$96 Find Cheap Flights from Chicago O'Hare Airport to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from O'Hare Intl to South America departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from O'Hare Intl to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$492
Bogotá
Bogotá1 stop$309
Medellín
Medellín1 stop$292
Sao Paulo
Sao Paulo1 stop$541
Rio de Janeiro
Rio de Janeiro1 stop$488
Santiago
Santiago1 stop$655
Cartagena
Cartagena1 stop$312
Quito
Quito2 stops$403
Guayaquil
Guayaquil1 stop$390
Cali
Cali2 stops$448
Cusco
Cusco2 stops$538
Pereira
Pereira1 stop$406
Georgetown
Georgetown1 stop$407
Montevideo
Montevideo1 stop$715
Barranquilla
Barranquilla1 stop$366
Santa Marta
Santa Marta1 stop$371
Asuncion
Asuncion2 stops$1,034
Lima
Lima1 stop$492
Bogotá
Bogotá1 stop$309
Medellín
Medellín1 stop$292
Sao Paulo
Sao Paulo1 stop$541
Rio de Janeiro
Rio de Janeiro1 stop$488
Santiago
Santiago1 stop$655
Cartagena
Cartagena1 stop$312
Quito
Quito2 stops$403
Guayaquil
Guayaquil1 stop$390
Cali
Cali2 stops$448
Cusco
Cusco2 stops$538
Pereira
Pereira1 stop$406
Georgetown
Georgetown1 stop$407
Montevideo
Montevideo1 stop$715
Barranquilla
Barranquilla1 stop$366
Santa Marta
Santa Marta1 stop$371
Asuncion
Asuncion2 stops$1,034

Book Cheap O'Hare Intl to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from O'Hare Intl to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from O'Hare Intl to South America

Thu, Feb 5 - Tue, Feb 10
Spirit Airlines Logo
8:43 pm - 2:15 pm
ORD
-
MDE
16h 32m1 stop
Spirit Airlines Logo
3:15 pm - 1:13 pm
MDE
-
ORD
22h 58m2 stops
$292Spirit Airlines
Fri, Jan 16 - Mon, Jan 19
Copa Airlines Logo
7:35 am - 4:59 pm
ORD
-
MDE
8h 24m1 stop
Copa Airlines Logo
5:00 am - 12:46 pm
MDE
-
ORD
8h 46m1 stop
$302Copa Airlines
Tue, Jan 27 - Tue, Feb 3
American Airlines Logo
8:09 am - 9:10 pm
ORD
-
MDE
12h 01m2 stops
American Airlines Logo
7:00 am - 8:53 pm
MDE
-
ORD
14h 53m2 stops
$304American Airlines
Mon, Feb 2 - Thu, Feb 5
United Airlines Logo
9:05 pm - 10:05 pm
ORD
-
MDE
24h 00m1 stop
United Airlines Logo
10:45 am - 12:28 am
MDE
-
ORD
14h 43m1 stop
$310United Airlines
Mon, Feb 9 - Tue, Feb 24
Avianca Logo
10:20 pm - 5:30 am
ORD
-
BOG
6h 10mnonstop
Avianca Logo
2:50 pm - 8:20 pm
BOG
-
ORD
6h 30mnonstop
$314Avianca
Mon, Jan 19 - Wed, Jan 21
American Airlines Logo
3:55 pm - 3:30 pm
ORD
-
CTG
22h 35m1 stop
American Airlines Logo
4:30 pm - 7:22 am
CTG
-
ORD
15h 52m2 stops
$315American Airlines
Wed, Mar 11 - Tue, Mar 17
Avianca Logo
11:20 pm - 12:30 pm
ORD
-
CTG
13h 10m1 stop
Avianca Logo
10:10 am - 9:20 pm
CTG
-
ORD
11h 10m1 stop
$323Avianca
Wed, Feb 4 - Thu, Feb 19
LATAM Airlines Logo
11:15 am - 5:17 am
ORD
-
UIO
17h 02m2 stops
LATAM Airlines Logo
7:00 pm - 10:08 am
UIO
-
ORD
16h 08m2 stops
$403LATAM Airlines
Wed, Feb 4 - Wed, Mar 18
LATAM Airlines Logo
9:55 am - 9:35 pm
ORD
-
UIO
10h 40m1 stop
LATAM Airlines Logo
7:00 pm - 10:05 am
UIO
-
ORD
15h 05m2 stops
$409LATAM Airlines
Sun, Apr 12 - Wed, Apr 15
United Airlines Logo
7:35 am - 11:25 pm
ORD
-
UIO
15h 50m1 stop
United Airlines Logo
12:35 am - 10:03 am
UIO
-
ORD
9h 28m1 stop
$417United Airlines
Booking Insights

