$297 Find Cheap Flights from South America to San Francisco - Compare and Save

KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to San Francisco.

KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from South America is likely to change within 7 days, so travelers know whether to wait or book now.

Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to South America with another airline.

Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.