$151 Find Cheap Flights from San Diego to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Diego to South America departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from San Diego to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$533
Bogotá
Bogotá1 stop$357
Buenos Aires
Buenos Aires1 stop$725
Rio de Janeiro
Rio de Janeiro1 stop$750
Santiago
Santiago1 stop$691
Cartagena
Cartagena1 stop$457
Quito
Quito1 stop$381
Guayaquil
Guayaquil1 stop$430
Cali
Cali2 stops$542
Cusco
Cusco2 stops$575
Montevideo
Montevideo2 stops$972
Asuncion
Asuncion1 stop$1,039
Lima
Lima1 stop$533
Bogotá
Bogotá1 stop$357
Buenos Aires
Buenos Aires1 stop$725
Rio de Janeiro
Rio de Janeiro1 stop$750
Santiago
Santiago1 stop$691
Cartagena
Cartagena1 stop$457
Quito
Quito1 stop$381
Guayaquil
Guayaquil1 stop$430
Cali
Cali2 stops$542
Cusco
Cusco2 stops$575
Montevideo
Montevideo2 stops$972
Asuncion
Asuncion1 stop$1,039

Book Cheap San Diego to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Diego to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Diego to South America

Wed, May 13 - Wed, May 20
Copa Airlines Logo
10:00 pm - 5:26 pm
SAN
-
BOG
17h 26m
1 stop
Copa Airlines Logo
4:59 am - 6:30 pm
BOG
-
SAN
15h 31m
1 stop
$357Copa Airlines
Wed, Sep 23 - Wed, Sep 30
United Airlines Logo
8:00 am - 7:20 pm
SAN
-
BOG
9h 20m
1 stop
United Airlines Logo
8:30 am - 7:55 pm
BOG
-
SAN
13h 25m
2 stops
$362United Airlines
Tue, Oct 20 - Thu, Nov 12
United Airlines Logo
8:00 am - 4:54 am
SAN
-
BOG
18h 54m
1 stop
United Airlines Logo
8:15 am - 9:53 pm
BOG
-
SAN
16h 38m
1 stop
$371United Airlines
Sun, May 10 - Thu, May 14
Delta Logo
10:25 pm - 1:40 pm
SAN
-
BOG
13h 15m
1 stop
Delta Logo
2:55 pm - 9:39 am
BOG
-
SAN
20h 44m
1 stop
$376Delta
Wed, May 13 - Wed, May 20
GOL Logo
7:15 am - 10:30 pm
SAN
-
BOG
13h 15m
1 stop
GOL Logo
6:30 am - 10:51 pm
BOG
-
SAN
18h 21m
2 stops
$378GOL
Thu, May 14 - Fri, May 22
American Airlines Logo
6:15 am - 10:30 pm
SAN
-
BOG
14h 15m
1 stop
American Airlines Logo
12:50 pm - 10:58 am
BOG
-
SAN
24h 08m
1 stop
$381American Airlines
Wed, May 13 - Sun, May 17
Copa Airlines Logo
10:00 pm - 12:32 pm
SAN
-
UIO
12h 32m
1 stop
Copa Airlines Logo
3:07 am - 6:30 pm
UIO
-
SAN
17h 23m
1 stop
$381Copa Airlines
Mon, Oct 19 - Sun, Nov 8
Delta Logo
9:40 pm - 1:40 pm
SAN
-
BOG
14h 00m
1 stop
Delta Logo
9:00 am - 8:18 pm
BOG
-
SAN
14h 18m
1 stop
$385Delta
Mon, May 11 - Sat, May 16
LATAM Airlines Logo
6:45 pm - 5:50 pm
SAN
-
BOG
21h 05m
2 stops
LATAM Airlines Logo
10:35 am - 11:15 pm
BOG
-
SAN
14h 40m
2 stops
$390LATAM Airlines
Sun, May 10 - Wed, May 13
LATAM Airlines Logo
6:15 am - 10:10 pm
SAN
-
LIM
13h 55m
1 stop
LATAM Airlines Logo
12:00 pm - 11:15 pm
LIM
-
SAN
13h 15m
1 stop
$545LATAM Airlines
Booking Insights

KAYAK's insights & trends for San Diego to South America flights

Get data-powered insights and trends into flights from San Diego to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Diego to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Diego to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Diego to South America is April, when tickets cost $177 (return) on average. On the other hand, the most expensive months are December and January, when the average cost of round-trip tickets is $1,644 and $238 respectively.

How far in advance should I book a flight from San Diego to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Diego to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Diego to South America, you should book around 2 weeks before departure, which saves you about 8% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 17 weeks before departure.

