$143 Find Cheap Flights from Chicago O'Hare Airport to South America - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from O'Hare Intl to South America departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 21% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from O'Hare Intl to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$654
Bogotá
Bogotá1 stop$391
Medellín
Medellín1 stop$409
Sao Paulo
Sao Paulo1 stop$561
Rio de Janeiro
Rio de Janeiro1 stop$613
Santiago
Santiago2 stops$652
Cartagena
Cartagena1 stop$353
Quito
Quito2 stops$459
Guayaquil
Guayaquil1 stop$395
Cali
Cali2 stops$421
Cusco
Cusco2 stops$650
Georgetown
Georgetown1 stop$519
Pereira
Pereira2 stops$462
Barranquilla
Barranquilla1 stop$396
Montevideo
Montevideo1 stop$965
Santa Marta
Santa Marta1 stop$439
Asuncion
Asuncion1 stop$919
Lima
Lima2 stops$654
Bogotá
Bogotá1 stop$391
Medellín
Medellín1 stop$409
Sao Paulo
Sao Paulo1 stop$561
Rio de Janeiro
Rio de Janeiro1 stop$613
Santiago
Santiago2 stops$652
Cartagena
Cartagena1 stop$353
Quito
Quito2 stops$459
Guayaquil
Guayaquil1 stop$395
Cali
Cali2 stops$421
Cusco
Cusco2 stops$650
Georgetown
Georgetown1 stop$519
Pereira
Pereira2 stops$462
Barranquilla
Barranquilla1 stop$396
Montevideo
Montevideo1 stop$965
Santa Marta
Santa Marta1 stop$439
Asuncion
Asuncion1 stop$919

Book Cheap O'Hare Intl to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from O'Hare Intl to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from O'Hare Intl to South America

Wed, Sep 23 - Mon, Sep 28
Copa Airlines Logo
3:20 pm - 8:40 am
ORD
-
CTG
17h 20m
1 stop
Copa Airlines Logo
6:20 am - 1:02 am
CTG
-
ORD
18h 42m
1 stop
$353Copa Airlines
Tue, Oct 20 - Sun, Oct 25
Avianca Logo
11:20 pm - 1:35 pm
ORD
-
CTG
14h 15m
1 stop
Avianca Logo
7:15 am - 9:20 pm
CTG
-
ORD
14h 05m
1 stop
$361Avianca
Fri, Sep 11 - Sat, Sep 19
American Airlines Logo
7:00 pm - 12:35 pm
ORD
-
CTG
17h 35m
1 stop
American Airlines Logo
1:35 pm - 12:32 am
CTG
-
ORD
10h 57m
1 stop
$365American Airlines
Fri, Sep 18 - Sun, Sep 27
Copa Airlines Logo
3:20 pm - 2:05 pm
ORD
-
CTG
22h 45m
1 stop
Copa Airlines Logo
6:20 am - 1:02 am
CTG
-
ORD
18h 42m
1 stop
$368Copa Airlines
Fri, Sep 11 - Thu, Sep 17
American Airlines Logo
8:55 pm - 12:35 pm
ORD
-
CTG
15h 40m
2 stops
American Airlines Logo
1:35 pm - 12:32 am
CTG
-
ORD
10h 57m
1 stop
$370American Airlines
Fri, Aug 14 - Sat, Aug 22
LATAM Airlines Logo
6:25 pm - 1:05 pm
ORD
-
CTG
18h 40m
1 stop
LATAM Airlines Logo
2:30 pm - 8:44 am
CTG
-
ORD
18h 14m
1 stop
$373LATAM Airlines
Sun, Oct 18 - Fri, Oct 23
Avianca Logo
11:20 pm - 1:35 pm
ORD
-
CTG
14h 15m
1 stop
Avianca Logo
9:00 am - 9:20 pm
CTG
-
ORD
12h 20m
1 stop
$381Avianca
Sat, Sep 12 - Fri, Sep 25
United Airlines Logo
7:05 am - 10:00 pm
ORD
-
BOG
14h 55m
1 stop
United Airlines Logo
8:30 am - 12:23 am
BOG
-
ORD
15h 53m
1 stop
$391United Airlines
Sat, Sep 12 - Fri, Sep 25
United Airlines Logo
7:05 am - 10:00 pm
ORD
-
BOG
14h 55m
1 stop
United Airlines Logo
8:30 am - 12:23 am
BOG
-
ORD
15h 53m
1 stop
$395United Airlines
Wed, Aug 26 - Wed, Sep 9
LATAM Airlines Logo
3:25 pm - 1:40 pm
ORD
-
BOG
22h 15m
1 stop
LATAM Airlines Logo
2:55 pm - 11:59 pm
BOG
-
ORD
9h 04m
1 stop
$399LATAM Airlines
Booking Insights

