable that people fly 90% less. Just put the damn price up and put some proper chairs in. But business, yay.

Delta’s staff is unmatched. From the gate agents, to the pilots, to the flight attendants… all top of the industry.

The flight was delayed for about 2 hrs. Other than it, it was good.

The 777’s economy seat’s legroom was more tolerable than expected. I appreciate the reclining mechanism which slides the seat forward to minimize cannibalizing the space behind. The food was terrible: very salty.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Complimentary light meal would be appreciated. But great flight crew service on all legs

Flight delayed for more than 16 hrs and no effort was spent to provide an alternate

We had turbulence ever 1/2 hr or so and the captains announcements were SOOOO LOUD

Women boarding passengers at the gate was absolutely rude and disrespectful of passengers. The flight attendant was absolutely delightful! Smiling and connected with the passengers. So happy. The seats are cramped and uncomfortable but I guess that’s just the way it is Communication regarding flight was excellent

it was a very short flight so my expectations were low.

Entertainment kept turning itself off. Gave up on watching a movie.

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

Dloght delayed by 2.5 hrs . Common theme in my last four american floghts

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

My seat was assigned last row behind restrooms No legroom’s I’m very Pettit Still was not comfortable Food choice was excellent

The worst Airline ever. They centered my second flight and leave me in NY. They don’t have any representatives at the airport and they don’t respond to calls. Basically I got stuck. I will never purchase through there again.

The chicken wrap was tiny ($13 for what looked like a 1/3 of a normal wrap?) and disgusting.

Mediocre would be best description. Food bland. Seat biz class uncomfortable to sleep. Crew never dimmed lights completely in an overnight flight to Europe. Would avoid AA if possible.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Massimo, flight attendant was very authentic, attentive - wonderful. Food/wrap was just okay.

Experience was great. The best part is the free Wi-Fi connection which helps me to work on the flight

Everything you need to know for your flight to South America

Information on your arrival and departure airports