$138 Find Cheap Flights from Santa Ana to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to South America departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Best South America Flight Deals from Santa Ana

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Lima
Lima1 stop$656
Bogotá
Bogotá2 stops$323
Cartagena
Cartagena2 stops$527
Santiago
Santiago2 stops$1,004
Quito
Quito2 stops$727
Cali
Cali2 stops$631
Guayaquil
Guayaquil2 stops$576
Cusco
Cusco2 stops$2,022
Georgetown
Georgetown1 stop$800
Barranquilla
Barranquilla2 stops$563
Lima
Lima1 stop$656
Bogotá
Bogotá2 stops$323
Cartagena
Cartagena2 stops$527
Santiago
Santiago2 stops$1,004
Quito
Quito2 stops$727
Cali
Cali2 stops$631
Guayaquil
Guayaquil2 stops$576
Cusco
Cusco2 stops$2,022
Georgetown
Georgetown1 stop$800
Barranquilla
Barranquilla2 stops$563

Cheap Flights from Santa Ana to South America

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.

Recent round-trip flight deals from Santa Ana to South America

Recommended round-trip deals departing in the coming months from the most popular airlines that fly from Santa Ana to South America.
Discover the best prices for you by selecting your travel dates on KAYAK.
Spirit Airlines Logo
4:27 pm - 1:05 pmSNA-BOG
18h 38m2 stops
Spirit Airlines Logo
2:07 pm - 10:52 amBOG-SNA
22h 45m2 stops
$323Spirit Airlines
Find Deal
Thu, May 22 - Fri, May 30
Spirit Airlines Logo
6:45 am - 1:05 pmSNA-BOG
28h 20m2 stops
Spirit Airlines Logo
2:00 pm - 11:50 amBOG-SNA
23h 50m2 stops
$332Spirit Airlines
Find Deal
Thu, May 22 - Tue, Jun 17
 Logo
6:45 am - 11:47 pmSNA-MDE
39h 02m3 stops
 Logo
2:13 pm - 10:52 amMDE-SNA
22h 39m2 stops
Mon, Jun 2 - Fri, Jun 6
United Airlines Logo
12:08 pm - 4:54 amSNA-BOG
14h 46m1 stop
United Airlines Logo
12:14 am - 8:43 pmBOG-SNA
22h 29m2 stops
$513United Airlines
Find Deal
Wed, Oct 8 - Fri, Oct 24
United Airlines Logo
11:30 am - 4:54 amSNA-BOG
15h 24m2 stops
United Airlines Logo
12:14 am - 12:44 pmBOG-SNA
14h 30m2 stops
$517United Airlines
Find Deal
Wed, Oct 8 - Fri, Oct 24
 Logo
3:00 pm - 5:20 pmSNA-GYE
24h 20m2 stops
 Logo
4:15 am - 10:00 pmGYE-SNA
19h 45m2 stops
Thu, May 29 - Thu, Jun 5
American Airlines Logo
6:47 pm - 11:20 amSNA-BOG
14h 33m2 stops
American Airlines Logo
12:25 am - 9:18 amBOG-SNA
10h 53m1 stop
$582American Airlines
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Sat, Aug 2 - Fri, Aug 8
American Airlines Logo
6:53 pm - 10:30 pmSNA-BOG
25h 37m1 stop
American Airlines Logo
12:25 am - 10:33 amBOG-SNA
12h 08m1 stop
$588American Airlines
Find Deal
Sat, Aug 2 - Fri, Aug 8
LATAM Airlines Logo
6:45 am - 7:18 pmSNA-BOG
10h 33m1 stop
LATAM Airlines Logo
9:00 am - 10:08 pmBOG-SNA
15h 08m1 stop
$653LATAM Airlines
Find Deal
Thu, Jul 24 - Thu, Jul 31
LATAM Airlines Logo
6:45 am - 7:18 pmSNA-BOG
10h 33m1 stop
LATAM Airlines Logo
10:15 am - 10:08 pmBOG-SNA
13h 53m2 stops
$657LATAM Airlines
Find Deal
Thu, Jul 24 - Thu, Jul 31
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KAYAK's insights & trends for Santa Ana to South America flights

Get data-powered insights and trends into flights from Santa Ana to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Santa Ana to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santa Ana to South America is November, when tickets cost $622 (return) on average. On the other hand, the most expensive months are August and January, when the average cost of round-trip tickets is $1,558 and $1,152 respectively.

What’s the cheapest day of the week to fly from John Wayne (Santa Ana) to South America?

The average price of all round-trip flights from Santa Ana to South America clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to South America on a Monday and more expensive on a Tuesday. On your return trip to John Wayne (Santa Ana), you should consider flying back on a Saturday, and avoid Wednesdays for better deals.


Good to know

Low seasonAugust
High seasonApril
Cheapest flight$138
Best time to beat the crowds with an average 0% drop in price.
Most popular time to fly with an average 15% increase in price.
Flight from John Wayne (Santa Ana) to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the afternoon, when round-trip flights cost $773 on average. The most expensive time of day to fly to South America is generally in the morning, which is peak travel time and where the average cost of a ticket is $900.