KAYAK's insights & trends for O'Hare Intl to South America flights

Get data-powered insights and trends into flights from O'Hare Intl to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Chicago O'Hare Intl Airport to South America flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South America from Chicago O'Hare Intl Airport found in the last 5 days was to Bogotá, at $422 round-trip. The most popular route is from Chicago O'Hare Intl Airport (ORD) to Bogotá (BOG), and the cheapest round-trip airline ticket found on this route in the last 5 days was $422.

Can I save money by flying with a layover from Chicago O'Hare Intl Airport to South America?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $597, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Chicago O'Hare Intl Airport to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Chicago O'Hare Intl Airport to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Chicago O'Hare Intl Airport to South America is February, when tickets cost $441 (return) on average. On the other hand, the most expensive months are December and October, when the average cost of round-trip tickets is $937 and $850 respectively.

How far in advance should I book a flight from Chicago O'Hare Intl Airport to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Chicago O'Hare Intl Airport to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Chicago O'Hare Intl Airport to South America, you should book around 2 weeks before departure, which saves you about 8% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 4 weeks before departure.

Good to know

Low seasonOctober
Cheapest flight$143
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 23% increase in price.
Flight from Chicago O'Hare Airport to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Chicago O'Hare Airport to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Chicago O'Hare Airport to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Chicago O'Hare Airport to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Chicago O'Hare Airport to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Chicago O'Hare Airport to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Chicago O'Hare Airport to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Chicago O'Hare Airport to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Chicago O'Hare Airport to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from O'Hare Intl to South America

 
Need help choosing which airline to fly with from O'Hare Intl to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1569 reviews
6.8Entertainment
8.1Crew
7.4Comfort
6.9Food
7.8Boarding
Airline reviews

Same as the previous flight as far as comfort and food. Entertainment didn’t have a watchable screen so everything would need to be watched on your own device in which they didn’t have a charging port that accommodated my iPhone. Seats were very uncomfortable. Staff was very friendly.

6.0 GoodAnonymous, May 2026
PTY - LAX
Read more Copa Airlines reviews

Same as the previous flight as far as comfort and food. Entertainment didn’t have a watchable screen so everything would need to be watched on your own device in which they didn’t have a charging port that accommodated my iPhone. Seats were very uncomfortable. Staff was very friendly.

Do not book it’s a scam! They stole $1200 from me

Seats were awful. Media should have been included for such a long flight.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

I always enjoy flying Copa. There are very few airlines where I can enjoy a comfortable sleep in-flight. The snacks weren't the best, but they sufficed. The in-flight entertainment was fantastic, and I crossed another movie off my watch list.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Simply as follows:- First, there was no vegetarian option for the meal Second, only 2 washrooms for the entire economy class.

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

LATAM clearly does not have well-established policies re: luggage for international flights to Lima followed by domestic flights within Peru (in my case, from Lima to Cuzco). On the way in, they forced me to pay $50 in Lima to check my second carry on bag (the three bags were included in the fare from JFK to Lima). On the return trip, they told me at check in that I would have to pay $50 again at the gate (she said they couldn't accept the money at check in) Then, at the gate, they initially told me I would have to pay several hundred dollars to check the big bag through to JFK. I protested, and showed them a print out of an email saying the checked bag was included between LIM and JFK. Than a second woman showed up, and told me I wouldn't have to pay anything at all -- which was great news, of course -- but that means I was incorrectly charged the extra $50 on the incoming flight. Basically, just a mess. Also, their website is completely non-functional -- it was very cleear that all the airport staff knew the website was nonfunctional, too.

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

LATAM is a great airline who takes care of there guests. They consistently walk around and see if you need water in addition to taking care of all the passengers. The chicken in process is really easy and I’m always offered a chance for an upgrade which I appreciate.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Horrible! Several delays and then was cancelled! I spent over 24 hours in the airport and was unable to get a hotel or food voucher.

Smooth travel. Immediate update prior flight delay so I can arrange myself properly without too rush.

Boarded early; and arrived home 40 mins early. After a long flight, it’s nice to be back home early. These flights have no amenities; no snacks. So need to bring your own

A long delay. Don't travel late in the day.

Super friendly with lots of drink options an entertainment. Friendly crew.

The crew was great. Very friendly and responsive. The plane was old, small and tight. We ran out of overhead space and I had to check. Middle seat was particularly tight.

