MAD - VVI

$422 Find Cheap Flights from Madrid to Santa Cruz de la Sierra

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Madrid to Santa Cruz de la Sierra departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Santa Cruz de la Sierra

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Madrid to Santa Cruz de la Sierra, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Madrid to Santa Cruz de la Sierra, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Madrid to Santa Cruz de la Sierra (MAD-VVI)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Madrid to Santa Cruz de la Sierra that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Madrid to Santa Cruz de la Sierra

Sun, Feb 15 - Mon, Mar 16
Iberia Logo
9:00 pm - 3:00 amMAD-VVI
11h 00mnonstop
Iberia Logo
10:05 pm - 1:55 pmVVI-MAD
10h 50mnonstop
$843Iberia
Find Deal
Tue, Mar 17 - Tue, Apr 14
Avianca Logo
1:20 am - 2:35 amMAD-VVI
30h 15m1 stop
Avianca Logo
2:55 am - 11:30 pmVVI-MAD
14h 35m1 stop
$847Avianca
Find Deal
Sun, Feb 15 - Fri, Feb 27
Avianca Logo
1:20 am - 2:35 amMAD-VVI
30h 15m1 stop
Avianca Logo
3:40 am - 1:25 pmVVI-MAD
28h 45m1 stop
$887Avianca
Find Deal
Sun, Nov 9 - Sat, Nov 15
Avianca Logo
1:20 am - 2:35 amMAD-VVI
30h 15m1 stop
Avianca Logo
3:40 am - 4:35 amVVI-MAD
19h 55m1 stop
$962Avianca
Find Deal
Wed, Nov 12 - Wed, Nov 26
Avianca Logo
10:50 am - 2:35 amMAD-VVI
20h 45m1 stop
Avianca Logo
3:40 am - 11:20 pmVVI-MAD
14h 40m1 stop
$963Avianca
Find Deal
Thu, Nov 6 - Mon, Nov 17
Avianca Logo
1:20 am - 2:35 amMAD-VVI
30h 15m1 stop
Avianca Logo
3:40 am - 1:25 pmVVI-MAD
28h 45m1 stop
$994Avianca
Find Deal
Fri, Oct 31 - Mon, Nov 17
Avianca Logo
10:50 am - 2:35 amMAD-VVI
20h 45m1 stop
Avianca Logo
3:40 am - 1:25 pmVVI-MAD
28h 45m1 stop
$995Avianca
Find Deal
Wed, Nov 12 - Wed, Nov 26
Multiple Airlines Logo
9:10 pm - 2:35 amMAD-VVI
34h 25m3 stops
Multiple Airlines Logo
3:40 am - 11:20 amVVI-MAD
26h 40m3 stops
$1,006Multiple Airlines
Find Deal
Sun, Mar 22 - Sat, Apr 18
United Airlines Logo
11:05 am - 10:50 pmMAD-VVI
40h 45m2 stops
United Airlines Logo
1:15 am - 8:05 amVVI-MAD
48h 50m2 stops
$1,084United Airlines
Find Deal
Mon, Nov 24 - Sat, Dec 6
United Airlines Logo
11:05 am - 10:46 pmMAD-VVI
40h 41m2 stops
United Airlines Logo
1:09 am - 8:05 amVVI-MAD
25h 56m2 stops
$1,088United Airlines
Find Deal

Everything you should know

Our travelers' advice
AI-generated summary based on content written by travel experts
Air Europa offers speedy Wi-Fi for all needs.
Iberia serves Spanish cuisine with two meals onboard.
Expert advice
Expert advice
Expert advice
Expert advice
Top airlines
Iberia
Cheapest • from $843 (round-trip)
Air Europa
Best reviews • 7.0 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
3 weeks
in advance
Our data shows that travelers who book at least 3 weeks in advance save around 20% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
May
Cheapest • 25% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Nonstop flights
5 days a week
There are direct flights from Madrid to Santa Cruz de la Sierra 5 days a week: Mon, Wed, Fri, Sat, Sun.
Direct flights
Direct flights
Direct flights
Direct flights
Cheapest round-trip
$843
Overall average: $929
Iberia
Sun 2/15Mon 3/16
MAD - VVI • Non-stop
Cheapest one-way
$422
Typical prices: $346-452
Avianca
Wed 3/4
MAD - VVI • 1 stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santa Cruz de la Sierra!
Booking Insights