Top 3 airlines serving from Santa Ana to South America

Need help choosing which airline to fly with from Santa Ana to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1767 reviews
7.4Comfort
7.6Boarding
7.0Entertainment
6.7Food
8.1Crew
Airline reviews

We departed and landed on time, the aircraft was clean and comfortable, the crew were lovely. Online checkin worked well and the self service bag drop at the airport worked well. The a/c was an Airbus A330 and has been fitted with a good entertainment system with lots of choice in many languages. The price I paid for the flight was competitive with other airlines apart from the budget carriers, none of whom I was familiar with so I stuck to an airline I have used in previous visits to South America.

8.0 ExcellentPaul, Apr 2025BOG - SCL
Read more LATAM Airlines reviews

We departed and landed on time, the aircraft was clean and comfortable, the crew were lovely. Online checkin worked well and the self service bag drop at the airport worked well. The a/c was an Airbus A330 and has been fitted with a good entertainment system with lots of choice in many languages. The price I paid for the flight was competitive with other airlines apart from the budget carriers, none of whom I was familiar with so I stuck to an airline I have used in previous visits to South America.

We didn’t have any entertainment. I tried to go online without success. The airplane was extremely cold and they didn’t have blankets.

It was good, however the airplane was really cold. We received snacks and the crew was friendly.

Delta has an outstanding service. They are courteous and punctual most of the time. The flight departed a half hour late but we arrived 15 minutes early.

Not sure why there are so many security checks at this airport. Consistently annoying showing passport over and over, checking carryons at gate all the while trying to make tight connection. Basically it was uncomfortable crowded cabin with meidiocre service

Although the flight is goof and the crew is good, the way the airline charges you for every service is ridiculous.

Plane never left the ground. Mech issues - entire trip was rerouted through united.

I liked everything, this was classed as premium economy but it was much better than Lufthansas business class. Lovely staff, comfortable plane and an excellent seat arrangement. A very pleasant surprise.

Everything was good except the check in. Could not do it online neither on the machines in the airport. Needed special assistance from the airline desk clerk

No entertainment but not expected. Unless you are referring to monitor that you can use. Then Al, was fine on all flights.

Everything is good except the dinner and breakfast. The sandwich is very delicious. Toilet is clean, I only use one of them. Flight attendants are very nice. 👍👍

The gate was too far away for the connecting flight

Compared with other carriers business class for an overnight was not worth the extra expense.

Seats were comfortable. It’s was so cold and very uncomfortable. I paid 2000 miles for wifi service that was choppy the whole flight. Would like to be reimbursed for my miles Food was so disappointing. Three cold and terrible meals for $3000 round trip. This needs to be better.

Easy to board. Flight was super crowded though so I didn't sleep well on that cross country red-eye flight. The aisles seem ot have gotten narrower and the seat smaller whn luggage and people are getting bigger so it would be AWESOME to have more space and breathing room in general ;)

Pilot Erika DeLong made us feel safe and at ease in a frankly scary time to be flying. Her warm smile and greeting and excellent command of the aircraft in foggy bumpy weather helped us all to calm our nerves and get us home safely.

Plenty of room for me and the cat in Premium Economy. Seat was comfortable. Boarding was a breeze. The lady at the special check-in desk was great, super helpful and professional.

Smooth flight. As always dinner could have been more generous. Breakfast was great.

AWFUL. I have had the experience of traveling with many airlines across the world, and hands down United Airlines is the worst. Not one flight was on time, and I don’t think I met one crew member or staff member who wasn’t rude.

Old and out of date plane, it seem like every time I fly with united there’s and issue. We were delayed,

Very helpful ground crew after an earlier flight delay and being rebooked on a different flight.

British Airways staff are very polite and willing to help.

The plane was late and then sat on the runway for almost 45 minutes before taking off.

We kept being told that the flight was full and that all overhead compartments were full and therefore had to check in our hand luggage. We were some of the last people to board and noticed that there was still sufficient space in the overhead compartments. We were obliged to check in hand luggage when there was space and so had to wait at luggage retrieval which took a while to then noticed damage to our luggage - not a great experience!

Worst seats I’ve ever had !!! The seats were very narrow and uncomfortable and misaligned with the seats in front of mine leading to bottom of the seat in front of mine pressing on my legs for 15.5 hours !

This was an overnight flight. There was no meal service in first class, just a simple snack basket was offered along with beverages. There should have been some type of continental breakfast prior to arrival in PHL. As an Executive Platinum American Airlines Advantage member, I received no name recognition from the first class flight attendant. When disembarking at PHL, the flight attendants were more interested in their cell phones than saying "thank you" to the passengers as they disembarked.

The flight was quick and to the point. The crew just did their job w/o excessive talking and everything was just perfect.

Awkward carry on process. Forced to check all carry on. No overhead space of worthiness. Left delayed, but made up the time. Crew was amicable.

Amazingly comfy flight - I had upgraded for a reasonable price and it was worth it. The food also was good.

Had to wait on pilot and crew to depart and had to wait to arrive at the gate because they only had 2 crews working. Delays, delays....Planes just keep getting smaller and tighter and they nickle and dime for everything. When will an airline actually wake up and make flying more enjoyable?

Everything you need to know for your flight to South America

Information on your arrival and departure airports

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