Several missed and almost missed connections. It felt like everything was being patched together last minute without enough resources and it ended up being an extremely stressful experience that basically ruined our weekend on the west coast. What a waste.

Crew was friendly. Seats are too narrow, particularly when a big person is in the adjacent seat, but I understand this is due to smaller planes usually flight into Lincoln. I have experienced several flight delays going out and coming into Lincoln airport, I say maybe 50% or higher of the flights I've taken out of this airport have been delayed.

Great flight. Boarded efficiently. Arrived early at CLT. There was no in flight entertainment on this aircraft. Great crew.

The seat was comfortable. There was a lot of turbulence. If it weren't for that,it would have been okay.

Significant delays on my trip to Chicago and my trip back to NY

Delayed by 5 hours and I had to wit in the airport for more than 6+ hours.

I’ve got 31F seat and window seat . My 2 co passengers was AA crew members and they were very rude attitude and when I was going to use bathroom their gestures was very different and awkward and the guy beside me completely occupied the hand rest and I was really uncomfortable

It was so much better than expected, Ohare is not such a pleasant experience but American Airlines with the new, clean aeroplane and free Wi-Fi was outstanding and the crew so pleasant and helpful.

It wa sort of on time; the cab was left with some trash

My pillow had a shoe print on it, when I asked if I can have another pillow, I was told “I’m sorry but it is one pillow per guest, do YOU want to turn it inside out” to which I responded , no thanks I will go without. This is generally not ok, but For the price tag I paid flying business this is absolutely unacceptable. Hopefully American Airlines can update their accommodations to bedding that is not tossed on the ground and stepped on, or at least have a couple of extra pillows in hand, incase someone had decided to step on the pillows for what ever reason

American Airlines II: Delay Boogaloo. Multiple gate changes, delays, boarded and then MORE delays. I hate to say this won’t matter, but posting stuff about major corporations in 2026 is a post-modern “scream into the void.” Was multiple hours late coming home, so there you go.

Our flight was cancelled while we are on our way to the airport. So, no notice. We were rescheduled to another airline with a 2 hour later takeoff and so arrived at our destination on time. We pre-paid American Airlines $190 to upgrade our seats. No refund. So no use for AA or Kayak.

Terrible, horrible, disappointing- without telling us they changed planes and moved and separated our seats to opposite sides - said they changed seats putting us together - got to airport to find no, they did not - we sat opposing sides of plane - food overly salty to inedible, never saw stewardess but once - it was terrible

The airplane was an old model, the overhead didn’t have enough room for people’s items and made boarding and boarding disappointing and stressful. Crew allowed passengers to bring more than the permitted baggage sizes.

Seats are absolutely not comfortable and large enough. There’s a limit and you stepped over it. I understand that there’s a business class, however for the price it costs, it’s just plain stupid for a 50 minute flight.

After boarding, there was a small issue with the aircraft which caused a delay of about 45 minutes. During boarding and while passengers were being seated, the plane was being refueled. There were also a lot of unusual noises during the flight, which was not very reassuring. In addition, there was no WiFi or entertainment available.

The worst experience I've ever had because the "people" @ Avianca wouldn't let me fly because they said I needed a round trip ticket

Seating was tight. Seats don't recline. Initial flight was cancelled. Lost two days of vacation.

It was delayed and I lost my connection flight to Cali and I missed my Mom's funeral

I actually upgraded to the medium level of seats from basic and even doing that it may have been physically the most uncomfortable flight I have ever had. They packed everyone like is a train to death camp. It was a red eye so I hoped to get some sleep but it was physically impossible to find a comfortable way to rest. I met other folks on the same flight and they said the same thing. It was an utterly miserable flight and if I have any other options I will never fly with them again

Provide free food and drinks on an international flight. Add updated head rests

Deplaning was a mess, I sat in business (seats are horrible) and the front door had a problem so we had to deplane from the rear exit. The stairs were not tall enough to reach so there was a large step down from the plane to the top of the stairs.

Staff are the rudest in the industry … awful customer service … will never fly Avianca again

Pros: we leave and arrive on time Cons: the most uncomfortable seats ever. You cant recline at all your seats. No entertainment No TVs flight attendants didn't provide even a glass of water. You have to go to back of the airplane and ask for one. I am Colombian and I remember seeing the flight attendants very neat, elegants which is or was a staple of Avianca.it was one with tennis shoes, no male up, the hair was messy... that was really odd.

Everything you need to know for your flight to South America

Information on your arrival and departure airports