$296 Find Cheap Flights from John Wayne (Santa Ana) to South America - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Santa Ana to South America

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Sort by: Cheapest
Cartagena, Colombia
9h 21m2 stops
from $606per person
Quito, Ecuador
9h 19m2 stops
from $673per person
Lima, Peru
12h 40m2 stops
from $780per person
Santa Cruz de la Sierra, Bolivia
15h 27m4 stops
from $786per person
Georgetown, Guyana
12h 20m2 stops
from $960per person
Sao Paulo, Brazil
14h 08m2 stops
from $1,016per person
Santiago, Chile
13h 25m2 stops
from $1,044per person
Buenos Aires, Argentina
14h 09m2 stops
from $1,148per person
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Booking Insights

KAYAK's insights & trends for Santa Ana to South America flights

Get data-powered insights and trends into flights from Santa Ana to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from John Wayne (Santa Ana) to South America?

The cheapest month for flights from John Wayne (Santa Ana) to South America is April, when tickets cost $0 (return) on average. On the other hand, the most expensive months are June and October, when the average cost of round-trip tickets is $1,785 and $1,462 respectively.

Good to know

Cheapest flight

$296
Flight from John Wayne (Santa Ana) to Quito

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Santa Ana to South America

 
Need help choosing which airline to fly with from Santa Ana to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 10215 reviews
7.3Comfort
8.1Crew
7.1Entertainment
6.7Food
7.7Boarding
Airline reviews

Food was very bad Crew was not so welcoming. Chairs was so uncomfortable

2.0 MediocreAnonymous, Sep 2026
Read more United Airlines reviews

Food was very bad Crew was not so welcoming. Chairs was so uncomfortable

Flight was on time, clean, etc. Despite connecting to your wi fi I was unable to use your app to watch entertainment.

The business class had to wait to board last. Unacceptable

The air hostess was excellent. I have taken so many flight domestic and international, this is the first time the air hostess was so caring. She was a delight

Return Premium Economy section to the smaller section with comfortable seats. Add internet, upgrade the meals, and upgrade/update the Movies and Music onboard.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Very poor the plane itself was really old, slight smell that couldn’t be named. I didn’t even get a boarding pass UNTIL AFTER clearing security! Even then, they said when I get to my connected flight I’ll get my 2nd boarding pass there! A bit ridiculous!

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

the head jack on my seat didn't work and the power outlet didn't work for my seat

Had to pay for WiFi, delayed start, and sat on the runway forever.

British Airways canceled our original flight and rebooked us on Air Canada one day later. As a result, we lost one day of our Geneva trip and incurred financial losses for a prepaid hotel night and a day trip that we were unable to use.

On time and stellar premium class service. Not liking non LCD display in seat backs - miss the convenience of not using your own device.

The WiFi didn’t work entire flight, couldn’t watch a movie. The recline button didn’t work

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

The flight encountered a delay exceeding 4 hours. The food voucher issued was valued at $12, insufficient to cover our meal expenses. Consequently, I was unable to take my medication, leading to a drop in blood sugar levels and exacerbating my anxiety.

Flights were on time. That's the main consideration since I had to change planes. The entertainment was whatever you bring with you and the food (in Economy) is non-existant. Neither of those was a surprise.

The gate crew did try to help, however they lacked the information as to whether the flight will operate or not. Being delayed 6 hours and in a limbo on whether the flight will operate or not is not fun. The airline having staffing issues is not encouraging at all.

Flight was delayed and missed connecting flight. Did not give warning about delay until we showed up at the airport. Not good.

I love to be able to connect my own devices to the entertainment system. It works great!

More options for your flight to South America

Complete your trip to South America with a hotel stay or car rental