KAYAK's insights & trends for O'Hare Intl to South America flights

Get data-powered insights and trends into flights from O'Hare Intl to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Chicago O'Hare Intl Airport to South America flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South America from Chicago O'Hare Intl Airport found in the last 72 hours was to Bogotá, at $296 round-trip. The most popular route is from Chicago O'Hare Intl Airport (ORD) to Bogotá (BOG), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $296.

Can I save money by flying with a layover from Chicago O'Hare Intl Airport to South America?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $596, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Chicago O'Hare Intl Airport to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Chicago O'Hare Intl Airport to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Chicago O'Hare Intl Airport to South America is April, when tickets cost $528 (return) on average. On the other hand, the most expensive months are December and August, when the average cost of round-trip tickets is $789 and $657 respectively.

What’s the cheapest day of the week to fly from Chicago O'Hare Airport to South America?

The average price of all round-trip flights from Chicago O'Hare Intl Airport to South America clicked on KAYAK for each day over the last 12 months.

For Chicago O'Hare Airport to South America, Wednesday is the cheapest day to fly on average and Saturday is the most expensive. Flying from South America back to Chicago O'Hare Airport, the best deals are generally found on Sunday, with Monday being the most expensive.

How far in advance should I book a flight from Chicago O'Hare Intl Airport to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Chicago O'Hare Intl Airport to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Chicago O'Hare Intl Airport to South America, you should book around 2 weeks before departure, which saves you about 10% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 9 weeks before departure.

Good to know

Low seasonOctober
Cheapest flight$106
Best time to beat the crowds with an average 11% drop in price.
Most popular time to fly with an average 31% increase in price.
Flight from Chicago O'Hare Airport to Cartagena

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Chicago O'Hare Airport to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Chicago O'Hare Airport to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Chicago O'Hare Airport to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Chicago O'Hare Airport to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Chicago O'Hare Airport to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Chicago O'Hare Airport to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Chicago O'Hare Airport to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Chicago O'Hare Airport to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the afternoon, when round-trip flights cost $599 on average. Morning departures are around 4% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally at night, which is peak travel time and where the average cost of a ticket is $758.

Reviews of the top 5 airlines serving from O'Hare Intl to South America

 
Need help choosing which airline to fly with from O'Hare Intl to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1554 reviews
7.4Comfort
8.1Crew
7.8Boarding
6.8Entertainment
6.9Food
Airline reviews

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

6.0 GoodZach, Oct 2025
DEN - PTY
Read more Copa Airlines reviews

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Some of the Air hostesses are not that friendly. Need improvement

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

Great experience with a crew always thinking in the passenger

I selected first class expecting excetional service. It was mediocre at best. The food service was cold, meal choices was poor and on one leg they did provide dessert. I did enjoy the lay day seat but the movies were old and nothing current. Boarding the plane is always hot. So boarding is quite warm until your in the air. I took a small personal air fan. Update the meals and movies.

Very happy with my flight. I would definitely recommend it.

Did upgrade, travel in business it was great (more room I could sleep)

It was ok. However, the food was quite poor since I don't eat pasta.

Good flight, boarding ok and crew very nice. Flight was not full so I was able to be very comfortable. Blanket and pillow provided with was good as it was very cold during the flight . Food was very good(small snack sandwich and an excellent piece of orange cake). Overall good flight, no complaints.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Really bad experience – delayed for 6 hours without any notice, no food or drinks provided, and stuck in the horrible Cartagena airport.