KAYAK's insights & trends for Madrid to Santa Cruz de la Sierra flights

Get data-powered insights and trends into flights from Madrid to Santa Cruz de la Sierra to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Madrid to Santa Cruz de la Sierra?

The average price of all round-trip flights from Madrid to Santa Cruz de la Sierra clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santa Cruz de la Sierra on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Monday is the most expensive day to fly from Madrid to Santa Cruz de la Sierra. For your return ticket, we recommend flying on a Wednesday and avoiding Saturdays for the best deals.

What is the cheapest month to fly from Madrid to Santa Cruz de la Sierra?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Madrid to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Madrid to Santa Cruz de la Sierra is May, where tickets cost $791 (return) on average. On the other hand, the most expensive months are December and August, where the average cost of round-trip tickets is $1,431 and $1,389 respectively.

Can I save money by flying with a layover from Madrid to Santa Cruz de la Sierra?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $837, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Madrid to Santa Cruz de la Sierra?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Madrid to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Madrid to Santa Cruz de la Sierra, you should book around 3 weeks before departure, which saves you about 20% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Expert advice

Expert advice for your flight from Madrid to Santa Cruz de la Sierra

 
Snippets provided in this section are AI-generated based on a summarization of KAYAK-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Airlines
Iberia

Iberia’s Business class offers roomy seating with all-aisle access and comfortable bedding.


Enjoy Spanish cuisine with two meals and a variety of beverages on long-haul flights.

Read more about Iberiaby Marisa Garcia
Air Europa

Air Europa offers speedy Wi-Fi with packages for all needs during your flight.


Air Europa provides special meals including diabetic, gluten-free, and vegan options on transatlantic flights.

Our travel experts
Marisa Garcia

Marisa Garcia

Expert on Iberia

Marisa Garcia

Marisa Garcia

Marisa knows planes inside and out, spending 16 years working on aircraft in hangars at airports around the world. She is an aviation industry expert, specialized in airline interiors and regulations. Ten years ago, she pivoted to journalism. She shares her insights in leading aviation, travel, and business publications and on her site FlightChic.

Read more
Laura Ratliff

Laura Ratliff

Expert on Air Europa

Laura Ratliff

Laura Ratliff

Laura Ratliff is a New York-based writer and editor. She lives in downtown Brooklyn with her husband and their beloved dogs. Originally from Texas, she now considers New York City her home. She typically spends more than 200,000 miles on a plane each year and stays in plenty of hotels.

Read more

Good to know

Low seasonApril
Cheapest flight$422
Best time to beat the crowds with an average 15% drop in price.
Most popular time to fly with an average 36% increase in price.
Flight from Madrid to Santa Cruz de la Sierra

When to book flights from Madrid to Santa Cruz de la Sierra

Are your dates flexible? Find out the best times to travel from Madrid to Santa Cruz de la Sierra based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Madrid to Santa Cruz de la Sierra

  • What is the cheapest flight from Madrid to Santa Cruz de la Sierra?

    In the last 3 days, the lowest price for a flight from Madrid to Santa Cruz de la Sierra was $422 for a one-way ticket and $843 for a round-trip.

  • Do I need a passport to fly between Madrid and Santa Cruz de la Sierra?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Madrid and on arrival in Santa Cruz de la Sierra.

  • Which airlines offer Wi-Fi service onboard planes from Madrid to Santa Cruz de la Sierra?

