$267 Find Cheap Flights from South America to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Francisco departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$439
Overall average: $528
Avianca
Tue 5/5Wed 5/13
MDE - SFO • 1 stop
Cheapest one-way
$267
Typical prices: $338-$550
Multiple Airlines
Mon 2/23
MDE - SFO • 3 stops
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Flight Deals
Useful Info
Flight Deals

Cheap Flights from South America to San Francisco

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South America to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South America to San Francisco

Tue, May 5 - Wed, May 13
Avianca Logo
3:15 am - 12:50 pm
MDE
-
SFO
11h 35m1 stop
Avianca Logo
2:15 pm - 2:05 am
SFO
-
MDE
9h 50m1 stop
$439Avianca
Mon, Apr 6 - Mon, Apr 13
Avianca Logo
3:15 am - 12:50 pm
MDE
-
SFO
11h 35m1 stop
Avianca Logo
2:15 pm - 2:05 am
SFO
-
MDE
9h 50m1 stop
$440Avianca
Tue, Feb 10 - Mon, Feb 23
Copa Airlines Logo
2:24 pm - 11:20 pm
BOG
-
SFO
11h 56m1 stop
Copa Airlines Logo
12:42 am - 12:05 am
SFO
-
BOG
20h 23m1 stop
$444Copa Airlines
Wed, Feb 4 - Mon, Feb 9
United Airlines Logo
1:30 am - 4:50 pm
BOG
-
SFO
18h 20m1 stop
United Airlines Logo
7:10 pm - 10:35 pm
SFO
-
BOG
24h 25m1 stop
$450United Airlines
Thu, Mar 19 - Tue, Apr 7
LATAM Airlines Logo
6:15 am - 12:22 am
BOG
-
SFO
20h 07m2 stops
LATAM Airlines Logo
11:35 pm - 2:25 pm
SFO
-
BOG
12h 50m1 stop
$456LATAM Airlines
Mon, Feb 2 - Sat, Feb 28
LATAM Airlines Logo
8:35 am - 8:55 am
BOG
-
SFO
27h 20m2 stops
LATAM Airlines Logo
8:00 am - 4:45 pm
SFO
-
BOG
29h 45m2 stops
$458LATAM Airlines
Tue, Apr 7 - Thu, Apr 30
Copa Airlines Logo
6:10 am - 11:40 pm
BOG
-
SFO
19h 30m1 stop
Copa Airlines Logo
8:35 pm - 5:07 pm
SFO
-
BOG
18h 32m1 stop
$479Copa Airlines
Mon, Jan 26 - Wed, Feb 4
American Airlines Logo
10:35 pm - 11:02 am
SCL
-
SFO
17h 27m1 stop
American Airlines Logo
8:00 am - 8:15 am
SFO
-
SCL
19h 15m1 stop
$536American Airlines
Sat, Feb 7 - Tue, Mar 3
American Airlines Logo
10:30 pm - 7:12 pm
SCL
-
SFO
25h 42m1 stop
American Airlines Logo
11:35 pm - 8:05 am
SFO
-
SCL
27h 30m1 stop
$537American Airlines
Thu, Apr 9 - Mon, Apr 13
United Airlines Logo
5:51 am - 7:16 am
COR
-
SFO
29h 25m2 stops
United Airlines Logo
6:55 pm - 3:51 am
SFO
-
COR
28h 56m2 stops
$1,246United Airlines
Useful Info

Good to know

Low seasonFebruary
Cheapest flight$267
Best time to beat the crowds but there is an average 1% increase in price.
Most popular time to fly with an average 3% increase in price.
Flight from Medellín to San Francisco

FAQs for booking flights from South America to San Francisco

  • How does KAYAK find such low prices on flights from South America to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South America to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South America to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to South America with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South America to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from South America to San Francisco

 
Need help choosing which airline to fly with from South America to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1562 reviews
6.8Entertainment
7.4Comfort
7.8Boarding
8.1Crew
6.8Food
Airline reviews

The flight was good overall. Everything went smoothly, although the landing was a bit rough. Still, it was a pleasant experience

8.0 ExcellentAnonymous, Dec 2025
PTY - CUR
Read more Copa Airlines reviews

The flight was good overall. Everything went smoothly, although the landing was a bit rough. Still, it was a pleasant experience

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

Simply as follows:- First, there was no vegetarian option for the meal Second, only 2 washrooms for the entire economy class.

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

horrible service, food was an embarrassment, no charging for cellphones, stay away

the food served was an embarrassment. No connection for charging the cellphone... What a crappy airline.

