$233 Find Cheap Flights from South America to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Francisco departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to San Francisco

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 24% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Useful Info
Flight Deals

Cheap Flights from South America to San Francisco

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South America to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South America to San Francisco

ons., sep. 16 - ons., sep. 30
American Airlines Logo
11:45 pm - 7:16 pm
BOG
-
SFO
21h 31m
1 stop
American Airlines Logo
6:36 am - 10:57 pm
SFO
-
BOG
14h 21m
1 stop
$390American Airlines
ons., sep. 9 - ons., sep. 23
American Airlines Logo
7:00 am - 10:20 pm
BOG
-
SFO
17h 20m
2 stops
American Airlines Logo
6:45 am - 10:57 pm
SFO
-
BOG
14h 12m
2 stops
$394American Airlines
ons., sep. 16 - ons., sep. 23
United Airlines Logo
8:30 am - 6:29 pm
BOG
-
SFO
11h 59m
1 stop
United Airlines Logo
4:40 pm - 4:54 am
SFO
-
BOG
10h 14m
1 stop
$417United Airlines
ons., maj 6 - søn., maj 17
United Airlines Logo
8:30 am - 11:59 pm
BOG
-
SFO
17h 29m
1 stop
United Airlines Logo
5:00 am - 4:54 am
SFO
-
BOG
21h 54m
1 stop
$418United Airlines
ons., maj 13 - søn., maj 17
Copa Airlines Logo
9:15 am - 11:40 pm
MDE
-
SFO
16h 25m
1 stop
Copa Airlines Logo
8:16 pm - 8:15 am
SFO
-
MDE
9h 59m
1 stop
$477Copa Airlines
fre., maj 1 - tir., maj 12
Copa Airlines Logo
3:10 pm - 11:40 pm
MDE
-
SFO
10h 30m
1 stop
Copa Airlines Logo
1:12 am - 2:45 pm
SFO
-
MDE
11h 33m
1 stop
$493Copa Airlines
tir., maj 5 - lør., maj 9
Avianca Logo
9:10 am - 11:55 pm
GYE
-
SFO
16h 45m
2 stops
Avianca Logo
2:15 pm - 8:55 am
SFO
-
GYE
16h 40m
2 stops
$567Avianca
tor., maj 21 - ons., maj 27
Avianca Logo
3:05 am - 12:50 pm
LIM
-
SFO
11h 45m
1 stop
Avianca Logo
2:15 pm - 3:30 am
SFO
-
LIM
11h 15m
1 stop
$593Avianca
man., aug. 24 - lør., sep. 5
LATAM Airlines Logo
11:25 pm - 11:59 am
SCL
-
SFO
15h 34m
1 stop
LATAM Airlines Logo
7:00 am - 4:35 am
SFO
-
SCL
18h 35m
1 stop
$603LATAM Airlines
tor., aug. 6 - tor., sep. 17
LATAM Airlines Logo
11:25 pm - 3:44 pm
SCL
-
SFO
19h 19m
1 stop
LATAM Airlines Logo
8:55 am - 5:35 am
SFO
-
SCL
16h 40m
1 stop
$604LATAM Airlines
Useful Info

Good to know

Low seasonFebruary
Cheapest flight$233
Best time to beat the crowds with an average 8% drop in price.
Most popular time to fly with an average 3% increase in price.
Flight from Medellín to San Francisco

FAQs for booking flights from South America to San Francisco

  • How does KAYAK find such low prices on flights from South America to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South America to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South America to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to South America with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South America to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from South America to San Francisco

 
Need help choosing which airline to fly with from South America to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
Copa AirlinesOverall score based on 1578 reviews
7.8Boarding
7.4Comfort
6.8Food
8.1Crew
6.8Entertainment
Airline reviews

Do not book it’s a scam! They stole $1200 from me

2.0 MediocreTalicia, Mar 2026
PTY - RDU
Read more Copa Airlines reviews

Do not book it’s a scam! They stole $1200 from me

Flight got delayed; had to go through security three times.