    Iberia, Lufthansa, Vueling, and Qatar Airways offer inflight Wi-Fi service on the Madrid to Santa Cruz de la Sierra flight route.

  • Which aircraft models fly most regularly from Madrid to Santa Cruz de la Sierra?

    The Airbus A330-200 is the aircraft model that flies most regularly on the Madrid to Santa Cruz de la Sierra flight route.

  • Which airline alliances offer flights from Madrid to Santa Cruz de la Sierra?

    Star Alliance, and SkyTeam are the airline alliances operating flights between Madrid and Santa Cruz de la Sierra, with Star Alliance being the most commonly used for this route.

  • On which days can I fly direct from Madrid to Santa Cruz de la Sierra?

    You can catch a nonstop flight from Madrid to Santa Cruz de la Sierra on on Monday, Wednesday, Friday, Saturday, and Sunday.

  • Which is the best airline for flights from Madrid to Santa Cruz de la Sierra, Air Europa or BoA?

    The two airlines most popular with KAYAK users for flights from Madrid to Santa Cruz de la Sierra are Air Europa and BoA. With an average price for the route of $980 and an overall rating of 7.0, Air Europa is the most popular choice. BoA is also a great choice for the route, with an average price of $1,207 and an overall rating of 6.8.

  • How does KAYAK find such low prices on flights from Madrid to Santa Cruz de la Sierra?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Madrid to Santa Cruz de la Sierra.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Madrid to Santa Cruz de la Sierra?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Cruz de la Sierra from Madrid is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Madrid to Santa Cruz de la Sierra?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Cruz de la Sierra with an airline and back to Madrid with another airline. Booking your flights between Madrid and VVI can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Madrid to Santa Cruz de la Sierra?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Cruz de la Sierra from Madrid up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Madrid to Santa Cruz de la Sierra

  • Looking for a cheap flight? 25% of our users found flights on this route for $513 or less one-way.

Prefer to fly direct from Madrid to Santa Cruz de la Sierra?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl.
Find which airlines fly direct from Madrid Barajas Airport to Santa Cruz de la Sierra Viru Viru Intl Airport, which days they fly and book direct flights.

Direct departures

Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl

Monday

Air Europa, BoA

Air Europa, BoA

Wednesday

Air Europa, BoA

Air Europa, BoA

Friday

BoA

BoA

Saturday

Air Europa

Air Europa

Sunday

BoA, Air Europa

BoA, Air Europa

See more direct flights

Direct returns

Santa Cruz de la Sierra Viru Viru Intl to Madrid Barajas

Monday

BoA, Air Europa

BoA, Air Europa

Tuesday

Air Europa, BoA

Air Europa, BoA

Thursday

Air Europa, BoA

Air Europa, BoA

Saturday

Air Europa, BoA

Air Europa, BoA

Sunday

BoA

BoA

See more direct flights

Reviews of the top 3 airlines serving from Madrid to Santa Cruz de la Sierra

 
See real verified KAYAK customer reviews for airlines flying from Madrid to Santa Cruz de la Sierra. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Madrid to Santa Cruz de la Sierra? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.0
Air EuropaOverall score based on 562 reviews
7.5Crew
7.1Boarding
6.9Comfort
6.6Entertainment
6.3Food
Airline reviews

Great staff, just very far from the main terminal, had to run to connect my flight. I had 90 minutes to spare. But my flight from Chicago was delayed also.

8.0 ExcellentJustin, Sep 2025MAD - AGP
Read more Air Europa reviews

Great staff, just very far from the main terminal, had to run to connect my flight. I had 90 minutes to spare. But my flight from Chicago was delayed also.

My luggage is lost and nowhere to be found, no response from airline

Boarding was a shitshow. Had to bus to the gate. No separate bus and boarding process for Business Class.

The plane was very old, no power outlets. We also had to wait a long time to board. They kept moving us to different lines before we actually could step foot on the plane. We ended up being delayed an hour but we were never told or informed for any reason. After the meal I asked for a coffee which the flight attendant forgot and I had to ask again. Overall not the worst but not the best experience.