Great experience with a crew always thinking in the passenger

The flighr attandants were very rude they ignored me didnt offer me anything to drink throughoit the 4 hour flight i feel i was targeted and ignored because i was a darkskin latino man.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

It was good but only meal served is very less. Meantime good to add rice and chicken in one of meal

Teeny tiny bathrooms, crew was not realistic about when we'd arrive.

On the way my flight entertainment wouldn’t work the screen went black and no matter how many times I tried to turn it on it wouldn’t. Food was surprisingly good but the tray tables were tiny so you couldn’t get anything else on the table. The seats hardly go back and are not overly comfortable. Wouldn’t fly United again.

Flight was late - I was downgraded from first class to coach

Movie selection is good. Crew did not understand mileage program and were no help. Sick later. Food?

United needs to step up their game. Delayed flight leaving Seattle, San Francisco. Older aircraft, not very comfortable.

The flight attendants were very rude, beyond comprehension. I took a business class from London to SFO for the first time on United. When I asked for a second piece of bread during dinner, the serving attendant threw a 3rd bread on my plate and said, “here. You can have this one too”! I couldn’t believe the rudeness of the attendant. Most all attendants were very rude, unhelpful, sing the food was absolutely disgusting. Never fly United internationally in business class. My flight back to SFO was a nightmare!!

7 hours delayed due to operational issues on United’s end. Basically laziness.

Flight from Rome to SFO was excellent compared To our flight to Europe from SFO. The food was much tastier. You can see how UNITED is skimping, though. Instead of getting something mid flight you had to ask for it. It was not automatically served. There was a cookie at the end of the arrival meal, for example that tasted like it just came out of a box. They used to serve a little container of nuts, now … a tiny container of nuts, mixed with pretzels. This was business class that you really have to pay for! But this is minor complaints compared to the overall. My major complaint is the position of the even numbered seats by the windows. You have to turn around to see your window & the positioning as some other controls are harder to get at. This is compared to the odd number seat that are perfectly aligned.

The food quality sucks. One must starve if they do not eat flesh Or wheat based products Some variety would be expected. The trivial amount of snacks and or food is inhumane

Everything about the flight was lovely. My only suggestion would be to offer a few more options of tv series from Apple TV or HBO.

After the door had been closed, the cockpit makes an announcement that catering is running late and it is not the airline's fault. It is their fault in the sense that we had to sit for 2 hours or more when we could have stayed in the terminal. Poor communications between catering and airline. This caused a young man to lose his temper and he went storming out hitting objects. He had complained to the gate agent that he had already waited at the gate 7 hours and when can the airplane leave? Airilnes do a poor job of explaining delays, maintenance issues, etc. whereas being truthful may gain more sympathy or understanding.

We were told the flight was delayed 5 times, then it was moved to the next day.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

Loved the crew . Absolutely no complaints. Except for luggage lost

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

We are too tired and frustrated to comment politely at this point

The business class seats are dated and uncomfortable. The space is bare minimum and there is absolutely no privacy. For $4K, this is not what I expect.

The flight crew was rude. We were in first class and no one even offered water until an hour after we were in the air. Horrible experience

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

only a bag of chips and a bottle of water in business class was served

Provide free food and drinks on an international flight. Add updated head rests

Boarding was late due to the company’s that cleaned the aircraft (very poorly done) and the catering company. The entertainment system was not working for this six hour flight, uncomfortable seats in business (barely any cushion or recline). The airline staff is very good but the planes are horrible and not well maintained.

Deplaning was a mess, I sat in business (seats are horrible) and the front door had a problem so we had to deplane from the rear exit. The stairs were not tall enough to reach so there was a large step down from the plane to the top of the stairs.

I handed in my suitcase in perfect condition at SAL Airport. And in MIA Airport I received it with one corner broken and the wheels bent.

I like the crew members they're very friendly. Clean plane. The flight was on time. I dont like the comfort my car seat its better that the plane seats. They charge for everything. This airline was very good. Now it's a low cost airline

No free snacks nor drinks on very short 30min flight. Entertainment system is over wifi to your own phone or tablet, which is good but often a show or movie just stops and refuses to continue

This low cost airline looks and fells more like a local bus. In a 6 hour flight not being able to recline a seat is torture. The only thing available with no charge is a glass of water provided by, mostly, rude staff. Our luggage didn’t arrive

6 hour flight and have to pay for everything 100 dollars to add a carry-on bag is insane

Horrible experience. Flight cancelled. Arrived at destination 12 hs later. No one gave us an answer or any information. Very very poor service. We won’t ever travel again with Avianca

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