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

The movies offered were great. Staff were very pleasant and very efficient.

After a delay at the gate, C3, at Ohare on Sunday, I left my Blk ski coat on the bench at the gate, lost! Please review my lob claim, thx.

Very nice flight love the small aircraft. We had a wonderful flight attendant. Nice to see someone that really enjoys her job. Don't have her name but had a southern accent.

Very thoughtful flight attendant offered me water immediately since I had run to make my connection.

Seats in waiting area and on plane hard as rock. Fast internet on the flight was great! Crew was kind.

Always wish for more healthy, gluten free options. We have to bring our own.

Having a long layover, I was very appreciative of the ability to stand by for an earlier flight. Other airlines like Delta have refused this to me in the past, just to be mean (because my ticket class wasn't high enough). United went out of their way to help me get to my destination early, which I really appreciated given that it was the third leg of a 24+ hour journey for me.

Other than a way way too cold cabinets for the entire flight, all was great

Excellent flight. Smooth, efficient boarding. Quick flight. Arrived early at STL.

Not the fault of United—weather, reroute around weather, time sitting on tarmac, arrived couple hours late, too late for train into city necessitating a much pricier cab but weather…can’t be helped.

We loved the steward on the plane. He made the night enjoyable

The plane was late, when we did board the plane was as cold as a freezer. I was freezing the entire flight, no blankets. Lost miserable flight I’ve ever had.

My wife and I love to travel, so we fly a lot. We've already logged 381,075 miles and with practically every major airline. But this flight was very disappointing. It started off well, with no delays and a new plane. But when lunchtime approached, all that good impression was ruined. Instead of white tablecloths, we were offered small, dark placemats, which, as it turned out, were perfectly adequate for the food. All the food offered—and my wife and I only took fish, and the meat—was not just bad, it was downright disgusting and not heated enough. The same applies to the appetizers. This was the first time in many years of traveling that we've been offered such disgusting food.

Lost luggage stuck no clothes and no word after 2 days leaving on cruise no stuff or clothes

3 hour weather delay followed by 1 hour (and counting) maintenance delay. UGH!

After we'd boarded , they canceled the flight. The crew didn't even know , we just all received text messages. Then after they deplaned us , AA was just like "too bad, go F your self, we sure ain't gonna help you"

After a two hour delay, my flight was CANCELLED! No pilot available. Such BS.

Amazing food, great staff, with one noticable detail missing ...but no seat entertainment in any of aircraft ...I am not a fan

I wish American Airlines would change the airline industry by loading the plane back to front instead of front to back. Planes would board so much more smoothly and quickly.

I have long legs, my foot was out in the aisle and when a flight attendant came walking by and I didn't notice, instead of saying "excuse me" or anything like that, she kicked my foot. Extremely rude

No free snacks nor drinks on very short 30min flight. Entertainment system is over wifi to your own phone or tablet, which is good but often a show or movie just stops and refuses to continue

I like the crew they're very friendly. I don't like. on five hour flight they not offered snacks. Any drink. Not even coffee

Not even water is offered on the flight. You cannot lean back on the seats and the seats are so narrow you can’t avoid rubbing elbows with the person next to you.

I couldnt recline the seat. Other than that crew was very attentive and helpful. Thsnk you

I had to go to the boarding counter for them to enter my return flight as it’s not with Avianca. There was a long queue as there were lots of people being called to the counter.

This low cost airline looks and fells more like a local bus. In a 6 hour flight not being able to recline a seat is torture. The only thing available with no charge is a glass of water provided by, mostly, rude staff. Our luggage didn’t arrive

6 hour flight and have to pay for everything 100 dollars to add a carry-on bag is insane

Did not fly with Pakistan International Airlines. Have never flown with Pakistan International Airlines.

Boarding, crew were excellent, food was ok and entertainment need to improve

The seats were uncomfortable and barely reclined at all. Very little leg room despite being business class. The crew was friendly and the food was good. Had to use my own phone for in-flight entertainment.

Everything you need to know for your flight to South America

Information on your arrival and departure airports