Find Deals on Flights from Chicago to South America

Depart
Return
1 adult
Adults
18-64
Seniors
65+
Youths
12-17
Children
2-11
Seat Infants
under 2
Lap Infants
under 2
Students
under 26
The price shown for each flight will be the average for all passengers including any infants.
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Dates flexible? Here are the best fares found in the past 48 hours...

Book cheap flights from Chicago to South America

(Round-trip)
Depart: Mon Jan 30 2017 Return: Tue Feb 7 2017 Trip spans 9 days
Spirit Airlines
Spirit Airlines
ORD
MDE
19h 10m
1 stop
MDE
ORD
20h 55m
1 stop
Depart: Thu Feb 23 2017 Return: Thu Mar 2 2017 Trip spans 8 days
Copa Airlines
Copa Airlines
ORD
BAQ
14h 09m
1 stop
BAQ
ORD
8h 20m
1 stop
Depart: Wed Apr 5 2017 Return: Tue Apr 11 2017 Trip spans 7 days
Major Airline
Major Airline
ORD
UIO
26h 37m
1 stop
UIO
ORD
29h 47m
1 stop
Depart: Sat Jan 28 2017 Return: Fri Feb 3 2017 Trip spans 7 days
JetBlue
JetBlue
ORD
CTG
25h 58m
1 stop
CTG
ORD
8h 17m
1 stop
Depart: Sat Jun 24 2017 Return: Sun Jul 2 2017 Trip spans 9 days
Avianca
Avianca
ORD
BOG
8h 26m
1 stop
BOG
ORD
8h 41m
1 stop
Depart: Sat Feb 18 2017 Return: Sat Feb 25 2017 Trip spans 8 days
Aeromexico
Aeromexico
ORD
BOG
22h 08m
1 stop
BOG
ORD
13h 04m
1 stop
Depart: Tue Feb 14 2017 Return: Mon Feb 20 2017 Trip spans 7 days
LATAM Airlines
LATAM Airlines
ORD
SMR
30h 40m
2 stops
SMR
ORD
23h 31m
2 stops
Depart: Sat Feb 4 2017 Return: Thu Feb 9 2017 Trip spans 6 days
Delta
Delta
MDW
CTG
6h 53m
1 stop
CTG
MDW
9h 01m
1 stop
Depart: Sat Dec 31 2016 Return: Thu Jan 12 2017 Trip spans 13 days
American Airlines
American Airlines
ORD
CCS
17h 33m
2 stops
CCS
ORD
20h 21m
2 stops
Depart: Tue Jan 17 2017 Return: Thu Jan 26 2017 Trip spans 10 days
LATAM Airlines
LATAM Airlines
ORD
GYE
30h 15m
2 stops
GYE
ORD
11h 24m
1 stop
Depart: Sun Feb 12 2017 Return: Fri Feb 17 2017 Trip spans 6 days
Spirit Airlines
Spirit Airlines
ORD
CTG
7h 31m
1 stop
CTG
ORD
8h 35m
1 stop
Depart: Wed Apr 26 2017 Return: Mon May 1 2017 Trip spans 6 days
Copa Airlines
Copa Airlines
ORD
BAQ
13h 54m
1 stop
BAQ
ORD
8h 20m
1 stop
Depart: Tue Jan 24 2017 Return: Tue Feb 14 2017 Trip spans 22 days
Major Airline
Major Airline
ORD
UIO
11h 56m
1 stop
UIO
ORD
9h 10m
1 stop
Depart: Sat Feb 11 2017 Return: Fri Feb 17 2017 Trip spans 7 days
Spirit Airlines
Spirit Airlines
ORD
CTG
18h 27m
1 stop
CTG
ORD
8h 35m
1 stop
Depart: Wed Mar 15 2017 Return: Mon Mar 20 2017 Trip spans 6 days
JetBlue
JetBlue
ORD
BOG
27h 11m
1 stop
BOG
ORD
12h 01m
1 stop
Depart: Sat Mar 4 2017 Return: Sat Mar 11 2017 Trip spans 8 days
Aeromexico
Aeromexico
ORD
BOG
22h 08m
1 stop
BOG
ORD
23h 03m
1 stop
Depart: Mon Mar 6 2017 Return: Sat Mar 11 2017 Trip spans 6 days
Copa Airlines
Copa Airlines
ORD
BAQ
13h 54m
1 stop
BAQ
ORD
8h 20m
1 stop
Depart: Fri May 12 2017 Return: Sun May 28 2017 Trip spans 17 days
Major Airline
Major Airline
ORD
BAQ
21h 48m
1 stop
BAQ
ORD
9h 30m
1 stop
Depart: Wed Apr 12 2017 Return: Sun Apr 16 2017 Trip spans 5 days
Avianca
Avianca
ORD
MDE
8h 20m
1 stop
MDE
ORD
8h 15m
1 stop
Depart: Sun Mar 19 2017 Return: Thu Mar 23 2017 Trip spans 5 days
Delta
Delta
MDW
CTG
6h 50m
1 stop
CTG
MDW
8h 17m
1 stop
* Prices are per person and are for e–tickets and include all taxes & fees in USD.

We attempt to get accurate prices, however, prices are not guaranteed.

Here's why:

We’re not the seller.
At KAYAK we don’t set the prices, so it’s not possible for us to guarantee what other companies are selling.

We compile tonnes of data for you
Our service lets you quickly and easily compare results from hundreds of travel sites at once. In this sense, KAYAK is a search engine and we can't guarantee prices we find.

Why aren’t prices accurate 100% of the time?
Prices on airline seats, hotel rooms and car rentals can change frequently. Several people may also be trying to buy the same travel option simultaneously. As a result, you may find, on occasion, that certain prices are no longer available.

If you have more questions or if you have a bad price to report to us,
please send us an email and someone from our team will get back to you promptly.

Airports
Origin

Chicago
only $298
only $448
Destination

Caracas
$549
Santa Marta
$441
Guayaquil
$574
Medellin
$298
Cartagena
$351
Quito
$379
Bogotá
$410
Barranquilla
$316