Copa staff at PTY and one particular crew member were unhelpful & rude.

A lot things happened in this trip.The fly should be less stress.

The flight was good overall. Everything went smoothly, although the landing was a bit rough. Still, it was a pleasant experience

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

Simply as follows:- First, there was no vegetarian option for the meal Second, only 2 washrooms for the entire economy class.

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Nothing I like, I missed this connection b/c of an earlier flight delay. I had to stay one more night and I paid out my own pocket. LATAM failed to send me to a safe and decent hotel.

It was delayed for 2 hours. Then when we arrived they took us on a very uncomfortable bus and left us there. The bus driver wouldn't let us out because no one from Latam was there. Everything was disaster.

LATAM is a great airline who takes care of there guests. They consistently walk around and see if you need water in addition to taking care of all the passengers. The chicken in process is really easy and I’m always offered a chance for an upgrade which I appreciate.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

The flight was delayed from take off because only one runway was operational in San Francisco.

Several missed and almost missed connections. It felt like everything was being patched together last minute without enough resources and it ended up being an extremely stressful experience that basically ruined our weekend on the west coast. What a waste.

Checking in united could not figure out my star alliance gold. Baggage did not get marked priority and didn't receive boarding passes. When got to SFO lounge personal fixed everything Immediately

Meals were poor and service rendered on return flight was mediocre as compared to the flight we took to Germany earlier where the attendants were more attentive, energetic, and mindful of passengers' needs. Thumbs up to crew of UA 58. Thumbs down to UA 59..

Flight left on time, arrived early, pleasant staff provided water, coffee, etc. access to bathrooms was reasonable and were well maintained. blankets were available, lots of entertainment options. LUGGAGE SERVICE WAS GREAT. I got my one checked bag quickly and was able to make a bus connection for a 2 hour bus ride saving me from waiting another 1.5 hours.

Wonderful in-seat entertainment with seatback screens and huge selection of quality movies. The ability to bluetooth connect headphones was amazing.

we did a return flight from Paris CDG to SFO. This trip was much better than the departing flight SFO to CDG. The food was better quality, the crew was nicer, and the interior of the plane seemed cleaner.

Horrible service no Wi-Fi connection on both leg of the flight and they are refusing to fix bad service

We got to get extended leg room in Econ plus that was great. It was nice having our own dietary needs met with our meals, and the connecting flights had it as well. Only negative were the seats my bottom was/is really sore after a ten plus hour flight. Those seats are horrible, understandable for as many people use them. So we are going to purchase a gel seat pad.

Flight to Japan was was better across the board than the return to USA. Entertainment: Movie selection was old and not to my liking. Way too many woke choices. Not enough selections for sports or drama. Service: some of the crew were great. Not all. I paid for business class. a premium. Some of the crew thought they 'had' t do there job instead of wanting to serve and be polite. Food: Way to Japan was good. Way back to USA bad. Boarding: Wat out did not offer Business only; had to go thru general. If you pay for business, you should get business perks. Suggest you look for other than United for travel to Asia

American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

To have arrived on time and not 3 hours late after having already spent $100 to change to an earlier flight, only to arrive back home close to the original flight time.

American Airlines is a miserable experience. It is predictably miserable, in the sense that every time I fly American, I brace myself for the certainty that it will be unpleasant and uncomfortable. But it is unpredictable in the sense that I never know if the flight will be on time or delayed nine hours (both happened to me this week). I never know if I will be able to sit in the seat that I selected when I purchased the ticket or if I will be told by Customer Service (!!!) that I must relocate from first class to a seat in the back of the aircraft with no explanation (both happened to me this week). Will the food be frozen and half defrosted, or scalding hot? Will the drinks be warm? Will the flight attendants be surly and mean? Will the toilets be cramped and foul? Will the seats be narrow and uncomfortable? Will there be a real electric outlet at the seat, or just an unreliable USB-2 port? Will there be enough seats in the boarding lounge or just a few? Will the boarding process be smooth and efficient, or will the gate agents mess it up and delay it needlessly for 30 or 40 minutes? Will the catering and cleaning crew be prompt or will they take an extra 30 minutes? Will the brakes on the aircraft work properly, or will the pilot delay takeoff for four hours while the ground crew attends to what can only be described as routine maintenance that should have been done the night before? I've eexperienced every one of these unpleasant things this year, 2026. The only thing I can reliably count on is that American will find a new way to make the experience of flying as miserable as they possibly can.

