Find Cheap Flights from Chicago to South America

Depart
Return
1 adult
Adults
18-64
Seniors
65+
Youths
12-17
Children
2-11
Seat Infants
under 2
Lap Infants
under 2
The price shown for each flight will be the average for all passengers including any infants.
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Dates flexible? Here are the best fares found in the past 48 hours...

Book cheap flights from Chicago to South America

(Round-trip)
Depart: Tue Jan 30 2018 Return: Wed Feb 7 2018 Trip spans 9 days
Spirit Airlines
Spirit Airlines
ORD
MDE
18h 52m
1 stop
MDE
ORD
9h 42m
1 stop
Depart: Mon Feb 12 2018 Return: Wed Feb 21 2018 Trip spans 10 days
Interjet
Interjet
ORD
BOG
12h 55m
1 stop
BOG
ORD
23h 35m
1 stop
Depart: Sat Oct 28 2017 Return: Mon Oct 30 2017 Trip spans 3 days
Copa Airlines
Copa Airlines
ORD
BAQ
8h 45m
1 stop
BAQ
ORD
8h 22m
1 stop
Depart: Sat Oct 28 2017 Return: Sat Nov 4 2017 Trip spans 8 days
Multiple Airlines
Multiple Airlines
ORD
MDE
19h 52m
1 stop
MDE
ORD
9h 00m
1 stop
Depart: Tue Jan 23 2018 Return: Tue Jan 30 2018 Trip spans 8 days
Spirit Airlines
Spirit Airlines
ORD
CTG
18h 21m
1 stop
CTG
ORD
10h 23m
1 stop
Depart: Wed Jan 24 2018 Return: Wed Jan 31 2018 Trip spans 8 days
Spirit Airlines
Spirit Airlines
ORD
CTG
7h 29m
1 stop
CTG
ORD
10h 23m
1 stop
Depart: Tue Feb 13 2018 Return: Wed Feb 21 2018 Trip spans 9 days
Interjet
Interjet
ORD
BOG
12h 55m
1 stop
BOG
ORD
23h 35m
1 stop
Depart: Thu Nov 30 2017 Return: Sat Dec 9 2017 Trip spans 10 days
Copa Airlines
Copa Airlines
ORD
BOG
20h 50m
1 stop
BOG
ORD
8h 06m
1 stop
Depart: Wed Nov 29 2017 Return: Mon Dec 4 2017 Trip spans 6 days
Multiple Airlines
Multiple Airlines
ORD
MDE
17h 35m
1 stop
MDE
ORD
9h 39m
1 stop
Depart: Wed Jan 17 2018 Return: Wed Jan 31 2018 Trip spans 15 days
Spirit Airlines
Spirit Airlines
ORD
MDE
18h 52m
1 stop
MDE
ORD
9h 42m
1 stop
Depart: Thu Feb 15 2018 Return: Sun Feb 25 2018 Trip spans 11 days
Interjet
Interjet
ORD
BOG
21h 55m
1 stop
BOG
ORD
11h 30m
1 stop
Depart: Sat Nov 4 2017 Return: Sun Nov 12 2017 Trip spans 9 days
Copa Airlines
Copa Airlines
ORD
BAQ
8h 39m
1 stop
BAQ
ORD
8h 22m
1 stop
Depart: Thu Feb 1 2018 Return: Wed Feb 14 2018 Trip spans 14 days
Multiple Airlines
Multiple Airlines
ORD
CTG
18h 21m
1 stop
CTG
ORD
8h 36m
1 stop
Depart: Fri Feb 16 2018 Return: Sun Feb 25 2018 Trip spans 10 days
Interjet
Interjet
ORD
BOG
12h 55m
1 stop
BOG
ORD
11h 30m
1 stop
Depart: Fri Feb 23 2018 Return: Sun Mar 4 2018 Trip spans 10 days
Copa Airlines
Copa Airlines
ORD
BAQ
14h 14m
1 stop
BAQ
ORD
17h 14m
1 stop
Depart: Sat Nov 11 2017 Return: Wed Nov 15 2017 Trip spans 5 days
Spirit Airlines
Spirit Airlines
ORD
MDE
18h 58m
1 stop
MDE
ORD
9h 39m
1 stop
Depart: Mon Nov 27 2017 Return: Tue Dec 5 2017 Trip spans 9 days
Multiple Airlines
Multiple Airlines
ORD
CTG
10h 06m
1 stop
CTG
ORD
18h 38m
1 stop
Depart: Thu Feb 8 2018 Return: Fri Feb 16 2018 Trip spans 9 days
Interjet
Interjet
ORD
BOG
12h 55m
1 stop
BOG
ORD
23h 35m
1 stop
Depart: Wed Dec 6 2017 Return: Tue Dec 12 2017 Trip spans 7 days
Copa Airlines
Copa Airlines
ORD
BOG
16h 15m
1 stop
BOG
ORD
25h 22m
1 stop
Depart: Wed Jan 24 2018 Return: Mon Jan 29 2018 Trip spans 6 days
Spirit Airlines
Spirit Airlines
ORD
MDE
18h 52m
1 stop
MDE
ORD
9h 42m
1 stop
* Prices are per person and are for e–tickets and include all taxes & fees in USD.

We attempt to get accurate prices, however, prices are not guaranteed.

Here's why:

We’re not the seller.
At KAYAK we don’t set the prices, so it’s not possible for us to guarantee what other companies are selling.

We compile tonnes of data for you
Our service lets you quickly and easily compare results from hundreds of travel sites at once. In this sense, KAYAK is a search engine and we can't guarantee prices we find.

Why aren’t prices accurate 100% of the time?
Prices on airline seats, hotel rooms and car rentals can change frequently. Several people may also be trying to buy the same travel option simultaneously. As a result, you may find, on occasion, that certain prices are no longer available.

If you have more questions or if you have a bad price to report to us,
please send us an email and someone from our team will get back to you promptly.

^ The fares displayed in KAYAK ads found on other sites include all taxes and fees for economy class travel and were found by KAYAK users in the last 72 hours. Seats are limited and may not be available on all flights and days. Fares are subject to change and may not be available on all flights or dates of travel. Some carriers charge additional fees for extra checked bags. Please check the carriers' sites.
Airports
Origin

Chicago
$309
Destination

Medellin
$309
Cartagena
$323
Bogotá
$375
Barranquilla
$376