Find Cheap Flights from South America to Chicago

Depart
Return
1 adult
Adults
18-64
Seniors
65+
Youths
12-17
Children
2-11
Seat Infants
under 2
Lap Infants
under 2
The price shown for each flight will be the average for all passengers including any infants.
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Dates flexible? Here are the best fares found in the past 48 hours...

Book cheap flights from South America to Chicago

(Round-trip)
Depart: Thu Nov 9 2017 Return: Thu Nov 16 2017 Trip spans 8 days
Copa Airlines
Copa Airlines
CLO
ORD
8h 00m
1 stop
ORD
CLO
9h 08m
1 stop
Depart: Fri Nov 3 2017 Return: Sat Nov 11 2017 Trip spans 9 days
Spirit Airlines
Spirit Airlines
MDE
ORD
19h 43m
1 stop
ORD
MDE
18h 58m
1 stop
Depart: Fri Nov 3 2017 Return: Thu Nov 16 2017 Trip spans 14 days
Multiple Airlines
Multiple Airlines
MDE
ORD
19h 43m
1 stop
ORD
MDE
17h 35m
1 stop
Depart: Sun Jan 21 2018 Return: Sat Jan 27 2018 Trip spans 7 days
Interjet
Interjet
BOG
ORD
20h 45m
1 stop
ORD
BOG
21h 55m
1 stop
Depart: Wed Oct 25 2017 Return: Thu Nov 9 2017 Trip spans 16 days
Avianca
Avianca
GYE
ORD
19h 13m
2 stops
ORD
GYE
8h 40m
1 stop
Depart: Fri Nov 3 2017 Return: Sat Nov 11 2017 Trip spans 9 days
American Airlines
American Airlines
GYE
ORD
11h 53m
1 stop
ORD
GYE
10h 34m
1 stop
Depart: Sat Oct 21 2017 Return: Fri Oct 27 2017 Trip spans 7 days
Delta
Delta
UIO
ORD
17h 06m
2 stops
ORD
UIO
14h 11m
2 stops
Depart: Fri Nov 10 2017 Return: Sat Nov 25 2017 Trip spans 16 days
Aeromexico
Aeromexico
MDE
ORD
13h 29m
1 stop
ORD
MDE
15h 44m
1 stop
Depart: Thu Dec 14 2017 Return: Thu Feb 8 2018 Trip spans 57 days
Copa Airlines
Copa Airlines
CLO
ORD
18h 50m
1 stop
ORD
CLO
30h 08m
1 stop
Depart: Wed Dec 6 2017 Return: Tue Jan 16 2018 Trip spans 42 days
Spirit Airlines
Spirit Airlines
CTG
ORD
10h 20m
1 stop
ORD
CTG
7h 29m
1 stop
Depart: Tue Nov 14 2017 Return: Tue Nov 21 2017 Trip spans 8 days
Multiple Airlines
Multiple Airlines
CTG
ORD
18h 38m
1 stop
ORD
CTG
10h 06m
1 stop
Depart: Wed Nov 8 2017 Return: Wed Nov 15 2017 Trip spans 8 days
Avianca
Avianca
GYE
ORD
8h 29m
1 stop
ORD
GYE
8h 40m
1 stop
Depart: Fri Oct 27 2017 Return: Wed Nov 22 2017 Trip spans 27 days
Copa Airlines
Copa Airlines
BOG
ORD
8h 43m
1 stop
ORD
BOG
11h 22m
1 stop
Depart: Wed Nov 8 2017 Return: Sun Nov 12 2017 Trip spans 5 days
American Airlines
American Airlines
GYE
ORD
15h 17m
2 stops
ORD
GYE
14h 26m
1 stop
Depart: Fri Nov 3 2017 Return: Sat Nov 11 2017 Trip spans 9 days
Interjet
Interjet
BOG
ORD
11h 35m
1 stop
ORD
BOG
21h 55m
1 stop
Depart: Wed Dec 6 2017 Return: Mon Jan 15 2018 Trip spans 41 days
Multiple Airlines
Multiple Airlines
CTG
ORD
10h 20m
1 stop
ORD
CTG
9h 21m
1 stop
Depart: Wed Dec 6 2017 Return: Thu Jan 18 2018 Trip spans 44 days
Spirit Airlines
Spirit Airlines
CTG
ORD
10h 20m
1 stop
ORD
CTG
18h 21m
1 stop
Depart: Sun Nov 12 2017 Return: Mon Nov 20 2017 Trip spans 9 days
Aeromexico
Aeromexico
MDE
ORD
22h 54m
1 stop
ORD
MDE
15h 44m
1 stop
Depart: Thu Nov 2 2017 Return: Mon Nov 20 2017 Trip spans 19 days
Copa Airlines
Copa Airlines
BOG
ORD
8h 43m
1 stop
ORD
BOG
8h 41m
1 stop
Depart: Mon Oct 23 2017 Return: Sun Oct 29 2017 Trip spans 7 days
Delta
Delta
UIO
ORD
14h 53m
2 stops
ORD
UIO
16h 22m
1 stop
* Prices are per person and are for e–tickets and include all taxes & fees in USD.

We attempt to get accurate prices, however, prices are not guaranteed.

Here's why:

We’re not the seller.
At KAYAK we don’t set the prices, so it’s not possible for us to guarantee what other companies are selling.

We compile tonnes of data for you
Our service lets you quickly and easily compare results from hundreds of travel sites at once. In this sense, KAYAK is a search engine and we can't guarantee prices we find.

Why aren’t prices accurate 100% of the time?
Prices on airline seats, hotel rooms and car rentals can change frequently. Several people may also be trying to buy the same travel option simultaneously. As a result, you may find, on occasion, that certain prices are no longer available.

If you have more questions or if you have a bad price to report to us,
please send us an email and someone from our team will get back to you promptly.

Airports
Origin

Cali
$415
Guayaquil
$452
Medellin
$428
Cartagena
$435
Quito
$493
Bogotá
$423
Destination

Chicago
$415