Good to know

Low seasonNovember
Cheapest flight$151
Best time to beat the crowds with an average 11% drop in price.
Most popular time to fly with an average 27% increase in price.
Flight from San Diego to Quito

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Diego to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Diego to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Diego to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Diego to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Diego to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Diego to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Diego to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Diego to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from San Diego to South America

 
Need help choosing which airline to fly with from San Diego to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8465 reviews
8.5Crew
7.8Entertainment
7.2Food
8.1Boarding
7.9Comfort
Airline reviews

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

10.0 ExcellentTeresa, Apr 2026
SMF - LAX
Read more Delta reviews

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

N Everything was perfect from boarding to assistance to baggage in Tampa

Loved the crew! Sucks that we went from 1 hour and 8 minute layover to a 3 hour layover. But weather sucks like that.

Fast, lovely scenery, great info on the Delta flight screen about landmarks we were flying over. Great landing!

Long flight but comfortable and not freezing as I have experienced on Hawaiian flights to the islands. They gave us blankets just in case. Nice touch.

I took seat 15A in anticipation of window seat, there is no window.

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

Entire experience from check in to landing was amazing the flight crew was excellent and friendly. Seats were comfortable.

Boarding was confusing from staff telling going to preboard and than to group 1 Airplane was not cooling at the beginning

Avoid at all costs. My wife had to stay back on a connecting flight as her parents flight was delayed. 10 days later on the way back they cancelled all our flights. We had to rebook all four of us on the next days flight.

Friendly crew, good food options, food not the best and seats not as comfy but that’s typical.

The food is terrible I ask for water never got transport my mother we’re late and my sister from Lima was the worst waiting to long for wheelchair

Copa staff at PTY and one particular crew member were unhelpful & rude.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

I always enjoy flying Copa. There are very few airlines where I can enjoy a comfortable sleep in-flight. The snacks weren't the best, but they sufficed. The in-flight entertainment was fantastic, and I crossed another movie off my watch list.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

We were not allowed to carry a bottle of water onto the 8 hour flight.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor, the airline was not able to help me move flights.

The way the Pilot made all announcements, specially the way he congratulated the entire crew as the best team ever, making a comment that due to them they were able to shorter the delay to the destination. Amazing flight .

Some crew were unfriendly or in some cases just straight up rude.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Outstanding service, efficient & friendly crew, flight was safe, comfortable & on time

United Airline crews were very friendly and very attentive. 12 hours flight was gone like in a shorter one.

Food was surprisingly delicious. Space in the seat is horrible when the seating front is reclined. Movie offerings were terrible. Crew was friendly and helpful.

Flight itself excellent, but delayed so missed connection & got to destination 2 hrs later

Due to cancellation of connecting flight (Lufthansa) I didn’t fly with United

It was a red-eye, but the flight felt surprisingly quick. The seats were very comfortable, and that made resting much easier. I also want to thank the gentleman seated next to me, who graciously moved so my mom could sit beside me. We slept almost the entire way. The cabin crew was respectful in not disturbing us, while also being courteous and professional throughout. Thank you, United.

Boarding was again a "free for all". We were boarding group 4, and almost the entire plane was able to board before us. It's a shame that someone who follows the rules, gets the short end of the stick. Not fair.

It was perfect! I've never flown with United before, but I definitely will in the future

Boarding gate at LAX was too crowded—two gates next to one another

On time departure and early arrival. Flight attendant very nice.

The business class layout of chairs was weired. You are sitting directly across stranger.,

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

Friendly crew is the only nice thing. Seats uncomfortable. Food and snacks horrible. Movies were the same as the first 10 hour flight two weeks before

Was not able to do a online check-in because the American Airlines system doesn't store our visa or other passport information, allowing us to have a trouble-free check-in. We were forced to have to check-in at the counter which Changes are upgrade status given that we were not able to check in much earlier.

Good flight, seated and had a water within 5 minutes. Crew was hospitable.

We left at 1030 am pacific from LA and supposed to land at 7 pm Eastern in NY. They made a detour, stopped in Philadelphia and didn’t land till 1130 PM Eastern!!! Worst flight experience with no pilot communication with no explanation as to what was going on. Everyone was very frustrated to say the least.

I cancelled my ticket less than 24 hours deadline but I didn’t get refunded.

Flight boarded from Gate 159B, the farthest gate in the LAX Bradley Terminal. While the flight operated on time, the first class cabin attendant made no recognition of my being an Advantage Executive Platinum member.

Everything you need to know for your flight to South America

Information on your arrival and departure airports