Wifi was spotty. Tray table was very dirty when I sat down.

The WiFi would not connect enough for me to do my actual work. It permaspooled, disconnected, said it was connected, then wouldn't open an email... it was frustrating. I am not a tall person, 5'4" - and I felt cramped with little room to reach into my bag under the seat in front of me. I feel sorry for anyone taller than me having to fly. the one positive thing I will add, is the overhead bins are roomy enough to manage more bags than other carriers.

Buying ticket from kayak instant booking was a huge mistake, never to be repeated again! The Kayak didn’t book the tickets directly, it handed it off to a third party Underpricer, that booked a code shared American Airlines flight operated by Cathay Pacific!! When managing the booking American Airlines would recognize the itinerary but wouldn’t let me do anything stating, the flight is operated by Cathay Pacific so go to their website. Cathay Pacific would recognize the itinerary, neither by reservation ID or ticket number…asking to reach out to the third party Underpricer….calling Underpricer resulted in no help like seat requests, mileage number or upgrade request, 15hr layover accommodation voucher guidance…so net in net avoid booking through three layers of intermediaries

Going non stop to lax like I paid for. Not stopping in MCI for gas. Too long of delays

Flight was on time. Cabin attendants made no recognition of my name or being an Advantage Executive Platinum member.

Delayed for mechanical and no updates on what was happening and how long the delay might be.

Seating was tight. Seats don't recline. Initial flight was cancelled. Lost two days of vacation.

Horrible experience with Avianca, they delayed their flight and when we arrived to NYC, AVIANCA took 1 hr y 30 mins to park the airplane and all passenger get off the plane, it made me lost all my trains to get back home and I came back to my place at 3 am instead of 12 am. On the top of that their plane seat are so uncomfortable and is not enough space and killed my legs and knees, Avianca used to be good when it was a Colombian company, now after Brasilian company bought them, their service quality is bad and their flights are delayed and oversold.

only a bag of chips and a bottle of water in business class was served

Provide free food and drinks on an international flight. Add updated head rests

Boarding was late due to the company’s that cleaned the aircraft (very poorly done) and the catering company. The entertainment system was not working for this six hour flight, uncomfortable seats in business (barely any cushion or recline). The airline staff is very good but the planes are horrible and not well maintained.

I handed in my suitcase in perfect condition at SAL Airport. And in MIA Airport I received it with one corner broken and the wheels bent.

I like the crew members they're very friendly. Clean plane. The flight was on time. I dont like the comfort my car seat its better that the plane seats. They charge for everything. This airline was very good. Now it's a low cost airline

No free snacks nor drinks on very short 30min flight. Entertainment system is over wifi to your own phone or tablet, which is good but often a show or movie just stops and refuses to continue

This low cost airline looks and fells more like a local bus. In a 6 hour flight not being able to recline a seat is torture. The only thing available with no charge is a glass of water provided by, mostly, rude staff. Our luggage didn’t arrive

6 hour flight and have to pay for everything 100 dollars to add a carry-on bag is insane

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Calistoga
Marina
Rohnert Park
Emeryville
Pacifica
Capitola
Millbrae
Campbell
Newark
Mill Valley
Novato
Windsor
Union City
Belmont
West Sacramento
Richmond
American Canyon
Corte Madera
Los Altos
Jenner

Everything you need to know for your flight to San Francisco

Information on the airport you'll fly into in San Francisco