Need to pay for headsets, water, or any extra except air to breath.

Sitting space was very tight and I am not big or fat (I am 5'10" 178 Lb), so eating was very challenging. The rest was good.

Sitting space was very tight, so eating was difficult. But everything else was good.

12 hours flight. Only one meal, not enough food. At the galley only water during the flight. Lavatories not clean. Headsets at extra cost.

Need to pay for a cup of water. No food. Need to pay for headsets.

Everything should improve! Service like a low cost but prices like a premium airline. Crew in general with bad manners arguing for everything. You pay for priority access but then they use buses, so your loose your advantage to put your carry on first. That was the purpose for paying for priority. Bording is a nightmare, people accessing the plane for bothering doors, front and rear, no matter which line do you have.

The crew was great, professional and polite. Good meal too. The flight was full and we departed on time out of Miami. I did feel cramped in my seat for the long overnight flight, which made it hard to sleep

This airline and their crew is so professional and kind, the trip was short and easy.

It was a very smooth process. Everything about the Airline like a well oiled machine.

Muy horrible experiencia, cambiaron dos veces la hora del vuelo resultando en una espera exagerada. No dan información oportuna. Abordadnos el avión retrasado el vuelo y esperamos dentro del avión por 35’ más mientras subían como 6 carros de cajas al avión. Muy mala logística y servicio.

6 horas de retraso en el vuelo sin ninguna explicación por parte de la aerolínea.

Always late, the service is a sandwich, no comfort at all…

They had a problem with their air conditioning system and we almost had heat strokes because they blasted HEATED AIR for almost 40 minutes and there was literally no air. This is the worst airline in Bolivia. Can't believe we have no other options sometimes.

BOA is truly the worst airline in Bolivia. It's a shame we sometimes need to use it cause we have no more options.

BOA airplanes are so old and dirty, the bathroom was so nasty, it smelled so bad and had tape all over the cabinets. My chair wouldn't recline, we had no entertainment, the flight was super cold. The only positive thing about this flight is that I feel it's so old that they even serve food, like in the past! I travel a lot and nowadays the companies only serve some snacks or sometimes offer something to eat if you pay. Not the case with this flight. Never again flying with BOA. They are definetly the worst.

This airline is always THE WORST. They seem to have flights moving to other times (late) 90% of the time. The airplanes are old, and the landing (i really don't know why) is 90% of the time shaky. I actually never buy tickets from BOA, I prefer other airlines by far.

Usb plugs for charging your phone does not work in every flight. uncomfortable chairs even in higher categories.

Luggage lost and nowhere to be found, no response from either airline regarding my bag

Not what it used to be. The sale of food makes them look greedy!

No food, terms when selling are not clear. To pricy for the service in general

It was horrible. My experience with Avianca. I didn’t know it was Pakistan international Airlines but anyway, whatever it is it is bad horrible you guys need to upgrade everything in those planes. And you guys charge $130 for a carry-on did they wanna let me in with my carry-on that I travel everywhere with the luggage you guys are such a dog thank you

why did we have to go through security mid flight

The incoming plane was late and no information was shared. They even announced we would board in 10 muntes 40 minutes prior to the plane arriving, and the website said until takeoff that we had taken off an hour earlier

Seats are very tight even in Plus, no complimentary snacks or beverage

Flight to Bogotá delayed by 3 h Missed connection from Bogotá to Guayaquil. Avianca unable to bring us to Baltra on time Overall delay 36h. We missed boat departure from galagos. Overall 10 day trip needed to be cancelled. Avianca was completely un-professional.

i think the flight was late because they were so strict about measuring everyone's personal items to try and charge them $119. It was really petty and made us late.

Everything you need to know for your flight from Madrid to Santa Cruz de la Sierra

Information on your arrival and departure airports

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